抗老化蛋白SMP30を用いた心不全の新規治療戦略

• 研究課題/領域番号: 21590935
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 循環器内科学
• 研究機関: 福島県立医科大学
• 研究代表者: 竹石 恭知 福島県立医科大学, 医学部, 教授 (40272067)
• 研究分担者: 齋藤 修一 福島県立医科大学, 医学部, 准教授 (20274962)
• 連携研究者: 石神 昭人 東京都健康長寿医療センター研究所, 分子老化制御部門, 研究副部長 (50270658)
• 研究期間 (年度): 2009 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円); 2011年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2010年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円); 2009年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円)
• キーワード: 加齢 / 心不全 / 酸化ストレス / アンジオテンシンII / アポトーシス / 遺伝子操作マウス / 老化

研究概要

SMP30遺伝子ノックアウトマウスでは野生型マウスに比し、アンジオテンシンII投与後、心機能は低下し、NADPHオキシダーゼ活性の上昇、ROS産生の増加、c-Jun-N terminal kinaseリン酸化活性の上昇、Bax/Bcl比の増大、カスパーゼ活性の上昇、TUNEL陽性細胞数の増加が認められた。SMP30は抗酸化作用、抗アポトーシス作用を介して心筋細胞保護作用を有することが示唆された。

研究成果

• [雑誌論文] Crucial role of membrane type 1 matrix metalloproteinase(MT1-MMP) in RhoA/Rac1-dependent signaling pathways in thrombin-stimulated endothelial cells (2011)
  • 著者名/発表者名: Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, Hu C, Okamoto Y, Takuwa Y, Takeishi Y
  • 雑誌名: J Atheroscler Thromb 巻: 18 ページ: 762-773
  • NAID: 130004845389
  • 査読あり
• [雑誌論文] Differential regulation of diacylglycerol kinase isoform in human failing hearts (2011)
  • 著者名/発表者名: Bilim O, Shishido T, Toyama S, Suzuki S, Sasaki T, Kitahara T, Sadahiro M, Takeishi Y, Kubota I
  • 雑誌名: J Cardiothorac Surg 巻: 6 ページ: 65-65
  • 査読あり
• [雑誌論文] Diacylglycerol kinase inhibits ventricular tachyarrhythmias in a mouse model of heart failure-roles of canonical transient receptor potential(TRPC) channels- (2011)
  • 著者名/発表者名: Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M
  • 雑誌名: Circ J 巻: 75 ページ: 2333-2342
  • 査読あり
• [雑誌論文] Involvement of membrane type 1-matrix metalloproteinase(MT1-MMP) in RAGE activation signaling pathways (2011)
  • 著者名/発表者名: Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, Matsui T, Yamagishi S, Ando K, Sakamoto T, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y
  • 雑誌名: J Cell Physiol 巻: 226 ページ: 1554-1563
  • 査読あり
• [雑誌論文] Long-term clinical outcomes after deferral of percutaneous coronary intervention of intermediate coronary stenoses based on coronary pressure-derived fractional flow reserve (2011)
  • 著者名/発表者名: Misaka T, Kunii H, Mizukami H, Sakamoto N, Nakazato K, Takeishi Y
  • 雑誌名: J Cardiol 巻: 58 ページ: 32-37
  • NAID: 10031159571
  • 査読あり
• [雑誌論文] Very late stent thrombosis and neointimal plaque rupture after implantation of sirolimus-eluting stents : observations with angiography (2011)
  • 著者名/発表者名: Sakamoto N, Nakazato K, Misaka T, Mizukami H, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • 雑誌名: Cardiovasc Intervent Ther 巻: 26 ページ: 263-268
  • 査読あり
• [雑誌論文] Impairment of FOS mRNA induction by a translation inhibitor puromycin in granulocytes from myelodysplastic syndrome patients (2011)
  • 著者名/発表者名: Shikama Y, XiaoMin F, Shichishima T, Ono T, Noji H, Ikeda K, Ogawa K, Takeishi Y, Kimura J
  • 雑誌名: Brit J Haematol 巻: 154 ページ: 525-527
  • 査読あり
• [雑誌論文] Suppressive effects of valsartan on microalbuminuria and CRP in patients with metabolic syndrome(Val-Mets) (2011)
  • 著者名/発表者名: Shishido T, Konta T, Nishiyama S, Miyashita T, Miyamoto T, Takasaki S, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • 雑誌名: Clin Exp Hypertens 巻: 33 ページ: 117-123
  • 査読あり
• [雑誌論文] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event (2011)
  • 著者名/発表者名: Suzuki S, Shishido T, Ishino M, Katoh S, Sasaki T, Nishiyama S, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • 雑誌名: Eur J Clin Invest 巻: 41 ページ: 759-766
  • 査読あり
• [雑誌論文] Adaptive servo ventilation improves cardiac dysfunction and prognosis in chronic heart failure patients with Cheyne-Stokes respiration (2011)
  • 著者名/発表者名: Yoshihisa A, Shimizu T, Owada T, Nakamura Y, Iwaya S, Yamauchi H, Miyata M, Hoshino Y, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • 雑誌名: Int Heart J 巻: 52 ページ: 218-223
  • NAID: 130000971165
  • 査読あり
• [雑誌論文] Ezetimibe and vascular inflammation (2011)
  • 著者名/発表者名: Ishibashi T, Takeishi Y
  • 雑誌名: Curr Vasc Pharmacol 巻: 9 ページ: 99-108
  • 査読あり
• [雑誌論文] Pleiotropic effects of ARB in diabetes mellitus (2011)
  • 著者名/発表者名: Saitoh S, Takeishi Y
  • 雑誌名: Curr Vasc Pharmacol 巻: 9 ページ: 136-144
  • 査読あり
• [雑誌論文] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event (2011)
  • 著者名/発表者名: Suzuki S, Takeishi Y, et al
  • 雑誌名: European Journal of Clinical Investigation 巻: 41 号: 7 ページ: 759-766
  • DOI: 10.1111/j.1365-2362.2010.02465.x
  • 査読あり
• [雑誌論文] Adaptive servo ventilation improves cardiac dysfunction and prognosis in chronic heart failure patients with Cheyne-Stokes respiration (2011)
  • 著者名/発表者名: Yoshihisa A, Takeishi Y, et al
  • 雑誌名: International Heart Journal 巻: 52 ページ: 218-223
  • NAID: 130000971165
  • 査読あり
• [雑誌論文] Crucial role of membrane type 1 matrix metalloproteinase (MT1-MMP) in RhoA/Rac1-dependent signaling pathways in thrombin-stimulated endothelial cells (2011)
  • 著者名/発表者名: Ando K, Takeishi Y, et al
  • 雑誌名: Journal of Atherosclerosis and Thrombosis 巻: 18 ページ: 762-773
  • NAID: 130004845389
  • 査読あり
• [雑誌論文] Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure-roles of canonical transient receptor potential (TRPC) channels- (2011)
  • 著者名/発表者名: Hirose M, Takeishi Y, et al
  • 雑誌名: Circulation Journal 巻: 75 ページ: 2333-2342
  • NAID: 10029459214
  • 査読あり
• [雑誌論文] Differential regulation of diacylglycerol kinase isoform in human failing hearts (2011)
  • 著者名/発表者名: Bilim O, Takeishi Y, et al
  • 雑誌名: Journal of Cardiothoracic Surgery 巻: 6 ページ: 65-65
  • 査読あり
• [雑誌論文] Impairment of FOS mRNA induction by a translation inhibitor puromycin in granulocytes from myelodysplastic syndrome patients (2011)
  • 著者名/発表者名: Shikama Y, Takeishi Y, et al
  • 雑誌名: British Journal of Haematology 巻: 154 ページ: 525-527
  • 査読あり
• [雑誌論文] Involvement of membrane type1-matrix metalloproteinase(MT1-MMP) in rage activation signalingpathways (2011)
  • 著者名/発表者名: Kamioka M, Ishibashi T, Ohkawara H, Eguchi R, Sugimoto K, Uekita H, Matsui T, Yamagishi SI, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y.
