膵嚢胞性腫瘍の病態予測における包括的ゲノム解析の応用

• 研究課題/領域番号: 23591010
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 消化器内科学
• 研究機関: 東京大学
• 研究代表者: 多田 稔 東京大学, 医学部附属病院, 講師 (80302719)
• 研究分担者: 立石 敬介 東京大学, 医学部附属病院, 講師 (20396948) ; 毛利 大 東京大学, 医学部附属病院, 特任臨床医 (20582513)
• 研究期間 (年度): 2011 – 2013
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 5,200千円 (直接経費: 4,000千円、間接経費: 1,200千円); 2013年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円); 2012年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円); 2011年度: 2,210千円 (直接経費: 1,700千円、間接経費: 510千円)
• キーワード: IPMN

研究概要

25例のIPMNについてKras, Braf, PIK3CAの変異と、p16, smad4の欠失、p53蓄積を検討した。Kras変異はgastric-typeに多く、PIK3CA変異はintestinalの一例に認めた。smad1/5/8のリン酸化がintestinal-typeで多いことを見出し、報告した(J.Gastroenterol. 2012 47(2):203-13)。さらに、膵がん細胞株および臨床検体で増幅を認めた遺伝子のうち、ノックダウンの結果から上皮間葉転換を促進する分子を見出した。この分子のIPMNにおける関与を解析中である。

研究成果

• [雑誌論文] Disease-Specific Mortality Among Patients With Intraductal Papillary Mucinous Neoplasm of the Pancreas (2014)
  • 著者名/発表者名: Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Takahara N, Uchino R, Hamada T, Miyabayashi K, Yamamoto K, Mizuno S, Mohri D, Kogure H, Sasaki T, Yamamoto N, Hirano K, Ijichi H, Tateishi K, Koike K
  • 雑誌名: Clin Gastroenterol Hepatol 巻: 12(3) (2013 Jul 25) 号: 3 ページ: 486-91
  • DOI: 10.1016/j.cgh.2013.06.032
  • 査読あり
• [雑誌論文] Clinical outcomes of chemotherapy for diabetic and nondiabetic patients with pancreatic cancer : better prognosis with statin use in diabetic patients (2013)
  • 著者名/発表者名: Nakai Y, Isayama H, Sasaki T, Mizuno S, Sasahira N, Kogure H, Kawakubo K, Yamamoto N, Hirano K, Ijichi H, Tateishi K, Tada M, Koike K
  • 雑誌名: Pancreas 巻: 42(2) ページ: 202-8
• [雑誌論文] Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer (2013)
  • 著者名/発表者名: Takahara N, Nakai Y, Isayama H, Sasaki T, Satoh Y, Takai D, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Mohri D, Kawakubo K, Kogure H, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tada M, Yatomi Y, Koike K
  • 雑誌名: Cancer Chemother Pharmacol 巻: 71(1) ページ: 85-92
• [雑誌論文] Duodenal metal stent placement is a risk factor for biliary metal stent dysfunction : an analysis using a time-dependent covariate (2013)
  • 著者名/発表者名: Hamada T, Nakai Y, Isayama H, Sasaki T, Kogure H, Kawakubo K, Sasahira N, Yamamoto N, Togawa O, Mizuno S, Ito Y, Hirano K, Toda N, Tada M, Koike K
  • 雑誌名: Surg Endosc 巻: 27(4) ページ: 1243-8
• [雑誌論文] The results of the Tokyo trial of prevention of post-ERCP pancreatitis with risperidone (Tokyo P3R): a multicenter, randomized, phase II, non-placebo-controlled trial (2013)
  • 著者名/発表者名: Tsujino T, Isayama H, Nakai Y, Ito Y, Togawa O, Toda N, Arizumi T, Kogure H, Yamamoto K, Mizuno S, Yashima Y, Yagioka H, Sasaki T, Matsubara S, Yamamoto N, Hirano K, Sasahira N, Tada M, Koike K
  • 雑誌名: J Gastroenterol 巻: 48(8) ページ: 982-8
  • NAID: 10031195124
• [雑誌論文] False pancreas divisum : a complication of post-endoscopic retrograde pancreatography pancreatitis (2013)
  • 著者名/発表者名: Gonoi W, Akahane M, Tada M, Ohtomo K
  • 雑誌名: Jpn J Radiol 巻: 31(2) ページ: 148-51
