血清レプチン、アディポネクチンと潜在性動脈硬化進展度に関する研究

• 研究課題/領域番号: 23590823
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 公衆衛生学・健康科学
• 研究機関: 京都女子大学
• 研究代表者: 中村 保幸 京都女子大学, 家政学部, 教授 (20144371)
• 研究分担者: 上島 弘嗣 滋賀医科大学, 医学部公衆衛生学講座, 名誉教授 (70144483) ; 三浦 克之 滋賀医科大学, 医学部公衆衛生学講座, 教授 (90257452)
• 研究期間 (年度): 2011 – 2013
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 5,330千円 (直接経費: 4,100千円、間接経費: 1,230千円); 2013年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円); 2012年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円); 2011年度: 3,250千円 (直接経費: 2,500千円、間接経費: 750千円)
• キーワード: 潜在的動脈硬化 / レプチン / アディポネクチン / 冠動脈石灰化 / 頸動脈内膜-中膜肥厚 / 頸動脈内膜-中膜肥厚度 / 頸動脈内中膜肥厚 / 潜在性動脈硬化 / 疫学研究

研究概要

720人の一般住民男性を対象にアディポサイトカインとCT検査による冠動脈石灰化(CAC, Agaston score　(AS)>=10)と頸動脈内膜-中膜肥厚度（IMT）を用いて検討した。レプチン(lep)およびアディポネクチン(adip)を重回帰分析で解析するといずれもIMTとは関連がなかった。一方CACの有無をロジスティック解析で検討すると、年齢のみで調整した場合log-lepはCACと正の関連があったが、さらにBMI等を調整因子に加えるとlog-lepはCACと有意な負の関連が現れてきた。log-adipとCACの間には何ら有意な関連は無かった。