  • 雑誌名: J Cell Physiol 巻: 226(6) 号: 6 ページ: 1554-1563
  • DOI: 10.1002/jcp.22492
  • 査読あり
• [雑誌論文] Long-term chnical outcomes after deferral of percutaneous coronary intervention of intermediate coronary stenoses based on coronary pressure-derived fractional flow reserve (2011)
  • 著者名/発表者名: Misaka T, Takeishi Y, et al
  • 雑誌名: Journal of Cardiology 巻: 58 ページ: 32-37
  • 査読あり
• [雑誌論文] Suppressive effects of valsartan on microalbuminuria and CRP in patients with metabolic syndrome (Val-Mets) (2011)
  • 著者名/発表者名: Shishido T, Takeishi Y, et al
  • 雑誌名: Clinical and Experimental Hypertension 巻: 33 ページ: 117-123
  • 査読あり
• [雑誌論文] Very late stent thrombosis and neointimal plaque rupture after implantation of sirolimus-eluting stents : observations with angiography, IVUS and OCT (2011)
  • 著者名/発表者名: Sakamoto N, Takeishi Y, et al
  • 雑誌名: Cardiovascular Intervention and Therapeutics 巻: 26 ページ: 263-268
  • 査読あり
• [雑誌論文] Ezetimibe and vascular inflammation (Review) (2011)
  • 著者名/発表者名: Ishibashi T, Takeishi Y, et al
  • 雑誌名: Current Vascular Pharmacology 巻: 9 ページ: 99-108
• [雑誌論文] Pleiotropic effects of ARB in diabetes mellitus (Review) (2011)
  • 著者名/発表者名: Saitoh S, Takeishi Y, et al
  • 雑誌名: Current Vascular Pharmacology 巻: 9 ページ: 136-144
• [雑誌論文] Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure (2010)
  • 著者名/発表者名: Bilim O, Takeishi Y, Kitahara T, Ishino M, Sasaki T, Suzuki S, Shishido T, Kubota I
  • 雑誌名: J Card Fail 巻: 16 ページ: 873-879
  • 査読あり
• [雑誌論文] Advanced glycation end product mediated matrix metallo-proteinase-9 and apoptosis via renin-angiotensin system in type 2 diabetes (2010)
  • 著者名/発表者名: Ishibashi T, Kawaguchi M, Sugimoto K, Uekita H, Sakamoto N, Yokoyama K, Maruyama Y, Takeishi Y
  • 雑誌名: J Atheroscler Thromb 巻: 17 ページ: 578-589
  • NAID: 130004845318
  • 査読あり
• [雑誌論文] Tricuspid valvular dysplasia and its differentiation from Ebstein's anomaly (2010)
  • 著者名/発表者名: Iwai-Takano M, Watanabe M, Otake H, Kobayashi A, Oikawa M, Machii H, Misaka T, Watanabe T, Takeishi Y
  • 雑誌名: J Echocardiogr 巻: 8 ページ: 137-139
  • NAID: 10027703318
  • 査読あり
• [雑誌論文] Blockade of renin-angiotensin system attenuates advanced glycation end products-mediated signaling pathways (2010)
  • 著者名/発表者名: Kamioka M, Ishibashi T, Sugimoto K, Uekita H, Nagai R, Sakamoto N, Ando K, Ohkawara H, Teramoto T, Maruyama Y, Takeishi Y
  • 雑誌名: J Atheroscler Thromb 巻: 17 ページ: 590-600
  • NAID: 130004845319
  • 査読あり
• [雑誌論文] Metabolic regulation of coronary vascular tone : role of hydrogen peroxide, purinergic components, and angiotensin (2010)
  • 著者名/発表者名: Kaneshiro T, Saitoh S, Machii H, Yamaguchi O, Ishibashi T, Maruyama Y, Takeishi Y
  • 雑誌名: Eur J Pharmacol 巻: 645 ページ: 127-134
  • 査読あり
• [雑誌論文] Serum midkine as a predictor of cardiac events in patients with chronic heart failure (2010)
  • 著者名/発表者名: Kitahara T, Shishido T, Suzuki S, Katoh S, Sasaki T, Ishino M, Nitobe J, Miyamoto T, Miyashita T, Watanabe T, Takeishi Y, Kubota I
  • 雑誌名: J Card Fail 巻: 16 ページ: 308-313
  • 査読あり
• [雑誌論文] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • 著者名/発表者名: Machii H, Saitoh S, Kaneshiro T, Takeishi Y
  • 雑誌名: Mech Ageing Dev 巻: 131 ページ: 710-717
  • 査読あり
• [雑誌論文] Prognostic study of cardiac and renal events in Japanese patients with chronic kidney disease and cardiovascular risk using myocardial perfusion SPECT : J-ACCESS 3 study design (2010)
  • 著者名/発表者名: Nakamura S, Yuhei K, Hase H, Hatta T, Nishimura S, Moroi M, Nakagawa S, Kasai T, Kusuoka H, Takeishi Y, Nakajima K, Momose M, Takehana K, Nanasato M, Yoda S, Nishina H, Matsumoto N, Nishimura T
  • 雑誌名: Ther Apher Dial 巻: 14 ページ: 379-385
  • 査読あり
• [雑誌論文] A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation (2010)
  • 著者名/発表者名: Ogawa K, Ikeda K, Furukawa M, Harada-Shirado K, Mashimo Y, Takahashi H, Matsumoto H, Kimura S, Shichishima-Nakamura A, Ohkawara H, Hashimoto Y, Asahi K, Noji H, Ohto H, Takeishi Y
  • 雑誌名: Fukushima J Med Sci 巻: 56 ページ: 151-156
  • NAID: 130000419024
  • 査読あり
• [雑誌論文] Hematopoietic stem cell transplantation in the department of hematology (2010)
  • 著者名/発表者名: Ogawa K, Noji H, Furukawa M, Harada-Shirado K, Mashimo Y, Takahashi H, Matsumoto H, Kimura S, Shichishima-Nakamura A, Ohkawara H, Ikeda K, Ohto H, Takeishi Y
  • 雑誌名: Fukushima J Med Sci 巻: 56 ページ: 107-114
  • 査読あり
• [雑誌論文] Preventive effects of pravastatin on thrombin-triggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo (2010)
  • 著者名/発表者名: Ohkawara H, Ishibashi T, Saitoh S, Inoue N, Sugimoto K, Kamioka M, Uekita H, Kaneshiro T, Ando K, Takuwa Y, Maruyama Y, Takeishi Y
  • 雑誌名: Cardiovasc Res 巻: 88 ページ: 492-501
  • 査読あり
• [雑誌論文] Hydrogen peroxide generated from cardiac myocytes impacts metabolic dilation in coronary arterioles (2010)
  • 著者名/発表者名: Otake A, Saitoh S, Takeishi Y
  • 雑誌名: Int Heart J 巻: 51 ページ: 125-128
  • NAID: 130000250204
  • 査読あり
• [雑誌論文] High serum level of neopterin is a risk factor of patients with heart failure (2010)
  • 著者名/発表者名: Sasaki T, Takeishi Y, Suzuki S, Niizeki T, Kitahara T, Katoh S, Ishino M, Shishido T, Kubota I
  • 雑誌名: Int J Cardiol 巻: 145 ページ: 318-318
  • NAID: 120002190675
  • 査読あり
• [雑誌論文] Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes (2010)