  • NAID: 210000168608
• [雑誌論文] High alcohol consumption increases the risk of pancreatic stone formation and pancreatic atrophy in autoimmune pancreatitis (2013)
  • 著者名/発表者名: Hirano K, Tada M, Isayama H, Watanabe T, Saito T, Uchino R, Hamada T, Miyabayashi K, Mizuno S, Mohri D, Sasaki T, Kogure H, Yamamoto N, Sasahira N, Toda N, Takahara N, Yagioka H, Akiyama D, Ito Y, Koike K
  • 雑誌名: Pancreas 巻: 42(3) ページ: 502-5
• [雑誌論文] Japanese multicenter estimation of WallFlex duodenal stent for unresectable malignant gastric outlet obstruction (2013)
  • 著者名/発表者名: Sasaki T, Isayama H, Maetani I, Nakai Y, Kogure H, Kawakubo K, Mizuno S, Yagioka H, Matsubara S, Ito Y, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Koike K
  • 雑誌名: Dig Endosc 巻: 25(1) ページ: 1-6
  • NAID: 130004555333
• [雑誌論文] One-step, simultaneous triple endoscopic nasobiliary drainage for hilar biliary stricture (2013)
  • 著者名/発表者名: Kawakubo K, Isayama H, Mizuno S, Hirano K, Yamamoto N, Takahara N, Miyabayashi K, Mohri D, Sasaki T, Kogure H, Sasahira N, Tada M, Koike K
  • 雑誌名: Dig Endosc 巻: 25(1) ページ: 76-9
• [雑誌論文] Risk for mortality from causes other than pancreatic cancer in patients with intraductal papillary mucinous neoplasm of the pancreas (2013)
  • 著者名/発表者名: Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Takahara N, Miyabayashi K, Yamamoto K, Mizuno S, Mohri D, Kogure H, Sasaki T, Yamamoto N, Tateishi R, Hirano K, Ijichi H, Tateishi K, Koike K
  • 雑誌名: Pancreas 巻: 42(4) ページ: 687-91
• [雑誌論文] A multicenter phase II trial of gemcitabine and candesartan combination therapy in patients with advanced pancreatic cancer : GECA2 (2013)
  • 著者名/発表者名: Nakai Y, Isayama H, Ijichi H, Sasaki T, Takahara N, Ito Y, Matsubara S, Uchino R, Yagioka H, Arizumi T, Hamada T, Miyabayashi K, Mizuno S, Yamamoto K, Kogure H, Yamamoto N, Hirano K, Sasahira N, Tateishi K, Tada M, Koike K
  • 雑誌名: Invest New Drugs 巻: 31(5) ページ: 1294-9
• [雑誌論文] Diabetes is a useful diagnostic clue to improve the prognosis of pancreatic cancer (2013)
  • 著者名/発表者名: Mizuno S, Nakai Y, Isayama H, Takahara N, Miyabayashi K, Yamamoto K, Kawakubo K, Mohri D, Kogure H, Sasaki T, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Ijichi H, Tateishi K, Tada M, Koike K
  • 雑誌名: Pancreatology 巻: 13(3) ページ: 285-9
• [雑誌論文] A pilot study of salvage irinotecan monotherapy for advanced biliary tract cancer (2013)
  • 著者名/発表者名: Sasaki T, Isayama H, Nakai Y, Takahara N, Satoh Y, Takai D, Kogure H, Yamamoto N, Hirano K, Tada M, Yatomi Y, Koike K
  • 雑誌名: Anticancer Res 巻: 233(6) ページ: 2619-22
• [雑誌論文] Results of the Tokyo trial of prevention of post-ERCP pancreatitis with risperidone-2: a multicenter, randomized, placebo-controlled, double-blind clinical trial (2013)
  • 著者名/発表者名: Uchino R, Isayama H, Tsujino T, Sasahira N, Ito Y, Matsubara S, Takahara N, Arizumi T, Toda N, Mohri D, Togawa O, Yagioka H, Yanagihara Y, Nakajima K, Akiyama D, Hamada T, Miyabayashi K, Mizuno S, Kawakubo K, Kogure H, Sasaki T, Yamamoto N, Nakai Y, Hirano K, Tada M, Koike K
