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2023 年度 実施状況報告書

Nutritional approach for the cognitive frailty prevention: a 22-years cohort study of older Japanese community-dwellers.

研究課題

研究課題/領域番号 22K17847
研究機関国立研究開発法人国立長寿医療研究センター

研究代表者

張 シュ  国立研究開発法人国立長寿医療研究センター, 研究所 老年学・社会科学研究センター, 研究員 (00874471)

研究期間 (年度) 2022-04-01 – 2026-03-31
キーワードrisk factors / cognitive frailty / cohort
研究実績の概要

This study aims to elucidate: 1) dietary factors that play important roles in preventing cognitive frailty (CF) (through different pathways); 2) possible mechanisms of any associations identified; and 3) risk factors modifying nutrition approaches for preventing and improving CF.
My main task this year was to collect data on subjective cognitive decline using the Memory Complaint Questionnaire in Japanese (MAC-Q-J) in the NILS-LSA 10th wave survey. In addition, I examined the effects of various risk factors on the transition from robustness to CF using 14 years of cognitive function and frailty data. I found differences in the effects of different risk factors on the transition pathways in a multi-state model. This result suggests the need for targeted interventions for CF prevention.

現在までの達成度 (区分)
現在までの達成度 (区分)

2: おおむね順調に進展している

理由

The 10th survey is well underway and gathering useful information for further analysis. It provides useful data for defining CF in the future.
Based on the existing risk factor assessment data and 14 years of cognitive function and frailty data, I was able to secure a certain number of subjects and examine association between risk factors and CF development. The findings obtained will be submitted to international academic journals.

今後の研究の推進方策

I will utilize the data collected using the MAC-Q in the new round of the NILS-LSA survey (10th) to more accurately determine the CF status of the participants. These data will be further analyzed.

次年度使用額が生じた理由

Due to the analysis taking longer than initially planned, we have postponed the submission of documents to the next fiscal year. Additionally, because the preparation of the 10th survey has taken longer than anticipated, we have carried over funds from this year's 10th survey to the next fiscal year. The amount incurred in the next fiscal year will be used primarily for the 10th NILS-LSA survey, as well as costs associated with conference presentations and paper publication.

  • 研究成果

    (8件)

すべて 2024 2023

すべて 雑誌論文 (3件) (うち国際共著 1件、 査読あり 3件、 オープンアクセス 3件) 学会発表 (5件) (うち国際学会 5件、 招待講演 3件)

  • [雑誌論文] Associations of dietary patterns and longitudinal brain-volume change in Japanese community-dwelling adults: results from the national institute for longevity sciences-longitudinal study of aging2024

    • 著者名/発表者名
      Zhang Shu、Sala Giovanni、Nakamura Akinori、Kato Takashi、Furuya Kanae、Shimokata Hiroshi、Gao Xiang、Nishita Yukiko、Otsuka Rei
    • 雑誌名

      Nutrition Journal

      巻: 23 ページ: 34

    • DOI

      10.1186/s12937-024-00935-3

    • 査読あり / オープンアクセス
  • [雑誌論文] Comparative Analysis of Intrinsic Capacity Impairments, Determinants, and Clinical Consequences in Older Community-Dwellers in Japan and Taiwan: Longitudinal Studies Showing Shared Traits and Distinct Presentations2023

    • 著者名/発表者名
      Zhang S.、Peng L.-N.、Otsuka R.、Liang C.-K.、Nishita Y.、Arai H.、Chen Liang-Kung
    • 雑誌名

      The Journal of nutrition, health and aging

      巻: 27 ページ: 1038~1046

    • DOI

      10.1007/s12603-023-2020-z

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Twenty-year prospective cohort study of the association between a Japanese dietary pattern and incident dementia: the NILS-LSA project2023

    • 著者名/発表者名
      Zhang Shu、Otsuka Rei、Nishita Yukiko、Tange Chikako、Tomida Makiko、Ando Fujiko、Shimokata Hiroshi、Arai Hidenori
    • 雑誌名

      European Journal of Nutrition

      巻: 62 ページ: 1719~1729

    • DOI

      10.1007/s00394-023-03107-x

    • 査読あり / オープンアクセス
  • [学会発表] Epidemiology of Physio-Cognitive Decline Syndrome in Older Community-Dwellers: A Cross-Sectional and Longitudinal Study2023

    • 著者名/発表者名
      Zhang S、Otsuka R、Nishita Y、Arai H
    • 学会等名
      International symposium for healthy longevity
    • 国際学会 / 招待講演
  • [学会発表] Differences in Physio-Cognitive Decline Syndrome and intrinsic capacity decline among community-dwelling older adults in Japan and Taiwan: a cross-national multi-cohort comparison2023

    • 著者名/発表者名
      Zhang S、Otsuka R、Nishita Y、Arai H
    • 学会等名
      IAGG-Asia Oceania Regional Congress 2023
    • 国際学会 / 招待講演
  • [学会発表] The association between dietary patterns, cognitive function, and brain atrophy among Japanese community-dwellers2023

    • 著者名/発表者名
      Zhang S、Otsuka R、Nishita Y
    • 学会等名
      IAGG-Asia Oceania Regional Congress 2023
    • 国際学会 / 招待講演
  • [学会発表] Longitudinal transition trajectories of Physio-Cognitive Decline Syndrome in older Japanese community-dwellers2023

    • 著者名/発表者名
      Zhang S、Huang ST、Tange C、Nishita Y、Arai H、Chen LK、Otsuka R
    • 学会等名
      The 9th Asian Conference for Frailty and Sarcopenia
    • 国際学会
  • [学会発表] Modification role of body mass index in the interaction between cognitive decline and physical decline in older adults2023

    • 著者名/発表者名
      Zhang S、Sala G、Nishita Y、Otsuka R
    • 学会等名
      The 19th Congress of the European Geriatric Medicine Society
    • 国際学会

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公開日: 2024-12-25  

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