HTLV-1遺伝子(HBZ,Tax)のATLL腫瘍発生・臨床病理への関与の解明

• 研究課題/領域番号: 20390104
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 人体病理学
• 研究機関: 久留米大学
• 研究代表者: 大島 孝一 久留米大学, 医学部, 教授 (50203766)
• 研究分担者: 杉田 保雄 久留米大学, 医学部, 教授 (80216316)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 19,890千円 (直接経費: 15,300千円、間接経費: 4,590千円); 2010年度: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円); 2009年度: 3,640千円 (直接経費: 2,800千円、間接経費: 840千円); 2008年度: 12,480千円 (直接経費: 9,600千円、間接経費: 2,880千円)
• キーワード: ウイルス / 病理学 / ATLL / HTLV-I / 腫瘍 / HBZ / HTLV-1

研究概要

成人T細胞性白血病/リンパ腫(ATLL)の発症において、HTLV-1のtax遺伝子が中心的な役割を担うと考えられてきたが、新規に、HBZ遺伝子が、taxを抑制する可能性が示唆されている。HBZの発現を解析したところ、ATLL培養細胞やモデルマウスで発現が確認でき、ATLL症例でもHBZの発現が確認できた。一方、Taxの発現は少数であった。また、制御性T 細胞に関連したFoxP3の発現が、ATLL症例の約3割でみられ、これらの症例には、高率に日和見感染症がみられた。

研究成果

• [雑誌論文] Regression of rectal mucosa-associated lymphoid tissue (MALT) lymphoma after antibiotic treatments. (2010)
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  • 雑誌名: Pathol Int. 60(6) ページ: 438-42
  • NAID: 10029332141
• [雑誌論文] Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL) (2010)
  • 著者名/発表者名: Niino D, Komohara Y, Murayama T, Aoki R, Kimura Y, Hashikawa K, Kiyasu J, Takeuchi M, Suefuji N, Sugita Y, Takeya M, Ohshima K
  • 雑誌名: Pathol Int. 60(4) ページ: 278-83
  • NAID: 10029331443
• [雑誌論文] Ueda RPhase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody (2010)
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  • 雑誌名: in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma J Clin Oncol. 20;28(9) ページ: 1591-8
• [雑誌論文] Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in Peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell Lymphoma. (2010)
  • 著者名/発表者名: Asano N, Suzuki R, Ohshima K, Kagami Y, Ishida F, Yoshino T, Ogawa H,Morishima Y, Nakamura S
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  • NAID: 10026401157
• [雑誌論文] Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma. (2010)
  • 著者名/発表者名: Sato H, Oka T, Shinnou Y, Kondo T, Washio K, Takano M, Takata K, Morito T, Huang X, Tamura M, Kitamura Y, Ohara N, Ouchida M, Ohshima K, Shimizu K, Tanimoto M, Takahashi K, Matsuoka M, Utsunomiya A, Yoshino T
  • 雑誌名: Am J Pathol. 176(1) ページ: 402-15
• [雑誌論文] Linkage of expression of chemokine receptors (OXCR3 and CCR4) and cytotoxic molecules in Peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell Lymphoma. (2010)
  • 著者名/発表者名: Asano N, Ohshima K, et al.
  • 雑誌名: Int J Hematol. 巻: 91 ページ: 426-435
  • 査読あり
• [雑誌論文] Phase I study of KW-0761 a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma (2010)
  • 著者名/発表者名: Yamamoto K, Ohshima K, et al.
  • 雑誌名: J Clin Oncol. 巻: 28 ページ: 1591-1598
  • 査読あり
• [雑誌論文] Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL). (2010)
  • 著者名/発表者名: Niino D, Ohshima K, et al.
  • 雑誌名: Pathol Int. 巻: 60 ページ: 278-283
  • NAID: 10029331443
  • 査読あり
• [雑誌論文] Regression of rectal mucosa-associated lymphoid tissue (MALI) lymphoma after antibiotic treatments. (2010)
  • 著者名/発表者名: Niino D, Ohshima K, et al.
