薬物-腫瘍遺伝学的支援検査の樹立

• 研究課題/領域番号: 21390182
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 病態検査学
• 研究機関: 長崎大学
• 研究代表者: 上平 憲 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80108290)
• 研究分担者: 長谷川 寛雄 長崎大学, 病院, 講師 (00398166) ; 山田 恭暉 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (60145232)
• 研究期間 (年度): 2009 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 18,330千円 (直接経費: 14,100千円、間接経費: 4,230千円); 2011年度: 2,470千円 (直接経費: 1,900千円、間接経費: 570千円); 2010年度: 7,540千円 (直接経費: 5,800千円、間接経費: 1,740千円); 2009年度: 8,320千円 (直接経費: 6,400千円、間接経費: 1,920千円)
• キーワード: 腫瘍検査学 / 個別化医療 / IL-28B / 分子標的療法 / Genomic Test / SNP / Bio-marker / IL28B / Genediagnostics / IFN-r / oncogenomics / 遺伝子検査 / Ras

研究概要

現在、国民の30%は癌死で、近い将来の高齢化社会では、70%のヒトはがんに1度は苦しむであろうと言われている。従って、理想的な医療モデルと言われるPersonalized Oncologyの促進をはかることを国民広く望んでいる。
特に、臨床検査の立場から「がん細胞の免疫形質特性(Immunophenotype)や遺伝子特性(Cytogenetic)の評価と同時に個体の体質的特性(生殖細胞遺伝子情報)と腫瘍ゲノム特性とを会わせ、同時にPersonalized Oncologyの発展に寄与出来るgenomic test systemを構築することを目的とし、一部実施した。

研究成果

• [雑誌論文] Paradoxical expression of IL-28B mRNA in peripheral blood in human T-cell leukemia virus Type-1 mono-infection and Co-infection with hepatitis C Virus (2012)
  • 著者名/発表者名: Kamihira S, Usui T, Ichikawa T, Uno N, Morinaga Y, Mori S, Ngai K, Sasaki D, Hasegawa H, Yanagihara K, Honnda T, Ymada Y, Iwanaga M, Kanematu T, Nkao K
  • 雑誌名: Epub ahead of print 巻: Virol J 9(1) ページ: 40-40
• [雑誌論文] Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa (2012)
  • 著者名/発表者名: Itonaga H, Tsushima H, Hata T, Matsuo E, Imanishi D, Imaizumi Y, Kawaguchi Y, Fukushima T, Doi Y, Mori S, Kamihira S, Tomonaga M, Miyazaki Y
  • 雑誌名: Int J Hematol 巻: 95(2) ページ: 209-13
  • NAID: 10030267492
• [雑誌論文] Paradoxical expression of IL-28B mRNA in peripheral blood in human T-cell leukemia virus Type-1 mono-infection and Co-infection with hepatitis C Virus (2012)
  • 著者名/発表者名: Kamihira S, Usui T, Ichikawa T, Uno N, Morinaga Y, Mori S, Ngai K, Sasaki D, asegawa H, Yanagihara K, Honnda T, Ymada Y, Iwanaga M, Kanematu T, Nkao K
  • 雑誌名: Virol J.2012 Feb 15;9(1):40 巻: 9(1)(Epub ahead of print) ページ: 40-40
  • 査読あり
• [雑誌論文] Nationwide survey of adult T-cell leukemia/ lymphoma(ATL) in Japan (2011)
  • 著者名/発表者名: Yamada Y, Atogami S, Hasegawa H, Kamihira S, Soda M, Satake M, Yamaguchi K
  • 雑誌名: Rinsho Ketsueki 巻: 52(11) ページ: 1765-71
  • NAID: 10030462510
• [雑誌論文] Suppressor of cytokine signal 3 and IL28 genetic variation predict the viral response to peginterferon and ribavirin (2011)
  • 著者名/発表者名: Miyaaki H, Ichikawa T, Yatsuhashi H, Taura N, Miuma S, Usui T, Mori S, Kamihira S, Tanaka Y, Mizokami M, Nakao K
  • 雑誌名: Hepatol Res 巻: 41(12) ページ: 1216-1222
  • NAID: 10031144200
• [雑誌論文] Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/ lymphoma cells (2011)
  • 著者名/発表者名: Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
  • 雑誌名: Leuk Lymphoma 巻: 52(6) ページ: 1108-17
  • NAID: 120006984995
• [雑誌論文] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/ lymphoma cells via activation of a novel RAIDD-caspase-2 pathway (2011)
  • 著者名/発表者名: Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
  • 雑誌名: Leukemia 巻: 25(4) ページ: 575-87
  • NAID: 120006984803
• [雑誌論文] leukemia/ lymphoma as a target for epigenetic therapy (2011)
  • 著者名/発表者名: Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
  • 雑誌名: Haematologica 巻: 96(5) ページ: 712-9
• [雑誌論文] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis (2011)
  • 著者名/発表者名: Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T
