血管内皮増殖因子およびその受容体の遺伝子多型を用いた加齢黄斑変性の個別化医療

• 研究課題/領域番号: 22791653
• 研究種目: 若手研究(B)
• 配分区分: 補助金
• 研究分野: 眼科学
• 研究機関: 京都大学
• 研究代表者: 山城 健児 京都大学, 医学研究科, 助教 (80399617)
• 研究期間 (年度): 2010 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 4,030千円 (直接経費: 3,100千円、間接経費: 930千円); 2011年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円); 2010年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
• キーワード: 眼細胞生物学 / 加齢黄斑変性 / 血管内皮前駆細胞 / 遺伝子多型 / 血管内皮増殖因子

研究概要

血管内皮増殖因子(VEGF)遺伝子の一塩基多型であるrs699946は、加齢黄斑変性の発症とは相関を認めなかったが、抗VEGF治療に対する反応性に影響を与えることが分かった。治療開始前にこの一塩基多型を調べることによって、各患者に最適な治療方法が選択できると考えられた。

研究成果

• [雑誌論文] Significance ofC2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population (2012)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, TajimaK, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 53 ページ: 794-8
• [雑誌論文] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography (2012)
  • 著者名/発表者名: Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N.
  • 雑誌名: Am J Ophthalmol
  • NAID: 120004161067
• [雑誌論文] Relationship between retinalmorphological findings and visual function in age-related macular degeneration (2012)
  • 著者名/発表者名: Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N.
  • 雑誌名: Graefes Arch Clin Exp Ophthalmol
• [雑誌論文] Vascular endothelial growth factor gene polymorphisms and choroidalneovascularization in highly myopic eyes (2012)
  • 著者名/発表者名: Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, Miyake M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci
• [雑誌論文] Factors Associated With the Response of Age-Related Macular Degeneration to Intravitreal Ranibizumab Treatment (2012)
  • 著者名/発表者名: Yamashiro K, Tomita K, Tsujikawa A, Nakata I, Akagi-Kurashige Y, Miyake M, Ooto S, Tamura H, Yoshimura N
  • 雑誌名: Am J Ophthalmol 巻: (in press)
  • 査読あり
• [雑誌論文] Vascular endothelial growth factor gene polymorphisms and choroidal neovascularization in highly myopic eyes (2012)
  • 著者名/発表者名: Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, Miyake M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: (in press) 号: 4 ページ: 2349-53
  • DOI: 10.1167/iovs.11-9405
  • 査読あり
• [雑誌論文] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography (2012)
  • 著者名/発表者名: Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N
  • 雑誌名: Am J Ophthalmol 巻: (in press) 号: 6 ページ: 1133-1143.e1
  • DOI: 10.1016/j.ajo.2011.12.013
  • NAID: 120004161067
  • 査読あり
• [雑誌論文] Relationship between retinal morphological findings and visual function in age-related macular degeneration (2012)
  • 著者名/発表者名: Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N
  • 雑誌名: Graefes Arch Clin Exp Ophthalmol 巻: (in press) 号: 8 ページ: 68-80
  • DOI: 10.1007/s00417-012-1928-5
  • NAID: 120004873995
  • 査読あり
• [雑誌論文] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population (2012)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 53 号: 2 ページ: 794-798
  • DOI: 10.1167/iovs.11-8468
  • 査読あり
• [雑誌論文] Association of elastin genepolymorphism to age-related maculardegeneration and polypoidal choroidal vasculopathy (2011)
  • 著者名/発表者名: Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida T, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 ページ: 8780-4
• [雑誌論文] Development of polypoidal lesions inage-related macular degeneration (2011)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakata I, Yoshimura N.
  • 雑誌名: Eye(Lond) 巻: 25 ページ: 481-8
• [雑誌論文] Association of lesion size and visual prognosis to polypoidal choroidal vasculopathy (2011)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N.
  • 雑誌名: Am J Ophthalmol 巻: 151 ページ: 961-972
  • NAID: 120003184066
• [雑誌論文] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy (2011)
  • 著者名/発表者名: Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N.
  • 雑誌名: Retina 巻: 31 ページ: 527-34
  • NAID: 120004225529
• [雑誌論文] Association between the SERPING1 gene and age-related macular degeneration andpolypoidal choroidal vasculopathy in Japanese. (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, MatsuoK, Tajima K, Matsuda F, Yoshimura N.
  • 雑誌名: PLoS One 巻: 6 ページ: 19108-19108
• [雑誌論文] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, SaitoK, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N.
  • 雑誌名: Ophthalmology 巻: 118 ページ: 1408-15
• [雑誌論文] VEGFgene polymorphism and response tointravitreal bevacizumab and tripletherapy in age-related macular degeneration. (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Nakanishi H, Tsujikawa A, Otani A, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol 巻: 55 ページ: 435-43
• [雑誌論文] Prognostic factors for visual outcomes 2-years after intravitreal bevacizumab for myopicchoroidal neovascularization (2011)
  • 著者名/発表者名: Nakanishi H, Tsujikawa A, Yodoi Y, Ojima Y, Otani A, Tamura H, Yamashiro K, Ooto S, Yoshimura N.