  • 雑誌名: Gastrointest Endosc 巻: 78(6) ページ: 842-50
• [雑誌論文] A retrospective study of S-1 and oxaliplatin combination chemotherapy in patients with refractory pancreatic cancer (2013)
  • 著者名/発表者名: Takahara N, Isayama H, Nakai Y, Sasaki T, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Kogure H, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tateishi K, Tada M, Koike K
  • 雑誌名: Cancer Chemother Pharmacol 巻: 72(5) ページ: 985-90
• [雑誌論文] A retrospective study of gemcitabine and cisplatin combination therapy as second-line treatment for advanced biliary tract cancer (2013)
  • 著者名/発表者名: Sasaki T, Isayama H, Nakai Y, Takahara N, Akiyama D, Yagioka H, Kogure H, Matsubara S, Ito Y, Yamamoto N, Sasahira N, Hirano K, Toda N, Tada M, Koike K
  • 雑誌名: Chemotherapy 巻: 59(2) ページ: 106-11
• [雑誌論文] Trimming a covered metal stent during hepaticogastrostomy by using argon plasma coagulation (2013)
  • 著者名/発表者名: Hamada T, Nakai Y, Isayama H, Saito K, Kogure H, Sasaki T, Yamamoto N, Hirano K, Tada M, Koike K
  • 雑誌名: Gastrointest Endosc 巻: 78(6) ページ: 817-817
• [雑誌論文] A retrospective analysis of early CA19-9 change in salvage chemotherapy for refractory pancreatic cancer (2013)
  • 著者名/発表者名: Nakai Y, Isayama H, Sasaki T, Takahara N, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Yamamoto K, Mohri D, Kogure H, Yamamoto N, Hirano K, Ijichi H, Tateishi K, Tada M, Koike K
  • 雑誌名: Cancer Chemother Pharmacol 巻: 72(6) ページ: 1291-7
• [雑誌論文] A novel, fully covered laser-cut nitinol stent with antimigration properties for nonresectable distal malignant biliary obstruction : a multicenter feasibility study (2013)
  • 著者名/発表者名: Isayama H, Kawakubo K, Nakai Y, Inoue K, Gon C, Matsubara S, Kogure H, Ito Y, Tsujino T, Mizuno S, Hamada T, Uchino R, Miyabayashi K, Yamamoto K, Sasaki T, Yamamoto N, Hirano K, Sasahira N, Tada M, Koike K
  • 雑誌名: Gut Liver 巻: 7(6) ページ: 725-30
• [雑誌論文] Risk factors and early signs of pancreatic cancer in diabetes : screening strategy based on diabetes onset age (2013)
  • 著者名/発表者名: Mizuno S, Nakai Y, Isayama H, Yanai A, Takahara N, Miyabayashi K, Yamamoto K, Kawakubo K, Mohri D, Kogure H, Sasaki T, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Ijichi H, Tateishi K, Akanuma M, Tada M, Koike K
  • 雑誌名: J Gastroenterol 巻: 48(2) ページ: 238-46
  • NAID: 10031156309
• [雑誌論文] Risk for mortality from causes other than pancreatic cancer in patients with intraductal papillary mucinous neoplasm of the pancreas (2013)
  • 著者名/発表者名: Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Takahara N, Miyabayashi K, Yamamoto K, Mizuno S, Mohri D, Kogure H, Sasaki T, Yamamoto N, Tateishi R, Hirano K, Ijichi H, Tateishi K, Koike K
  • 雑誌名: Pancreas 巻: 42(4) 号: 4 ページ: 687-91
  • DOI: 10.1097/mpa.0b013e318270ea97
  • 査読あり
• [雑誌論文] Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals. (2013)
  • 著者名/発表者名: Miyabayashi K, Ijichi H, Mohri D, Tada M, Yamamoto K, Asaoka Y, Ikenoue T, Tateishi K, Nakai Y, Isayama H, Morishita Y, Omata M, Moses HL, Koike K.