  • 雑誌名: Pathol Int 巻: 60 ページ: 438-442
  • 査読あり
• [雑誌論文] Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma (2010)
  • 著者名/発表者名: Sato H, Ohshima K, et al.
  • 雑誌名: Am J Pathol. 176 ページ: 402-15
  • 査読あり
• [雑誌論文] Prognostic significance of S-phase kinase-associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma : effects of rituximab. (2009)
  • 著者名/発表者名: Seki R, Ohshima K, Fujisaki T, Uike N, Kawano F, Gondo H, Makino S, Eto T, Moriuchi Y, Taguchi F, Kamimura T, Tsuda H, Shimoda K, Okamura T
  • 雑誌名: Ann Oncol. 4(Epub ahead of print)
• [雑誌論文] Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis. (2009)
  • 著者名/発表者名: Nomura Y, Takeuchi M, Yoshida S, Sugita Y, Niino D, Kimura Y, Shimizu K, Aoki R, Suefuji N, Hirose S, Kikuchi M, Ohshima K.
  • 雑誌名: Pathol Int. 59(9) ページ: 631-5
  • NAID: 10027381460
• [雑誌論文] Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era. (2009)
  • 著者名/発表者名: Seki R, Ohshima K, Fujisaki T, Uike N, Kawano F, Gondo H, Makino S, Eto T, Moriuchi Y, Taguchi F, Kamimura T, Tsuda H, Ogawa R, Shimoda K, Yamashita K, Suzuki K, Suzushima H, Tsukazaki K, Higuchi M, Utsunomiya A, Iwahashi M, Imamura Y, Tamura K, Suzumiya J, Yoshida M, Abe Y, Matsumoto T, Okamura T
  • 雑誌名: Cancer Sci. 100(10) ページ: 1842-7
  • NAID: 10027195531
• [雑誌論文] Phase I/II Study of Concurrent Chemoradiotherapy for Localized Nasal Natural Killer/T-Cell Lymphoma : Japan Clinical Oncology Group Study JCOG0211. (2009)
  • 著者名/発表者名: Yamaguchi M, Tobinai K, Oguchi M, Ishizuka N, Kobayashi Y, Isobe Y, Ishizawa K, Maseki N, Itoh K, Usui N, Wasada I, Kinoshita T, Ohshima K, Matsuno Y, Terauchi T, Nawano S, Ishikura S, Kagami Y, Hotta T, Oshimi K
  • 雑誌名: J Clin Oncol. 5(Epub ahead of print)
• [雑誌論文] Hepatocellular apoptosis associated with cytotoxic T/natural killer-cell infiltration in chronic active EBV infection. (2009)
  • 著者名/発表者名: Nomura Y, Kimura H, Karube K, Yoshida S, Sugita Y, Niino D, Shimizu K, Kimura Y, Aoki R, Kiyasu J, Takeuchi M, Hashikawa K, Hirose S, Ohshima K
  • 雑誌名: Pathol Int. 59(7) ページ: 438-42
  • NAID: 10027380607
• [雑誌論文] Clinical significance of co-expression of CD21 and LFA-1 in B-cell lymphoma. (2009)
  • 著者名/発表者名: Tanimoto K, Yakushijin Y, Fujiwara H, Otsuka M, Ohshima K, Sugita A, Sakai A, Hato T, Hasegawa H, Yasukawa M
  • 雑誌名: Int J Hematol. 89(4) ページ: 497-507
  • NAID: 10025161350
• [雑誌論文] Oncogene associated cDNA microarray analysis shows PRAME gene expression is a marker for response to anthracycline containing chemotherapy in patients with diffuse large B-cell lymphoma. (2009)
  • 著者名/発表者名: Kawano R, Karube K, Kikuchi M, Takeshita M, Tamura K, Uike N, Eto T, Ohshima K, Suzumiya J
  • 雑誌名: J Clin Exp Hematop. 49(1) ページ: 1-7
  • NAID: 10025683555
• [雑誌論文] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity. (2009)
