細胞膜機能と骨代謝動態からみたメタボリックシンドロームの病態生理

2013 年度 研究成果報告書

• 研究課題/領域番号: 23590901
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 内科学一般(含心身医学)
• 研究機関: 関西医療大学
• 研究代表者: 津田 和志 関西医療大学, 保健医療学部, 教授 (90217315)
• 研究期間 (年度): 2011 – 2013
• キーワード: 高血圧 / メタボリックシンドローム / 細胞膜fluidity / 電子スピン共鳴 / 赤血球 / nitric oxide / 酸化ストレス / 慢性腎臓病

研究概要

本研究では高血圧での慢性腎臓病(CKD)と細胞膜機能異常との関連を検討した。高血圧患者の赤血球膜fluidityは正常血圧群に比し低下していた。また、estimated-glomerular filtration rate(eGFR)が低いほど膜fluidityは減少し、eGFRと膜fluidityの低下は酸化ストレスの増加や血漿nitric oxide代謝産物の減少と有意に相関した。一方、高齢女性高血圧患者の骨塩含量は正常血圧群に比し減少していた、以上からCKDによる膜機能調節機構や骨代謝動態が高血圧やメタボリックシンドロームの成因に一部関与すると考えられた。

研究成果

• [雑誌論文] Role of hyperleptinemia in the regulation of cardiac function (2014)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Hypertension 巻: 63 ページ: e1
• [雑誌論文] Sympatho-inhibitory effect of diltiazem and prevention of aneurysm formation (2014)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Hypertension 巻: 63 ページ: e12
• [雑誌論文] Asymmetric dimethylarginine and DDAH transcript variants in cardio- vascular and cerebrovascular diseases (2014)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Am J Hypertens 巻: 27 ページ: 497
• [雑誌論文] Letter regarding article, Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction (2014)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Stroke 巻: 45 ページ: e46
• [雑誌論文] Chronic kidney disease predicts impaired membrane microviscosity of red blood cells in hypertensive and normotensive subjects. an electron spin resonance study (2013)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Int Heart J 巻: 54 ページ: 154-159
• [雑誌論文] Angiotensin-(1-7) and bradykinin in baroreceptor reflex sensitivity in hypertension (2013)
  • 著者名/発表者名: Tsuda K, Nautiyal M, Chappell MC, Diz DI
  • 雑誌名: Hypertension 巻: 61 ページ: e19-20
• [雑誌論文] Roles of sex steroid hormones and nitric oxide in the regulation of sympathetic nerve activity in women (2013)
  • 著者名/発表者名: Tsuda K, Carter JR, Fu Q, Minson MT, Joyner MJ
  • 雑誌名: Hypertension 巻: 61 ページ: e36-37
• [雑誌論文] Low serum adiponectin levels and endothelial dysfunction in childhood hypertension (2013)
  • 著者名/発表者名: Tsuda K, Brambilla P, Antolini L, Street ME, Giussani M, Galbiati S, Valsecchi MG, Stella A, Zucchotti GV, Bernasconi S, Genovsi S
  • 雑誌名: Am J Hypertens 巻: 26 ページ: 717-718
• [雑誌論文] Hyperhomocysteinemia and oxidative stress levels are associated with impaired membrane fluidity of red blood cells in hypertensive and normotensive men : an electron spin resonance investigation (2013)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Int J Clin Med 巻: 4 ページ: 58-65
• [雑誌論文] Letter regarding article, Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging (2013)
  • 著者名/発表者名: Tsuda K, Pena-Silva RA, Faraci FM, Heistad DD
  • 雑誌名: Stroke 巻: 44 ページ: e34-35
• [雑誌論文] Hypoadiponectinemia and endogenous nitric oxide synthase inhibitor in hypertension (2013)
  • 著者名/発表者名: Tsuda K, Xing W, Ji L, Li Y, Gao F, Yan W, Liu P, Sun L, Tao L, Zhang H
  • 雑誌名: Hypertension 巻: 62 ページ: e4-5
• [雑誌論文] Letter regarding article, Low plasma arginine : asymmetric dimethylarginine ratios predict mortality after intracranial aneurysm rupture (2013)
  • 著者名/発表者名: Tsuda K, Staalso JM, Romner B, Olsen NV
  • 雑誌名: Stroke 巻: 44 ページ: e92-93