  • 雑誌名: Cancer Res 巻: 73 号: 7 ページ: 2221-34
  • DOI: 10.1158/0008-5472.can-12-1453
  • 査読あり
• [雑誌論文] Intraductal papillary mucinous neoplasm was associated with pancreatic carcinogenesis, but not with systemic carcinogenesis (2012)
  • 著者名/発表者名: Kawakubo K, Tada M, Koike K
  • 雑誌名: Surgery 巻: 152(1) ページ: 141-2
• [雑誌論文] Meandering main pancreatic duct as a relevant factor to the onset of idiopathic recurrent acute pancreatitis (2012)
  • 著者名/発表者名: Gonoi W, Akai H, Hagiwara K, Akahane M, Hayashi N, Maeda E, Yoshikawa T, Kiryu S, Tada M, Uno K, Ohtsu H, Okura N, Koike K, Ohtomo K
  • 雑誌名: PLoS One 巻: 7(5) ページ: 37652-37652
• [雑誌論文] One- and two-step self-expandable metal stent placement for distal malignant biliary obstruction : a propensity analysis (2012)
  • 著者名/発表者名: Hamada T, Nakai Y, Isayama H, Togawa O, Kogure H, Kawakubo K, Tsujino T, Sasahira N, Hirano K, Yamamoto N, Ito Y, Sasaki T, Mizuno S, Toda N, Tada M, Koike K
  • 雑誌名: J Gastroenterol 巻: 47(11) ページ: 1248-56
  • NAID: 10031126957
• [雑誌論文] Long-term prognosis of autoimmune pancreatitis in terms of glucose tolerance (2012)
  • 著者名/発表者名: Hirano K, Isogawa A, Tada M, Isayama H, Takahara N, Miyabayashi K, Mizuno S, Mohri D, Kawakubo K, Sasaki T, Kogure H, Yamamoto N, Sasahira N, Toda N, Nagano R, Yagioka H, Yashima Y, Hamada T, Ito Y, Koike K
  • 雑誌名: Pancreas 巻: 41(5) ページ: 691-5
• [雑誌論文] Autoimmune pancreatitis with low serum immunoglobulin G4 level associated with annular pancreas (2012)
  • 著者名/発表者名: Hirano K, Matsubara S, Tada M, Isayama H, Sasahira N, Koike K
  • 雑誌名: Pancreas 巻: 41(5) ページ: 811-3
• [雑誌論文] Lower incidence of biliary carcinoma in patients with primary sclerosing cholangitis and high serum levels of immunoglobulin E (2012)
  • 著者名/発表者名: Hirano K, Tada M, Mizuno S, Isayama H, Takahara N, Nagano R, Hamada T, Miyabayashi K, Ito Y, Mohri D, Kawakubo K, Sasaki T, Kogure H, Yamamoto N, Sasahira N, Yamashiki N, Sugawara Y, Kokudo N, Toda N, Koike K
  • 雑誌名: Clin Gastroenterol Hepatol 巻: 10(1) ページ: 79-83
  • NAID: 40019405097
• [雑誌論文] Management of malignant gastric outlet obstruction with a modified triple-layer covered metal stent (2012)
  • 著者名/発表者名: Isayama H, Sasaki T, Nakai Y, Togawa O, Kogure H, Sasahira N, Yashima Y, Kawakubo K, Ito Y, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • 雑誌名: Gastrointest Endosc 巻: 75(4) ページ: 757-63
• [雑誌論文] Simultaneous duodenal metal stent placement and EUS-guided choledochoduodenostomy for unresectable pancreatic cancer (2012)
  • 著者名/発表者名: Kawakubo K, Isayama H, Nakai Y, Sasahira N, Kogure H, Sasaki T, Hirano K, Tada M, Koike K
  • 雑誌名: Gut Liver 巻: 6(3) ページ: 399-402
• [雑誌論文] Risk factors for pancreatitis following transpapillary self-expandable metal stent placement (2012)
  • 著者名/発表者名: Kawakubo K, Isayama H, Nakai Y, Togawa O, Sasahira N, Kogure H, Sasaki T, Matsubara S, Yamamoto N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • 雑誌名: Surg Endosc 巻: 26(3) ページ: 771-6
• [雑誌論文] Mucosal hyperplasia in an uncovered portion of partially covered metal stent (2012)
  • 著者名/発表者名: Kawakubo K, Isayama H, Sasahira N, Kogure H, Miyabayashi K, Hirano K, Tada M, Koike K
  • 雑誌名: World J Gastrointest Endosc 巻: 4(9) ページ: 432-3