  • 著者名/発表者名: Shichishima T, Ikeda K, Takahashi N, Kameoka J, Tajima K, Murai K, Tamai Y, Shichishima-Nakamura A, Akutsu K, Noji H, Okamoto M, Kimura H, Harigae H, Oyamada T, Kamesaki T, Takeishi Y, Sawada K
  • 雑誌名: Int J Hematol 巻: 91 ページ: 602-610
  • NAID: 10026401926
  • 査読あり
• [雑誌論文] The nitric oxide synthase family and left ventricular diastolic function (2010)
  • 著者名/発表者名: Takeishi Y
  • 雑誌名: Circ J 巻: 74 ページ: 2556-2557
  • NAID: 10027424100
  • 査読あり
• [雑誌論文] Survival of a refractory ventricular fibrillation by cooperative treatments (2010)
  • 著者名/発表者名: Tase C, Ohno Y, Hasegawa A, Tsukada Y, Shimada J, Ikegami Y, Sakamoto N, Takeishi Y
  • 雑誌名: Fukushima J Med Sci 巻: 56 ページ: 139-143
  • NAID: 130000419022
  • 査読あり
• [雑誌論文] Flow mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome (2010)
  • 著者名/発表者名: Yoshihisa A, Owada T, Hoshino Y, Miyata M, Misaka T, Sato T, Suzuki S, Sakamoto N, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishibashi T, Takeishi Y
  • 雑誌名: Fukushima J Med Sci 巻: 56 ページ: 115-120
  • NAID: 130000419018
  • 査読あり
• [雑誌論文] A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stern-cell transplantation (2010)
  • 著者名/発表者名: Ogawa K, Takeishi Y, et al
  • 雑誌名: Fukushima Journal of Medical Science 巻: 56 ページ: 151-156
  • 査読あり
• [雑誌論文] Advanced glycation end product-mediated matrix metallo-proteinase-9 and apoptosis via renin-angiotensin system in type 2 diabetes (2010)
  • 著者名/発表者名: Ishibashi T, Takeishi Y, et al
  • 雑誌名: Journal of Atherosclerosis and Thrombosis 巻: 17 ページ: 578-589
  • NAID: 130004845318
  • 査読あり
• [雑誌論文] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • 著者名/発表者名: Machii H, Takeishi Y, et al
  • 雑誌名: Mechanisms of Ageing and Development 巻: 131 ページ: 710-717
  • 査読あり
• [雑誌論文] Blockade of renin-angiotensin system attenuates advanced glycation end products-mediated signaling pathways (2010)
  • 著者名/発表者名: Kamioka M, Takeishi Y, et al
  • 雑誌名: Journal of Atherosclerosis and Thrombosis 巻: 17 ページ: 590-600
  • NAID: 130004845319
  • 査読あり
• [雑誌論文] Flow-mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome (2010)
  • 著者名/発表者名: Yoshihisa A, Takeishi Y, et al
  • 雑誌名: Fukushima Journal of Medical Science 巻: 56 ページ: 115-120
  • NAID: 130000419018
  • 査読あり
• [雑誌論文] Hematopoietic stem cell transplantation in the department of hematology, Fukushima Medical University (2010)
  • 著者名/発表者名: Ogawa K, Takeishi Y, et al
  • 雑誌名: Fukushima Journal of Medical Science 巻: 56 ページ: 107-114
  • NAID: 130000419017
  • 査読あり
• [雑誌論文] High serum level of neopterin is a risk factor of patients with heart failure (2010)
  • 著者名/発表者名: Sasaki T, Takeishi Y, et al
  • 雑誌名: International Journal of Cardiology 巻: 145 ページ: 318-318
  • NAID: 120002190675
  • 査読あり
• [雑誌論文] Hydrogen peroxide generated from cardiac myocytes impacts metabolic dilation in coronary arterioles (2010)
  • 著者名/発表者名: Otake A, Takeishi Y, et al
  • 雑誌名: International Heart Journal 巻: 51 ページ: 125-128
  • NAID: 130000250204
  • 査読あり
• [雑誌論文] Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes (2010)
  • 著者名/発表者名: Shichishima T, Takeishi Y, et al
  • 雑誌名: International Journal of Hematology 巻: 91 ページ: 602-610
  • NAID: 10026401926
  • 査読あり
• [雑誌論文] Metabolic regulation of coronary vascular tone : role of hydrogen peroxide, purinergic components, and angiotensin (2010)
  • 著者名/発表者名: Kaneshiro T, Takeishi Y, et al
  • 雑誌名: European Journal of Pharmacology 巻: 645 ページ: 127-134
  • 査読あり
• [雑誌論文] Preventive effects of pravastatin on thrombin-triggered vascular responses via Akt/eNOS and RhoA/Racl pathways in vivo (2010)
  • 著者名/発表者名: Ohkawara H, Takeishi Y, et al
  • 雑誌名: Cardiovascular Research 巻: 88 ページ: 492-501
  • 査読あり
• [雑誌論文] Prognostic study of cardiac and renal events in Japanese patients with chronic kidney disease and cardiovascular risk using myocardial perfusion SPELT : J-ACCESS 3 study design (2010)
  • 著者名/発表者名: Nakamura S, Takeishi Y, et al
  • 雑誌名: Therapeutic Apheresis and Dialysis 巻: 14 ページ: 379-385
  • 査読あり
• [雑誌論文] Serum midkine as a predictor of cardiac events in patients with chronic heart failure (2010)
  • 著者名/発表者名: Kitahara T, Takeishi Y, et al
  • 雑誌名: Journal of Cardiac Failure 巻: 16 ページ: 308-313
  • 査読あり
• [雑誌論文] Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure (2010)
  • 著者名/発表者名: Bilim O, Takeishi Y, et al
  • 雑誌名: Journal of Cardiac Failure 巻: 16 ページ: 873-879
  • 査読あり
• [雑誌論文] Survival of a refractory ventricular fibrillation by cooperative treatments (2010)
  • 著者名/発表者名: Tase C, Takeishi Y, et al
  • 雑誌名: Fukushima Journal of Medical Science 巻: 56 ページ: 139-143
  • NAID: 130000419022
  • 査読あり
• [雑誌論文] The nitric oxide synthase family and left ventricular diastolic function (2010)
  • 著者名/発表者名: Takeishi Y
  • 雑誌名: Circulation Journal 巻: 74 ページ: 2556-2557
  • NAID: 10027424100
  • 査読あり
• [雑誌論文] Tricuspid valvular dysplasia and its differentiation from Ebstein's anomaly (2010)
  • 著者名/発表者名: Takano M, Takeishi Y, et al
  • 雑誌名: Journal of Echocardiography 巻: 8 ページ: 137-139
  • NAID: 10027703318
  • 査読あり
• [雑誌論文] Factors correlated with plasma renin activity in general Japanese population (2009)
  • 著者名/発表者名: Abiko H, Konta T, Hao Z, Takasaki S, Suzuki K, Ichikawa K, Ikeda A, Shibata Y, Takeishi Y, Kawata S, Kato T, Kubota I
  • 雑誌名: Clin Exp Nephrol 巻: 13 ページ: 130-137