  • 雑誌名: Blood 巻: 117(2) ページ: 500-9
• [雑誌論文] Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers (2011)
  • 著者名/発表者名: Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, Okayama A
  • 雑誌名: Int J Cancer 巻: 128(6) ページ: 1335-43
• [雑誌論文] Nationwide survey of adult T-cell leukemia/lymphoma (ATL) in Japan (2011)
  • 著者名/発表者名: Yamada Y, Atogami S, Hasegawa H, Kamihira S, Soda M, Satake M, Yamaguchi K
  • 雑誌名: Rinsho Ketsueki 巻: 52(11) ページ: 1765-71
  • NAID: 10030462510
  • 査読あり
• [雑誌論文] Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells (2011)
  • 著者名/発表者名: Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
  • 雑誌名: Leuk Lymphoma 巻: 52(6) ページ: 1108-17
  • NAID: 120006984995
  • 査読あり
• [雑誌論文] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway (2011)
  • 著者名/発表者名: Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
  • 雑誌名: Leukemia 巻: 25(4) ページ: 575-87
  • NAID: 120006984803
  • 査読あり
• [雑誌論文] Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers (2011)
  • 著者名/発表者名: Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, and Okayama A
  • 雑誌名: Int J Cancer 巻: 128 号: 6 ページ: 1335-43
  • DOI: 10.1002/ijc.25450
  • 査読あり
• [雑誌論文] Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy (2011)
  • 著者名/発表者名: Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
  • 雑誌名: Haematologica 巻: 96(5) ページ: 712-9
  • 査読あり
• [雑誌論文] Intra-and inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays : a multi-center study (2010)
  • 著者名/発表者名: Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T
  • 雑誌名: Cancer Sci 巻: 101(11) ページ: 2361-7
  • NAID: 10027833409
• [雑誌論文] Human T-cell leukemia virus type I(HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers : a nationwide prospective study in Japan (2010)
  • 著者名/発表者名: Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi Kq
  • 雑誌名: Joint Study on Predisposing Factors of ATL Development investigators, Blood 巻: 116(8) ページ: 1211-9
• [雑誌論文] Long-term study of indolent adult T-cell leukemia-lymphoma (2010)
  • 著者名/発表者名: Takasaki Y, Iwanaga M, Imaizumi Y, Tawara M, Joh T, Kohno T, Yamada Y, Kamihira S, Ikeda S, Miyazaki Y, Tomonaga M, Tsukasaki K
  • 雑誌名: Blood 巻: 115(22) ページ: 4337-43
• [雑誌論文] CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells (2010)
  • 著者名/発表者名: Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y
  • 雑誌名: J Biol Chem 巻: 285(20) ページ: 15511-22
• [雑誌論文] Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/ lymphoma in Nagasaki, Japan (2010)
  • 著者名/発表者名: Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y
  • 雑誌名: J Med Virol 巻: 82(4) ページ: 668-74
• [雑誌論文] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma (2010)
  • 著者名/発表者名: Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R
  • 雑誌名: J Clin Oncol 巻: 28(9) ページ: 1591-8
• [雑誌論文] First Japanese patient treated with parathyroid hormone peptide immunization for refractory hypercalcemia caused by metastatic parathyroid carcinoma (2010)
  • 著者名/発表者名: Horie I, Ando T, Inokuchi N, Mihara Y, Miura S, Imaizumi M, Usa T, Kinoshita N, Sekine I, Kamihara S, Eguchi K
  • 雑誌名: Endocr J 巻: 57(4) ページ: 287-92
• [雑誌論文] Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan. (2010)
  • 著者名/発表者名: Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y
  • 雑誌名: J Med Virol 2010 巻: 82(4) ページ: 668-674
  • 査読あり
• [雑誌論文] CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. (2010)
  • 著者名/発表者名: Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y
  • 雑誌名: J Biol Chem 巻: 285(20) ページ: 15511-22
  • 査読あり
