乳房超音波画像診断におけるコンピュータ支援診断システムの開発と有用性の臨床評価

• 研究課題/領域番号: 23700578
• 研究種目: 若手研究(B)
• 配分区分: 基金
• 研究分野: 医用システム
• 研究機関: 三重大学
• 研究代表者: 中山 良平 三重大学, 医学部附属病院, 助教 (20402688)
• 研究期間 (年度): 2011 – 2012
• 研究課題ステータス: 完了 (2012年度)
• 配分額: 2,860千円 (直接経費: 2,200千円、間接経費: 660千円); 2012年度: 910千円 (直接経費: 700千円、間接経費: 210千円); 2011年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円)
• キーワード: 画像診断システム / 病理組織型 / 乳房超音波検査 / computer-aided diagnosis / breast mass / histological / ultrasonographic image

研究概要

本研究では,医師が乳房超音波画像診断で着目している病変形態を形態的特徴量として定量化する手法を確立し,その形態的特徴量に基づいて,病理組織型の可能性を評価するコンピュータ支援診断(CADx)システムを開発した.そして,そのCADxシステムの解析結果を医師が参考にすることにより,医師の鑑別診断能が大幅に向上することを観察者実験で確認した.

研究成果

• [雑誌論文] Improved Differential Diagnosis of Breast Masses on Ultrasonographic Images with a Computer-aided Diagnosis Scheme for Determining Histological Classifications (2013)
  • 著者名/発表者名: Kashikura Y, Nakayama R, Hizukuri A, Noro A, Nohara Y, Nakamura T, Ito M, Kimura H, Yamashita M, Hanamura N, Ogawa T
  • 雑誌名: Academic Radiology 巻: 20(4) ページ: 471-477
• [雑誌論文] Computerized Determination Scheme for Histological Classification of Breast Mass Using Objective Features Corresponding to Clinicians' Subjective Impressions on Ultrasonographic Images. (2013)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Kashikura Y, Takase H, Kawanaka H, Ogawa T, Tsuruoka S
  • 雑誌名: Journal of Digital Imaging 巻: Apr 号: 5 ページ: 1-13
  • DOI: 10.1007/s10278-013-9594-7
  • 査読あり
• [雑誌論文] Improved Differential Diagnosis of Breast Masses on Ultrasonographic Images with a Computer-aided Diagnosis Scheme for Determining Histological Classifications. (2013)
  • 著者名/発表者名: Kashikura Y, Nakayama R, Hizukuri A, Noro A, Nohara Y, Nakamura T, Ito M, Kimura H, Yamashita M, Hanamura N, Ogawa T
  • 雑誌名: Academic Radiology 巻: 20(4) 号: 4 ページ: 471-477
  • DOI: 10.1016/j.acra.2012.11.007
  • 査読あり
• [雑誌論文] Computerized Classification Method for Histological Classifications of Masses using Objective Features Based on Clinicians' Subjective Impressions. Proc. of the 6th International Conference on Soft Computing and Intelligent Systems and The 13th International Symposium on Advanced Intelligent Systems (2012)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Kashikura Y, Kawanaka H, Takase H, Ogawa T, Tsuruoka S
  • 雑誌名: Kobe
• [雑誌論文] Computer-aided Diagnosis Scheme for Determining Histological Classification of Breast Masses Using Clinical Features and Texture Features. Proc. of the Fourth International Workshop on Regional Innovation Studies - Biomedical Engineering - (2012)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Kashikura Y, Kawanaka H, Takase H, Ogawa T, Tsuruoka S
  • 雑誌名: Tsu ページ: 83-86
• [雑誌論文] Computerized Segmentation Method for Individual Calcifications within Clustered Microcalcifications while Maintaining Their Shapes on Magnification Mammograms (2012)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Nakako N, Kawanaka H, Takase H, Yamamoto K, TsuruokaS
  • 雑誌名: Journal of Digital Imaging 巻: 25(3) ページ: 377-386
• [雑誌論文] Computer-aided Detection Scheme for Sentinel Lymph Nodes in Lymphoscintigrams Using Symmetrical Property around Mapped Injection Point (2012)
  • 著者名/発表者名: Nakayama R, Hizukuri A, Yamamoto K, Nakako N, Nagasawa N, Takeda K
  • 雑誌名: Journal of Digital Imaging 巻: 25(1) ページ: 148-154
• [雑誌論文] Computerized Classification Method for Histological Classifications of Masses using Objective Features Based on Clinicians’ Subjective Impressions. (2012)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Kashikura Y, Kawanaka H, Takase H, Ogawa T, Tsuruoka S.
