次世代シークエンサーを用いた統合的遺伝子解析による慢性Ｃ型肝炎の病態解明

• 研究課題/領域番号: 23390195
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 消化器内科学
• 研究機関: 山梨大学
• 研究代表者: 榎本 信幸 山梨大学, 医学工学総合研究部, 教授 (20251530)
• 研究分担者: 前川 伸哉 山梨大学, 医学工学総合研究部, 講師 (70397298)
• 研究期間 (年度): 2011-04-01 – 2014-03-31
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 19,370千円 (直接経費: 14,900千円、間接経費: 4,470千円); 2013年度: 6,110千円 (直接経費: 4,700千円、間接経費: 1,410千円); 2012年度: 6,110千円 (直接経費: 4,700千円、間接経費: 1,410千円); 2011年度: 7,150千円 (直接経費: 5,500千円、間接経費: 1,650千円)
• キーワード: HCV / HCC / 次世代シークエンス / プロテアーゼ阻害剤 / NS5A阻害剤 / コア蛋白 / ISDR / インターフェロン / リバビリン / 次世代シークエンシング

研究概要

Ｃ型肝炎ウイルスは変異が多く、宿主においては多様な変異体の集合体(quasispecies)となって、抗ウイルス治療あるいは肝炎の進展や肝発癌に関与することが考えられてきたが、従来詳細な検討は技術的に困難であった。本研究では、次世代シークエンス技術を導入し、quasispeciesとその動態の詳細な解析をコア領域、プロテアーゼ領域、NS5A領域に対して行うことにより、ＨＣＶのquasispeciesとその動態変化がDAA治療あるいは肝発癌過程といった病態に密接に関連することを明らかとした。

研究成果

• [雑誌論文] Once-daily simeprevir in combination with pegylated-interferon and ribavirin : a new horizon in the era of direct-acting antiviral agent therapy for chronic hepatitis C (2014)
  • 著者名/発表者名: Maekawa S, Enomoto N
  • 雑誌名: J Gastroenterol 巻: 49(1) ページ: 163-4
  • 査読あり
• [雑誌論文] Once-daily simeprevir in combination with pegylated-interferon and ribavirin: a new horizon in the era of direct-acting antiviral agent therapy for chronic hepatitis C. (2014)
  • 著者名/発表者名: Maekawa S, Enomoto N
  • 雑誌名: J Gastroenterol. 巻: 49(1) 号: 12 ページ: 163-164
  • DOI: 10.1371/journal.pone.0082299
  • 査読あり
• [雑誌論文] Inhibitory effects of caffeic Acid phenethyl ester derivatives on replication of hepatitis C virus (2013)
  • 著者名/発表者名: Shen H, Yamashita A, Nakakoshi M, Yokoe H, Sudo M, Kasai H, Tanaka T, Fujimoto Y, Ikeda M, Kato N, Sakamoto N, Shindo H, Maekawa S, Enomoto N, Tsubuki M, Moriishi K
  • 雑誌名: PLoS One 巻: 17;8(12)
  • 査読あり
• [雑誌論文] Association of splenic MR elastographic findings with gastroesophageal varices in patients with chronic liver disease (2013)
  • 著者名/発表者名: Morisaka H, Motosugi U, Ichikawa S, Sano K, Ichikawa T, Enomoto N
  • 雑誌名: J Magn Reson Imaging
  • 査読あり
• [雑誌論文] Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma (2013)
  • 著者名/発表者名: Tsuchiya K, Asahina Y, Matsuda S, Muraoka M, Nakata T, Suzuki Y, Tamaki N, Yasui Y, Suzuki S, Hosokawa T, Nishimura T, Ueda K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Izumi N
  • 雑誌名: Cancer 巻: 15;120(2) ページ: 229-37
  • 査読あり
• [雑誌論文] Deep-sequencing analysis of the association between the quasispecies nature of the hepatitis C virus core region and disease progression (2013)
  • 著者名/発表者名: Miura M, Maekawa S, Takano S, Komatsu N, Tatsumi A, Asakawa Y, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
  • 雑誌名: J Virol 巻: 87(23) ページ: 12541-51
  • 査読あり
• [雑誌論文] Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C (2013)
  • 著者名/発表者名: Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N
  • 雑誌名: J Gastroenterol
  • 査読あり
• [雑誌論文] MR-based measurements of portal vein flow and liver stiffness for predicting gastroesophageal varices (2013)