  • 著者名/発表者名: Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
  • 雑誌名: Int J Cancer. 1;124(11) ページ: 2607-15
• [雑誌論文] Expression of CXCL12 on pseudopalisading cells and proliferating microvessels in glioblastomas : an accelerated growth factor in glioblastomas. (2009)
  • 著者名/発表者名: Komatani H, Sugita Y, Arakawa F, Ohshima K, Shigemori M
  • 雑誌名: Int J Oncol. 34(3) ページ: 665-72
• [雑誌論文] Correlation of decreased survival and IL-18 in bone metastasis. (2009)
  • 著者名/発表者名: Okamoto M, Azuma K, Hoshino T, Imaoka H, Ikeda J, Kinoshita T, Takamori S, Ohshima K, Edakuni N, Kato S, Iwanaga T, Aizawa H
  • 雑誌名: Intern Med. 48(10) ページ: 763-73
  • NAID: 130000121774
• [雑誌論文] for the International Peripheral T-cell Lymphoma Project. The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma : analysis of 126 patients from the International Peripheral T-cell Lymphoma Project. (2009)
  • 著者名/発表者名: Suzumiya J, Ohshima K, Tamura K, Karube K, Uike N, Tobinai K, Gascoyne RD, Vose JM, Armitage JO, Weisenburger DD
  • 雑誌名: Ann Oncol. 20 ページ: 715-721
• [雑誌論文] rray comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma. (2009)
  • 著者名/発表者名: Nakagawa M, Nakagawa-Oshiro A, Karnan S, Tagawa H, Utsunomiya A, Nakamura S, Takeuchi I, Ohshima K, Seto M
  • 雑誌名: Clin Cancer Res. 1;15(1) ページ: 30-8
• [雑誌論文] Array comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma (2009)
  • 著者名/発表者名: Nakagawa M, Ohshima K, et al.
  • 雑誌名: Clin Cancer Res 15 ページ: 30-38
  • 査読あり
• [雑誌論文] The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma : analysis of 126 patients from the International Peripheral T-cell Lymphoma Project (2009)
  • 著者名/発表者名: Suzumiya J, Ohshima K, et al.
  • 雑誌名: Ann Oncol. 20 ページ: 715-721
  • 査読あり
• [雑誌論文] Correlation of decreased survival and IL-18 in bone metastasis (2009)
  • 著者名/発表者名: Okamoto M, Ohshima K, et al.
  • 雑誌名: Intern Med. 48 ページ: 763-73
  • NAID: 130000121774
  • 査読あり
• [雑誌論文] Expression of CXCL12 on pseudopalisading cells and proliferating micro vessels in glioblastomas : an accelerated growth factor in glioblastomas (2009)
  • 著者名/発表者名: Komatani H, Ohshima K, et al.
  • 雑誌名: Int J Oncol. 34 ページ: 665-72
  • 査読あり
• [雑誌論文] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV 1-infected T cells through enhanced NF-kappaB activity (2009)
  • 著者名/発表者名: Tomita M, Ohshima K, et al.
  • 雑誌名: Int J Cancer. 124 ページ: 2607-15
  • 査読あり
• [雑誌論文] Oncogene associated cDNA microarray analysis shows PRAME gene expression is a marker for response to anthracycine containing chemotherapy in patients with diffuse large B-cell lymphoma (2009)
  • 著者名/発表者名: Kawano R, Ohshima K, et al.
  • 雑誌名: J Clin Exp Hematop. 49 ページ: 1-7
  • 査読あり
• [雑誌論文] linical significance of co-expression of CD21 and LFA-1 in B-cell lymphoma (2009)
  • 著者名/発表者名: Tanimoto K, Ohshima K, et al.
