拍動流体外循環と肋間動脈圧モニターによる胸腹部大動脈瘤の対麻痺予防

• 研究課題/領域番号: 21591798
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 胸部外科学
• 研究機関: 広島大学
• 研究代表者: 末田 泰二郎 広島大学, 大学院・医歯薬学総合研究科, 教授 (10162835)
• 研究期間 (年度): 2009 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円); 2011年度: 780千円 (直接経費: 600千円、間接経費: 180千円); 2010年度: 910千円 (直接経費: 700千円、間接経費: 210千円); 2009年度: 2,990千円 (直接経費: 2,300千円、間接経費: 690千円)
• キーワード: 心臓大血管外科学 / 脊髄虚血 / 対麻痺 / 胸腹部大動脈瘤 / 運動誘発電位 / 知覚誘発電位 / 拍動流体外循環 / 定常流体外循環

研究概要

胸腹部大動脈瘤手術中の最悪合併症である術中脊髄虚血による対麻痺発生を予防するため遮断大動脈の下半身動脈灌流を拍動流体外循環にして脊髄栄養動脈(前脊髄動脈)の側副血流が増加するか動物実験で検討した。下行大動脈の単純分節遮断で脊髄運動誘発電位は著明に低下した。下半身灌流を定常流から拍動流に変えると脊髄運動誘発電位は正常に回復した。胸腹部大動脈瘤手術における大動脈遮断中の下半身拍動流灌流は有用であった。