  • 雑誌名: Proc. of the 6th International Conference on Soft Computing and Intelligent Systems and The 13th International Symposium on Advanced Intelligent Systems 巻: 1 ページ: 1-4
  • 査読あり
• [雑誌論文] Computer-aided Diagnosis Scheme for Determining Histological Classification of Breast Masses Using Clinical Features and Texture Features. (2012)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Kashikura Y, Kawanaka H, Takase H, Ogawa T, Tsuruoka S.
  • 雑誌名: Proc. of the Fourth International Workshop on Regional Innovation Studies - Biomedical Engineering - 巻: 1 ページ: 83-86
  • 査読あり
• [雑誌論文] Computerized Segmentation Method for Individual Calcifications within Clustered Microcalcifications while Maintaining Their Shapes on Magnification Mammograms. (2012)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Nakako N, Kawanaka H, Takase H, Yamamoto K, Tsuruoka S
  • 雑誌名: Journal of Digital Imaging 巻: 25(3) 号: 3 ページ: 377-386
  • DOI: 10.1007/s10278-011-9420-z
  • 査読あり
• [雑誌論文] Computer-aided Detection Scheme for Sentinel Lymph Nodes in Lymphoscintigrams Using Symmetrical Property around Mapped Injection Point. (2012)
  • 著者名/発表者名: Nakayama R, Hizukuri A, Yamamoto K, Nakako N, Nagasawa N, Takeda K.
  • 雑誌名: Journal of Digital Imaging 巻: 25(1) 号: 1 ページ: 148-154
  • DOI: 10.1007/s10278-011-9396-8
  • 査読あり
• [雑誌論文] Computerized Quantification Method for Objective Features based on Clinicians' Subjective Ratings of Breast Masses on Ultrasonographic Images. Proc. the Third International Workshop on Regional Innovation Studies - Biomedical Engineering - (2011)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Kashikura Y, Ogawa T, Tsuruoka S
  • 雑誌名: Tsu ページ: 33-36
• [雑誌論文] Evaluation of Objective Similarity Measures for Selecting Similar Images of Mammographic Lesions (2011)
  • 著者名/発表者名: Nakayama R, Abe H, Shiraishi J, Doi K
  • 雑誌名: Evaluation of Objective Similarity Measures for Selecting Similar Images of Mammographic Lesions 巻: 24(1) ページ: 75-85
• [雑誌論文] Computerized Quantification Method for Objective Features based on Clinicians’ Subjective Ratings of Breast Masses on Ultrasonographic Images (2011)
  • 著者名/発表者名: Akiyoshi Hizukuri, Ryohei Nakayama, Yumi Kashikura, Tomoko Ogawa, Shinji Tsuruoka
  • 雑誌名: Proc. the Third International Workshop on Regional Innovation Studies - Biomedical Engineering - 巻: 1 ページ: 33-36
  • 査読あり
• [雑誌論文] Computerized Determination Scheme for Histological Classification of Breast Mass Using Objective Features Corresponding to Clinicians' Subjective Impressions on Ultrasonographic Images
  • 著者名/発表者名: Hizukuri A, Nakayama R, Kashikura Y, Takase H, Kawanaka H, Ogawa T, Tsuruoka S
  • 雑誌名: Journal of Digital Imaging 巻: (in publish)
• [学会発表] Usefulness of Computer-aided Diagnosis Scheme for Determining Histological Classifications of Breast Masses on Ultrasonographic Images (2012)
  • 著者名/発表者名: Nakayama R, Kashikura Y, Honda E, Hizukuri A, Nakako N, Namba K, Sakuma H
  • 学会等名: RSNA2012
  • 発表場所: Chicago
• [学会発表] Improved Differential Diagnosis of Breast Masses on Ultrasonographic Images with CAD Scheme for Determining Histological Classifications (2012)
  • 著者名/発表者名: Kashikura Y, Nakayama R, Hizukuri A, Nohara Y, Yamashita M, Ogawa T
  • 学会等名: RSNA2012
  • 発表場所: Chicago
• [学会発表] 乳房超音波画像上の腫瘤病変に対する医師の主観的印象に基づいた画像特徴の定量化法 (2012)
  • 著者名/発表者名: 檜作彰良, 中山良平, 柏倉由実, 小川朋子, 鶴岡信治
  • 学会等名: 平成24年度日本生体医工学会東海支部大会
  • 発表場所: 名古屋
• [学会発表] Computer-aided Detection Scheme for Clustered Microcalcifications in Telediagnostic System via Telemedicine Network (2012)