• [雑誌論文] Angiotensin-(1-7) in the central nervous system regulation of blood pressure and renin-angiotensin system (2013)
  • 著者名/発表者名: Tsuda K, Vargic J, Ferrario M
  • 雑誌名: Am J Hypertens 巻: 26 ページ: 1174-1175
• [雑誌論文] Glutamate receptors and presympathetic neuronal hyperactivity of the central nervous system in hypertension (2013)
  • 著者名/発表者名: Tsuda K, Ye ZU, Li DP, Pan HL
  • 雑誌名: Hypertension 巻: 62 ページ: e33-34
• [雑誌論文] Chronic kidney disease and membrane microviscosity in hypertension -an electron spin resonance study- (2013)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: J Jpn Coll Angiol 巻: 53 ページ: 179-183
• [雑誌論文] Letter regarding article, Association of Chronic kidney disease with cerebral microbleeds in patients with primary intracerebral hemorrhage (2013)
  • 著者名/発表者名: Tsuda K, Ovbiagele B, Kidwell CS
  • 雑誌名: Stroke 巻: 44 ページ: e231-232
• [雑誌論文] Aerobic exercise and circulatory dysfunction in resistant hypertension (2012)
  • 著者名/発表者名: Tsuda K, Dimeo F, Pagonas N, Westhoff TH
  • 雑誌名: Hypertension 巻: 60 ページ: e45-46
• [雑誌論文] Associations between high-sensitivity C-reactive protein and membrane fluidity of red blood cells in hypertensive elderly men : an electron spin resonance study (2012)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Int J Hypertens 巻: 2012 ページ: 292803
  • DOI: 10.1155/2012/292803
• [雑誌論文] Renin-angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension (2012)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Int J Hypertens 巻: 2012 ページ: 474870
  • DOI: 10.1155/2012/474870
• [雑誌論文] Associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men : an electron spin resonance investigation (2012)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Adv Biosci Biotech 巻: 3 ページ: 1020-1027
• [雑誌論文] Roles of adiponectin and oxidative stress in the regulation of membrane microviscosity of red blood cells in hypertensive men-an electron spin resonance study (2011)
  • 著者名/発表者名: Tsuda K
  • 雑誌名: Journal of Obesity 巻: 2011 ページ: 548140
  • DOI: 10.1155/2011/54814
• [雑誌論文] Letter regarding article, Endothelial activation in lacunar stroke subtype (2011)
  • 著者名/発表者名: Tsuda K, Knottnerus ILH, Staals J, van Oostenbrugge RJ
  • 雑誌名: Stroke 巻: 42 ページ: e34-35
• [雑誌論文] Letter regarding article, Vitamin D deficiency is associated with subclinical carotid atherosclerosis : the Northern Manhattan study (2011)
  • 著者名/発表者名: Tsuda K, Walker MD, Silverberg SJ
  • 雑誌名: Stroke 巻: 42 ページ: e639-640
• [雑誌論文] Letter regarding article, Receptor activity-modifying protein-1 augments cerebrovascular responses to calcitonin gene-related peptide and inhibits angiotensin II-induced vascular dysfunction (2011)
  • 著者名/発表者名: Tsuda K, Chrissobolis S, Russo AF, Faraci FM
  • 雑誌名: Stroke 巻: 42 ページ: e24-25
• [学会発表] 細胞膜機能からみた高血圧の血管内皮障害とAdipokineによる調節機構-電子スピン共鳴法を用いた検討- (2013)
  • 著者名/発表者名: 津田和志
  • 学会等名: 第54回日本脈管学会総会シンポジウム
  • 発表場所: 東京
  • 年月日: 20131000
• [学会発表] Resistin predicts impaired membrane microviscosity of red blood cells and microcirculatory dysfunction in hypertensive men : an electron spin resonance study (2013)
  • 著者名/発表者名: Tsuda K
  • 学会等名: Featured Research Sessions at the 77th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Tokyo, Japan
  • 年月日: 20130300