研究成果

• [雑誌論文] Distal repair using the frozen elephant trunk technique to treat an extended mycotic aneurysm of the aortic arch (2011)
  • 著者名/発表者名: Naomichi Uchida, Akira Katayama, Miwa Sutoh, Taijiro Sueda
  • 雑誌名: Interact Cardiovasc Thorac Surg 巻: 13 ページ: 682-683
  • 査読あり
• [雑誌論文] New method for absolute spinal cord ischemia protection in rabbit (2011)
  • 著者名/発表者名: Bagus Herlambang, Kazumasa Orihashi, Taketomo Mizukami, Shinya Takahashi, Naomichi Uchida, Eiso Hiyama, TaijiroSueda
  • 雑誌名: J Vas Surg 巻: 54 ページ: 1109-1116
  • 査読あり
• [雑誌論文] Cold blood spinoplegia under motor-evoked potential monitoring during thoracic aortic surgery (2011)
  • 著者名/発表者名: Shinya Takahashi, Kazumasa Orihashi, Katsuhiko Imai, Teketomo Mizukami, Taiichi Takasaki, Taijiro Sueda
  • 雑誌名: J Thorac Cardiovasc Surg 巻: 141 ページ: 755-761
  • 査読あり
• [雑誌論文] One-stage total thoracic aortic repair for mega-aorta using frozen elephant trunk technique (2011)
  • 著者名/発表者名: Naomichi Uchida, Akira Katayama, Masatsugu Kuraoka, Taijiro Sueda
  • 雑誌名: Interac tCardiovasc Thorac Surg 巻: 13 ページ: 419-420
  • 査読あり
• [雑誌論文] Up-to-date therapy for aortic aneurysm (2011)
  • 著者名/発表者名: Taijiro Sueda
  • 雑誌名: Nihon Geka Gakkai Zasshi 巻: 112 ページ: 4-4
  • NAID: 110008440710
• [雑誌論文] New method for absolute spinal cord ischemia protection in rabbits (2011)
  • 著者名/発表者名: Bagus Herlambang, T.Sueda
  • 雑誌名: Journal of Vascular Surgery 巻: 54 号: 4 ページ: 1109-1116
  • DOI: 10.1016/j.jvs.2011.04.043
  • 査読あり
• [雑誌論文] Cold blood spinoplegia under motor-evoked potential monitoring during thoracic aortic surgery (2011)
  • 著者名/発表者名: Shinya Takahashi, T.Sueda
  • 雑誌名: J.Thoracic & Cardiovasc Surg 巻: 141 ページ: 755-761
  • 査読あり
• [雑誌論文] Sodium 4-pnhenylbutyrate protects against spinal cord ischemia by inhibition of endoplasmic reticuluam stress (2010)
  • 著者名/発表者名: Taketomo Mizukami, KazumasaOrihashi, Bagus Herlambang, ShinyaTakahashi, Makoto Hamaishi, Kenji Okda, Taijiro Sueda
  • 雑誌名: J Vas Surg 巻: 52 ページ: 1580-1586
  • 査読あり
• [雑誌論文] Cold blood spinoplegia under motor-evoked potential monitoring during thoracic aortic surgery (2010)
  • 著者名/発表者名: Takahashi Shinya, Sueda Taijiro
  • 雑誌名: J Thorac Cardiovasc Surg 巻: 141 ページ: 755-761
  • 査読あり
• [雑誌論文] Sodium 4-phenylbutyrate protects against spinal cord ischemia by inhibition of endoplasmic reticulum stress (2010)
  • 著者名/発表者名: Mizukami Taketomo, Sueda Taijiro
  • 雑誌名: J Vasc Surg 巻: 52 ページ: 1580-1586
  • 査読あり
• [雑誌論文] Surgical intervention of patent ductus venosus (2010)
  • 著者名/発表者名: Kamimatsuse Arata, Sueda Taijiro
  • 雑誌名: Pediatr Surg Int 巻: 26 ページ: 1026-1030
  • 査読あり
• [雑誌論文] 心大血管手術における脳合併症回避のための統合的脳灌流モニター (2009)
  • 著者名/発表者名: 末田泰二郎, 他
  • 雑誌名: 広島医学 62 ページ: 142-146
  • NAID: 40016612202
  • 査読あり
• [学会発表] Motor evoked potential monitoring with cold blood spinoplegia and multi-slice computed tomography facilitated thoracic and thoracoabdominal aortic surgery (2012)
  • 著者名/発表者名: S.Takahashi, Taijiro Sueda
  • 学会等名: 20^<th> Annual Meeting of Asian Society for Cardiovascular Thoracic Surgery
  • 発表場所: Bali, Indonesia
  • 年月日: 2012-03-10
• [学会発表] Open stent-grafting for distal aortic arch aneurysm and acute type A dissection (2012)
  • 著者名/発表者名: Taijiro Sueda
  • 学会等名: 20^<th> Annual Meeting of Asian Society for Cardiovascular Thoracic Surgery
  • 発表場所: Bali, Indonesia(招待講演)
  • 年月日: 2012-03-09
• [学会発表] Open stent-grafting for distal aortic arch aneurysm and acute type A dissection(invited lecture) (2012)
  • 著者名/発表者名: Taijiro Sueda
  • 学会等名: 20^<th> Annual Meeting of Asian Society forCardiovascular and Thoracic Surgery
  • 発表場所: Bali Indonesia'
• [学会発表] Motor evoked potentials and MD-CT can predictspinal cord injury during thoracic andthoracabdominal aortic surgery (2012)
  • 著者名/発表者名: Shinya Takahashi, Naomichi Uchida, Taiichi Takasaki, Keijiro Katayama, Tatsuya Kurosaki, Taijiro Sueda
  • 学会等名: 20^<th> Annual Meeting of Asian Society forCardiovascular and Thoracic Surgery
  • 発表場所: Bali Indonesia
• [学会発表] Long-term results after transaortic open stent grafting for distal thoracic aortic aneurysm (2011)
  • 著者名/発表者名: Taijiro Sueda
  • 学会等名: 60^<th> Eur.Society for Cardiovascular Surgery
  • 発表場所: Moskow, Rossia
  • 年月日: 2011-05-22
• [学会発表] Cold bood spinoplegia under motor-evoked potential monitoring detects essential spinal cord supplying artery (2011)
  • 著者名/発表者名: Shinya Takahashi, Taiichi Takasaki, Katsuhiko Imai, Kazumasa orihashi, Taijiro Sueda
  • 学会等名: 21^<th> World Congress of the World Society ofCardio-Thoracic Surgeons
  • 発表場所: Berlin Germany
