心筋虚血再灌流傷害の発生におけるTRPCチャネルの役割の検討

• 研究課題/領域番号: 22590205
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 生理学一般
• 研究機関: 滋賀医科大学
• 研究代表者: 松浦 博 滋賀医科大学, 医学部, 教授 (60238962)
• 研究分担者: 小嶋 亜希子 滋賀医科大学, 医学部, 助教 (50447877) ; 尾松 万里子 滋賀医科大学, 医学部, 准教授 (80161397) ; 林 維光 滋賀医科大学, 医学部, 助教 (80242973)
• 研究期間 (年度): 2010 – 2012
• 研究課題ステータス: 完了 (2012年度)
• 配分額: 4,420千円 (直接経費: 3,400千円、間接経費: 1,020千円); 2012年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円); 2011年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2010年度: 2,080千円 (直接経費: 1,600千円、間接経費: 480千円)
• キーワード: 生体膜 / チャネル / トランスポーター / 能動輸送 / 心筋虚血再灌流傷害 / TRPCチャネル / Ca2+過負荷 / 細胞過拘縮 / ランゲンドルフ灌流法 / 2-APB / LaCl3 / 再疎通療法 / 活性酸素種 / 過酸化水素 / 共焦点レーザ顕微鏡 / 細胞内Ca^<2+>イメージング / 過拘縮 / パッチクランプ法 / Ca^<2+>パラドックス / マウス心室筋細胞 / fluo-3 / 虚血再灌流傷害 / Ca^<2+>過負荷

研究概要

心筋虚血再灌流傷害は再灌流時に発生する細胞内Ca2+過負荷に起因していることが知られている.本研究課題では,この細胞内Ca2+過負荷に,心筋細胞膜のTRPC (Transient Receptor Potential Canonical) チャネルを通るCa2+流入が関与していることを,単離マウス心臓のランゲンドルフ灌流法,ならびに単離マウス心室筋細胞に対する細胞内Ca2+イメージング法を用いて明らかにした.臨床の場では,急性心筋梗塞に対する再疎通療法の際に虚血再灌流傷害が発生しうることが知られているが,本研究成果は,その予防や治療にTRPCチャネル阻害の有効性を示唆するものである

研究成果

• [雑誌論文] Sevoflurane Protects Ventricular Myocytes against Oxidative Stress-induced Cellular Ca2+Overload and Hypercontracture (2013)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • 雑誌名: Anesthesiology
  • 査読あり
• [雑誌論文] Irbesartan-mediated AT1receptor blockade attenuates hyposmostic-induced enhancement of IKscurrent and prevents shortening of action potential duration in atrial myocytes (2013)
  • 著者名/発表者名: Wu J, Ding W-G, Zhao J, Zang W-J, Matsuura H, Horie M
  • 雑誌名: J Renin Angiotensin Aldosterone Syst
  • 査読あり
• [雑誌論文] Ischemic survival and constitutively active autophagy in self-beating atypically- shaped cardiomyocytes (ACMs): characterization of a new subpopulation of heart cells (2013)
  • 著者名/発表者名: Omatsu-Kanbe M, Matsuura H
  • 雑誌名: J Physiol Sci 巻: 63 ページ: 17-29
  • NAID: 10031169584
  • 査読あり
• [雑誌論文] Ischemic survival and constitutively active autophagy in self-beating atypically-shaped cardiomyocytes (ACMs): Characterization of a new subpopulation of heart cells (2013)
  • 著者名/発表者名: Omatsu-Kanbe M, Matsuura H
  • 雑誌名: J Physiol Sci 巻: 63 号: 1 ページ: 17-29
  • DOI: 10.1007/s12576-012-0236-5
  • NAID: 10031169584
  • 査読あり
• [雑誌論文] Irbesartan-mediated AT1 receptor blockade attenuates hyposmostic-induced enhancement of IKs current and prevents shortening of action potential duration in atrial myocytes. (2013)
  • 著者名/発表者名: Wu J, Ding W-G, Zhao J, Zang W-J, Matsuura H, Horie M
  • 雑誌名: J Renin Angiotensin Aldosterone Syst 巻: in press 号: 4 ページ: 1-7
  • DOI: 10.1177/1470320312474855
  • 査読あり
• [雑誌論文] Sevoflurane protects ventricular myocytes against oxidative stress-induced cellular Ca2+ overload and hypercontracture. (2013)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • 雑誌名: Anesthesiology 巻: in press