  • 雑誌名: Int J Hematol. 89 ページ: 497-507
  • 査読あり
• [雑誌論文] Hepatocellular apoptosis associated with cytotoxic T/natural killer-cell in filtration in chronic active EBV infection (2009)
  • 著者名/発表者名: Nomura Y, Ohshima K, et al.
  • 雑誌名: Pathol Int. 59 ページ: 438-42
  • 査読あり
• [雑誌論文] Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era (2009)
  • 著者名/発表者名: Soki R, Ohshima K, et al.
  • 雑誌名: Cancer Sci. 100 ページ: 1842-7
  • NAID: 10027195531
  • 査読あり
• [雑誌論文] Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis (2009)
  • 著者名/発表者名: Nomura Y, Ohshima K, et al.
  • 雑誌名: Pathol Int. 59 ページ: 631-5
  • NAID: 10027381460
  • 査読あり
• [雑誌論文] Outcomes of 59 children with lymphoblastic lymphoma receiving an intensive AL-type therapy without prophlactic cranial irradiation.A report from Japanese children's cancer and leukemia study group NH 960 traial (2009)
  • 著者名/発表者名: Tsurusawa M, Ohshima K, et al.
  • 雑誌名: 日本小児血液学会誌 23 ページ: 244-250
  • 査読あり
• [雑誌論文] (2009)
  • 著者名/発表者名: 大島孝一、新野大介
  • 雑誌名: WHO分類第4版による白血病・悪性リンパ系腫瘍の病態学(押味和夫 木崎昌弘 田丸淳一編)(中外医学社) ページ: 250-268
• [雑誌論文] IL-21 is expressed in Hodgkin lymphoma and activates STAT5 : evidence that activated STAT5 is required for Hodgkin lymphomagenesis. (2008)
  • 著者名/発表者名: Scheeren FA, Diehl SA, Smit LA, Beaumont T, Naspetti M, Bende RJ, Blom B, Karube K, Ohshima K, van Noesel CJ, Spits H
  • 雑誌名: Blood. 1;111(9) ページ: 4706-15
• [雑誌論文] Histological characteristics of 21 Papua New Guinean children with high-grade B-cell lymphoma, which is frequently associated with EBV infection. (2008)
  • 著者名/発表者名: Nomura Y, Lavu EK, Muta K, Niino D, Takeshita M, Hirose S, Nakamura S, Yoshino T, Kikuchi M, Ohshima K
  • 雑誌名: Pathol Int. 58(11) ページ: 695-700
  • NAID: 10027378284
• [雑誌論文] Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes. (2008)
  • 著者名/発表者名: Kikuchi A, Nakamura N, Kuze T, Sasaki Y, Abe M, Ohno H, Akasaka T, Nakamura S, Ohshima K, Ando K
  • 雑誌名: Leuk Res. 32(8) ページ: 1176-82
• [雑誌論文] Downregulation of RCAS1 and upregulation of cytotoxic T cells affects synovial proliferation and apoptosis in rheumatoid arthritis. (2008)
  • 著者名/発表者名: Yoshida S, Higuchi F, Ishibashi Y, Goto M, Sugita Y, Nomura Y, Karube K, Shimizu K, Aoki R, Komatani H, Hashikawa K, Kimura Y, Nakashima M, Nagata K, Ohshima K
  • 雑誌名: J Rheumatol. 35(9) ページ: 1716-22
• [雑誌論文] Estimation of the relationship between caspase-3 expression and clinical outcome of Burkitt's and Burkitt-like lymphoma. (2008)
  • 著者名/発表者名: Nomura Y, Yoshida S, Karube K, Takeshita M, Hirose S, Nakamura S, Yoshino T, Kikuchi M, Ohshima K
  • 雑誌名: Cancer Sci. 99(8) ページ: 1564-9
  • NAID: 10024009675
• [雑誌論文] BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation. (2008)