  • 著者名/発表者名: Nakayama R, Nakako N, Hizukuri A, Nagasawa N, Kobayashi S, Takeda K, NambaK
  • 学会等名: CARS2012
  • 発表場所: Pisa
• [学会発表] Improvement of CAD scheme for histological classification of masses on ultrasonographic images by using objective features based on clinicians' subjective impressions (2012)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Kashikura Y, Ogawa T, Tsuruoka S
  • 学会等名: CARS 2012
  • 発表場所: Pisa
• [学会発表] Usefulness of Computer-aided Diagnosis Scheme for Determining Histological Classifications of Breast Masses on Ultrasonographic Images. (2012)
  • 著者名/発表者名: Nakayama R, Kashikura Y, Honda E, Hizukuri A, Nakako N, Namba K, Sakuma H.
  • 学会等名: RSNA2012
  • 発表場所: シカゴ
• [学会発表] Improved Differential Diagnosis of Breast Masses on Ultrasonographic Images with CAD Scheme for Determining Histological Classifications. (2012)
  • 著者名/発表者名: Kashikura Y, Nakayama R, Hizukuri A, Nohara Y, Yamashita M, Ogawa T.
  • 学会等名: RSNA2012
  • 発表場所: シカゴ
• [学会発表] 平成24年度日本生体医工学会東海支部大会 (2012)
  • 著者名/発表者名: 檜作彰良, 中山良平, 柏倉由実, 小川朋子, 鶴岡信治.
  • 学会等名: 平成24年度日本生体医工学会東海支部大会
  • 発表場所: 名古屋
• [学会発表] Computer-aided Detection Scheme for Clustered Microcalcifications in Telediagnostic System via Telemedicine Network (2012)
  • 著者名/発表者名: Nakayama R, Nakako N, Hizukuri A, Nagasawa N, Kobayashi S, Takeda K, Namba K
  • 学会等名: CARS2012
  • 発表場所: ピサ
• [学会発表] Improvement of CAD scheme for histological classification of masses on ultrasonographic images by using objective features based on clinicians’ subjective impressions. (2012)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Kashikura Y, Ogawa T, Tsuruoka S
  • 学会等名: CARS 2012
  • 発表場所: ピサ
• [学会発表] Construction of Telediagnostic System via Telemedicine Network with Computer-aided Diagnosis (CAD) Scheme for Determining Histological Classification of Clustered Microcalcifications in Mammograms (2011)
  • 著者名/発表者名: Nakayama R, Namba K, Hizukuri A, NakakoN, Takeda K
  • 学会等名: RSNA2011
  • 発表場所: Chicago
• [学会発表] Introduction of Computer-aided Detection (CAD) Scheme for Clustered Microcalcifications in Mammograms to Telediagnostic System via Telemedicine Network (2011)
  • 著者名/発表者名: Nakayama R, Namba K, Nagasawa N, NakakoN, Hizukuri A, Kobayashi S, Sakuma H, Takeda K
  • 学会等名: RSNA2011
  • 発表場所: Chicago
• [学会発表] Computer-aided Diagnosis Scheme for Determining Histological Classifications of Breast Masses Using Objective Features Based on Clinicians' Subjective Impressions on Ultrasonographic Images (2011)
  • 著者名/発表者名: Hizukuri A, Nakayama R, Namba K, NakakoN, Sakuma H, Takeda K, Tsuruoka S
  • 学会等名: RSNA2011
  • 発表場所: Chicago
• [学会発表] 乳房超音波画像における腫瘤像の病理組織型の分類法 (2011)
  • 著者名/発表者名: 檜作彰良, 中山良平, 柏倉由実, 中子敦雄, 川中普晴, 高瀬治彦, 小川朋子, 鶴岡信治
  • 学会等名: 電子情報通信学会技術報告
  • 発表場所: 名古屋
• [学会発表] Computer-aided Diagnosis Scheme for Determining Histological Classifications of Breast Masses Using Objective Features Based on Clinicians’ Subjective Impressions on Ultrasonographic Images (2011)
  • 著者名/発表者名: Akiyoshi Hizukuri, Ryohei Nakayama, Kiyoshi Namba, Nobuo Nakako, Hajime Sakuma, Kan Takeda, Shinji Tsuruoka
  • 学会等名: RSNA2011
  • 発表場所: シカゴ
• [学会発表] Computer-aided Diagnosis Scheme Based on Histological Classifications of Breast Masses on Ultrasonographic Images (2011)
  • 著者名/発表者名: Akiyoshi Hizukuri, Ryohei Nakayama, Yumi Kashikura, Nobuo Nakako, Tomoko Ogawa, Shinji Tsuruoka
  • 学会等名: CARS2011
  • 発表場所: ベルリン
• [図書] 実践医用画像解析ハンドブック (2013)
  • 著者名/発表者名: 中山良平,他
  • 出版者: オーム社