副甲状腺の腫瘍化機構とカルシウム感知受容体の意義

• 研究課題/領域番号: 20591101
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 内分泌学
• 研究機関: 大阪市立大学
• 研究代表者: 今西 康雄 大阪市立大学, 大学院・医学研究科, 講師 (50326253)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円); 2010年度: 780千円 (直接経費: 600千円、間接経費: 180千円); 2009年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円); 2008年度: 2,210千円 (直接経費: 1,700千円、間接経費: 510千円)
• キーワード: 副甲状腺アデノーマ / 2次性副甲状腺機能亢進症 / 副甲状腺ホルモン / 副甲状腺機能亢進症 / 副甲状腺腫瘍

研究概要

シナカルセト塩酸塩は、カルシウム受容体(CaR)をアロステリックに活性化し、副甲状腺ホルモン(PTH)の分泌を抑制する。原発性副甲状腺機能亢進症モデルマウスを用い、シナカルセト塩酸塩の副甲状腺細胞増殖抑制作用について検討したところ、過形成の部位のみならず、アデノーマ様にCaRの低下した副甲状腺においても細胞増殖抑制作用を呈し、副甲状腺細胞増殖による病態の進行を抑制することが示唆された。

研究成果

• [雑誌論文] Reduction of whole PTH/intact PTH ratio as a predictor of bone metabolism in cinacalcet treatment of hemodialysis patients with secondary hyperparathyroidism (2011)
  • 著者名/発表者名: Kurajoh M, Inaba M, Okuno S, Nagayama H, Yamada S, Imanishi Y, Ishimura E, Shoji S, Yamakawa T, Nishizawa Y
  • 雑誌名: Osteoporos Int 22 ページ: 923-930
  • 査読あり
• [雑誌論文] Cinacalcet HCl suppresses cyclin D1 oncogene-derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism (2011)
  • 著者名/発表者名: Imanishi, Y.
  • 雑誌名: Calcif Tissue Int 巻: (In press)
  • 査読あり
• [雑誌論文] Reduction of whole PTH/intact PTH ratio as a predictor of bone metabolism in cinacalcet treatment of hemodialysis patients with secondary hyperparathyroidism. (2011)
  • 著者名/発表者名: Kurajoh, M.
  • 雑誌名: Osteoporosis International 巻: 22 ページ: 923-30
  • 査読あり
• [雑誌論文] Association of glycated albumin, but not glycated hemoglobin, with calcaneus quantitative ultrasound in male hemodialysis patients with type 2 diabetes mellitus (2010)
  • 著者名/発表者名: Yamada S, Inaba M, Okada S, Imanishi Y, Mori K, Emoto M, Ishimura E, Nishizawa Y
  • 雑誌名: Metabolism 59 ページ: 390-394
  • 査読あり
• [雑誌論文] Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus (2010)
  • 著者名/発表者名: Tamori A, Enomoto M, Kobayashi S, Iwai S, Morikawa H, Sakaguchi H, Habu D, Shiomi S, Imanishi Y, Kawada N
  • 雑誌名: J Viral Hepat 17 ページ: 123-129
  • 査読あり
• [雑誌論文] Effects of raloxifene treatment on the structural geometry of the proximal femur in Japanese women with osteoporosis (2010)
  • 著者名/発表者名: Takada J, Miki T, Imanishi Y, Nakatsuka K, Wada H, Naka H, Yoshizaki T, Iba K, Beck TJ, Yamashita T
  • 雑誌名: J Bone Miner Metab 28 ページ: 561-567
  • NAID: 10027684055
  • 査読あり
• [雑誌論文] Beneficial effect of risedronate on arterial thickening and stiffening with a reciprocal relationship to its effect on bone mass in female osteoporosis patients : a longitudinal study (2010)
  • 著者名/発表者名: Okamoto K, Inaba M, Furumitsu Y, Ban A, Mori N, Yukioka K, Imanishi Y, Nishizawa Y
  • 雑誌名: Life Sci 87 ページ: 686-691
  • 査読あり
• [雑誌論文] The administration of an active vitamin D(3) analogue reduced the serum concentrations of 1-84 and truncated parathyroid hormone in pseudohypoparathyroidism type Ib patients (2010)
  • 著者名/発表者名: Ishii A, Imanishi Y, Kurajoh M, Nagata Y, Kobayashi K, Miki T, Inaba M, Nishizawa Y
  • 雑誌名: Endocr J 57 ページ: 609-614
  • 査読あり
• [雑誌論文] The levels of somatostatin receptors in causative tumors of oncogenic osteomalacia are insufficient for their agonist to normalize serum phosphate levels (2010)
  • 著者名/発表者名: Ishii A, Imanishi Y, Kobayashi K, Hashimoto J, Ueda T, Miyauchi A, Koyano HM, Kaji H, Saito T, Oba K, Komatsu Y, Kurajoh M, Nagata Y, Goto H, Wakasa K, Sugimoto T, Miki T, Inaba M, Nishizawa Y
  • 雑誌名: Calcif Tissue Int 86 ページ: 455-462
  • 査読あり
• [雑誌論文] Poor muscle quality rather than reduced lean body mass is responsible for the lower serum creatinine level in hemodialysis patients with diabetes mellitus (2010)
  • 著者名/発表者名: Inaba M, Kurajoh M, Okuno S, Imanishi Y, Yamada S, Mori K, Ishimura E, Yamakawa T, Nishizawa Y
  • 雑誌名: Clin Nephrol 74 ページ: 266-272
  • 査読あり
• [雑誌論文] Association of glycated albumin, but not glycated hemoglobin, with calcaneus quantitative ultrasound in male hemodialysis patients with type 2 diabetes mellitus. (2010)
  • 著者名/発表者名: Yamada, S.