  • 査読あり
• [雑誌論文] KCNE3 T4A as the genetic basis of Brugada-pattern electrocardiogram (2012)
  • 著者名/発表者名: Nakajima T, Wu J, Kaneko Y, Ashihara T, Ohno S, Irie T, Ding W-G, Matsuura H, Kurabayashi M, Horie M
  • 雑誌名: Circ J 巻: 76 ページ: 2763-2772
  • NAID: 10031126046
  • 査読あり
• [雑誌論文] Electrophysiological Importance of Embryonic Stem Cell-Derived Cardiac Progenitors (2012)
  • 著者名/発表者名: Kojima A, Matsuura H
  • 雑誌名: Circ J 巻: 76 ページ: 2746-2747
  • NAID: 10031126043
  • 査読あり
• [雑誌論文] Presence of store-operated Ca2+entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane (2012)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • 雑誌名: Br J Anaesth 巻: 109 ページ: 352-360
  • 査読あり
• [雑誌論文] Inhibitory effects of sevoflurane on pacemaking activity of sinoatrial node cells in guinea-pig heart (2012)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • 雑誌名: Br J Pharmacol 巻: 166 ページ: 2117-2135
  • 査読あり
• [雑誌論文] Phenotype Variability in Patients Carrying KCNJ2 Mutations (2012)
  • 著者名/発表者名: Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding W-G, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang W-J, Ito M, Matsuura H, Horie M
  • 雑誌名: Circ Cardiovasc Genet 巻: 5 ページ: 344-353
  • 査読あり
• [雑誌論文] Postnatal developmental decline in IK1in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk method. (2012)
  • 著者名/発表者名: Hoshino S, Omatsu-Kanbe M, Nakagawa M, Matsuura H
  • 雑誌名: Pflugers Arch 巻: 463 ページ: 649-668
  • 査読あり
• [雑誌論文] 17β-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Clcurrent in rabbit articular chondrocytes (2012)
  • 著者名/発表者名: Kumagai K, Imai S, Toyoda F, Okumura N, Isoya E, Matsuura H, Matsusue Y
  • 雑誌名: Br J Pharmacol 巻: 166 ページ: 702-720
  • 査読あり
• [雑誌論文] Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors (2012)
  • 著者名/発表者名: Wu J, Ding W-G, Matsuura H, Horie M
  • 雑誌名: Pflugers Arch 巻: 463 ページ: 625-633
  • 査読あり
• [雑誌論文] GHGKHKNK octapeptide (P-5m) inhibits metastasis of HCCLM3 cell lines via regulation of MMP-2 expression in in vitro and in vivo studies (2012)
  • 著者名/発表者名: Han X, Yan DM, Zhao XF, Matsuura H, Ding W-G, Li P, Jiang S, Du BR, Du PG, Zhu X
  • 雑誌名: Molecules 巻: 17 ページ: 1357-1372
  • 査読あり
• [雑誌論文] Phenotype variability in patients carrying KCNJ2 mutations. (2012)
  • 著者名/発表者名: Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding W-G, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang W-J, Ito M, Matsuura H, Horie M
  • 雑誌名: Circ Cardiovasc Genet 巻: 5 号: 3 ページ: 344-353
  • DOI: 10.1161/circgenetics.111.962316
  • 査読あり
• [雑誌論文] Presence of store-operated Ca2+ entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane (2012)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H & Nosaka S.