  • 著者名/発表者名: Morisaka H, Motosugi U, Ichikawa T, Sano K, Ichikawa S, Araki T, Enomoto N
  • 雑誌名: Magn Reson Med Sci 巻: 12(2) ページ: 77-86
  • NAID: 10031183920
  • 査読あり
• [雑誌論文] Presence of a hypovascular hepatic nodule showing hypointensity on hepatocyte-phase image is a risk factor for hypervascular hepatocellular carcinoma (2013)
  • 著者名/発表者名: Ichikawa S, Ichikawa T, Motosugi U, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H, Araki T
  • 雑誌名: J Magn Reson Imaging 巻: 39(2) ページ: 293-7
  • 査読あり
• [雑誌論文] Impaired brain activity in cirrhotic patients with minimal hepatic encephalopathy : Evaluation by near-infrared spectroscopy (2013)
  • 著者名/発表者名: Nakanishi H, Kurosaki M, Nakanishi K, Tsuchiya K, Noda T, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Itakura J, Anami K, Asahina Y, Enomoto N, Higuchi T, Izumi N
  • 雑誌名: Hepatol Res
  • 査読あり
• [雑誌論文] Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1 (2013)
  • 著者名/発表者名: Saibara T, Enomoto N, Kaneko S, Chayama K, Sata M, Imawari M, Onishi S, Okita K
  • 雑誌名: Hepatol Res
  • 査読あり
• [雑誌論文] α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C (2013)
  • 著者名/発表者名: Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N
  • 雑誌名: Hepatology 巻: 58(4) ページ: 1253-62
  • 査読あり
• [雑誌論文] IL-28B (IFN-λ3) and IFN-α synergistically inhibit HCV replication (2013)
  • 著者名/発表者名: Shindo H, Maekawa S, Komase K, Miura M, Kadokura M, Sueki R, Komatsu N, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
  • 雑誌名: J Viral Hepat 巻: 20(4) ページ: 281-9
  • 査読あり
• [雑誌論文] Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C (2013)
  • 著者名/発表者名: Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Matsuura K, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Tokunaga K, Mizokami M, Izumi N
  • 雑誌名: J Med Virol 巻: 85(3) ページ: 449-58
  • 査読あり
• [雑誌論文] Serum RANTES level influences the response to pegylated interferon and ribavirin therapy in chronic hepatitis C (2013)
  • 著者名/発表者名: Komase K, Maekawa S, Miura M, Sueki R, Kadokura M, Shindo H, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
  • 雑誌名: Hepatol Res 巻: 43(8) ページ: 865-75
  • NAID: 10031194591
  • 査読あり
• [雑誌論文] Bayesian prediction for liver fibrosis staging : combined use of elastography and serum fibrosis markers (2013)
  • 著者名/発表者名: Motosugi U, Ichikawa T, Araki T, Matsuda M, Fujii H, Enomoto N
  • 雑誌名: Hepatology 巻: 58(1) ページ: 450-1
  • 査読あり
• [雑誌論文] Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma : a preliminary case-control study (2013)
  • 著者名/発表者名: Motosugi U, Ichikawa T, Koshiishi T, Sano K, Morisaka H, Ichikawa S, Enomoto N, Matsuda M, Fujii H, Araki T
  • 雑誌名: Eur Radiol 巻: 23(1) ページ: 156-62
  • 査読あり
• [雑誌論文] Inhibitory effects of caffeic Acid phenethyl ester derivatives on replication of hepatitis C virus. (2013)
  • 著者名/発表者名: Shen H, Yamashita A, Nakakoshi M, Yokoe H, Sudo M, Kasai H, Tanaka T, Fujimoto Y, Ikeda M, Kato N, Sakamoto N, Shindo H, Maekawa S, Enomoto N, Tsubuki M, Moriishi K.