  • NAID: 10025586090
  • 査読あり
• [雑誌論文] Diacylglycerol kinase inhibits Gaq-induced atrial remodeling in transgenic mice (2009)
  • 著者名/発表者名: Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M
  • 雑誌名: Heart Rhythm 巻: 6 ページ: 78-84
  • 査読あり
• [雑誌論文] Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Japanese women (2009)
  • 著者名/発表者名: Ichikawa K, Konta T, Emi M, Toriyama S, Takasaki S, Ikeda A, Shibata Y, Takabatake N, Takeishi Y, Kato T, Kawata S, Kubota I
  • 雑誌名: Kidney Int 巻: 76 ページ: 183-189
  • 査読あり
• [雑誌論文] In a non-diabetic Japanese population, the combination of macroalbuminuria and increased urine beta 2-microglobulin predicts a decline of renal function (2009)
  • 著者名/発表者名: Ikeda A, Konta T, Takasaki S, Hao Z, Suzuki K, Sato H, Shibata Y, Takeishi Y, Kato T, Kawata S, Kubota I
  • 雑誌名: Nephrol Dial Transpl 巻: 24 ページ: 841-847
  • 査読あり
• [雑誌論文] Combination of conventional biomarkers for risk stratification in chronic heart failure (2009)
  • 著者名/発表者名: Niizeki T, Takeishi Y, Kitahara T, Suzuki S, Sasaki T, Ishino M, Kubota I
  • 雑誌名: J Cardiol 巻: 53 ページ: 179-187
  • NAID: 10025183000
  • 査読あり
• [雑誌論文] RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits (2009)
  • 著者名/発表者名: Ohkawara H, Ishibashi T, Shiomi M, Sugimoto K, Uekita H, Kamioka M, Takuwa Y, Teramoto T, Maruyama Y, Takeishi Y
  • 雑誌名: J Atheroscler Thromb 巻: 16 ページ: 846-856
  • NAID: 10026144512
  • 査読あり
• [雑誌論文] Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+signaling pathways in endothelial cells (2009)
  • 著者名/発表者名: Sakamoto N, Ishibashi T, Sugimoto K, Sawamura T, Sakamoto T, Inoue N, Saitoh S, Kamioka M, Uekita H, Ohkawara H, Suzuki K, Teramoto T, Maruyama Y, Takeishi Y
  • 雑誌名: J Cell Physiol 巻: 220 ページ: 706-715
  • 査読あり
• [雑誌論文] LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells (2009)
  • 著者名/発表者名: Sugimoto K, Ishibashi T, Sawamura T, Inoue N, KamiokaM, Uekita H, Ohkawara H, Sakamoto T, Sakamoto N, Okamoto Y, Takuwa Y, Kakino A, Fujita Y, Tanaka T, Teramoto T, Maruyama Y, Takeishi Y
  • 雑誌名: Cardiovasc Res 巻: 84 ページ: 127-136
  • 査読あり
• [雑誌論文] Mast cells contribute to flow restoration by bone marrow cell transplantation in rats with ischemic limbs (2009)
  • 著者名/発表者名: Tajima H, Iwai-Takano M, Yaoita H, Ogawa K, Yamaki T, Takeishi Y, Maruyama Y
  • 雑誌名: Int Heart J 巻: 50 ページ: 247-257
  • NAID: 130000108089
  • 査読あり
• [雑誌論文] A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD (2009)
  • 著者名/発表者名: Takabatake N, Toriyama S, Igarashi A, Tokairin Y, Takeishi Y, Konta T, Inoue S, Abe S, Shibata Y, Kubota I
  • 雑誌名: Biochem Bioph Res Co 巻: 381 ページ: 554-559
  • 査読あり
• [雑誌論文] Regulation of coronary vascular tone via redox modulation in the α1-adrenergic-angiotensin-endothelin axis of the myocardium (2009)
  • 著者名/発表者名: Yamaguchi O, Kaneshiro T, Saitoh S, Ishibashi T, Maruyama Y, Takeishi Y
  • 雑誌名: Am J Physiol-Heart C 巻: 296
  • 査読あり
• [雑誌論文] Participation of mast cells in angiogenesis in the border zone of myocardial infarction in rats (2009)
  • 著者名/発表者名: Yamaki T, Iwai-Takano M, Yaoita H, Ogawa K, Tajima H, Takeishi Y, Maruyama Y
  • 雑誌名: J Med Ultrason 巻: 36 ページ: 119-127
  • NAID: 10025328115
  • 査読あり
• [雑誌論文] Role of Toll-like receptor mediated signaling pathway in ischemic heart (2009)
  • 著者名/発表者名: Takeishi Y, Kubota I
  • 雑誌名: Front Biosci 巻: 14 ページ: 2553-2558
  • 査読あり
• [雑誌論文] A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD (2009)
  • 著者名/発表者名: Takabatake N, Takeishi Y, et al
  • 雑誌名: Biochemical and Biophysical Research Communications 4 ページ: 554-559
  • 査読あり
• [雑誌論文] Combination of conventional biomarkers for risk stratification in chronic heart failure (2009)
  • 著者名/発表者名: Niizeki T, Takeishi Y, et al
  • 雑誌名: Journal of Cardiology 2 ページ: 179-187
  • NAID: 10025183000
  • 査読あり
• [雑誌論文] Diacylglycerol kinase ζ inhibits G α q-induced atrial remodeling in transgenic mice (2009)
  • 著者名/発表者名: Hirose M, Takeishi Y, et al
  • 雑誌名: Heart Rhythm 1 ページ: 78-84
  • 査読あり
• [雑誌論文] Factors correlated with plasma renin activity in general Japanese population (2009)
  • 著者名/発表者名: Abiko H, Takeishi Y, et al
  • 雑誌名: Clinical and Experimental Nephrology 2 ページ: 130-137
  • NAID: 10025586090
  • 査読あり
• [雑誌論文] Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Javanese women (2009)
  • 著者名/発表者名: Ichikawa K, Takeishi Y, et al
  • 雑誌名: Kidney International 2 ページ: 183-189
  • 査読あり
• [雑誌論文] In a non-diabetic Japanese population, the combination of macroalbuminuria and increased urine beta 2-microglobulin predicts a decline of renal function : the Takahata study (2009)
  • 著者名/発表者名: Ikeda A, Takeishi Y, et al
  • 雑誌名: Nephrology Dialysis Transplantation 3 ページ: 841-847
  • 査読あり
• [雑誌論文] LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells (2009)
  • 著者名/発表者名: Sugimoto K, Takeishi Y, et al
  • 雑誌名: Cardiovascular Research 1 ページ: 127-136
  • 査読あり
• [雑誌論文] Mast cells contribute to flow restoration by bone marrow cell transplantation in rats with ischemic limbs (2009)
  • 著者名/発表者名: Tajima H, Takeishi Y, et al
  • 雑誌名: International Heart Journal 2 ページ: 247-257
  • NAID: 130000108089
  • 査読あり
• [雑誌論文] Participation of mast cells in angiogenesis in the border zone of myocardial infarction in rats (2009)
  • 著者名/発表者名: Yamaki T, Takeishi Y, et al