  • 雑誌名: Eye(Lond) 巻: 25 ページ: 375-81
• [雑誌論文] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography. (2011)
  • 著者名/発表者名: Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 ページ: 4971-8
• [雑誌論文] Association of 15q14 and 15q25 with high myopia in Japanese (2011)
  • 著者名/発表者名: Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 ページ: 4853-8
• [雑誌論文] Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy (2011)
  • 著者名/発表者名: Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida I, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 号: 12 ページ: 8780-8784
  • DOI: 10.1167/iovs.11-8205
  • 査読あり
• [雑誌論文] Treatment of polypoidal choroidal vasculopathy with photodynamic therapy combined with intravitreal injections of ranibizumab (2011)
  • 著者名/発表者名: Tomita K, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Otani A, Nakayama Y, Yoshimura N
  • 雑誌名: Am J Ophthalmol 巻: 153 号: 1 ページ: 68-80
  • DOI: 10.1016/j.ajo.2011.07.001
  • NAID: 120003726137
  • 査読あり
• [雑誌論文] VEGF gene polymorphism and response to intravitreal bevacizumab and triple therapy in age-related macular degeneration (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Nakanishi H, Tsujikawa A, Otani A, Yoshimura N
  • 雑誌名: Jpn J Ophthalmol 巻: 55 号: 5 ページ: 435-43
  • DOI: 10.1007/s10384-011-0061-z
  • NAID: 10029688706
  • 査読あり
• [雑誌論文] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography (2011)
  • 著者名/発表者名: Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 号: 8 ページ: 4971-4978
  • DOI: 10.1167/iovs.11-7729
  • 査読あり
• [雑誌論文] Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
  • 雑誌名: PLoS One 巻: 6 号: 4 ページ: e19108-e19108
  • DOI: 10.1371/journal.pone.0019108
  • 査読あり
• [雑誌論文] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N
  • 雑誌名: Ophthalmology 巻: 118 号: 7 ページ: 1408-15
  • DOI: 10.1016/j.ophtha.2010.12.011
  • 査読あり
• [雑誌論文] Association of 15q14 and 15q25 with high myopia in Japanese (2011)
  • 著者名/発表者名: Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 号: 7 ページ: 4853-4858
  • DOI: 10.1167/iovs.11-7311
  • 査読あり
• [雑誌論文] Association of Lesion Size and Visual Prognosis to Polypoidal Choroidal Vasculopathy. (2011)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N.
  • 雑誌名: Am J Ophthalmol. 巻: (in press)
  • NAID: 120003184066
  • 査読あり
• [雑誌論文] Genetic Variants in Pigment Epithelium-Derived Factor Influence Response of Polypoidal Choroidal Vasculopathy to Photodynamic Therapy. (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N.
  • 雑誌名: Ophthalmology. 巻: (in press)
  • 査読あり
• [雑誌論文] Association of 15q14 and 15q25 with High Myopia in Japanese. (2011)
  • 著者名/発表者名: Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci. 巻: (in press)
  • 査読あり
• [雑誌論文] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy. (2011)
  • 著者名/発表者名: Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N.
  • 雑誌名: Retina. 巻: 31 ページ: 527-534
  • NAID: 120004225529
  • 査読あり
• [雑誌論文] Sterile endophthalmitis after intravitreal injection of bevacizumabobtained from a single batch (2010)
  • 著者名/発表者名: Yamashiro K, Tsujikawa A, Miyamoto K, Oh H, Otani A, Tamuara H, Ooto S, Sasahara M, Iwama D, Yoshimura N.
  • 雑誌名: Retina 巻: 30 ページ: 485-90
  • NAID: 120002949750
• [雑誌論文] Treatment of polypoidal choroidal vasculopathy byintravitreal injection of bevacizumab (2010)
  • 著者名/発表者名: Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol 巻: 54 ページ: 310-9
• [雑誌論文] Punctate hyper fluorescent spotsassociated with central serouschorioretinopathy as seen on indocyaninegreen angiography (2010)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N.
  • 雑誌名: Retina 巻: 30 ページ: 801-9
• [雑誌論文] Intravitreal bevacizumab for type 1 idiopathic macular telangiectasia (2010)
  • 著者名/発表者名: Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N.
  • 雑誌名: Eye(Lond) 巻: 24 ページ: 1492-7
• [雑誌論文] Thickness of photoreceptor layers inpolypoidal choroidal vasculopathy and central serous chorioretinopathy (2010)
  • 著者名/発表者名: Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N.
  • 雑誌名: Graefes Arch Clin Exp Ophthalmol 巻: 248 ページ: 1077-86
• [雑誌論文] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laserophthalmoscopy (2010)
  • 著者名/発表者名: Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N.
  • 雑誌名: Ophthalmology 巻: 117 ページ: 1809-2
• [雑誌論文] Restoration of outer segments of foveal photoreceptors after resolution of central serouschorioretinopathy (2010)
  • 著者名/発表者名: Ojima Y, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol 巻: 54 ページ: 55-60
• [雑誌論文] Joint effect of cigarette smoking and CFH andLOC387715/HTRA1 polymorphisms onpolypoidal choroidal vasculopathy (2010)
  • 著者名/発表者名: Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 51 ページ: 6183-7