• [雑誌論文] Clinical utility of single-operator cholangiopancreatoscopy using a SpyGlass probe through an endoscopic retrograde cholangiopancreatography catheter (2012)
  • 著者名/発表者名: Kawakubo K, Isayama H, Sasahira N, Kogure H, Takahara N, Miyabayashi K, Mizuno S, Yamamoto K, Mohri D, Sasaki T, Yamamoto N, Nakai Y, Hirano K, Tada M, Koike K
  • 雑誌名: J Gastroenterol Hepatol 巻: 27(8) ページ: 1371-6
• [雑誌論文] Endoscopic removal of a spontaneously fractured biliary uncovered self-expandable metal stent (2012)
  • 著者名/発表者名: Kawakubo K, Isayama H, Tsujino T, Nakai Y, Sasahira N, Kogure H, Hamada T, Nagano R, Miyabayashi K, Yamamoto K, Mohri D, Sasaki T, Ito Y, Yamamoto N, Hirano K, Tada M, Koike K
  • 雑誌名: Dig Endosc 巻: 24(3) ページ: 182-4
• [雑誌論文] Comparison of CT findings of biliary tract changes with autoimmune pancreatitis and extrahepatic bile duct cholangiocarcinoma (2012)
  • 著者名/発表者名: Maeda E, Akahane M, Yoshioka N, Takao H, Matsuda I, Kamiya K, Hirano K, Tada M, Ohtsu H, Fukushima N, Ohtomo K
  • 雑誌名: Jpn J Radiol 巻: 30(3) ページ: 227-34
  • NAID: 210000163116
• [雑誌論文] Incidental pancreatic cysts found by magnetic resonance imaging and their relationship with pancreatic cancer (2012)
  • 著者名/発表者名: Matsubara S, Tada M, Akahane M, Yagioka H, Kogure H, Sasaki T, Arizumi T, Togawa O, Nakai Y, Sasahira N, Hirano K, Tsujino T, Isayama H, Toda N, Kawabe T, Ohtomo K, Omata M
  • 雑誌名: Pancreas 巻: 41(8) ページ: 1241-6
• [雑誌論文] Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression (2012)
  • 著者名/発表者名: Mohri D, Asaoka Y, Ijichi H, Miyabayashi K, Kudo Y, Seto M, Ohta M, Tada M, Tanaka Y, Ikenoue T, Tateishi K, Isayama H, Kanai F, Fukushima N, Tada M, Kawabe T, Omata M, Koike K
  • 雑誌名: J Gastroenterol 巻: 47(2) ページ: 203-13
  • NAID: 10030296319
• [雑誌論文] Phase I trial of gemcitabine and candesartan combination therapy in normotensive patients with advanced pancreatic cancer : GECA1 (2012)
  • 著者名/発表者名: Nakai Y, Isayama H, Ijichi H, Sasaki T, Kogure H, Yagioka H, Miyabayashi K, Mizuno S, Yamamoto K, Mouri D, Kawakubo K, Yamamoto N, Hirano K, Sasahira N, Tateishi K, Tada M, Koike K
  • 雑誌名: Cancer Sci 巻: 103(8) ページ: 1489-92
• [雑誌論文] A multicentre randomised phase II trial of gemcitabine alone vs gemcitabine and S-1 combination therapy in advanced pancreatic cancer : GEMSAP study (2012)
  • 著者名/発表者名: Nakai Y, Isayama H, Sasaki T, Sasahira N, Tsujino T, Toda N, Kogure H, Matsubara S, Ito Y, Togawa O, Arizumi T, Hirano K, Tada M, Omata M, Koike K
  • 雑誌名: Br J Cancer 巻: 106(12) ページ: 1934-9
• [雑誌論文] Role of intervention for biliary and gastric/intestinal obstruction in gastric cancer with peritoneal metastasis (2012)
  • 著者名/発表者名: Nakai Y, Ishigami H, Isayama H, Sasaki T, Kawakubo K, Kogure H, Emoto S, Yamaguchi H, Kitayama J, Yamamoto N, Sasahira N, Hirano K, Tada M, Koike K
  • 雑誌名: J Gastroenterol Hepatol 巻: 27(12) ページ: 1796-800
• [雑誌論文] Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine (2012)
  • 著者名/発表者名: Sasaki T, Isayama H, Nakai Y, Mizuno S, Yamamoto K, Yagioka H, Yashima Y, Kawakubo K, Kogure H, Togawa O, Matsubara S, Ito Y, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • 雑誌名: Invest New Drugs 巻: 30(2) ページ: 708-13
• [雑誌論文] Predictive factors of solid food intake in patients with malignant gastric outlet obstruction receiving self-expandable metallic stents for palliation (2012)
