| 研究課題/領域番号 |
21K04846
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| 研究機関 | 北海道大学 |
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研究代表者 |
コビル アリフ 北海道大学, 理学研究院, 特任助教 (10724867)
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| 研究期間 (年度) |
2021-04-01 – 2024-03-31
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| キーワード | Artificial muscles |
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| 研究実績の概要 |
In this project, I aim to fabricate artificial muscles from a biomolecular motor system and DNA nanostructures. So far, I have used the biomolecular motor system microtubule-kinesin and DNA origami nanostructures. I have prepared aster-like, self-organized microtubule super-structures using DNA-conjugated microtubules and DNA origami. I have also been able to fabricate a hierarchically organized microtubule network. The network exhibits global dynamic behavior when ATP is provided in the presence of kinesin molecules. Apart from the main goal of this work, I have been trying to perform some additional works. In those additional works, I have explored collective motion of microtubules and utilization of the collectively moving microtubules for transportation of nanoscale cargo materials.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The current progress of the project is smooth as was planned initially. So far, no technical obstacles have been faced in this initial time of the project.
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| 今後の研究の推進方策 |
As the future plan, I want to have a deep control on the global, dynamic behavior of the hierarchical microtubule network that was formed using DNA conjugated microtubules, and DNA origami nanostructures. More specifically I want to demonstrate contractile responsiveness of this microtubule network like the contraction of muscles in living organisms. I also plan to control the kinetic of dynamic contraction of the microtubule network by fine tuning the number of kinesin molecule that interacts with the microtubules.
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| 次年度使用額が生じた理由 |
The reason for incurring amount to be used for next fiscal year is to purchase necessary reagents and materials for performing experiments.
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