  • 雑誌名: Br J Anaesth 巻: 109 号: 3 ページ: 352-360
  • DOI: 10.1093/bja/aes212
  • 査読あり
• [雑誌論文] Electrophysiological Importance of Embryonic Stem Cell-Derived Cardiac Progenitors (2012)
  • 著者名/発表者名: Kojima A, Matsuura H
  • 雑誌名: Circulation Journal 巻: 76 号: 12 ページ: 2746-2747
  • DOI: 10.1253/circj.CJ-12-1297
  • NAID: 10031126043
  • ISSN: 1346-9843, 1347-4820
  • 査読あり
• [雑誌論文] KCNE3 T4A as the Genetic Basis of Brugada-Pattern Electrocardiogram (2012)
  • 著者名/発表者名: Nakajima T, Ashihara T, et al.
  • 雑誌名: Circulation Journal 巻: 76 号: 12 ページ: 2763-2772
  • DOI: 10.1253/circj.CJ-12-0551
  • NAID: 10031126046
  • ISSN: 1346-9843, 1347-4820
  • 査読あり
• [雑誌論文] 17β-Estradiol inhibits the doxorubicin-induced apoptosis via block of volume-sensitive Cl− current in rabbit articular chondrocytes. (2012)
  • 著者名/発表者名: Kumagai K, Imai S, Toyota F, Okumura N, Matsuura H, Matsusue Y.
  • 雑誌名: Br J Pharmacol. 巻: 116 号: 2 ページ: 702-720
  • DOI: 10.1111/j.1476-5381.2011.01802.x
  • 査読あり
• [雑誌論文] Postnatal developmental decline in IK1in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk method (2012)
  • 著者名/発表者名: Hoshino S, Omatsu-Kanbe M, Nakagawa M, Matsuura H
  • 雑誌名: Pflugers Arch. 巻: 463 号: 5 ページ: 649-668
  • DOI: 10.1007/s00424-012-1084-0
  • 査読あり
• [雑誌論文] Autophagy is constitutively active in normal mouse sino-atrial nodal cells. (2011)
  • 著者名/発表者名: Omatsu-Kanbe M, Yamamoto T, Matsuura H
  • 雑誌名: Acta Histochem Cytochem 巻: 44 ページ: 223-231
  • NAID: 130000941524
  • 査読あり
• [雑誌論文] Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process (2011)
  • 著者名/発表者名: Tsuji-Wakisaka K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Dochi K, Matsuura H, Horie M
  • 雑誌名: Biochim Biophys Acta 巻: 1812 ページ: 1452-1459
  • 査読あり
• [雑誌論文] Sevoflurane protects ventricular myocytes from Ca2+paradox-mediated Ca2+overload by blocking the activation of transient receptor potential canonical channels (2011)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • 雑誌名: Anesthesiology 巻: 115 ページ: 509-522
  • 査読あり
• [雑誌論文] KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation (2011)
  • 著者名/発表者名: Ohno S, Zankov DP, Ding W-G, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M
  • 雑誌名: Circ Arrhythm Electrophysiol 巻: 4 ページ: 352-361
  • 査読あり
• [雑誌論文] Reply to "Letter to the editor: 'Validating the requirement for beat-to-beat coupling of the Ca2+clock and M clock in pacemaker cell normal automaticity'" (2011)
  • 著者名/発表者名: Himeno Y, Toyoda F, Matsuura H, Noma A
  • 雑誌名: Am J Physiol 巻: 300
  • 査読あり
• [雑誌論文] Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. (2011)
  • 著者名/発表者名: Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K, Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, Hiraoka M, Hisatome I
  • 雑誌名: Circ Res 巻: 108 ページ: 458-468
  • NAID: 130002130408
  • 査読あり
• [雑誌論文] Minor contribution of cytosolic Ca2+transients to the pacemaker rhythm in guinea pig sinoatrial node cells (2011)
  • 著者名/発表者名: Himeno Y, Toyoda F, Satoh H, Amano A, Cha CY, Matsuura H, Noma A
  • 雑誌名: Am J Physiol 巻: 300
  • 査読あり
• [雑誌論文] Lysophosphatidyl- choline enhances IKscurrents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways. (2011)
  • 著者名/発表者名: Ding W-G, Toyoda F, Ueyama H, Matsuura H