  • 雑誌名: Journal of Medical Ultrasonics 3 ページ: 119-127
  • NAID: 10025328115
  • 査読あり
• [雑誌論文] Regulation of coronary vascular tone via redox modulation in the α 1-adrenergic-angiotensin-endothelin axis the myocardium (2009)
  • 著者名/発表者名: Yamaguchi O, Takeishi Y, et al
  • 雑誌名: American Journal of Physiology (Heart and Circulatory Physiology) 1
  • 査読あり
• [雑誌論文] RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits (2009)
  • 著者名/発表者名: Ohkawara H, Takeishi Y, et al
  • 雑誌名: Journal of Atherosclerosis and Thrombosis 6 ページ: 846-856
  • NAID: 10026144512
  • 査読あり
• [雑誌論文] Role of Toll-like receptor mediated signaling pathway in ischemic heart (2009)
  • 著者名/発表者名: Takeishi Y, Kubota I
  • 雑誌名: Frontiers in Bioscience Jan.1 ページ: 2553-2558
  • 査読あり
• [雑誌論文] Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca^<2+> signaling pathways in endothelial cells (2009)
  • 著者名/発表者名: Sakamoto N, Takeishi Y, et al
  • 雑誌名: Journal of Cellular Physiology 3 ページ: 706-715
  • 査読あり
• [雑誌論文] (2009)
  • 著者名/発表者名: 泉田次郎, 竹石恭知
  • 雑誌名: みるみるマスター! 循環器ケアのトレーニングブック 100のキーワード&50のケース&250問クイズ (第1部 100のキーワードから修得する循環器ケア;KEY WORD 53 : MRI検査, KEY WORD 54 : CT検査, KEY WORD 55 : 運動負荷心電図検査, KEY WORD 56 : 電気生理検査)((株)メディカ出版) ページ: 124-131
• [雑誌論文] (2009)
  • 著者名/発表者名: 竹石恭知
  • 雑誌名: Annual Review循環器2009 (II. 疾患の病因と病態 3. Toll-like receptorと心臓リモデリング)(中外医学社) ページ: 66-75
• [雑誌論文] (2009)
  • 著者名/発表者名: 鈴木均, 竹石恭知
  • 雑誌名: 循環器検査のグノーティ・セアウトンー過信せず侮らず、謙虚で緻密な検査とは(3. 不整脈,失神:心臓電気生理検査で異常が出ないときは、睡眠時無呼吸症を疑え)((株)シナジー) ページ: 204-207
• [雑誌論文] Maturity-dependent fractionation of neutrophil progenitors : A new method to examine in vivo expression profiles of differentiation-regulating genes
  • 著者名/発表者名: Hu H, Shikama Y, Shichishima T, Ikeda K, Akutsu K, Ono T, Kimura H, Ogawa K, Noji H, Takeishi Y, Kimura J
  • 雑誌名: Exp Hematol 巻: (in press)
  • 査読あり
• [学会発表] Senescence marker protein-30 deficiency impairs myocardium-induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • 著者名/発表者名: Mizukami H, Takeishi Y, et al
  • 学会等名: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • 発表場所: Tokyo
  • 年月日: 2011-12-03
• [学会発表] Senescence marker protein 30 inhibits angiotensin II-induced cardiac remodeling (2011)
  • 著者名/発表者名: Misaka T, Takeishi Y, et al
  • 学会等名: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • 発表場所: Tokyo
  • 年月日: 2011-12-02
• [学会発表] Adaptive servo ventilation improves cardiac function and prognosis in chronic heart failure patients with Cheyne-Stokes respiration after cardiac resynchronization therapy (2011)
  • 著者名/発表者名: Miyata M, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-16
• [学会発表] Senescence marker protein 30 inhibits angiotensin II-induced cardiac remodeling (2011)
  • 著者名/発表者名: Misaka T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-16
• [学会発表] Comparisons of prognostic factors between chronic heart failure patients with and without atrial fibrillation (2011)
  • 著者名/発表者名: Sato T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-16
• [学会発表] Cardiac-specific overexpression of high mobility group box 1 (HMGB1) attenuates cardiac dysfunction induced by pressure overload (2011)
  • 著者名/発表者名: Funayama A, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Associaton 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-16
• [学会発表] Overnight use of adaptive servo ventilation reduces cardiac overbad and improves renal function in patients with chronic heart failure and Cheyne-Stokes respiration (2011)
  • 著者名/発表者名: Yoshihisa A, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-15
• [学会発表] Aging impairs endothelium-dependent dilation via thiol-oxidation in coronary arterioles in SMP 30 deficiency mice (2011)
  • 著者名/発表者名: Yamada S, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-15
• [学会発表] Overexpressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injury (2011)
  • 著者名/発表者名: Oikawa M, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-15
• [学会発表] Distinct prognostic factors in patients with chronic heart failure and chronic kidney-disease (2011)
  • 著者名/発表者名: Sato T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-14
• [学会発表] Senescence marker protein-30 deficiency impairs myocardium-induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • 著者名/発表者名: Mizukami H, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-14
• [学会発表] The importance of serial renal function measurements in chronic heart failure (2011)
  • 著者名/発表者名: Sato T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2011
  • 発表場所: Orlando, Florida USA
  • 年月日: 2011-11-14
• [学会発表] Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodeling (2011)
  • 著者名/発表者名: Misaka T, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2011
  • 発表場所: Paris, France
  • 年月日: 2011-08-31
• [学会発表] Common carotid artery Kinking is predictor of cardiovascular events : long term follow-up study using by carotid sonography (2011)
  • 著者名/発表者名: Watanabe T, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2011
  • 発表場所: Paris, France
  • 年月日: 2011-08-30
• [学会発表] Non-invasive detection of vascular dysfunction in sleep apnea syndrome by cardio-ankle vascular index and flow-mediated dilatation (2011)
  • 著者名/発表者名: Yoshihisa A, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2011
  • 発表場所: Paris, France
  • 年月日: 2011-08-30