  • 著者名/発表者名: Sasaki T, Isayama H, Nakai Y, Togawa O, Kogure H, Kawakubo K, Mizuno S, Yashima Y, Ito Y, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • 雑誌名: Dig Endosc 巻: 24(4) ページ: 226-30
• [雑誌論文] Endoscopic papillary balloon dilation for bile duct stones in patients on hemodialysis (2012)
  • 著者名/発表者名: Takahara N, Isayama H, Sasaki T, Tsujino T, Toda N, Sasahira N, Mizuno S, Kawakubo K, Kogure H, Yamamoto N, Nakai Y, Hirano K, Tada M, Omata M, Koike K
  • 雑誌名: J Gastroenterol 巻: 47(8) ページ: 918-23
  • NAID: 10031051346
• [雑誌論文] Acoustic radiation force impulse elastography for noninvasive assessment of chronic pancreatitis (2012)
  • 著者名/発表者名: Yashima Y, Sasahira N, Isayama H, Kogure H, Ikeda H, Hirano K, Mizuno S, Yagioka H, Kawakubo K, Sasaki T, Nakai Y, Tada M, Yoshida H, Omata M, Koike K
  • 雑誌名: J Gastroenterol 巻: 47(4) ページ: 427-32
  • NAID: 10030650116
• [雑誌論文] Preliminary report on a new, fully covered, metal stent designed for the treatment of pancreatic fluid collections (2012)
  • 著者名/発表者名: Yamamoto N, Isayama H, Kawakami H, Sasahira N, Hamada T, Ito Y, Takahara N, Uchino R, Miyabayashi K, Mizuno S, Kogure H, Sasaki T, Nakai Y, Kuwatani M, Hirano K, Tada M M, Koike K
  • 雑誌名: Gastrointest Endosc 巻: 77(5) ページ: 809-14
• [雑誌論文] Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression. (2012)
  • 著者名/発表者名: Mohri D, Asaoka Y, Ijichi H, Miyabayashi K, Kudo Y, Seto M, Ohta M, Tada M, Tanaka Y, Ikenoue T, Tateishi K, Isayama H, Kanai F, Fukushima N, Tada M, Kawabe T, Omata M, Koike K.
  • 雑誌名: J Gastroenterol 巻: 47 ページ: 203-13
  • NAID: 10030296319
  • 査読あり
• [雑誌論文] Carcinogenesis of IPMN (2012)
  • 著者名/発表者名: Tada M, Koike K.
  • 雑誌名: Nihon Shokakibyo Gakkai Zasshi 巻: 109 ページ: 178-82
  • NAID: 10030310304
  • 査読あり
• [雑誌論文] Intraductal papillary mucinous neoplasm was associated with pancreatic carcinogenesis, but not with systemic carcinogenesis. (2012)
  • 著者名/発表者名: Kawakubo K, Tada M, Koike K.
  • 雑誌名: Surgery 巻: 152 ページ: 141-2
  • 査読あり
• [雑誌論文] Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers (2011)
  • 著者名/発表者名: Tada M , Nakai Y, Sasaki T, Hamada T, Nagano R, Mohri D, Miyabayashi K, Yamamoto K, Kogure H, Kawakubo K, Ito Y, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tateishi K, Isayama H, Omata M, Koike K
  • 雑誌名: World J Clin Oncol 巻: 2(3) ページ: 158-63
• [雑誌論文] Increased liver elasticity in patients with biliary obstruction (2011)
  • 著者名/発表者名: Yashima Y, Tsujino T, Masuzaki R, Nakai Y, Hirano K, Tateishi R, Sasahira N, Isayama H, Tada M, Yoshida H, Kawabe T, Omata M
  • 雑誌名: J Gastroenterol 巻: 46 ページ: 86-91
  • NAID: 10029026715
• [雑誌論文] Pancreas divisum as a predisposing factor for chronic and recurrent idiopathic pancreatitis: initial in vivo survey (2011)
  • 著者名/発表者名: Gonoi W, Akai H, Hagiwara K, Akahane M, Hayashi N, Maeda E, Yoshikawa T, Tada M, Uno K, Ohtsu H, Koike K, Ohtomo K
  • 雑誌名: Gut 巻: 60(8) ページ: 1103-8
• [雑誌論文] Duodenal invasion is a risk factor for the early dysfunction of biliary metal stents in unresectable pancreatic cancer (2011)
  • 著者名/発表者名: Hamada T, Isayama H, Nakai Y, Togawa O, Kogure H, Kawakubo K, Tsujino T, Sasahira N, Hirano K, Yamamoto N, Arizumi T, Ito Y, Matsubara S, Sasaki T, Yagioka H, Yashima Y, Mohri D, Miyabayashi K, Mizuno S, Nagano R, Takahara N, Toda N, Tada M, Omata M, Koike K