  • 雑誌名: J Mol Cell Cardiol 巻: 50 ページ: 58-65
  • 査読あり
• [雑誌論文] Atrioventricular block-induced Torsades de Pointeswith clinical and molecular backgrounds similar to congenital long QT syndrome (2011)
  • 著者名/発表者名: Oka Y, Itoh H, Ding W-G, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Miyamoto A, Kawamura M, Matsuura H, Horie M
  • 雑誌名: Circ J 巻: 74 ページ: 2562-2571
  • 査読あり
• [雑誌論文] KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idio pathic ventricular fibrillation (2011)
  • 著者名/発表者名: Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattri T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M
  • 雑誌名: Circ Arrhythm Electrophysiol 巻: 4 号: 3 ページ: 352-361
  • DOI: 10.1161/circep.110.959619
  • 査読あり
• [雑誌論文] Sevoflurane protects ventricular myocytes from Ca2+paradox-mediated Ca2+overload by blocking the activation of transient receptor potential canonical channels (2011)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M,Matsuura H, Nosaka S
  • 雑誌名: Anesthesiology 巻: 115 号: 3 ページ: 509-522
  • DOI: 10.1097/aln.0b013e31822b7901
  • 査読あり
• [雑誌論文] Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process (2011)
  • 著者名/発表者名: Tsuji-Wakisaka K, Ashihara T, et al.
  • 雑誌名: BBA-Molecular Basis of Disease 巻: 1812 号: 11 ページ: 1452-1459
  • DOI: 10.1016/j.bbadis.2011.07.011
  • 査読あり
• [雑誌論文] Autophagy Is Constitutively Active in Normal Mouse Sino-Atrial Nodal Cells (2011)
  • 著者名/発表者名: Omatsu-Kanbe M, Yamamoto T, Matsuura H.
  • 雑誌名: Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ 巻: 44 号: 5 ページ: 223-231
  • DOI: 10.1267/ahc.11030
  • NAID: 130000941524
  • ISSN: 0044-5991, 1347-5800
  • 査読あり
• [雑誌論文] Lysophosphatidylcholine enhances I_<Ks> currents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways. (2011)
  • 著者名/発表者名: Ding WG, Toyoda F, Ueyama H, Matsuura H
  • 雑誌名: J Mol Cell Cardiol 巻: 50 ページ: 58-65
  • 査読あり
• [雑誌論文] Minor contribution of cytosolic Ca^<2+> transients to the pacemaker rhythm in guinea pig sinoatrial node cells. (2011)
  • 著者名/発表者名: Himeno Y, Toyoda F, Satoh H, Amano A, Cha CY, Matsuura H, Noma A
  • 雑誌名: Am J Physiol 巻: 300
  • 査読あり
• [雑誌論文] Reciprocal control of hERG stability by hsp70 and hsc70 with implication for restoration of LQT2 mutant stability. (2011)
  • 著者名/発表者名: Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai, A, Higaki K, Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, Hiraoka M, Hisatome I
  • 雑誌名: Circ Res 巻: 108 ページ: 458-468
  • NAID: 130002130408
  • 査読あり
• [雑誌論文] Presence and functional role of the rapidly activating delayed rectifier K+current in left and right atria of adult mice. (2010)
  • 著者名/発表者名: Nakamura H, Ding W-G, Sanada M, Maeda K, Kawai H, Maegawa H, Matsuura H
  • 雑誌名: Eur J Pharmacol 巻: 649 ページ: 14-22
  • 査読あり
• [雑誌論文] Ca2+paradox injury mediated through TRPC channels in mouse ventricular myocytes (2010)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • 雑誌名: Br J Pharmacol 巻: 161 ページ: 1734-1750
  • 査読あり
• [雑誌論文] Characterization of the rapidly activating delayed rectifier potassium current, IKr, in HL-1 mouse atrial myocytes (2010)
  • 著者名/発表者名: Toyoda F, Ding W-G, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H
  • 雑誌名: J Membr Biol 巻: 235 ページ: 73-87
  • 査読あり