• [学会発表] Tenascin-C level is related to coronary plaque rupture in patients with acute coronary syndrome (2011)
  • 著者名/発表者名: Sakamoto N, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2011
  • 発表場所: Paris, France
  • 年月日: 2011-08-30
• [学会発表] Acute benefical impact of adaptive servo ventilation on hemodynamic data in heart failure patients with Cheyne-Stokes respiration (2011)
  • 著者名/発表者名: Miyata M, Takeishi Y, et al
  • 学会等名: Congress of the Euaropean Society of Cardiology 2011
  • 発表場所: Paris, France
  • 年月日: 2011-08-30
• [学会発表] Adaptive servo ventilation improves cardiac function and long term prognosis in heart failure patients with Cheyne-Stokes respiration (2011)
  • 著者名/発表者名: Yoshihisa A, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2011
  • 発表場所: Paris, France
  • 年月日: 2011-08-29
• [学会発表] The relation of the decreasing rates of intrathoracic impedance and decompensated heart failure (2011)
  • 著者名/発表者名: Yamada S, Takeishi Y, et al
  • 学会等名: Heart Rhythm 2011, 32nd Annual Scientific Sessions
  • 発表場所: San Francisco, CA, USA
  • 年月日: 2011-05-06
• [学会発表] The assessment of circadian variation of late potential is useful for predicting the occurrence of ventricular tachycardia in patients with dilated cardiomyopathy (2011)
  • 著者名/発表者名: Kamiyama Y, Takeishi Y, et al
  • 学会等名: Heart Rhythm 2011, 32nd Annual Scientific Sessions
  • 発表場所: San Francisco, CA, USA
  • 年月日: 2011-05-06
• [学会発表] Early repolarization pattern on electrocardiogram and risk of sudden cardiac death : the circulatory risk in communities study (CIRCS) (2011)
  • 著者名/発表者名: Ohira T, Takeishi Y, et al
  • 学会等名: Nutrition, Physical Activity and Metabolism/Cardiovascular Disease Epidemiology and Prevention 2011 Scientific Sessions
  • 発表場所: Atlanta, GA, USA
  • 年月日: 2011-03-24
• [学会発表] Senescence marker protein 30 inhibits angiotensin II-induced cardiac remodeling (2011)
  • 著者名/発表者名: Misaka T, Suzuki S, Miyata M, Kobayashi A, Saitoh S, Takeishi Y
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Orlando, USA
• [学会発表] Distinct prognostic factors in patients with chronic heart failure and chronic kidney disease (2011)
  • 著者名/発表者名: Sato T, Misaka T, Ohwada T, Yamauchi H, Yoshihisa A, Suzuki H, Saitoh S, Takeishi Y
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Orlando, USA
• [学会発表] Overnight use of adaptive servo ventilation reduces cardiac overload and improves renal function in patients with chronic heart failure and Cheyne-Stokes respiration (2011)
  • 著者名/発表者名: Yoshihisa A, Suzuki S, Miyata M, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitho S, Takeishi Y
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Orlando, USA
• [学会発表] Comparisons of prognostic factors between chronic heart failure patients with and without atrial fibrillation (2011)
  • 著者名/発表者名: Sato T, Misaka T, Nakamura Y, Owada T, Yoshihisa A, Suzuki H, Saitoh S, Takeishi Y
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Orlando, USA
• [学会発表] Cardiac-specific overexpression of high mobility group box 1(HMGB1) attenuates cardiac dysfunction induced by pressure overload (2011)
  • 著者名/発表者名: Funayama A, Netsu S, Ishino M, Otaki Y, Honda S, Hasegawa H, Kadowaki S, Narumi T, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Woo C, Abe J, Kuwahara K, Nakao K, Takeishi Y, Kubota I
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Orlando, USA
• [学会発表] Senescence marker protein-30 deficiency impairs myocardium-induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • 著者名/発表者名: Mizukami H, Saitoh S, Yamada S, Machii H, Takeishi Y
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Orlando, USA
• [学会発表] The importance of serial renal function measurements in chronic heart failure (2011)
  • 著者名/発表者名: Sato T, Nakamura Y, Shimizu T, Misaka T, Yoshihisa A, Suzuki H, Saitoh S, Takeishi Y
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Orlando, USA
• [学会発表] Aging impairs endothelium dependent dilation via thiol-oxidation in coronary arterioles in SMP 30 deficiency mice (2011)
  • 著者名/発表者名: Yamada S, Saitoh S, Mizukami H, Machii H, Takeishi Y
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Orlando, USA
• [学会発表] Over expressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injury (2011)
  • 著者名/発表者名: Oikawa M, Lim S, Jeon K, Knight W, Miller C, Cai Y, Blaxall B, Abe J, Takeishi Y, Yan C
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Orlando, USA
• [学会発表] Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodeling (2011)
  • 著者名/発表者名: Misaka T, Suzuki S, Miyata M, Kobayashi A, Saitoh S, Ishigami A, Takeishi Y
  • 学会等名: Congress of the European Society of Cardiology
  • 発表場所: Paris, France
• [学会発表] Senescence marker protein-30 deficiency impairs myocardium induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • 著者名/発表者名: Mizukami H, Saitoh S, Yamada S, Machii H, Suzuki H, Takeishi Y
  • 学会等名: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • 発表場所: Tokyo
• [学会発表] Clinical utility of a novel index to evaluate left ventricular relaxation using aortic regurgitant velocity (2010)
  • 著者名/発表者名: Watanabe T, Takeishi Y, et al
  • 学会等名: EUROECHO 2010
  • 発表場所: Copenhagen, Denmark
  • 年月日: 2010-12-08
• [学会発表] Adaptive servo ventilation improves cardiac function and prognosis in heart failure patients with Cheyne-Stokes respiration (2010)