  • 雑誌名: Gastrointest Endosc 巻: 74(3) ページ: 548-55
• [雑誌論文] Significance of measuring IgG and IgG4 during follow-up of autoimmune pancreatitis (2011)
  • 著者名/発表者名: Hirano K, Tada M, Isayama H, Sasahira N, Koike K
  • 雑誌名: Pancreas 巻: 40(5) ページ: 788-91
• [雑誌論文] Covered metallic stenting for malignant distal biliary obstruction : clinical results according to stent type (2011)
  • 著者名/発表者名: Isayama H, Nakai Y, Kawakubo K, Kogure H, Togawa O, Hamada T, Ito Y, Sasaki T, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Tada M, Koike K
  • 雑誌名: J Hepatobiliary Pancreat Sci 巻: 18(5) ページ: 673-7
  • NAID: 10029688409
• [雑誌論文] Gemcitabine and oxaliplatin combination chemotherapy for patients with refractory pancreatic cancer (2011)
  • 著者名/発表者名: Isayama H, Nakai Y, Yamamoto K, Sasaki T, Mizuno S, Yagioka H, Yashima Y, Kawakubo K, Kogure H, Arizumi T, Togawa O, Ito Y, Matsubara S, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Tada M, Omata M, Koike K
  • 雑誌名: Oncology 巻: 80(1-2) ページ: 97-101
• [雑誌論文] Efficacy and safety of covered self-expandable metal stents for management of distal malignant biliary obstruction due to lymph node metastases (2011)
  • 著者名/発表者名: Kawakubo K, Isayama H, Nakai Y, Togawa O, Sasahira N, Kogure H, Sasaki T, Matsubara S, Yamamoto N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • 雑誌名: Surg Endosc 巻: 25(9) ページ: 3094-100
• [雑誌論文] Endoscopic transpapillary gallbladder drainage with replacement of a covered self-expandable metal stent (2011)
  • 著者名/発表者名: Kawakubo K, Isayama H, Sasahira N, Nakai Y, Kogure H, Sasaki T, Hirano K, Tada M, Koike K
  • 雑誌名: World J Gastrointest Endosc 巻: 3(2) ページ: 46-8
• [雑誌論文] Incidence of extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas (2011)
  • 著者名/発表者名: Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Yamamoto K, Kogure H, Sasaki T, Hirano K, Ijichi H, Tateishi K, Yoshida H, Koike K
  • 雑誌名: Gut 巻: 60(9) ページ: 1249-53
• [雑誌論文] Endoscopic bilateral metallic stenting for malignant hilar obstruction using newly designed stents (2011)
  • 著者名/発表者名: Kogure H, Isayama H, Kawakubo K, Sasaki T, Yamamoto N, Hirano K, Sasahira N, Tsujino T, Tada M, Koike K
  • 雑誌名: J Hepatobiliary Pancreat Sci 巻: 18(5) ページ: 653-7
  • NAID: 10029688346
• [雑誌論文] Newly designed large cell Niti-S stent for malignant hilar biliary obstruction : a pilot study (2011)
  • 著者名/発表者名: Kogure H, Isayama H, Nakai Y, Tsujino T, Ito Y, Yamamoto K, Mizuno S, Yagioka H, Kawakubo K, Sasaki T, Hirano K, Sasahira N, Tada M, Omata M, Koike K
  • 雑誌名: Surg Endosc 巻: 25(2) ページ: 463-7
• [雑誌論文] Fever-based antibiotic therapy for acute cholangitis following successful endoscopic biliary drainage (2011)
  • 著者名/発表者名: Kogure H, Tsujino T, Yamamoto K, Mizuno S, Yashima Y, Yagioka H, Kawakubo K, Sasaki T, Nakai Y, Hirano K, Sasahira N, Isayama H, Tada M, Kawabe T, Omata M, Harada S, Ota Y, Koike K
  • 雑誌名: J Gastroenterol 巻: 46(12) ページ: 1411-7
  • NAID: 10030295328
• [雑誌論文] Specific increase in serum autotaxin activity in patients with pancreatic cancer (2011)
  • 著者名/発表者名: Nakai Y, Ikeda H, Nakamura K, Kume Y, Fujishiro M, Sasahira N, Hirano K, Isayama H, Tada M, Kawabe T, Komatsu Y, Omata M, Aoki J, Koike K, Yatomi Y