• [雑誌論文] Self-beating atypically shaped cardiomyocytes survive a long-term postnatal development preserving expression of fetal cardiac genes in mice. (2010)
  • 著者名/発表者名: Omatsu-Kanbe M, Yamamoto T, Mori Y, Matsuura H
  • 雑誌名: J Histochem Cytochem 巻: 58 ページ: 543-551
  • 査読あり
• [雑誌論文] KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders. (2010)
  • 著者名/発表者名: Wu J, Shimizu W, Ding W-G, Ohno S, Toyoda F, Itoh H, Zang W-J, Miyamoto Y, Kamakura S, Matsuura H, Nademanee K, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M
  • 雑誌名: Heart Rhythm 巻: 7 ページ: 199-205
  • 査読あり
• [雑誌論文] Characterization of the rapidly activating delayed rectifier potassium current, 1_<Kr>, in HL-1 mouse atrial myocytes. (2010)
  • 著者名/発表者名: Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H
  • 雑誌名: J Membr Biol 巻: 235 ページ: 73-87
  • 査読あり
• [雑誌論文] Ca^<2+> paradox injury mediated through TRPC channels in mouse ventricular myocytes. (2010)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • 雑誌名: Br J Pharmacol 巻: 161 ページ: 1734-1750
  • 査読あり
• [雑誌論文] Presence and functional role of the rapidly activating delayed rectifier K^+ current in left and right atria of adult mice. (2010)
  • 著者名/発表者名: Nakamura H, Ding WG, Sanada M, Maeda K, Kawai H, Maegawa H, Matsuura H
  • 雑誌名: Eur J Pharmacol 巻: 649 ページ: 14-22
  • 査読あり
• [雑誌論文] Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to congenital long QT syndrome. (2010)
  • 著者名/発表者名: Oka Y, Itoh H, Ding WG, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Miyamoto A, Kawamura M, Matsuura H, Horie M
  • 雑誌名: Circ J 巻: 74 ページ: 2562-2571
  • NAID: 10027424141
  • 査読あり
• [学会発表] Calmodulin potentiates IKs in guinea-pig SA node cells by activating Ca2+/calmodulin-dependent protein kinase II. (2013)
  • 著者名/発表者名: Xie Y, Ding W-G, Matsuura H.
  • 学会等名: The 90thAnnual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
• [学会発表] COX-2 selective blocker inhibits the TNF-induced apoptosis in isolated rabbit articular chondrocytes. (2013)
  • 著者名/発表者名: Kumagai K, Imai S, Toyoda F, Maeda T, Kubo M, Matsuura H, Matsusue Y
  • 学会等名: The 90thAnnual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
• [学会発表] Requirement of autophagy in the development and ischemic tolelenace of self-beating atypically-shaped cardio- myocytes (ACMs), a new subpopulation of heart cells. (2013)
  • 著者名/発表者名: Omatsu-Kanbe M. Matsuura H
  • 学会等名: The 90thAnnual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
• [学会発表] The improved effect of hypothermic cultivation on the functional expression of human cardiac Kv1.5 channels (2013)
  • 著者名/発表者名: Ding W-G, Xie Y, Toyoda F, Bai JY. Matsuura H
  • 学会等名: The 90thAnnual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
• [学会発表] Positive correlation between Istand ICa,Lin guinea-pig sinoatrial node cells (2013)
  • 著者名/発表者名: Toyoda F, Ding W-G, Matsuura H
  • 学会等名: The 90thAnnual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
• [学会発表] Biophysiocal properties of Na channel in the S5-S6 high risk LQT3 mutations of the long QT syndrom (2013)
  • 著者名/発表者名: Aiba T, Toyoda F, Makita N, Matsuura H, Hagiwara N, Sumitomo N, Kamakura S, Shimizu W
  • 学会等名: American Heart Association Annual Meeting
  • 発表場所: Los Angels, USA.