  • 著者名/発表者名: Yoshihisa A, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] Olmesartan inhibits GTP-binding protein alpha q-induced atrial remodeling in transgenic mice (2010)
  • 著者名/発表者名: Hirose M, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] Coronary flow reserve predicts cardiovascular and cerebrovascular events in patients with chronic kidney disease (2010)
  • 著者名/発表者名: Sakamoto N, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] MT1-MMP controls Akt-dependent Fox01 activation in TNF-α-induced signaling pathways of endothelial cell apoptosis and haemostasis (2010)
  • 著者名/発表者名: Ohkawara H, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] MT1-MMP forms a complex with Gi and regulates eNOS expression at posttranscriptional mechanism in oxidized LDL stimulated-endothelial cells (2010)
  • 著者名/発表者名: Sugimoto K,, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • 著者名/発表者名: Machii H, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] Intrathoracic impedance change reflects reverse left ventricular remodeling in response to cardiac resynchronization therapy in chronic heart failure (2010)
  • 著者名/発表者名: Yamada S, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] Uric acid increases the incidence of ventricular arrhythmia in patients with left ventricular hypertrophy (2010)
  • 著者名/発表者名: Yamada S, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] Soluble lectin-like oxidized LDL receptor-1 (LOX-1) and LOX index are useful biomarkers for vulnerable plaques (2010)
  • 著者名/発表者名: Misaka T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] Anaemia and abnormal ventilatory response to exercise predict adverse clinical outcomes in chronic heart failure (2010)
  • 著者名/発表者名: Sato T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2010
  • 発表場所: Chicago, Illinois, USA
  • 年月日: 2010-11-13
• [学会発表] 自然免疫と心血管病 (2010)
  • 著者名/発表者名: 竹石恭知
  • 学会等名: Vascular and Brain Conference
  • 発表場所: 大阪(特別講演)
  • 年月日: 2010-10-30
• [学会発表] Membrane Type I Matrix Metalloproteinase (MT1-MMP) mediates thrombin-induced RhoA/Racl activation and their downstream signaling in endothelial cells (2010)
  • 著者名/発表者名: Ando K, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2010
  • 発表場所: Stockholm, Sweden
  • 年月日: 2010-08-29
• [学会発表] LOX-1 cooperates with renin-angiotensin system in monocyte adhesion-induced redox-sensitive and Ca^<2+> signaling pathways in endothelial cells (2010)
  • 著者名/発表者名: Sakamoto N, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2010
  • 発表場所: Stockholm, Sweden
  • 年月日: 2010-08-29
• [学会発表] Serum 8-OHdG levels predicts adverse clinical outcomes in patients with heart failure (2010)
  • 著者名/発表者名: Suzuki S, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2010
  • 発表場所: Stockholm, Sweden
  • 年月日: 2010-08-29
• [学会発表] Coronary flow reserve predicts cardiovascular and cerebrovascular events in patients with chronic kidney disease (2010)
  • 著者名/発表者名: Sakamoto N, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2010
  • 発表場所: Stockholm, Sweden
  • 年月日: 2010-08-29
• [学会発表] The long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction (2010)
  • 著者名/発表者名: Suzuki S, Takeishi Y, et al
  • 学会等名: Congress of the European Society of Cardiology 2010
  • 発表場所: Stockholm, Sweden
  • 年月日: 2010-08-29
• [学会発表] 心不全診療にバイオマーカーを活かす (2010)
  • 著者名/発表者名: 竹石恭知
  • 学会等名: BHK/ARCHフォーラム
  • 発表場所: 名古屋(特別講演)
  • 年月日: 2010-05-20
• [学会発表] Pivotal role of receptor for advanced glycation end products (RAGE) in hyperlipidemia-dependent atherosclerosis and molecular regulation (2010)
  • 著者名/発表者名: Uekita H, Takeishi Y, et al
  • 学会等名: 20th World Congress of the International Society for Heart Research (ISHR)
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-05-13
• [学会発表] The long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction (2010)
  • 著者名/発表者名: Suzuki S, Takeishi Y, et al
  • 学会等名: 20th World Congress of the International Society for Heart Research (ISHR)
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-05-13
• [学会発表] LOX-1 cooperates with renin-angiotensin system (RAS) in monocyte adhesion-induced redox-sensitive and Ca^<2+> signaling pathways in endothelial cells (ECs) (2010)
  • 著者名/発表者名: Sakamoto N, Takeishi Y, et al
  • 学会等名: 20th World Congress of the International Society for Heart Research (ISHR)
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-05-13
• [学会発表] Age-associated metabolic regulation in coronary vascular tone (2010)
  • 著者名/発表者名: Machii H, Takeishi Y, et al
  • 学会等名: 20th World Congress of the International Society for Heart Research (ISHR)
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-05-13
• [学会発表] Cardiac myocyte modulates coronary vascular tone through H2O2, ADP, and Angiotensin (2010)
  • 著者名/発表者名: Machii H, Takeishi Y, et al
  • 学会等名: 20th World Congress of the International Society for Heart Research (ISHR)
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-05-13
• [学会発表] Distinct prognostic factors in patients with chronic heart failure (CHF) and chronic kidney disease (CKD) (2010)
  • 著者名/発表者名: Sato T, Takeishi Y, et al
  • 学会等名: 20th World Congress of the International Society for Heart Research (ISHR)
