放射線分解型マイクロカプセルを使用した、放射線による抗癌剤標的療法の開発

2012 年度 研究成果報告書

• 研究課題/領域番号: 20591503
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 放射線科学
• 研究機関: 岩手医科大学
• 研究代表者: 原田 聡 岩手医科大学, 医学部, 講師 (20244931)
• 研究分担者: 世良 浩一郎 岩手医科大学, 医学部, 教授 (00230855) ; 神谷 富裕 独立行政法人日本原子力研究開発機構, 高崎量子応用研究所・ビーム技術開発課, ビーム技術開発室室長 (70370385)
• 研究期間 (年度): 2008 – 2012
• キーワード: 放射線治療生物学 / Drug delivery system

研究概要

放射線照射により、抗癌剤を放出するマイクロカプセルを作成した。本マイクロカプセルを、マウス左下腿に移植した実験首相周囲に皮下注射し、放射線を加えた所、抗癌剤-放射線の相乗効果により抗腫瘍効果が増強され、さらにカプセルの薬剤限局化作用により、抗癌剤の副作用が減少した。

研究成果

• [雑誌論文] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect (2012)
  • 著者名/発表者名: S. Harada, S. Ehara, K. Ishii, H. Yamazaki, S. Matsuyama, T. Sato, T. Kamiya, K.sera and Y. Saito.
  • 雑誌名: Int.J. PIXE 巻: Vol 22 ページ: 57-64
  • 査読あり
• [雑誌論文] Increa sing antitumor effects of chemoradiotherapy by drug efflux inhibition wit encapsulated RLIP -76. Int. (2011)
  • 著者名/発表者名: S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, T. Kamiya, T. Sakai, K. Arakawa, M. Saitoh, S. Oikawa and K. Sera.
  • 雑誌名: Int.J. PIXE 巻: Vol 21 ページ: 30-36
  • 査読あり
• [雑誌論文] Improved radiosensitive microcapsules using H2O2. (2010)
  • 著者名/発表者名: S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
  • 雑誌名: Improved radiosensitive microcapsules using H2O2. 巻: Vol 20 ページ: 30-36
  • 査読あり
• [雑誌論文] Targeted Delivery of Chemotherapeutic Agents by using Improved Radiosensitive Liquid-Core Microcapsules and Assessment of Their Antitumor Effect. (2009)
  • 著者名/発表者名: S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
  • 雑誌名: Int. J. Radiation Oncology, Biol. Phys 巻: Vol 175 ページ: 455-462
  • 査読あり
• [学会発表] I Imaging of premetastatic sites and prophylaxis of metastasis using radiosensitive nanocapsules via radiotherapy. (2012)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
  • 学会等名: 52th Annual meeting of American Society of Therapeutic Radiation Oncology
  • 発表場所: Boston , USA.
  • 年月日: 20121028-30
• [学会発表] Decreasing size of radiosensitive nanocapsules from micro to nano, and its increased antitumor effect and decrea sing antitumor effect. (2012)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: IJ PIXE
  • 年月日: 20120000
• [学会発表] Nanoparticle imaging of premetastatic sites and metastasis prophylaxis using radiation-induced release from liquid core nanocapsules (2012)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: 97th Annual Meeting of Radiological Society o f North America
  • 発表場所: Chicago, IL USA
  • 年月日: 2012-11-25
• [学会発表] Imaging and treatment of incipient metastasis using radiosensitive nanocapsules via 2 radiotherapy sessions (2011)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: 511h Annual meeting of American Society of Therapeutic Radiation Oncology
  • 発表場所: Miami FL , USA.
  • 年月日: 20111002-04
• [学会発表] Nanoparticle imaging of incipient metastasis and radiation-induced release of liquid-core nanocapsules for treatment of metastatic foci via O2 radiosensitization (2011)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: 96th Annual Meeting of Radiological Society of North America.
  • 発表場所: Chicago, IL USA
  • 年月日: 2011-11-28
• [学会発表] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect (2011)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Ke izoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa,Koichiro Sera
  • 学会等名: International Conference of BIO-PIXE 7.
  • 発表場所: Sendai Japan .
  • 年月日: 2011-10-31
• [学会発表] Targeting of anticancer drugs using liquid core microcapsules via radiotherapy. (2011)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: 2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit
  • 発表場所: Las Vegas NV USA .
  • 年月日: 2011-06-07
• [学会発表] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy. (2010)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: 511h Annual meeting of American Society of Therapeutic Radiation Oncology
  • 発表場所: San Diego CA, USA .
  • 年月日: 20101102-03
• [学会発表] Nanoparticle imaging of the metastatic potential of tumor cells and irradiation -induced release of liquid-core nanocapsules for inhibition of metastasis and O2 radiosensitization (2010)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: 95th Annual Meeting of Radiological Society of North America.
  • 発表場所: Chicago, IL USA
  • 年月日: 2010-11-28
• [学会発表] Inhibition Of Metastasis By Using Radiation-Sensitive Microcapsules (2010)
  • 著者名/発表者名: H Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
  • 学会等名: 12th International Conference on Particle Induced X-ray Emission and it is Analytical Applications.
  • 発表場所: Guildford UK
  • 年月日: 2010-07-01
• [学会発表] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation. (2009)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: 94th Annual Meeting of Radiological Society of North America.
  • 発表場所: Chicago, IL USA
  • 年月日: 2009-11-28
• [学会発表] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy. (2009)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: 501h Annual meeting of American Society of Therapeutic Radiation Oncology
  • 発表場所: Chicago IL USA .
  • 年月日: 2009-11-04
• [学会発表] The use of fluoroscopically detectable, tumor-infiltrating microcapsules enables multidrug targeting and endocytosis via radiotherapy. (2008)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
  • 学会等名: 50th Annual meeting of American Society of Therapeutic Radiation Oncology
  • 発表場所: Boston MA USA.
  • 年月日: 20080921-25
• [学会発表] Masakazu Oikawa, Koichiro Sera , Radiosensitization via oxygen effect by using microcapsules with a highly oxygenated liquid core that is released on irradiation (2008)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • 学会等名: 94th Annual Meeting of Radiological Society of North America.
  • 発表場所: Chicago, IL USA
  • 年月日: 2008-11-30
• [学会発表] Innovation of microcapsules that enables drug targeting through radiotherapy (2008)
  • 著者名/発表者名: Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera, Innovation of microcapsules tha
  • 学会等名: CAARI 2008
  • 発表場所: Dallas TX USA.
  • 年月日: 2008-08-10
• [学会発表] MEDICAL APPLICATION OF PARTICLE INDUCED X-RAY EMISSION. (2008)
  • 著者名/発表者名: Harada, Satoshi ; Ehara, Shigeru ; Ishii, Keizoh ; Yamazaki, Hiromichi ; Matsuyama, Shigeo ; Sakai, Takuro ; Obara, Yoshihiro ; Sato, Takahiro ; Oikawa, Masakazu ; Sera, Koichiro
  • 学会等名: International Symposium of Bio PIXE 6.
  • 発表場所: Richland, WA USA
  • 年月日: 2008-06-20