• [学会発表] 心房筋伸展によるAT1受容体を介した緩徐活性型遅延整流性K+電流(Iks)の増大 -心房細動のAT1受容体遮断薬によるアップストリーム治療のメカニズム- (2012)
  • 著者名/発表者名: 松浦 博,Zankov DP,堀江 稔
  • 学会等名: 第41回日本心脈管作動物質学会,シンポジウム「イオンチャネル研究の最先端」
  • 発表場所: 秋田
  • 年月日: 2012-02-11
• [学会発表] 心房筋伸展伸展によるAT_1受容体を介した緩徐活性型遅延整流性K+電流(I_Ks)の増大-心房細動のAT_1受容体遮断薬によるアップストリーム治療のメカニズム- (2012)
  • 著者名/発表者名: 松浦博, Dimnitar P Zankov, 堀江稔
  • 学会等名: 第41回日本心脈管作動物質学会,シンポジウム「イオンチャネル研究の最先端」
  • 発表場所: 秋田キャッスルホテル(秋田市)(招待講演)
  • 年月日: 2012-02-11
• [学会発表] Novel KCNQ1 missense mutation associated with juvenile-onset atrial fibrillation (2012)
  • 著者名/発表者名: Hasegawa K, Ohno S, Itoh H, Hattori T, Makiyama T, Toyoda F, Ding W-G, Chinushi M, Matsuura H, Horie M
  • 学会等名: American Heart Association Annual Meeting
  • 発表場所: Los Angels, USA
• [学会発表] Biophysical properties of Na channel in the S5-S6 high risk LQT3 mutations of the long QT syndrome (2012)
  • 著者名/発表者名: Takeshi Aiba, Futoshi Toyoda, Naomasa Makita, Hiroshi Matsuura, Nobuhisa Hagiwara, Naokata Sumitomo, Shiro Kamakura, and Wataru Shimizu et al
  • 学会等名: American Heart Association Annual Scientific Meeting
  • 発表場所: Los Angeles, USA
• [学会発表] Novel KCNQ1 missense mutation associated with juvenile-onset atrial fibrillation (2012)
  • 著者名/発表者名: Kanae Hasegawa, Seiko Ohno, Hideki Itoh, Tetuhisa Hattori, Takeru Makiyama, Futoshi Toyoda, Wei-Guang Ding, Masaomi Chinushi, Hiroshi Matsuura, and Minoru Horie
  • 学会等名: American Heart Association Annual Scientific Meeting
  • 発表場所: Los Angeles, USA
• [学会発表] Postnatal developmental changes in the TRPC channels in mouse cardiomyocytes (2011)
  • 著者名/発表者名: Hoshino S, Nakagawa M, Omatsu- Kanbe M, Matsuura H
  • 学会等名: Postnatal developmental changes in the TRPC channels in mouse cardiomyocytes
  • 発表場所: Granada, Spain
• [学会発表] Rapidly activating delayed rectifier K+current during post-natal development in mouse ventricle (2011)
  • 著者名/発表者名: Hoshino S, Nakagawa M, Omatsu-Kanbe M, Matsuura H
  • 学会等名: The 45thAnnual Meeting of Association for European Paediatric Cardiology
  • 発表場所: Granada, Spain
• [学会発表] Rapidly activating delayed rectifier K+ current during post-natal development in mouse ventricle (2011)
  • 著者名/発表者名: Hoshino S, Nakagawa M, Omatsu-Kanbe M, Matsuura H
  • 学会等名: The 45^<th> Annual Meeting of Association for European Paediatric Cardiology
  • 発表場所: スペイン
• [学会発表] Postnatal developmental changes in the TRPC channels in mouse cardiomyocytes (2011)
  • 著者名/発表者名: Hoshino S, Nakagawa M, Omatsu-Kanbe M, Matsuura H
  • 学会等名: The 45^<th> Annual Meeting of Association for European Paediatric Cardiology
