| 研究実績の概要 |
Previously, local perfusion of COA-Cl (0.05-1.0 mM) produced a significant and dose-dependent increase in dopamine (DA) levels, with the highest dose of 1.0 mM COA-Cl producing an approximately 5-fold increase in DA. Additionally, we showed that COA-Cl significantly enhanced DA release by 3.0 to 5.0-fold, accompanied by an increase in tyrosine hydroxylase at Ser31 and Ser40.
Here, we utilized 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse models of Parkinson’s disease to explore whether COA-Cl could reverse the loss of DA caused by MPTP in the dorsal striatum. Preliminary data revealed that COA-Cl restored DA levels, suggesting its potential restorative effects on DA depletion in mouse striatum.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
We aim to examine the effects of COA-Cl (0.05, 0.1, or 4.0 mM) combined with nicotine and/or ethanol on extracellular levels of DA and tyrosine hydroxylase phosphorylation in the dorsal striatum of MPTP-induced mouse model of PD. The rationale for this study is to investigate the role of COA-Cl alone or in combination with nicotine or ethanol in restoring dopamine function in the brain.
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