• [雑誌論文] First Japanese patient treated with parathyroid hormone peptide immunization for refractory hypercalcemia caused by metastatic parathyroid carcinoma. (2010)
  • 著者名/発表者名: Horie I, Ando T, Inokuchi N, Mihara Y, Miura S, Imaizumi M, Usa T, Kinoshita N, Sekine I, Kamihara S, Eguchi K
  • 雑誌名: Endocr J 巻: 57(4) ページ: 287-92
  • 査読あり
• [雑誌論文] Long-term study of indolent adult T-cell leukemia-lymphoma. (2010)
  • 著者名/発表者名: Takasaki Y, Iwanaga M, Imaizumi Y, Tawara M, Joh T, Kohno T, Yamada Y, Kamihira S, Ikeda S, Miyazaki Y, Tomonaga M, Tsukasaki K
  • 雑誌名: Blood 巻: 115(22) ページ: 4337-43
  • 査読あり
• [雑誌論文] Intra- and inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays : a multi-center study. (2010)
  • 著者名/発表者名: Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T
  • 雑誌名: Cancer Science 巻: 101(11) ページ: 2361-7
  • NAID: 10027833409
  • 査読あり
• [雑誌論文] HTLV-1 proviral load and disease progression in asymptomatic HTLV-1 carriers : A nationwide prospective Study in Japan (2010)
  • 著者名/発表者名: Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi K
  • 雑誌名: Blood 巻: 116(8) ページ: 1211-9
  • 査読あり
• [雑誌論文] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis. (2010)
  • 著者名/発表者名: Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake, K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T
  • 雑誌名: Blood 巻: 117(2) ページ: 500-9
  • 査読あり
• [雑誌論文] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. (2010)
  • 著者名/発表者名: Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R
  • 雑誌名: J Clin Oncol 巻: 28 ページ: 1591-1598
  • 査読あり
• [雑誌論文] Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopenia (2009)
  • 著者名/発表者名: Yamada Y, Okada M, Kamitamari A, Moriuchi H, Yanai M, Hano O, Tsukasaki K, Tsuruda K, Hasegawa H, Yanagihara K, Kamihira S
  • 雑誌名: Intern Med 巻: 48(22) ページ: 1967-71
  • NAID: 130000122220
• [雑誌論文] Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells (2009)
  • 著者名/発表者名: Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S
  • 雑誌名: Leukemia 巻: 23(11) ページ: 2090-101
  • NAID: 120006983888
• [雑誌論文] Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications (2009)
  • 著者名/発表者名: Osaka A, Yanagihara K, Yamada Y, Hasegawa H, Inokuchi N, Hayashi T, Komoda M, Nakamura S, Aoyama M, Sawada T, Kamihira S
  • 雑誌名: Tohoku J Exp Med 巻: 218(2) ページ: 99-105
  • NAID: 10025106239
• [雑誌論文] High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene (2009)
  • 著者名/発表者名: Doi Y, Sasaki D, Terada C, Mori S, Tsuruda K, Matsuo E, Miyazaki Y, Nagai K, Hasegawa H, Yanagihara K, Yamada Y, Kamihira S
  • 雑誌名: Int J Hematol 巻: 90(1) ページ: 37-43
  • NAID: 10025162376
• [雑誌論文] Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations (2009)
  • 著者名/発表者名: Kamihira S, Terada C, Sasaki D, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y
  • 雑誌名: Eur J Haematol 巻: 82(4) ページ: 301-7
• [雑誌論文] A novel role of serum cytochrome c as a tumor marker in patients with operable cancer (2009)
  • 著者名/発表者名: Osaka A, Hasegawa H, Yamada Y, Yanagihara K, Hayashi T, Mine M, Aoyama M, Sawada T, Kamihira S
  • 雑誌名: J Cancer Res Clin Oncol 巻: 135(3) ページ: 371-7
  • NAID: 120006983957
• [雑誌論文] Serum cytochrome c to indicate the extent of ongoing tumor cell death (2009)
  • 著者名/発表者名: Osaka A, Hasegawa H, Tsuruda K, Inokuchi N, Yanagihara K, Yamada Y, Aoyama M, Sawada T, Kamihira S
  • 雑誌名: Int J Lab Hematol 巻: 31(3) ページ: 307-14
• [雑誌論文] Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells. (2009)
  • 著者名/発表者名: Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S.