• [学会発表] Long-tem results of trans-aortic stent grafting for distal aortic arch aneurysm (2011)
  • 著者名/発表者名: Taijiro Sueda, Kazumasa Orihashi, Katsuhiko Imai, Tatsuya Kurosaki, Taiichi Takasaki, Shinya Takahashi, Zheko Naychov
  • 学会等名: 60^<th> Euro Society forCardiovascular Surgery
  • 発表場所: Moscow Russia
• [学会発表] Cold blood spinal cord protection under motor-evoked potential monitoring in thoracic aortic surgery (2011)
  • 著者名/発表者名: Shinya Takahshi, Kazumasa Orihashi, Taiichi Takasaki, Katsuhiko Imai, TaijiroSueda
  • 学会等名: The 7^<th> Japan-Korea Joint Meeting for Vascularsurgery
  • 発表場所: Okinawa Japan
• [学会発表] Transintercostal evoked potential during thoracic aortic surgery-retrospective and preliminary assessment- (2010)
  • 著者名/発表者名: Takahashi Shinya, Sueda Taijiro
  • 学会等名: 59^<th> Eur Society for Cardiovascular Surgery
  • 発表場所: Izmir, Turkey
  • 年月日: 2010-04-17
• [学会発表] Efficacy of transcranial stimulation-intercostals nerve recorded motor evoked potential (Tic-MEP) during thoracoabdominal aortic surgery (2010)
  • 著者名/発表者名: Takahashi Shinya, Sueda Taijiro
  • 学会等名: 59^<th> Eur Society for Cardiovascular Surgery
  • 発表場所: Izmir, Turkey
  • 年月日: 2010-04-17
• [学会発表] Transcranial stimulation-intercostal nerve recorded motor evoked potential reflects spinal cord ischemia in dog (2010)
  • 著者名/発表者名: Takahashi Shinya, Sueda Taijiro, et al
  • 学会等名: 18^<th> Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery
  • 発表場所: The Ashok Hotel(Delhi, India)
  • 年月日: 2010-02-28
• [学会発表] Trans-intercostal evoked potential during aortic surgery-retrospective and preliminary assessment- (2010)
  • 著者名/発表者名: Shinya Takahashi, Kazamasa Orihashi, Katsuhiko Imai, Taiichi Takasaki, TatsuyaKurosaki, Bagus Herlambang, TaijiroSueda
  • 学会等名: 59^<th> Euro Societyfor Cardiovascular Surgery
  • 発表場所: Izumir Turkey
• [学会発表] Efficacy of trans-cranial stimulation intrecostal nerve recorded motor evoked potential(Tic-MEP) during thoracoabdominal aortic surgery- (2010)
  • 著者名/発表者名: Shinya Takahashi, Kazamasa Orihashi, Katsuhiko Imai, Taiichi Takasaki, TatsuyaKurosaki, Taijiro Sueda
  • 学会等名: 59^<th> Euro Society for CardiovascularSurgery
  • 発表場所: Izumir Turkey
• [学会発表] Trans-cranial stimulation. intercostal nerve recorded motor evoked potential reflects spinal cord ischemia in dog (2010)
  • 著者名/発表者名: Shinya Takahashi, Kazamasa Orihashi, Katsuhiko Imai, Taiichi Takasaki, TatsuyaKurosaki, Taijiro Sueda
  • 学会等名: 18_<th> Annual Meeting ofAsian Society for Cardiovascular andThoracic Surgery
  • 発表場所: New Delhi India
• [学会発表] Protection of spinal cord during thoracic and thoracoabdominal aortic surgery using evoked spinal cord potential, cold blood spinal cord infusion and multi-detector computed tomography (2009)
  • 著者名/発表者名: Takahashi Shinya, Sueda Taijiro, et al
  • 学会等名: 58^<th> International Congress of European Society for Cardio-Vascular Surgery
  • 発表場所: Sofitel Victoria Hotel(Warsaw, Poland)
  • 年月日: 2009-05-01
• [学会発表] A newly developed transintercostal spinal cord evoked potential during thoracoabdominal aortic surgery (2009)
  • 著者名/発表者名: Takahashi Shinya, Sueda Taijiro, et al
  • 学会等名: 58^<th> International Congress of European Society for Cardio-Vascular Surgery
  • 発表場所: Sofitel Victoria Hotel(Warsaw, Poland)
  • 年月日: 2009-04-30
• [学会発表] A newly developed trans-intercostal spinal cord evoked potential during thoracoabdominal aortic surgery (2009)
  • 著者名/発表者名: Shinya Takahashi, Kazamasa Orihashi, Katsuhiko Imai, Taiichi Takasaki, TatsuyaKurosaki, Bagus Herlambang, TaijiroSueda
  • 学会等名: 58^<th> EuroSociety for Cardiovascular Surgery
  • 発表場所: Warsaw Poland
• [学会発表] Protection of spinal cord during thoracic and thoracoabdominal aortic surgery using evoked spinal cord potential, cold blood spinal cord infusion and multi-detector computed tomography (2009)
  • 著者名/発表者名: Shinya Takahashi, Kazamasa Orihashi, Katsuhiko Imai, Taiichi Takasaki, TatsuyaKurosaki, Bagus Herlambang, TaijiroSueda
  • 学会等名: 58^<th> Euro Society for Cardiovascular Surgery
  • 発表場所: Warsaw Poland
• [図書] 脈管専門医のための臨床脈管学 (2010)
  • 著者名/発表者名: 末田泰二郎
  • 出版者: メデイカルトリビューン
• [図書] Advances in underlying aortic disease (2009)
  • 著者名/発表者名: Kazumasa Orihashi, Taijiro Sueda, Springer Japan
• [産業財産権] Evoked spinal cord potential monitoring apparatus and evoked spinal cord potential monitoring system (2009)
  • 発明者名: Taijiro Sueda
  • 権利者名: Hiroshima University
  • 出願年月日: 2009-05-15
  • 外国
• [産業財産権] Evoked spinal cord potential monitoring apparatus and evoked spinal cord potential monitoring system (2009)
  • 発明者名: Taijiro Sueda
  • 権利者名: 広島大学
  • 出願年月日: 2009-05-15
  • 外国