  • 著者名/発表者名: Karube K, Ying G, Tagawa H, Niino D, Aoki R, Kimura Y, Hashikawa K, Suefuji N, Sugita Y, Nomura Y, Shimizu K, Yoshida S, Seto M, Ohshima K
  • 雑誌名: Mod Pathol. 21(8) ページ: 973-8
• [雑誌論文] De novo CD5+ diffuse large B-cell lymphoma : results of a detailed clinicopathological review in 120 patients. (2008)
  • 著者名/発表者名: Yamaguchi M, Nakamura N, Suzuki R, Kagami Y, Okamoto M, Ichinohasama R, Yoshino T, Suzumiya J, Murase T, Miura I, Ohshima K, Nishikori M, Tamaru J, Taniwaki M, Hirano M, Morishima Y, Ueda R, Shiku H, Nakamura S
  • 雑誌名: Haematologica. 93(8) ページ: 1195-202
• [雑誌論文] Lymphoma Committee of Japanese Childhood Cancer and Leukemia.Favourable outcomes in children with diffuse large B-cell lymphoma treated by a short-term ALL-like regimen : a report on the NHL960 study from the Japanese Childhood Cancer and Leukemia Study Group. (2008)
  • 著者名/発表者名: Tsurusawa M, Taga T, Horikoshi Y, Ogawa A, Kikuta A, Kanegane H, Matsushita T, Hyakuna N, Shimomura Y, Ohshima K
  • 雑誌名: Leuk Lymphoma. 49(4) ページ: 734-9
• [雑誌論文] High-grade mature B-cell lymphoma with Burkitt-like morphology : results of a clinicopathological study of 72 Japanese patients. (2008)
  • 著者名/発表者名: Nomura Y, Karube K, Suzuki R, Ying G, Takeshita M, Hirose S, Nakamura S, Yoshino T, Kikuchi M, Ohshima K
  • 雑誌名: Cancer Sci. 99(2) ページ: 246-52
  • NAID: 10024002025
• [雑誌論文] CAEBV Study Group. Review : Proposed categorization of pathological states of EBV-associated T/natural killer-cell lymphoproliferative disorder (LPD) in children and young adults : overlap with chronic active EBV infection and infantile fulminant EBV T-LPD. (2008)
  • 著者名/発表者名: Ohshima K, Kimura H, Yoshino T, Kim CW, Ko YH, Lee SS, Peh SC, Chan JK
  • 雑誌名: Pathol Int. 58(4) ページ: 209-17
• [雑誌論文] Estimation of apoptosis and cell proliferation in histiocytic necrotizing lymphadenitis using immunohistochemical double staining. (2008)
  • 著者名/発表者名: Nomura Y, Sugita Y, Yoshida S, Karube K, Shimizu K, Aoki R, Hirose S, Kikuchi M, Ohshima K
  • 雑誌名: Pathol Int. 58(2) ページ: 98-103
  • NAID: 10027375715
• [雑誌論文] The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma. (2008)
  • 著者名/発表者名: Karube K, Aoki R, Sugita Y, Yoshida S, Nomura Y, Shimizu K, Kimura Y, Hashikawa K, Takeshita M, Suzumiya J, Utsunomiya A, Kikuchi M, Ohshima K
  • 雑誌名: Mod Pathol. 21(5) ページ: 617-25
• [雑誌論文] Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas : Analysis of 490 cases. (2008)
  • 著者名/発表者名: Karube K, Aoki R, Nomura Y, Yamamoto K, Yoshida S, Shimizu K, Komatani H, Sugita Y, Ohshima K.
  • 雑誌名: Pathol Int. 58(2) ページ: 89-97
  • NAID: 10027375683
• [雑誌論文] Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lyinphom as : Analysis of 490 cases. (2008)
  • 著者名/発表者名: Karube K, Ohshima K., et al.
