高次認知機能とその可塑性の神経基盤と遺伝的基盤

• 研究課題/領域番号: 23700306
• 研究種目: 若手研究(B)
• 配分区分: 基金
• 研究分野: 認知科学
• 研究機関: 東北大学
• 研究代表者: 竹内 光 東北大学, 加齢医学研究所, 准教授 (50598399)
• 研究期間 (年度): 2011 – 2012
• 研究課題ステータス: 完了 (2012年度)
• 配分額: 4,290千円 (直接経費: 3,300千円、間接経費: 990千円); 2012年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円); 2011年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円)
• キーワード: 高次認知機能 / 神経系 / 脳イメージング / 可塑性 / 認知訓練 / 認知科学 / 遺伝的多型

研究概要

高次認知機能の個人差の関連の研究と、高次認知機能の訓練の引き起こす可塑性の神経基盤について研究を行った。縦断研究によりワーキングメモリ、処理速度といった認知機能の訓練の引き起こす種々の神経系の変化を明らかにすることができた。また、横断研究によりワーキングメモリ、一般知能、創造性といった高次認知機能やヒトの精神疾患と、主観的幸福において重要であるさまざまな認知指標の神経基盤を明らかにすることができた。

研究成果

• [雑誌論文] White matter structures associated with empathizing and systemizing inyoung adults (2013)
  • 著者名/発表者名: Takeuchi H, Taki Y, Thyreau B, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R
  • 雑誌名: Neuroimage 巻: 77(15) ページ: 222-236
  • URL: http://dx.doi.org/10.1016/j.neuroimage.2013.04.004
  • 査読あり
• [雑誌論文] Anatomical correlates of quality of life: Evidence from voxel-based morphometry (2013)
  • 著者名/発表者名: Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sassa Y, Sekiguchi A, Kotozaki Y, Nakagawa S, Nagase T, Miyauchi CM, Kawashma R
  • 雑誌名: Human Brain Mapping 巻: (In press)
  • URL: http://dx.doi.org/10.1002/hbm.22294
  • 査読あり
• [雑誌論文] Anatomical correlates of self-handicapping tendency (2013)
  • 著者名/発表者名: Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R
  • 雑誌名: Cortex 巻: 49(4) ページ: 1148-1154
  • URL: http://dx.doi.org/10.1016/j.cortex.2013.01.014
  • 査読あり
• [雑誌論文] White matter structures associated with emotional intelligence: evidence from diffusion tensor imaging (2013)
  • 著者名/発表者名: Takeuchi H, Taki Y, Sassa Y, HashizumeH, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R
  • 雑誌名: Human Brain Mapping 巻: 34(5) ページ: 1025-1034
  • URL: http://dx.doi.org/10.1002/hbm.21492
  • 査読あり
• [雑誌論文] White matter structures associated with empathizing and systemizing in young adults. (2013)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Neuroimage 巻: in press ページ: 222-236
  • DOI: 10.1016/j.neuroimage.2013.04.004
  • 査読あり
• [雑誌論文] Anatomical correlates of quality of life: Evidence from voxel-based morphometry. (2013)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Human Brain Mapping 巻: in press
  • 査読あり
• [雑誌論文] Anatomical correlates of self-handicapping tendency (2013)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Cortex 巻: in press 号: 4 ページ: 1148-1154
  • DOI: 10.1016/j.cortex.2013.01.014
  • 査読あり
• [雑誌論文] Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry. (2013)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Brain Structure and Function 巻: in press 号: 1 ページ: 71-83
  • DOI: 10.1007/s00429-012-0485-3
  • 査読あり
• [雑誌論文] Effects of working memory-training on functional connectivity and cerebral blood flow during rest. (2013)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Cortex 巻: in press 号: 8 ページ: 2106-2125
  • DOI: 10.1016/j.cortex.2012.09.007
  • 査読あり
• [雑誌論文] Brain structures associated with executive functions during everyday events in a non-clinical sample. (2013)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Brain Structure and Function 巻: in press 号: 4 ページ: 1017-1032
  • DOI: 10.1007/s00429-012-0444-z