• [学会発表] Cystatin C predicts membrane microviscosity of red blood cells and microcirculatory dysfunction in hypertension -an electron spin resonance study (2013)
  • 著者名/発表者名: Tsuda K
  • 学会等名: The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Tokyo, Japan
  • 年月日: 20130300
• [学会発表] 電子スピン共鳴からみた高血圧の細胞膜Microviscosityと腎動脈硬化-特にCKD関連動脈硬化と酸化ストレスとの関連から- (2012)
  • 著者名/発表者名: 津田和志
  • 学会等名: 第53回日本脈管学会シンポジウム
  • 発表場所: 東京
  • 年月日: 20121000
• [学会発表] Chronic kidney disease with albuminuria is associated with impaired membrane microviscosity in hypertensive subjects : an electron spin resonance study (2012)
  • 著者名/発表者名: Tsuda K
  • 学会等名: The 35th Annual Scientific Meeting of the Japanese Society of Hypertension (International Session)
  • 発表場所: Nagoya, Japan
  • 年月日: 20120900
• [学会発表] Role of hypercholesterolemia in the regulation of membrane microviscosity of red blood cells in hypertensive and normotensive men : an electron spin resonance study (2012)
  • 著者名/発表者名: Tsuda K
  • 学会等名: Asian Pacific Stroke Conference 2012
  • 発表場所: Tokyo
  • 年月日: 20120900
• [学会発表] Adiponectin and oxidative stress in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men : an electron spin resonance study (2012)
  • 著者名/発表者名: Tsuda K
  • 学会等名: Asian Pacific Stroke Conference 2012
  • 発表場所: Tokyo
  • 年月日: 20120900
• [学会発表] Electron spin resonance study on the modulatory effect of benidipine, a Ca-channel blocker, on membrane microviscosity of erythrocytes in hypertensive subjects (2012)
  • 著者名/発表者名: Tsuda K
  • 学会等名: Asian Pacific Stroke Conference 2012
  • 発表場所: Tokyo
  • 年月日: 20120900
• [学会発表] Oxidative stress, hyperhomocyteinemia, endothelial dysfunction and membrane microviscosity of red blood cells in hypertensive men -an electron spin resonance study (2012)
  • 著者名/発表者名: Tsuda K
  • 学会等名: The 76th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Fukuoka, Japan
  • 年月日: 20120300
• [学会発表] Chronic kidney disease predicts impaired membrane microviscosity of red blood cells and microcirculatory disorders in hypertension : an electron spin resonance study (2012)
  • 著者名/発表者名: Tsuda K
  • 学会等名: The 76th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Fukuoka, Japan
  • 年月日: 20120300
• [学会発表] Electron spin resonance study on modulatory effects of adiponectin and oxidative stress on membrane microviscosity of erythrocytes in hypertensive men (2011)
  • 著者名/発表者名: Tsuda K
  • 学会等名: The 34th Annual Scientific Meeting of the Japanese Society of Hypertension
  • 発表場所: Utsunomiya, Japan
  • 年月日: 20111000
• [学会発表] Electron spin resonance study on modulatory effects of a Ca-channel blocker, benidipine, on membrane microviscosity of erythrocytes in hypertensive subjects (2011)
  • 著者名/発表者名: Tsuda K
  • 学会等名: The 74th Annual Scientific Meeting of the Japanese Society of Nephrology
  • 発表場所: Yokohama, Japan
  • 年月日: 20110600
• [学会発表] Resistin is associated with chronic kidney disease (CKD) and microcirculatory dysfunction in hypertensive subjects
  • 著者名/発表者名: Tsuda K
  • 学会等名: The 36th Annual Scientific Meeting of the Japanese Societyof Hypertension
  • 発表場所: Osaka, Japan
  • 年月日: 00131000
• [図書] Bone mineral density in men and women with essential hypertension. In'Hypertension and Bone Loss', edited by Afrooz Afghani (2011)
  • 著者名/発表者名: Tsuda K
  • 総ページ数: 15-28
  • 出版者: Nova Science Publishers, Inc.