  • 雑誌名: Metabolism 巻: 59 ページ: 390-394
  • 査読あり
• [雑誌論文] Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus. (2010)
  • 著者名/発表者名: Tamori, A.
  • 雑誌名: J Viral Hepat 巻: 17 ページ: 123-129
  • 査読あり
• [雑誌論文] Effects of raloxifene treatment on the structural geometry of the proximal femur in Japanese women with osteoporosis. (2010)
  • 著者名/発表者名: Takada, J.
  • 雑誌名: J Bone Miner Metab 巻: 28 ページ: 561-567
  • 査読あり
• [雑誌論文] Beneficial effect of risedronate on arterial thickening and stiffening with a reciprocal relationship to its effect on bone mass in female osteoporosis patients : a longitudinal study. (2010)
  • 著者名/発表者名: Okamoto, K.
  • 雑誌名: Life Sci 巻: 87 ページ: 686-691
  • 査読あり
• [雑誌論文] The administration of an active vitamin D(3) analogue reduced the serum concentrations of 1-84 and truncated parathyroid hormone in pseudohypoparathyroidism type Ib patients. (2010)
  • 著者名/発表者名: Ishii, A.
  • 雑誌名: Endocr J 巻: 57 ページ: 609-614
  • 査読あり
• [雑誌論文] The levels of somatostatin receptors in causative tumors of oncogenic osteomalacia are insufficient for their agonist to normalize serum phosphate levels (2010)
  • 著者名/発表者名: Ishii, A.
  • 雑誌名: Calcif Tissue Int 巻: 86 ページ: 455-462
  • 査読あり
• [雑誌論文] The Levels of Somatostatin Receptors in Causative Tumors of Oncogenic Osteomalacia Are Insufficient for Their Agonist to Normalize Serum Phosphate Levels (2010)
  • 著者名/発表者名: Ishii, A.
  • 雑誌名: J Bone Miner Metab (In press)
  • 査読あり
• [雑誌論文] Effects of raloxifene treatment on structural geometry of the proximal femur in Japanese women with osteoporosis (2010)
  • 著者名/発表者名: Takada, J.
  • 雑誌名: J Bone Miner Metab (In press)
  • 査読あり
• [雑誌論文] The administration of an active vitamin D_3 analogue reduced the serum concentrations of 1-84 and truncated parathyroid hormone in pseudohypoparathyroidism type lb patients. (2010)
  • 著者名/発表者名: Ishii, A.
  • 雑誌名: Endcr J (In press)
  • 査読あり
• [雑誌論文] Poor muscle quality, but not reduced lean body mass, is responsible for a lower serum creatinine level in hemodialysis patients with diabetes mellitus. (2010)
  • 著者名/発表者名: Inaba, M.
  • 雑誌名: Clin Nephrol (In press)
  • 査読あり
• [雑誌論文] Association of glycated albumin, but not glycated hemoglobin, with calcaneus quantitative ultrasound in male hemodialysis patients with type 2 diabetes mellitus (2010)
  • 著者名/発表者名: Yamada, S.
  • 雑誌名: Metabolism 59 ページ: 390-394
  • 査読あり
• [雑誌論文] Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus (2010)
  • 著者名/発表者名: Tamori, A.