  • 査読あり
• [雑誌論文] Associations among imaging measures (2): The association between gray matter concentration and task-induced activation changes. (2013)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Human Brain Mapping 巻: in press 号: 1 ページ: 185-198
  • DOI: 10.1002/hbm.22167
  • 査読あり
• [雑誌論文] White matter structures associated with emotional intelligence: evidence from diffusion tensor imaging. (2013)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Human Brain Mapping 巻: 34 号: 5 ページ: 1025-1034
  • DOI: 10.1002/hbm.21492
  • 査読あり
• [雑誌論文] Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry (2012)
  • 著者名/発表者名: Takeuchi H, Taki Y, Nouchi R, Sekiguchi A, Kotozaki Y, Miyauchi CM, Yokoyama R, Iizuka K, Hashizume H, Nakagawa S, Kunitoki K, Sassa Y, Kawashima R
  • 雑誌名: Brain Structure and Function 巻: (In press)
  • URL: http://dx.doi.org/10.1007/s00429-012-0485-3
  • 査読あり
• [雑誌論文] Effects of working memory-training on functional connectivity and cerebral blood flow during rest (2012)
  • 著者名/発表者名: Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R
  • 雑誌名: Cortex 巻: (In press)
  • URL: http://dx.doi.org/10.1016/j.cortex.2012.09.007
  • 査読あり
• [雑誌論文] A voxel-based morphometry study of gray and white matter correlates of a need for uniqueness (2012)
  • 著者名/発表者名: Takeuchi H, Taki Y, Nouchi R, Sekiguchi A, Kotozaki Y, Miyauchi CM, Yokoyama R, Iizuka K, Hashizume H, Nakagawa S, Kunitoki K, Sassa Y, Kawashima R
  • 雑誌名: Neuroimage 巻: 63(3) ページ: 1119-1126
  • URL: http://dx.doi.org/10.1016/j.neuroimage.2012.08.037
  • 査読あり
• [雑誌論文] Brain structures associated with executive functions during everyday events in a non-clinical sample (2012)
  • 著者名/発表者名: Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R
  • 雑誌名: Brain Structure and Function 巻: (In press)
  • URL: http://dx.doi.org/10.1007/s00429-012-0444-z
  • 査読あり
• [雑誌論文] Associations among imaging measures (2): The association between gray matter concentration and task-inducedactivation changes (2012)
  • 著者名/発表者名: Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sassa Y, Sekiguchi A, Kotozaki Y, Nakagwa S, Nagase T, Miyauch CM, Kawashima R
  • 雑誌名: Human Brain Mapping 巻: (In press)
  • URL: http://dx.doi.org/10.1002/hbm.22167
  • 査読あり
• [雑誌論文] Effects of processing speed training on cognitive functions and neural systems.(review) (2012)
  • 著者名/発表者名: Takeuchi H, Kawashima R
  • 雑誌名: Reviews in the Neurosciences 巻: 23(3) ページ: 289-301
  • URL: http://dx.doi.org/10.1515/revneuro-2012-0035
• [雑誌論文] The association between resting functional connectivity and creativity (2012)
  • 著者名/発表者名: Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, Kawashima R
  • 雑誌名: Cerebral Cortex 巻: 22(12) ページ: 2921-2929
  • 査読あり
• [雑誌論文] Regional gray and white matter volume associated with Stroop interference: Evidence from voxel-based morphometry (2012)
  • 著者名/発表者名: Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R
  • 雑誌名: Neuroimage 巻: 59(3) ページ: 2899-2907
  • URL: http://dx.doi.org/10.1016/j.neuroimage.2011.09.064
  • 査読あり
• [雑誌論文] A voxel-based morphometry study of gray and white matter correlates of a need for uniqueness. (2012)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Neuroimage. 巻: 63 号: 3 ページ: 1119-1126