  • 雑誌名: PLoS One. 巻: 17 号: 1 ページ: 163-164
  • DOI: 10.1007/s00535-013-0926-7
  • 査読あり
• [雑誌論文] Association of splenic MR elastographic findings with gastroesophageal varices in patients with chronic liver disease. (2013)
  • 著者名/発表者名: Morisaka H, Motosugi U, Ichikawa S, Sano K, Ichikawa T, Enomoto N
  • 雑誌名: J Magn Reson Imaging. 巻: Nov 14 号: 1 ページ: 117-124
  • DOI: 10.1002/jmri.24505
  • 査読あり
• [雑誌論文] Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma. (2013)
  • 著者名/発表者名: Tsuchiya K, Asahina Y, Matsuda S, Muraoka M, Nakata T, Suzuki Y, Tamaki N, Yasui Y, Suzuki S, Hosokawa T, Nishimura T, Ueda K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Izumi N.
  • 雑誌名: Cancer. 巻: 15;120(2) 号: 2 ページ: 229-237
  • DOI: 10.1002/cncr.28384
  • 査読あり
• [雑誌論文] Deep-sequencing analysis of the association between the quasispecies nature of the hepatitis C virus core region and disease progression. (2013)
  • 著者名/発表者名: Miura M, Maekawa S, Takano S, Komatsu N, Tatsumi A, Asakawa Y, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N.
  • 雑誌名: J Virol. 巻: 87(23) 号: 23 ページ: 12541-12551
  • DOI: 10.1128/jvi.00826-13
  • 査読あり
• [雑誌論文] Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C. (2013)
  • 著者名/発表者名: Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N.
  • 雑誌名: J Gastroenterol. 巻: Jul 17
  • 査読あり
• [雑誌論文] MR-based measurements of portal vein flow and liver stiffness for predicting gastroesophageal varices. (2013)
  • 著者名/発表者名: Morisaka H, Motosugi U, Ichikawa T, Sano K, Ichikawa S, Araki T, Enomoto N
  • 雑誌名: Magn Reson Med Sci. 巻: 12(2) ページ: 77-86
  • NAID: 10031183920
  • 査読あり
• [雑誌論文] Presence of a hypovascular hepatic nodule showing hypointensity on hepatocyte-phase image is a risk factor for hypervascular hepatocellular carcinoma. (2013)
  • 著者名/発表者名: Ichikawa S, Ichikawa T, Motosugi U, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H, Araki T.
  • 雑誌名: J Magn Reson Imaging. 巻: 39(2) 号: 2 ページ: 293-297
  • DOI: 10.1002/jmri.24164
  • 査読あり
• [雑誌論文] Impaired brain activity in cirrhotic patients with minimal hepatic encephalopathy: evaluation by near infrared spectroscopy. (2013)
  • 著者名/発表者名: Nakanishi H,Asahina Y, Izumi N et al
  • 雑誌名: Hepatol Res 巻: in press 号: 3 ページ: 319-326
  • DOI: 10.1111/hepr.12127
  • 査読あり
• [雑誌論文] Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1. (2013)
  • 著者名/発表者名: Saibara T, Enomoto N, Kaneko S, Chayama K, Sata M, Imawari M, Onishi S, Okita K.