  • 雑誌名: Pathol Int. 58 ページ: 89-97
  • 査読あり
• [雑誌論文] The relationship of FOXP3 expression and clinicopatholo gical characteristies in adult T-cell leukemia/lymphoma (2008)
  • 著者名/発表者名: Karube K, Ohshima K., et al.
  • 雑誌名: Mod Pathol. 21 ページ: 617-25
  • 査読あり
• [雑誌論文] Estimation of apoptosis and cell proliferation in histiocytic necrotizing lymphadenitis using immunohistochemical double staining. (2008)
  • 著者名/発表者名: Nomura Y, Ohshima K., et al.
  • 雑誌名: Pathol Int. 58 ページ: 98-103
  • NAID: 10027375715
  • 査読あり
• [雑誌論文] High-grade mature B-cell lymphoma with Burkitt-like morphology : results of a clinicopathological study of 72 Japanese patients. (2008)
  • 著者名/発表者名: Nomura Y, Ohshima K., et al.
  • 雑誌名: Cancer Sci. 99 ページ: 246-52
  • NAID: 10024002025
  • 査読あり
• [雑誌論文] Periostin and bone marrow fibrosis. (2008)
  • 著者名/発表者名: Oku E, Ohshima K., et al.
  • 雑誌名: Int J Hematol. 88 ページ: 57-63
  • 査読あり
• [雑誌論文] Favourable outcomes in children with diffuse large B-cell lymphoma treated by a short-term ALL-like regimen : a report on the NHL960 study from the Japanese Childhood Cancer and Leukemia Study Group. (2008)
  • 著者名/発表者名: Tsurusawa M, Ohshima K., et al.
  • 雑誌名: Leuk Lymphoma. 49 ページ: 734-739
  • 査読あり
• [雑誌論文] De novo CD5+ diffuse large B-cell lymphoma : results of a detailed clinicopathological review in 120 patients. (2008)
  • 著者名/発表者名: Yamaguchi M, Ohshima K., et al.
  • 雑誌名: Haematologica 93 ページ: 1195-202
  • 査読あり
• [雑誌論文] BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation. (2008)
  • 著者名/発表者名: Karube K, Ohshima K, et al.
  • 雑誌名: Mod Pathol. 21 ページ: 973-8
  • 査読あり
• [雑誌論文] Estimation of the relationship between caspase-3 expression and clinical outcome of Burkitt' s and Burkitt-like lymphoma. (2008)
  • 著者名/発表者名: Nomura Y, Ohshima K, et al.
  • 雑誌名: Cancer Sci. 99 ページ: 1564-9
  • 査読あり
• [雑誌論文] Downregulation of RCASl and upregulati on of cytotoxic Tcells affects synovial proliferation and apoptosis in rheumatoid arthritis. (2008)
  • 著者名/発表者名: Yoshida S Ohshima K, et al.
  • 雑誌名: J Rheumatol. 35 ページ: 1716-22
  • 査読あり
• [雑誌論文] Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes. (2008)
  • 著者名/発表者名: Kikuchi A Ohshima K, et al.
  • 雑誌名: Leuk Res. 32 ページ: 1176-82
  • 査読あり
• [雑誌論文] Histological characteristics of 21 Papua New Guinean children with high-grade B-cell lymphoma, which is frequently associated with EBV infection. (2008)
  • 著者名/発表者名: Nomura Y, Ohshima K., et al.
  • 雑誌名: Pathol Int. 58 ページ: 695-700
  • NAID: 10027378284
  • 査読あり
• [図書] Adult T-cell leukemia/lymphoma p281-4、Swerdlow SH, Campo E, Harris NL et al. . (eds)WHO classification of tumor, Tumours of haematopoietic and lymphoid tissues. (2008)
  • 著者名/発表者名: K. Ohshima, ES Jaffe, M Kikuchi
  • 出版者: WHO Lyon