研究成果

• [雑誌論文] Impact of Metabolic Syndrome on the Risk of Cardiovascular Disease Mortality in the United States and in Japan (2014)
  • 著者名/発表者名: Liu L, Miura K, Fujiyoshi A, Kadota A, Miyagawa N, Nakamura Y, Ohkubo T, Okayama A, Okamura T, Ueshima H
  • 雑誌名: Am J Cardiol 巻: 113(1) ページ: 84-9
• [雑誌論文] Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • 著者名/発表者名: Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H
  • 雑誌名: J Atheroscler Thromb 巻: 20(10) ページ: 755-66
  • NAID: 130004444645
• [雑誌論文] Serum leptin and total dietary energy intake : The INTERLIPID Study (2013)
  • 著者名/発表者名: Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Okayama A, Turin TC, Choudhry SR, Rodriguez B, Curb JD, Stamler J
  • 雑誌名: Eur J Nutr 巻: 52(6) ページ: 1641-8
• [雑誌論文] Prognostic Values of Bundle Branch Blocks for Cardiovascular Mortality in Japanese (24 Year Follow-up of NIPPON DATA80) (2013)
  • 著者名/発表者名: Nakamura Y, Okamura T, Inohara T, Kohsaka S, Watanabe M, Higashiyama A, Kadota A, Okuda N, Ohkubo T, Nagasawa SY, Miura K, Okayama A, Ueshima H
  • 雑誌名: J Electrocardiol 巻: 46(4) ページ: 360-5
• [雑誌論文] Prognostic values of bundle branch blocks for cardiovascular mortality in Japanese (24 year follow-up of NIPPON DATA80) (2013)
  • 著者名/発表者名: Nakamura Y, Okamura T, Inohara T, et al.
  • 雑誌名: J Electrocardiol 巻: 46 号: 4 ページ: 360
  • DOI: 10.1016/j.jelectrocard.2013.03.009
  • URL: https://pure.teikyo.jp/en/publications/e1c3f567-4a27-4f79-9074-b190958e800f
  • 査読あり
• [雑誌論文] Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: A 24-year follow-up of Japanese men (2013)
  • 著者名/発表者名: Hisamatsu T, Miura K, Horie M. et al.
  • 雑誌名: Heart 巻: 99 号: 14 ページ: 1024
  • DOI: 10.1136/heartjnl-2012-303496
  • URL: https://pure.teikyo.jp/en/publications/24a61ade-d5c6-4406-ade3-17c94acb1ad8
  • 査読あり
• [雑誌論文] Serum leptin and total dietary energy intake: The INTERLIPID Study (2013)
  • 著者名/発表者名: Nakamura Y, Ueshima H, Okuda N, et al.
  • 雑誌名: Eur J Nutr 巻: 52 号: 6 ページ: 1641-1648
  • DOI: 10.1007/s00394-012-0469-3
  • 査読あり
• [雑誌論文] Serum leptin and total dietary energy intake: the INTERLIPID Study (2013)
  • 著者名/発表者名: Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Okayama A, Turin TC, Choudhry SR, Rodriguez B, Curb JD, Stamler J.
  • 雑誌名: Eur J Nutr 巻: 52 ページ: 1641-8
  • 査読あり
• [雑誌論文] Prognostic values of bundle branch blocks for Cardiovascular Mortality in Japanese (24 Year Follow-up of NIPPON DATA80) (2013)
  • 著者名/発表者名: Nakamura Y, Okamura T, Inohara T, Kohsaka S, Watanabe M, Higashiyama A, Kadota A, Okuda N, Ohkubo T, Nagasawa S, Miura K, Okayama A, Ueshima H
  • 雑誌名: J Electrocardiol 巻: 46 ページ: 360-65
  • 査読あり
• [雑誌論文] Relationship between health-related quality of life and clustering of metabolic syndrome diagnostic components (2012)
  • 著者名/発表者名: Katano S, Nakamura Y, Nakamura A, Suzukamo Y, Murakami Y, Tanaka T, Okayama A, Miura K, Okamura T, Fukuhara S, Ueshima H, HIPOP-OHP Research Group
  • 雑誌名: Qual Life Res 巻: 21(7) ページ: 1165-1170
• [雑誌論文] Prognostic Values of Clockwise and Counter-Clockwise Rotation for Cardiovascular Mortality in Japanese (24 Year Follow-up of NIPPON DATA80). (2012)
  • 著者名/発表者名: Nakamura Y, Okamura T, Higashiyama A, Watanabe M, Kadota A, Ohkubo T, Miura K, Kasagi F, Kodama K, Okayama A, Ueshima H.
  • 雑誌名: Circulation 巻: 125 ページ: 1226-33
  • 査読あり
• [雑誌論文] Prognostic values of clockwise and counterclockwise rotation for cardiovascular mortality in Japanese subjects: a 24-year follow-up of the National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in the Aged, 1980-2004 (NIPPON DATA80). (2012)
  • 著者名/発表者名: Nakamura Y, Okamura T, Higashiyama A, Watanabe M, Kadota A, Ohkubo T, Miura K, Kasagi F, Kodama K, Okayama A, Ueshima H
  • 雑誌名: Circulation 巻: 125 ページ: 1226-1233
  • 査読あり
• [雑誌論文] Research Group. Relation of dietary and lifestyle traits to difference in serum leptin of Japanese in Japan and Hawaii: The INTERLIPID study (2012)
  • 著者名/発表者名: 116.Nakamura Y, Ueshima H, Okuda N, Miura K, Kita Y, Okamura T, Turin TC, Okayama A, Rodriguez B, Curb JD, Stamler J