  • 雑誌名: Hepatol Res. 巻: Apr 19 号: 4 ページ: 410-419
  • DOI: 10.1111/hepr.12139
  • 査読あり
• [雑誌論文] α-fetoprotein levels afterinterferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C (2013)
  • 著者名/発表者名: Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M,Izumi N
  • 雑誌名: Hepatology 巻: (in press) 号: 4 ページ: 1253-1262
  • DOI: 10.1002/hep.26442
  • 査読あり
• [雑誌論文] IL-28B (IFN-λ3) and IFN-α synergistically inhibit HCV replication. (2013)
  • 著者名/発表者名: Shindo H
  • 雑誌名: J Viral Hepat. 巻: 20 号: 4 ページ: 281-289
  • DOI: 10.1111/j.1365-2893.2012.01649.x
  • 査読あり
• [雑誌論文] Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C. (2013)
  • 著者名/発表者名: Kurosaki M, Sakamoto N, Asahina Y, Izumi N et al
  • 雑誌名: J Med Virol 巻: 85 号: 3 ページ: 449-458
  • DOI: 10.1002/jmv.23497
  • 査読あり
• [雑誌論文] Serum RANTES level influences the response to pegylated interferon and ribavirin therapy in chronic hepatitis C. (2013)
  • 著者名/発表者名: Komase K, Maekawa S, Miura M, Sueki R, Kadokura M, Shindo H, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
  • 雑誌名: Hepatol Res. 巻: 43(8) 号: 8 ページ: 865-875
  • DOI: 10.1111/hepr.12032
  • NAID: 10031194591
  • 査読あり
• [雑誌論文] Magnetic resonance elastography for staging liver fibrosis in chronic hepatitis C (2012)
  • 著者名/発表者名: Ichikawa S, Motosugi U, Ichikawa T, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H, Araki T
  • 雑誌名: Magn Reson Med Sci 巻: 11(4) ページ: 291-7
  • NAID: 10031145229
  • 査読あり
• [雑誌論文] RETRY Study Group. Retreatment with peginterferon α-2a + ribavirin in patients who failed previous peginterferon α-2b + ribavirin combination therapy (2012)
  • 著者名/発表者名: Ueda T, Tsuchiya K, Hashimoto S, Inoue T, Enomoto N, Inao M, Tanaka A, Kaito M, Imazeki F, Nishiguchi S, Mochida S, Yokosuka O, Yatsuhashi H, Izumi N, Kudo M
  • 雑誌名: Dig Dis 巻: 30(6) ページ: 554-60
  • 査読あり
• [雑誌論文] Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp (2012)
  • 著者名/発表者名: Fujimoto Y, Salam KA, Furuta A, Matsuda Y, Fujita O, Tani H, Ikeda M, Kato N, Sakamoto N, Maekawa S, Enomoto N, de Voogd NJ, Nakakoshi M, Tsubuki M, Sekiguchi Y, Tsuneda S, Akimitsu N, Noda N, Yamashita A, Tanaka J, Moriishi K
  • 雑誌名: PLoS One 巻: 7(11)
  • 査読あり
• [雑誌論文] Correlation between pretreatment viral sequences and the emergence of lamivudine resistance in hepatitis B virus infection (2012)
  • 著者名/発表者名: Sueki R, Maekawa S, Miura M, Kadokura M, Komase K, Shindo H, Kanayama A, Ohmori T, Shindo K, Amemiya F, Nakayama Y, Uetake T, Inoue T, Sakamoto M, Enomoto N
  • 雑誌名: J Med Virol 巻: 84(9) ページ: 1360-1360
  • 査読あり
• [雑誌論文] Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia (2012)
  • 著者名/発表者名: Yamashita A, Salam KA, Furuta A, Matsuda Y, Fujita O, Tani H, Fujita Y, Fujimoto Y, Ikeda M, Kato N, Sakamoto N, Maekawa S, Enomoto N, Nakakoshi M, Tsubuki M, Sekiguchi Y, Tsuneda S, Akimitsu N, Noda N, Tanaka J, Moriishi K
  • 雑誌名: Mar Drugs 巻: 10(4) ページ: 744-61
  • 査読あり
• [雑誌論文] Retreatment with peginterferon α-2a + ribavirin in patients who failed previous peginterferon α-2b + ribavirin combination therapy (2012)
  • 著者名/発表者名: Ueda T
  • 雑誌名: Dig Dis. 巻: 30 号: 6 ページ: 554
  • DOI: 10.1159/000343064
  • 査読あり
• [雑誌論文] Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp. (2012)
  • 著者名/発表者名: Fujimoto Y
  • 雑誌名: PLoS One. 巻: 7 号: 11 ページ: 744-761
  • DOI: 10.1371/journal.pone.0048685
  • 査読あり