  • 発表場所: スペイン
• [学会発表] Nosaka S. Sevoflurane protects cardiomyocyte from Ca2+paradox by preserving SR Ca2+and blocking TRPC channel (2010)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H
  • 学会等名: American Society of Anesthesiologists Annual Meeting
  • 発表場所: San Diego, USA
  • 年月日: 2010-10-16
• [学会発表] Sevoflurane protects cardiomyocyte from Ca^<2+> paradox by preserving SR Ca 2+ and blocking TRPC channel. (2010)
  • 著者名/発表者名: Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • 学会等名: American Society of Anesthesiologists 2010 Annual Meeting
  • 発表場所: San Diego, CA, USA
  • 年月日: 2010-10-16
• [学会発表] Post-natal developmental changes in the TRPC channels in mouse heart (2010)
  • 著者名/発表者名: Hoshino S, Matsuura H, Omatsu-Kanbe M
  • 学会等名: The 87thAnnual Meeting of the Physiological Society of Japa
  • 発表場所: Morioka, Japan
  • 年月日: 2010-05-19
• [学会発表] Self-beating atypically-shaped cardiomyocytes (ACMs) survive a ling-term post-natal development whole preserving the expression of fetal cardiac gene in mice (2010)
  • 著者名/発表者名: Omatsu-Kanbe M, Matsuura H
  • 学会等名: The 87thAnnual Meeting of the Physiological Society of Japan
  • 発表場所: Morioka, Japan
  • 年月日: 2010-05-19
• [学会発表] Presence and properties of atypically-shaped cardiomyocyte derived from ventricular tissue of mouse heart (2010)
  • 著者名/発表者名: Matsuura H, Omatsu-Kanbe M
  • 学会等名: The 87thAnnual Meeting of the Physiological Society of Japan
  • 発表場所: Morioka, Japan
  • 年月日: 2010-05-19
• [学会発表] Presence and properties of atypically-shaped cardiomyocytes derived from ventricular tissue of mouse heart. (2010)
  • 著者名/発表者名: Matsuura H, Omatsu-Kanbe M
  • 学会等名: J Physiol Sci 60:S18
  • 発表場所: いわて県民情報交流センター(岩手県)
  • 年月日: 2010-05-19
• [学会発表] Self-beating atypically-shaped cardiomyocytes (ACMs) survive a long-term post-natal development while preserving the expression of fetal cardiac gene in mice. (2010)
  • 著者名/発表者名: Omatsu-Kanbe M, Matsuura H
  • 学会等名: J Physiol Sci 60:S269
  • 発表場所: いわて県民情報交流センター(岩手県)
  • 年月日: 2010-05-19
• [学会発表] Postnatal developmental changes in the TRPC channels in mouse heart. (2010)
  • 著者名/発表者名: Hoshino S, Matsuura H, Omatsu-Kanbe M
  • 学会等名: J Physiol Sci 60:S119
  • 発表場所: いわて県民情報交流センター(岩手県)
  • 年月日: 2010-05-19
• [図書] 医系物理学基礎 (2012)
  • 著者名/発表者名: 吉田不空雄,松浦 博,森川茂廣
  • 出版者: 三恵社
• [備考] 滋賀医科大学研究情報データベース
  • URL: http://www.shiga-med.ac.jp/db/index.php
• [備考] 滋賀医科大学研究情報データベース 研究者総覧・研究業績一覧 研究者検索
  • URL: http://www.shiga-med.ac.jp/db/index.php
• [備考]
  • URL: http://www.shiga-med.ac.jp/index.html