  • 雑誌名: Clin Biochem 巻: 44(8-9) ページ: 576-81
• [雑誌論文] Comorbidity, not age, is prognostic in patients with advanced pancreatic cancer receiving gemcitabine-based chemotherapy (2011)
  • 著者名/発表者名: Nakai Y, Isayama H, Sasaki T, Sasahira N, Tsujino T, Kogure H, Yagioka H, Yashima Y, Togawa O, Arizumi T, Matsubara S, Hirano K, Tada M, Omata M, Koike K
  • 雑誌名: Crit Rev Oncol Hematol 巻: 78(3) ページ: 252-9
• [雑誌論文] New method of covered wallstents for distal malignant biliary obstruction to reduce early stent-related complications based on characteristics (2011)
  • 著者名/発表者名: Nakai Y, Isayama H, Togawa O, Kogure H, Tsujino T, Yagioka H, Yashima Y, Sasaki T, Ito Y, Matsubara S, Hirano K, Sasahira N, Toda N, Tada M, Kawabe T, Omata M, Koike K
  • 雑誌名: Dig Endosc 巻: 23(1) ページ: 49-55
  • NAID: 10028188306
• [雑誌論文] Impact of introduction of wire-guided cannulation in therapeutic biliary endoscopic retrograde cholangiopancreatography (2011)
  • 著者名/発表者名: Nakai Y, Isayama H, Tsujino T, Sasahira N, Hirano K, Kogure H, Sasaki T, Kawakubo K, Yagioka H, Yashima Y, Mizuno S, Yamamto K, Arizumi T, Togawa O, Matsubara S, Yamamoto N, Tada M, Omata M, Koike K
  • 雑誌名: J Gastroenterol Hepatol 巻: 26(10) ページ: 1552-8
• [雑誌論文] Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer (2011)
  • 著者名/発表者名: Sasaki T, Isayama H, Nakai Y, Mizuno S, Yamamoto K, Yagioka H, Yashima Y, Kawakubo K, Kogure H, Togawa O, Matsubara S, Sasahira N, Hirano K, Tsujino T, Tada M, Omata M, Koike K
  • 雑誌名: Invest New Drugs 巻: 29(6) ページ: 1488-93
• [雑誌論文] Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy (2011)
  • 著者名/発表者名: Sasaki T, Isayama H, Nakai Y, Togawa O, Kogure H, Ito Y, Yamamoto K, Mizuno S, Yagioka H, Yashima Y, Kawakubo K, Arizumi T, Matsubara S, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • 雑誌名: Cancer Chemother Pharmacol 巻: 67(4) ページ: 847-53
• [雑誌論文] Clinical significance of bile cytology via an endoscopic nasobiliary drainage tube for pathological diagnosis of malignant biliary strictures (2011)
  • 著者名/発表者名: Yagioka H, Hirano K, Isayama H, Tsujino T, Sasahira N, Nagano R, Hamada T, Miyabayashi K, Ito Y, Mohri D, Kawakubo K, Kogure H, Sasaki T, Tada M, Koike K
  • 雑誌名: J Hepatobiliary Pancreat Sci 巻: 18(2) ページ: 211-5
  • NAID: 10029286323
• [学会発表] 膵嚢胞および10mm未満のIPMNの発癌リスクの検討 (2013)
  • 著者名/発表者名: 高木馨, 多田稔, 川畑修平, 斎藤友隆, 渡邉健雄, 内野里枝, 濱田毅, 水野卓, 宮林弘至, 木暮宏史, 佐々木隆, 山本夏代, 中井陽介, 平野賢二, 伊佐山浩通, 小池和彦
  • 学会等名: 第44回日本膵臓学会大会特別企画ディベート
  • 発表場所: 仙台
• [学会発表] IPMN経過観察における膵発癌リスクファクターの検討 (2012)
  • 著者名/発表者名: 川久保和道,多田稔,小池和彦
  • 学会等名: 第98回日本消化器病学会総会ワークショップ
  • 発表場所: 東京
• [学会発表] 分枝型IPMN経過観察中に発生した通常型膵癌診断の現状 (2012)
  • 著者名/発表者名: 川久保和道,多田稔,小池和彦
  • 学会等名: 第83回日本消化器内視鏡病学会総会ワークショップ
  • 発表場所: 東京
• [学会発表] IPMNにおける膵発癌危険因子の検討 (2012)
  • 著者名/発表者名: 川久保和道,多田稔,伊佐山浩通,笹平直樹,平野賢二,高原楠昊,宮林弘至,水野卓,毛利大,佐々木隆,木暮宏史,山本夏代,小池和彦
  • 学会等名: 第43回日本膵臓学会シンポジウム
  • 発表場所: 山形
• [学会発表] Risk of mortality other than pancreatic cancer in patients with intraductal papillary mucinous neoplasm of the pancreas (2012)
  • 著者名/発表者名: Kawakubo K, Tada M, Isayama H, Koike K
  • 学会等名: United European Gastroenterology Week 2012
  • 発表場所: Amsterdam
• [図書] 内科学 (2012)
  • 著者名/発表者名: 多田稔
  • 出版者: 膵管内乳頭粘液性腫瘍、膵嚢胞