  • 雑誌名: J Viral Hepat 17 ページ: 123-129
  • 査読あり
• [雑誌論文] Severe arterial hypertension: a possible complication of McCune-Albright syndrome (2009)
  • 著者名/発表者名: Ohata Y, Yamamoto T, Mori I, Kikuchi T, Michigami T, Imanishi Y, Satomura K, Ida S, Ozono K
  • 雑誌名: Eur J Pediatr 168 ページ: 871-876
  • 査読あり
• [雑誌論文] Osteosarcoma in a pregnant patient with McCune-Albright syndrome (2009)
  • 著者名/発表者名: Kanazawa I, Yamauchi M, Yano S, Imanishi Y, Kitazawa R, Nariai Y, Araki A, Kobayashi K, Inaba M, Maruyama R, Yamaguchi T, Sugimoto T
  • 雑誌名: Bone 45 ページ: 603-608
  • 査読あり
• [雑誌論文] Severe hypophosphatemic osteomalacia with fanconi syndrome, renal tubular acidosis, vitamin D deficiency and primary biliary cirrhosis (2009)
  • 著者名/発表者名: Bando H, Hashimoto N, Hirota Y, Sakaguchi K, Hisa I, Inoue Y, Imanishi Y, Seino S, Kaji H
  • 雑誌名: Intern Med 48 ページ: 353-358
  • NAID: 130000122377
  • 査読あり
• [雑誌論文] Cinacalcet in hyperfunctioning parathyroid diseases (2009)
  • 著者名/発表者名: Imanishi Y, Inaba M, Kawata T, Nishizawa Y
  • 雑誌名: Ther Apher Dial 13 Suppl 1
  • 査読あり
• [雑誌論文] Animal models of hyperfunctioning parathyroid diseases for drug development (2009)
  • 著者名/発表者名: Imanishi Y, Inaba M, Kawata T, Nishizawa Y
  • 雑誌名: Expert Opin Drug Discov 4 ページ: 727-740
  • 査読あり
• [雑誌論文] Cinacalcet in hyperfunctioning parathyroid diseases (2009)
  • 著者名/発表者名: Imanishi, Y.
  • 雑誌名: Ther Apher Dial 13
  • 査読あり
• [雑誌論文] Animal models of hyperfunctioning parathyroid diseases for drug development (2009)
  • 著者名/発表者名: Imanishi, Y.
  • 雑誌名: Expert Opin Drug Discov 4 ページ: 727-740
  • 査読あり
• [雑誌論文] (2009)
  • 著者名/発表者名: 今西康雄
  • 雑誌名: 【病気と薬パーフェクトBOOK 2009】16骨・関節疾患 くる病・骨軟化症(南山堂) ページ: 1558-1561
• [雑誌論文] Animal models of hyperfunctioning parathyroid diseases for drug development (2009)
  • 著者名/発表者名: Yasuo Imanishi, Masaaki Inaba, Takehisa Kawata, Yoshiki Nishizawa
  • 雑誌名: Expert Opinion On Drug Discovery (in press)
  • 査読あり
• [雑誌論文] Utility of serum tartrate-resistant acid phosphatase (TRACP5b) as a bone resorption marker in patients with chronic kidney disease : independence from renal dysfunction (2008)
  • 著者名/発表者名: Yamada S, Inaba M, Kurajoh M, Shidara K, Imanishi Y, Ishimura E, Nishizawa Y
  • 雑誌名: Clin Endocrinol (Oxf) 69 ページ: 189-196
  • 査読あり
• [雑誌論文] Serum Levels of TRAP5b, a New Bone Resorption Marker Unaffected by Renal Dysfunction, as a Useful Marker of Cortical Bone Loss in Hemodialysis Patients (2008)
  • 著者名/発表者名: Shidara K, Inaba M, Okuno S, Yamada S, Kumeda Y, Imanishi Y, Yamakawa T, Ishimura E, Nishizawa Y
  • 雑誌名: Calcif Tissue Int 82 ページ: 278-287
  • 査読あり
• [雑誌論文] Clinical and Biochemical Response of TNFRSF11A-Mediated Early-Onset Familial Paget Disease to Bisphosphonate Therapy (2008)
  • 著者名/発表者名: Riches PL, Imanishi Y, Nakatsuka K, Ralston SH
  • 雑誌名: Calcif Tissue Int 83 ページ: 272-275
  • 査読あり
• [雑誌論文] Association of increased active PTH(1-84) fraction with decreased GFR and serum Ca in predialysis CRF patients : modulation by serum 25-OH-D (2008)