• [雑誌論文] Inhibition of Hepatitis C Virus Replication and Viral Helicase by Ethyl Acetate Extract of the Marine Feather Star Alloeocomatella polycladia (2012)
  • 著者名/発表者名: Yamashita A, Maekawa S, et al
  • 雑誌名: Mar.Drugs 巻: 10 号: 4 ページ: 744-761
  • DOI: 10.3390/md10040744
  • 査読あり
• [雑誌論文] Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection. (2012)
  • 著者名/発表者名: Maekawa S
  • 雑誌名: Hepatology. 巻: 56(5) 号: 5 ページ: 1611-1621
  • DOI: 10.1002/hep.25826
  • 査読あり
• [雑誌論文] Causes of Thrombocytopenia in Chronic Hepatitis C Viral Infection (2012)
  • 著者名/発表者名: Osada M
  • 雑誌名: Clin Appl Thromb Hemost 巻: 12(Epub ahead of print) 号: 3 ページ: 272-280
  • DOI: 10.1177/1076029611429124
  • 査読あり
• [雑誌論文] Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis (2011)
  • 著者名/発表者名: Miura M, Maekawa S, Kadokura M, Sueki R, Komase K, Shindo H, Ohmori T, Kanayama A, Shindo K, Amemiya F, Nakayama Y, Kitamura T, Uetake T, Inoue T, Sakamoto M, Okada S, Enomoto N
  • 雑誌名: Hepatol Int
  • 査読あり
• [雑誌論文] Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients (2011)
  • 著者名/発表者名: Shindo H, Maekawa S, Komase K, Kadokura M, Sueki R, Miura M, Shindo K, Amemiya F, Kitamura T, Nakayama Y, Uetake T, Inoue T, Sakamoto M, Okada S, Asahina Y, Izumi N, Honda M, Kaneko S, Enomoto N
  • 雑誌名: Hepatol Int
  • 査読あり
• [雑誌論文] Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy (2011)
  • 著者名/発表者名: Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N
  • 雑誌名: PLoS One 巻: 6(9)
  • 査読あり
• [雑誌論文] Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy (2011)
  • 著者名/発表者名: Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N
  • 雑誌名: Hepatol Int
  • 査読あり
• [雑誌論文] A new method for induced fit docking (GENIUS) and its application to virtual screening of novel HCV NS3-4A protease inhibitors (2011)
  • 著者名/発表者名: Takaya D, Yamashita A, Kamijo K, Gomi J, Ito M, Maekawa S, Enomoto N, Sakamoto N, Watanabe Y, Arai R, Umeyama H, Honma T, Matsumoto T, Yokoyama S
  • 雑誌名: Bioorg Med Chem
  • 査読あり
• [雑誌論文] PERFECT Study Group. Cancer preventive effect of pegylated interferon α-2b plus ribavirin in a real-life clinical setting in Japan : PERFECT interim analysis (2011)
  • 著者名/発表者名: Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M
  • 雑誌名: Hepatol Res 巻: 41(10) ページ: 955-964
  • 査読あり
• [雑誌論文] Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors (2011)
  • 著者名/発表者名: Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M
  • 雑誌名: J Hepatol 巻: 54(3) ページ: 439-48
  • 査読あり
• [雑誌論文] Association of gene expression involving innate immunity and genetic variation in IL28B with antiviral response (2011)
  • 著者名/発表者名: Asahina Y, Tsuchiya K, Muraoka M, Tanaka K, Suzuki Y, Tamaki N, Hoshioka Y, Yasui Y, Katoh T, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nitta S, Sakamoto N, Izumi N
  • 雑誌名: Hepatology
  • 査読あり
• [雑誌論文] Relationship between polymorphisms of the inosine triphosphatase gene and anaemia or outcome after treatment with pegylated interferon and ribavirin (2011)
  • 著者名/発表者名: Kurosaki M, Tanaka Y, Tanaka K, Suzuki Y, Hoshioka Y, Tamaki N, Kato T, Yasui Y, Hosokawa T, Ueda K, Tsuchiya K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Asahina Y, Matsuura K, Sugauchi F, Enomoto N, Nishida N, Tokunaga K, Mizokami M, Izumi N
  • 雑誌名: Antivir Ther 巻: 16(5) ページ: 685-94
  • 査読あり