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-05-13
• [学会発表] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • 著者名/発表者名: Machii H, Saitoh S, Kaneshiro T, Takeishi Y
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Chicago, USA
• [学会発表] MT1-MMP controls Akt-dependent Fox01 activation in TNF-α-induced signaling pathways of endothelial cell apoptosis and haemostasis (2010)
  • 著者名/発表者名: Ohkawara H, Ishibashi T, Ando K, Sugimoto K, Sakamoto N, Uekita H, Takeishi Y
  • 学会等名: Scientific Sessions of American Heart Association
  • 発表場所: Chicago, Illinois, USA
• [学会発表] Age-associated metabolic regulation in coronary vascular tone (2010)
  • 著者名/発表者名: Machii H, Saitoh S, Kaneshiro T, Ishibashi T, Takeishi Y
  • 学会等名: 20th World Congress of the International Society for Heart Research(ISHR)
  • 発表場所: Kyoto, Japan
• [学会発表] Cardiac myocyte modulates coronary vascular tone through H2O2, ADP, and Angiotensin (2010)
  • 著者名/発表者名: Machii H, Saitoh S, Kaneshiro T, Ishibashi T, Takeishi Y
  • 学会等名: 20th World Congress of the International Society for Heart Research(ISHR)
  • 発表場所: Kyoto, Japan
• [学会発表] Akt cooperates with membrane type 1-matrix metalloproteinase (MT1-MMP) in TNF- α -induced signaling pathways of endothelial dysfunction and haemostasis (2009)
  • 著者名/発表者名: Ohkawara H, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] Metabolic regulation in coronary vascular tone : various vasodilative substances in myocardial_ischemia (2009)
  • 著者名/発表者名: Kaneshiro T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] Cooperation of MT1-MMP and LOX-1 for RhoA- and Racl-dependent signaling pathways in oxidized LDL-mediated endothelial dysfunction and atherosclerosis (2009)
  • 著者名/発表者名: Sugimoto K, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] Area strain by 3D wall motion tracking method is useful to detect adenosine-induced myocardial dysfunction : comparisons with 99mTc myocardial perfusion scintigraphy (2009)
  • 著者名/発表者名: Kobayashi A, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] LOX-1 mediates reriin-angiotensin system (RAS)-dependent redox-sensitive and Ca^<2+> signaling pathways induced in endothelial cells by monocyte ardhesion (2009)
  • 著者名/発表者名: Sakamoto N, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] High serum level of neopterin is a risk factor of patients with heart failure (2009)
  • 著者名/発表者名: Sasaki T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] The long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction (2009)
  • 著者名/発表者名: Suzuki S, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] 8-hydroxy-2'-deoxyguanosine predicts adverse clinical outcomes in patients with heart failure (2009)
  • 著者名/発表者名: Suzuki S, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] Relation of serum heat shock protein 60 level to severity and prognosis in chronic heart failure (2009)
  • 著者名/発表者名: Niizeki T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] High serum level of neopterin predicts cardiac events in chronic heart failure patients with preserved left ventricular systolic function (2009)
  • 著者名/発表者名: Sasaki T, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] Nicorandil inhibits ventricular remodeling and arrhythmias in a mouse model of chronic heart failure (2009)
  • 著者名/発表者名: Hirose M, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] Adaptive servo ventilation improves cardiac dysfunction in heart failure patients with cheyne- stokes respiration (2009)
  • 著者名/発表者名: Yoshihisa A, Takeishi Y, et al
  • 学会等名: Scientific Sessions of American Heart Association 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-14
• [学会発表] High-mobility group box 1 enhances angiogenesis, prevents cardiac remodeling, and improves survival after myocardial infarction in the chronicphase (2009)
  • 著者名/発表者名: Takeishi Y
  • 学会等名: Basic Cardiovascular Sciences Conference 2009 -Molecular Mechanisms of Cardiovascular Disease
  • 発表場所: Lake Las Vegas, Nevada, USA
  • 年月日: 2009-07-20
• [学会発表] HMGB1 improves cardiac dysfunction and survival in the chronic state after MI (2009)
  • 著者名/発表者名: Takeishi Y
  • 学会等名: Heart Failure 2009, European Society of Cardiology
  • 発表場所: Nice, France
  • 年月日: 2009-05-30
• [図書] C.慢性心不全の治療11.鉄欠乏状態の慢性心不全患者において、鉄欠乏性貧血治療薬ferric carboxymaltoseの静注は症状を改善するか? EBM循環器疾患の治療 (2012)
  • 著者名/発表者名: 及川雅啓,斎藤修一,竹石恭知
  • 出版者: 中外医学社
• [図書] X不整脈12.心臓ペースメーカーの選択と植込み患者の管理循環器疾患最新の治療 (2012)
  • 著者名/発表者名: 鈴木均,竹石恭知
  • 出版者: 南江堂
• [図書] 心硬化症候群症候群ハンドブック (2011)
  • 著者名/発表者名: 竹石恭知
  • 総ページ数: 174
  • 出版者: 中山書店
• [図書] 症候群ハンドブック心硬化症候群 (2011)
  • 著者名/発表者名: 竹石恭知
  • 総ページ数: 174
  • 出版者: 中山書店
• [図書] III救急外来から入院1.病態・血行動態をどのように把握するか血液マーカー徹底ガイド心不全Q & A-プレホスピタルから慢性期まで- (2010)
  • 著者名/発表者名: 義久精臣,小林淳,竹石恭知
  • 出版者: 総合医学社
• [図書] I.症候編1.全身的に見られる症候チアノーゼ今日の診断指針第6版 (2010)
  • 著者名/発表者名: 竹石恭知
  • 出版者: 医学書院
• [図書] 今日の診断指針 第6版(I.症候編 1.全身的に見られる症候 チアノーゼ) (2010)
  • 著者名/発表者名: 竹石恭知
  • 出版者: 医学書院
• [図書] 徹底ガイド 心不全Q&A-プレホスピタルから慢性期まで(III救急外来から入院 1.病態・血行動態をどのように把握するか?血液マーカー) (2010)
  • 著者名/発表者名: 義久精臣, 小林淳, 竹石恭知
  • 出版者: 総合医学社
• [図書] II.疾患の病因と病態3. Toll-like receptorと心臓リモデリングAnnual Review循環器 (2009)
  • 著者名/発表者名: 竹石恭知
  • 出版者: 中外医学社
• [図書] 3.不整脈,失神:心臓電気生理検査で異常が出ないときは、睡眠時無呼吸症を疑え循環器検査のグノーティ・セアウトンー過信せず侮らず、謙虚で緻密な検査とは (2009)
  • 著者名/発表者名: 鈴木均,竹石恭知
  • 出版者: シナジー