  • DOI: 10.1016/j.neuroimage.2012.08.037
  • 査読あり
• [雑誌論文] Effects of processing speed training on cognitive functions and neural systems. (2012)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Reviews in the neurosciences 巻: 23 号: 3 ページ: 289-301
  • DOI: 10.1515/revneuro-2012-0035
• [雑誌論文] The association between resting functional connectivity and creativity. (2012)
  • 著者名/発表者名: Hikaru Takeuchi
  • 雑誌名: Cerebral Cortex 巻: 22 号: 12 ページ: 2921-2929
  • DOI: 10.1093/cercor/bhr371
  • 査読あり
• [雑誌論文] Regionalgray and whitemattervolumeassociated with Stroop interference: Evidence from voxel-basedmorphometry (2012)
  • 著者名/発表者名: Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Rui Nouchi, Ai Fukushima, and Ryuta Kawashima
  • 雑誌名: NeuroImage 巻: 59 号: 3 ページ: 2899-2907
  • DOI: 10.1016/j.neuroimage.2011.09.064
• [雑誌論文] Effects of processing speed training on cognitive functions and neural systems. (2012)
  • 著者名/発表者名: Hikaru Takeuchi, and Ryuta Kawashima
  • 雑誌名: Reviews in the Neurosciences 巻: in press
• [雑誌論文] Cerebral blood flow during rest associates with general intelligence and creativity (2011)
  • 著者名/発表者名: Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, Kawashima R
  • 雑誌名: PLoS ONE 巻: 6(9)
  • 査読あり
• [雑誌論文] Verbal working memory performancecorrelates with regional white matter structures in the frontoparietal regions (2011)
  • 著者名/発表者名: Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R
  • 雑誌名: Neuropsychologia 巻: 49(12) ページ: 3466-3473
  • 査読あり
• [雑誌論文] Working memory training using mental calculation impacts regional gray matter of the frontal and parietal regions (2011)
  • 著者名/発表者名: Takeuchi H, Taki Y, Sassa Y, HashizumeH, Sekiguchi A, Fukushima A, KawashimaR
  • 雑誌名: PLoS ONE 巻: 6(8)
  • 査読あり
• [雑誌論文] Effects of training of processing speed on neural systems (2011)
  • 著者名/発表者名: Takeuchi H, Taki Y, Hashizume H, SassaY, Nagase T, Nouchi R, Kawashima R
  • 雑誌名: Journal of Neuroscience 巻: 31(34) ページ: 12139-12148
  • URL: http://dx.doi.org/10.1523/JNEUROSCI.4611-09.2010
  • 査読あり
• [雑誌論文] Effects of Training of Processing Speed on Neural Systems (2011)
  • 著者名/発表者名: Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, and Ryuta Kawashima
  • 雑誌名: The Journal of Neuroscience 巻: 31 号: 34 ページ: 12139-12148
  • DOI: 10.1523/jneurosci.2948-11.2011
• [学会発表] Functional connectivity and higher order cognitive functions (2013)
  • 著者名/発表者名: Takeuchi H
  • 学会等名: International Symposium on Computational Brain Science -Development and Aging of the Human Brain
  • 発表場所: Sendai, Japan
  • 年月日: 2013-03-26
• [学会発表] The effects of the training of multi tasks on brain structures (Chosen for Interactive Poster) (2011)
  • 著者名/発表者名: Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S,Miyauchi CM, Sassa Y, Kawashima R
  • 学会等名: 17th Annual Meeting of the Organization for Human Brain Mapping
  • 発表場所: Quebec, Canada
  • 年月日: 2011-06-27
• [学会発表] The effects of the training of multi tasks on brain structures (2011)
  • 著者名/発表者名: Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima
  • 学会等名: 17th Annual Meeting of the Organization for Human Brain Mapping
  • 発表場所: Quebec, Canada
• [備考] スタッフ紹介
  • URL: https://www.fbi.idac.tohoku.ac.jp/takeuchi/staff.html