  • 雑誌名: Leukemia 23(11) ページ: 2090-2101
  • NAID: 120006983888
  • 査読あり
• [雑誌論文] Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations (2009)
  • 著者名/発表者名: Kamihira S, Terada C, Sasaki D, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y.
  • 雑誌名: Eur J Haematol 82(4) ページ: 301-307
  • 査読あり
• [雑誌論文] Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopenia. (2009)
  • 著者名/発表者名: Yamada Y, Okada M, Kamitamari A, Moriuchi H, Yanai M, Hano O, Tsukasaki K, Tsuruda K, Hasegawa H, Yanagihara K, Kamihira S.
  • 雑誌名: Intern Med 48(22): ページ: 1967-71
  • NAID: 130000122220
  • 査読あり
• [雑誌論文] A novel role of serum cytochrome c as a tumor marker in patients with operable cancer. (2009)
  • 著者名/発表者名: Osaka A, Hasegawa H, Yamada Y, Yanagihara K, Hayashi T, Mine M, Aoyama M, Sawada T, Kamihira S
  • 雑誌名: J Cancer Res Clin Oncol 135(3) ページ: 371-7
  • NAID: 120006983957
  • 査読あり
• [雑誌論文] Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications. (2009)
  • 著者名/発表者名: Osaka A, Yanagihara K, Yamada Y, Hasegawa H, Inokuchi N, Hayashi T, Komoda M, Nakamura S, Aoyama M, Sawada T, Kamihira S
  • 雑誌名: Tohoku J Exp Med 218(2) ページ: 99-105
  • NAID: 10025106239
  • 査読あり
• [雑誌論文] High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene. (2009)
  • 著者名/発表者名: Doi Y, Sasaki D, Terada C, Mori S, Tsuruda K, Matsuo E, Miyazaki Y, Nagai K, Hasegawa H, Yanagihara K, Yamada Y, Kamihira S
  • 雑誌名: Int J Hematol 90(1) ページ: 37-43
  • NAID: 10025162376
  • 査読あり
• [雑誌論文] Serum cytochrome c to indicate the extent of ongoing tumor cell death. (2009)
  • 著者名/発表者名: Osaka A, Hasegawa H, Tsuruda K, Inokuchi N, Yanagihara K, Yamada Y, Aoyama M, Sawada T, Kamihira S
  • 雑誌名: Int J Lab Hematol 31(3) ページ: 307-14
  • 査読あり
• [学会発表] Overexpression of enhancer of zeste homolog 2 with trimelthylation of lysine 27 on histone H3 in ATL as a target for epigenetic therapy (2010)
  • 著者名/発表者名: Sasaki D
  • 学会等名: IJH
  • 発表場所: Kyoto
  • 年月日: 2010-10-23
• [学会発表] Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in ATL as a target for epigenetic therapy (2010)
  • 著者名/発表者名: Sasaki D
  • 学会等名: IJH
  • 発表場所: Kyoto
  • 年月日: 2010-10-23
• [学会発表] The Overexpression of Enhancer of Zeste Homologue 2 is Associated with Tumor Proliferation and Aggressive Behavior in Adult T-Cell Leukemia/ Lymphoma (2009)
  • 著者名/発表者名: Sasaki D, Kamihira S
  • 学会等名: ASH American Annual Meeting
  • 発表場所: USA
• [学会発表] 自然の実験系ATLに学ぶ臨床化 (2009)
  • 著者名/発表者名: 上平憲
  • 学会等名: 第49回日本臨床化学会学術集会
  • 発表場所: 長崎市
• [学会発表] MDSの形態学的異形性に基づく診断確度区分 (2009)
  • 著者名/発表者名: 鶴田一人、上平憲
  • 学会等名: 日本臨床検査医学会
  • 発表場所: 三重
• [学会発表] The Overexpression of Enhancer of Zeste Homologue 2 Is Associated withTumor Proliferati on and Aggressive Behavior in Adult T-Cell Leukemia/Lymphoma. (2009)
  • 著者名/発表者名: Daisuke Sasaki, Shimeru Kamihira
  • 学会等名: ASH American Annual Meeting
  • 発表場所: USA, New Orins
• [図書] 臨床検査ガイド2009-2010 (2009)
  • 著者名/発表者名: 上平憲
  • 出版者: 文光堂(東京)
• [図書] 臨床検査カレッジ (2009)
  • 著者名/発表者名: 上平憲
  • 出版者: 文光堂(東京)