  • 雑誌名: Nutr Metab Cardiovasc Dis 巻: 22 ページ: 14-22
  • 査読あり
• [雑誌論文] Relationship between Dietary and Other Lifestyle Habits and Cardiometabolic Risk Factors in Men (2011)
  • 著者名/発表者名: Katano S, Nakamura Y, Okuda N, Murakami Y, Chiba N, Yoshita K, Tanaka T, Tamaki J, Takebayashi T, Okayama A, Miura K, Okamura T, Ueshima H
  • 雑誌名: Diabetol Metab Syndr 巻: 3. ページ: 30-30
  • 査読あり
• [雑誌論文] Relationship between sleep duration and clustering of metabolic syndrome diagnostic components (2011)
  • 著者名/発表者名: Katano S, Nakamura Y, Nakamura A, Murakami Y, Tanaka T, Takebayashi T, Okayama A, Miura K, Okamura T, Ueshima H
  • 雑誌名: Diabetes Metab Syndr 巻: 4 ページ: 119-125
  • 査読あり
• [学会発表] Low-Carbohydrate-Diets and Cardiovascular and Total Mortality in Japanese. A 29-year Follow-up of NIPPON DATA80 (2014)
  • 著者名/発表者名: Nakamura Y, Miura K, Ueshima H, et al
  • 学会等名: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • 発表場所: San Francisco, CA
• [学会発表] 低炭水化物食と心血管死、総死亡の関連：NIPPON DATA80, 29年追跡結果 (2014)
  • 著者名/発表者名: 中村保幸他
  • 学会等名: 日本疫学会
  • 発表場所: 仙台
• [学会発表] Low-Carbohydrate-Diets and Cardiovascular and Total Mortality in Japanese. A 29-year Follow-up of NIPPON DATA80 (2014)
  • 著者名/発表者名: Nakamura Y, et al
  • 学会等名: American Heart Association, EPI/NPAM2014
  • 発表場所: San Francisco, CA, USA
• [学会発表] High-density Lipoprotein Particle Concentration is Independently Associated with Carotid Intima-media Thickness in Japanese Men (2013)
  • 著者名/発表者名: Zaid M, Fujiyoshi A, Miura K, Okamura T, Takashima N, Nakamura Y, Ueshima H, et al
  • 学会等名: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • 発表場所: New Orleans, LA
• [学会発表] The Relationship of Serum Marine-derived n-3 Fatty Acids and Carotid Intima-media Thickness Among General Japanese Men (2013)
  • 著者名/発表者名: K adota A, Miura K, Nakamura Y, Ueshima H, et al
  • 学会等名: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • 発表場所: New Orleans, LA
• [学会発表] Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein of Japanese in Japan and Japanese-Americans in Hawaii : The INTERLIPID Study (2013)
  • 著者名/発表者名: Nakamura Y, Ueshima H, Okuda N, Miura K, et al
  • 学会等名: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • 発表場所: New Orleans, LA
• [学会発表] Significant Inverse Association of Serum Docosahexaenoic Acid with Coronary Artery Calcification Among Men in the General Population in Japan (2013)
  • 著者名/発表者名: Sekikawa A, Miura K, Nakamura Y, Ueshima H, et al
  • 学会等名: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • 発表場所: New Orleans, LA
• [学会発表] Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein of Japanese in Japan and Japanese-Americans in Hawaii: The INTERLIPID Study (2013)
  • 著者名/発表者名: Nakamura Y, Ueshima H, Stamler J et al.
  • 学会等名: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • 発表場所: New Orleans
• [学会発表] Clockwise rotation was positively and counter-clockwise rotation was inversely associated with cardiovascular mortality in Japanese (24 Year Follow-up of NIPPON DATA80) (2012)
  • 著者名/発表者名: Nakamura Y, Okamura T, Miura K, Ueshima H, et al
  • 学会等名: European Society of Cardiology Congress 2012
  • 発表場所: Munich
• [学会発表] Fatty acids intakes and coronary heart disease mortality in Japan : NIPPON DATA90, 1990-2005 (2012)
  • 著者名/発表者名: Nakamura Y, Miura K, Ueshima H, et al
  • 学会等名: XVI International Symposium on Atherosclerosis
  • 発表場所: Sydney
• [学会発表] Saturated fatty acids intake, polyunsaturated fatty acid intake and coronary heart disease mortality in Japan : NIPPON DATA90 1990-2005 (2011)
  • 著者名/発表者名: Nakamura Y, Miura K, Ueshima H et al
  • 学会等名: European Society of Cardiology Congress 2011
  • 発表場所: Paris
• [学会発表] aturated fatty acids intake, polyunsaturated fatty acid intake and coronary heart disease mortality in Japan: NIPPON DATA90 1990-2005 (2011)
  • 著者名/発表者名: Y. NakamuraY. Kiyohara, T. Okamura, A. Higashiyama, M. Watanabe, A. Kadota, S. Nagasawa, K. Miura, H. Ueshima.
  • 学会等名: ESC Congress
  • 発表場所: Paris