  • 著者名/発表者名: Kurajoh M, Inaba M, Yamada S, Imanishi Y, Tsuchida T, Ishimura E, Nishizawa Y
  • 雑誌名: Osteoporos Int 19 ページ: 709-716
  • 査読あり
• [学会発表] Coexpressions of FGF-23 and MEPE in causative tumors of oncogenic osteomalacia (2010)
  • 著者名/発表者名: Nagata Y
  • 学会等名: ASBMR 32nd Annual Meeting
  • 発表場所: Metro Toronto Convention Center
  • 年月日: 2010-10-16
• [学会発表] Reduction of Whole PTH/Intact PTH Ratio is a Predictor of Bone Metabolism by Cinacalcet Treatment in Hemodialysis Patients with Secondary Hyperparathyroidism (2010)
  • 著者名/発表者名: Kurajoh M
  • 学会等名: ASBMR 32nd Annual Meeting
  • 発表場所: Metro Toronto Convention Center
  • 年月日: 2010-10-16
• [学会発表] Coexpressions of FGF-23 and MEPE in causative tumors of oncogenic osteomalacia. (2010)
  • 著者名/発表者名: Nagata, Y.
  • 学会等名: ASBMR 32nd Annual Meeting
  • 発表場所: Metro Toronto Convention Center
  • 年月日: 2010-10-16
• [学会発表] Suppression of Circulating Fibroblast Growth Factor-23 by Cinacalcet in Patients with Primary Hyperparathyroidism (2010)
  • 著者名/発表者名: Imanishi Y
  • 学会等名: 12th European Congress of Endocrinology
  • 発表場所: Prague Congress Centre
  • 年月日: 2010-04-27
• [学会発表] Octreotide therapies were unable to improve hypophosphatemia in oncogenic osteomalacia (2010)
  • 著者名/発表者名: Ishii A
  • 学会等名: 14th International Congress of Endocrinology (ICE2010)
  • 発表場所: Kyoto International Conference Center
  • 年月日: 2010-03-28
• [学会発表] Regulation of Circulating Fibroblast Growth Factor-23 by parathyroid hormone in Patients with Primary Hyperparathyroidism (2010)
  • 著者名/発表者名: Kurajoh M
  • 学会等名: 14th International Congress of Endocrinology (ICE2010)
  • 発表場所: Kyoto International Conference Center
  • 年月日: 2010-03-28
• [学会発表] Expressions of Somatostatin Receptors on Responsible Tumors are Insufficient for Their Agonist to Normalize Serum Phosphate Levels in Oncogenic Osteomalacia (2009)
  • 著者名/発表者名: Ishii A
  • 学会等名: ASBMR 31th Annual Meeting
  • 発表場所: Colorado Convention Center
  • 年月日: 2009-09-14
• [学会発表] Cinacalcet Suppresses Circulating Fibroblast Growth Factor-23 in Patients with Primary Hyperparathyroidism (2009)
  • 著者名/発表者名: Kurajoh M
  • 学会等名: ASBMR 31th Annual Meeting
  • 発表場所: Colorado Convention Center
  • 年月日: 2009-09-13
• [学会発表] Activation of Calcium-Sensing Receptor Accelerates Amino-terminal Truncation of Human Parathyroid Hormone (1-84) in the Patients with Primary Hyperparathyroidism (2009)
  • 著者名/発表者名: Imanishi Y
  • 学会等名: ASBMR 31th Annual Meeting
  • 発表場所: Colorado Convention Center
  • 年月日: 2009-09-12
• [学会発表] 心・血管系と骨 (2009)
  • 著者名/発表者名: 今西康雄
  • 学会等名: 第27回日本骨代謝学会
  • 発表場所: 大阪国際会議場
  • 年月日: 2009-07-24
• [学会発表] Dominant tissue accumulation of MIBI in parathyroid glands in uremic rats. (2008)
  • 著者名/発表者名: Yasuo Imanishi, Hiroaki Sano, Hideaki Hasegawa, et. al.
  • 学会等名: ASBMR 30th Annual Meeting
  • 発表場所: Montreal, Quebec, Canada
  • 年月日: 2008-09-13
• [図書] 骨代謝マーカー (2011)
  • 著者名/発表者名: 今西康雄
  • 出版者: 医薬ジャーナル社(In press)