• [雑誌論文] Staging liver fibrosis by using liver-enhancement ratio of gadoxetic acid-enhanced MR imaging : comparison with aspartate aminotransferase-to-platelet ratio index (2011)
  • 著者名/発表者名: Motosugi U, Ichikawa T, Oguri M, Sano K, Sou H, Muhi A, Matsuda M, Fujii H, Enomoto N, Araki T
  • 雑誌名: Magn Reson Imaging 巻: 29(8) ページ: 1047-52
  • 査読あり
• [雑誌論文] Expression of keratin 19 is related to high recurrence of hepatocellular carcinoma after radiofrequency ablation (2011)
  • 著者名/発表者名: Tsuchiya K, Komuta M, Yasui Y, Tamaki N, Hosokawa T, Ueda K, Kuzuya T, Itakura J, Nakanishi H, Takahashi Y, Kurosaki M, Asahina Y, Enomoto N, Sakamoto M, Izumi N
  • 雑誌名: Oncology 巻: 80(3-4) ページ: 278-88
  • 査読あり
• [雑誌論文] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C (2011)
  • 著者名/発表者名: Tanaka Y, Kurosaki M, Nishida N, Sugiyama M, Matsuura K, Sakamoto N, Enomoto N, Yatsuhashi H, Nishiguchi S, Hino K, Hige S, Itoh Y, Tanaka E, Mochida S, Honda M, Hiasa Y, Koike A, Sugauchi F, Kaneko S, Izumi N, Tokunaga K, Mizokami M
  • 雑誌名: Hum Mol Genet 巻: 20(17) ページ: 3507-16
  • 査読あり
• [雑誌論文] Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses (2011)
  • 著者名/発表者名: Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
  • 雑誌名: Gastroenterology 巻: 141(1)
  • 査読あり
• [雑誌論文] Outcome of hypovascular hepatic nodules revealing no gadoxetic acid uptake in patients with chronic liver disease (2011)
  • 著者名/発表者名: Motosugi U, Ichikawa T, Sano K, Sou H, Onohara K, Muhi A, Amemiya F, Enomoto N, Matsuda M, Fujii H, Araki T
  • 雑誌名: J Magn Reson Imaging 巻: 34(1) 号: 1 ページ: 88-94
  • DOI: 10.1002/jmri.22630
  • 査読あり
• [雑誌論文] Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis C (2011)
  • 著者名/発表者名: Miura M, Maekawa S, et.al
  • 雑誌名: Hepatol Int. 巻: 6 号: 1 ページ: 386-396
  • DOI: 10.1007/s12072-011-9307-6
  • 査読あり
• [雑誌論文] Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients (2011)
  • 著者名/発表者名: Honda M, (他17名, 16番目)
  • 雑誌名: Hepatol Int Epub ahead of print 巻: 2 号: 2 ページ: 482-490
  • DOI: 10.1007/s12072-011-9306-7
  • 査読あり
• [雑誌論文] A new method for induced fit docking (GENIUS) and its application to virtual screening of novel HCV NS3-4A protease inhibitors (2011)
  • 著者名/発表者名: Takaya D, Sakamoto N, et al.
  • 雑誌名: Bioorganic & Medicinal Chemistry 巻: 19(22) 号: 22 ページ: 6892-6905
  • DOI: 10.1016/j.bmc.2011.09.023
  • 査読あり
• [雑誌論文] Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy (2011)
  • 著者名/発表者名: Kadokura M, Nakagawa M, Sakamoto N, Watanabe M, et al.
  • 雑誌名: PLoS One 巻: 6(9) 号: 9 ページ: e24514-e24514
  • DOI: 10.1371/journal.pone.0024514
  • 査読あり
• [雑誌論文] Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses (2011)
  • 著者名/発表者名: Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
  • 雑誌名: Gastroenterology 巻: 141 号: 1 ページ: 1-5
  • DOI: 10.1053/j.gastro.2011.05.027
  • 査読あり
• [雑誌論文] Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy (2011)
  • 著者名/発表者名: Kadokura M
  • 雑誌名: Hepatol Int 巻: 5 ページ: 789-799
  • 査読あり
• [雑誌論文] Cancer preventive effect of pegylated interferon α-2b plus ribavirin in a real-life clinical setting in Japan: PERFECT interim analysis (2011)
  • 著者名/発表者名: Watanabe S
  • 雑誌名: Hepatol Res 巻: 41 号: 10 ページ: 955
  • DOI: 10.1111/j.1872-034x.2011.00847.x
  • 査読あり
• [雑誌論文] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C (2011)
  • 著者名/発表者名: Tanaka Y, Sakamoto N, et al.
  • 雑誌名: Human Molecular Genetics 巻: 20(17) 号: 17 ページ: 3507-3516
  • DOI: 10.1093/hmg/ddr249
  • 査読あり