• [雑誌論文] Single-nucleotide polymorphisms in the promoter region of matrixmetalloproteinase-1,-2, and-3 in Japanese with high myopia. (2010)
  • 著者名/発表者名: Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 51 ページ: 4432-6
• [雑誌論文] ARMS2/HTRA1 and CFHpolymorphisms are not associated withchoroidal neovascularization in highly myopic eyes of the elderly Japanese population (2010)
  • 著者名/発表者名: Nakanishi H, Gotoh N, Yamada R, Yamashiro K, Otani A, Hayashi H, Tsujikawa A, Shimada N, Ohno-Matsui K, Mochizuki M, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N.
  • 雑誌名: Eye(Lond) 巻: 24 ページ: 1078-84
• [雑誌論文] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen (2010)
  • 著者名/発表者名: Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N.
  • 雑誌名: Clin Experiment Ophthalmol 巻: 38 ページ: 483-8
• [雑誌論文] Macular hole formation following photodynamic therapycombined with intravitreal injection of bevacizumab and triamcinolone acetonide (2010)
  • 著者名/発表者名: Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol 巻: 54 ページ: 364-6
• [雑誌論文] CFH and ARMS2 variations in age-related macularde generation, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation (2010)
  • 著者名/発表者名: Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, OtaniA, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 51 ページ: 5914-9
• [雑誌論文] Prognostic factors of vitreous hemorrhage secondary to exudative age-related maculardegeneration (2010)
  • 著者名/発表者名: Hasegawa T, Otani A, Sasahara M, Gotoh N, Ooto S, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N.
  • 雑誌名: Am J Ophthalmol. 巻: 149 ページ: 322-329
  • NAID: 120001823762
• [雑誌論文] Haplotypeanalysis of the ARMS2/HTRA1 region in Japanese patients with typicalneovascular age-related macular degeneration or polypoidal choroidal vasculopathy. (2010)
  • 著者名/発表者名: Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol. 巻: 54 ページ: 609-14
• [雑誌論文] Genetic variants near TIMP3 and high-densitylipoprotein-associated loci influence susceptibility to age-related macular degeneration. (2010)
  • 著者名/発表者名: Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, BrooksM, Baratz KH, Brown WL, Brucker AJ, OrlinA, Brown G, Ho A, Regillo C, Donoso L, TianL, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A.
  • 雑誌名: Proc Natl Acad Sci USA. 巻: 107 ページ: 7401-6
• [雑誌論文] Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy. (2010)
  • 著者名/発表者名: Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol. 巻: 54 ページ: 609-614
  • NAID: 10027666485
  • 査読あり
• [雑誌論文] Macular hole formation following photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide. (2010)
  • 著者名/発表者名: Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol. 巻: 54 ページ: 364-366
  • NAID: 10027204735
  • 査読あり
• [雑誌論文] Treatment of polypoidal choroidal vasculopathy by intravitreal injection of bevacizumab. (2010)
  • 著者名/発表者名: Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol. 巻: 54 ページ: 310-319
  • NAID: 10027204523
  • 査読あり
• [雑誌論文] Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy. (2010)
  • 著者名/発表者名: Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci. 巻: 51 ページ: 6183-6187
  • 査読あり
• [雑誌論文] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy. (2010)
  • 著者名/発表者名: Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N.
  • 雑誌名: Ophthalmology. 巻: 117 ページ: 1800-1809
  • 査読あり
• [雑誌論文] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen. (2010)
  • 著者名/発表者名: Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N.
  • 雑誌名: Clin Experiment Ophthalmol. 巻: 38 ページ: 483-488
  • 査読あり
• [雑誌論文] CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation. (2010)
  • 著者名/発表者名: Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, Otani A, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci. 巻: 51 ページ: 5914-5919
  • 査読あり
• [雑誌論文] Single-nucleotide polymorphisms in the promoter region of matrix metal loproteinase-1, -2, and -3 in Japanese with high myopia. (2010)
  • 著者名/発表者名: Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci. 巻: 51 ページ: 4432-4436
  • 査読あり
• [雑誌論文] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. (2010)
  • 著者名/発表者名: Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL ; Complications of Age-Related Macular Degeneration Prevention Trial Research Group, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A.
  • 雑誌名: Proc Natl Acad Sci U S A. 巻: 107 ページ: 7401-7406
  • 査読あり
• [雑誌論文] Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy. (2010)
  • 著者名/発表者名: Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N.
  • 雑誌名: Graefes Arch Clin Exp Ophthalmol. 巻: 248 ページ: 1077-1086
  • NAID: 120002514711
  • 査読あり
• [雑誌論文] Punctate hyperfluorescent spots associated with central serous chorioretinopathy as seen on indocyanine green angiography. (2010)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N.
  • 雑誌名: Retina 巻: 30 ページ: 801-809
  • 査読あり