KAKEN — Research Projects | Researcher Number: 20093627

Search Results: 12 results / Researcher Number: 20093627

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1. A study examining the mechanism underlying the determination of the normal body temperature

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology(including physical medicine and nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE TATSUO 鳥取大学, 医学部, 教授
Project Period (FY)	2015-04-01 – 2018-03-31Completed
Keywords	体温 / 受精卵 / 視床下部 / マウス / 胎生期 / エピジェネティスク / 遺伝子発現 / 次世代シークエンサー / real-time RT-PCR / エポキシゲナーゼ
Outline of Final Research Achievements	We investigated the effect of changes in environmental temperature at the onset of life on the body temperature in mice. As a result, body temperature ...

Research Products of this project	Journal Article (6 results, of which Int'l Joint Research: 5 results, Peer Reviewed: 3 results, Open Access: 4 results) Presentation (9 results, of which Int'l Joint Research: 1 results) Remarks (1 results)

2. Chronic stress and atopic dermatitis:Research on preventive and therapeutic effects of odorant and its mechanism

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE TATSUO 鳥取大学, 医学部, 教授
Project Period (FY)	2012-04-01 – 2015-03-31Completed
Keywords	アトピー性皮膚炎 / 香料 / ストレス / 皮膚バリア / 角質水分量 / ピクリルクロライド
Outline of Final Research Achievements	We investigated whether inhalation of green odor or rose odor cures and/or prevents the atopic dermatitis (AD) induced in mice and human. The green od ...

Research Products of this project	Journal Article (6 results, of which Peer Reviewed: 6 results, Open Access: 1 results) Presentation (6 results) Remarks (1 results)

3. Exercise therapy for hypertension and diabetes mellitus: involvement of cross-adaptation to stress via inhibition of sympathetic nervous system

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Sports science
Research Institution	Tottori University
Principal Investigator	MIYOSHI Michio 鳥取大学, 医学部, 助教
Project Period (FY)	2010 – 2012Completed
Keywords	運動とトレーニング / 慢性運動 / ストレス / 交感神経 / 高血圧 / トレーニング / ノルエピネフリン / SHRラット / 運動療法 / アドレナリン / ノルアドレナリン / 運動 / 糖尿病
Research Abstract	We investigated effects of 4-weeks’ running training on the increases in blood pressure (BP) and catecholamine levels induced by a novel stress (immob ...

Research Products of this project	Journal Article (11 results, of which Peer Reviewed: 11 results) Presentation (10 results) Remarks (3 results)

4. Chronic stress and depressive disorder : Research on preventive effect of odorant and its mechanism

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE Tatsuo 鳥取大学, 医学部, 教授
Project Period (FY)	2009 – 2011Completed
Keywords	ストレス / うつ病 / 前頭前皮質 / 海馬 / 神経新生 / doublecortin / c-fos / Zif268 / 酪酸 / 緑の香り / 強制水泳試験 / 学習性無力試験 / immobility time / failure / ラット / 視床下部 / 下垂体 / 副腎
Research Abstract	We investigated whether inhalation of green odor(a mixture of equal amounts of trans-2-hexenal and cis-3-hexenal) cures and/or prevents the depressive ...

Research Products of this project	Journal Article (15 results, of which Peer Reviewed: 15 results) Presentation (16 results) Remarks (3 results)

5. Investigation on the mechanism underlying antipyretic effect of atrial natriuretic peptide within the brain

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE Tatsuo Tottori University
Project Period (FY)	2007 – 2008Completed
Keywords	心房性利尿ペプチド / 細菌性内毒素 / 発熱 / 脳 / 視床下部 / インターロイキン1 / 心房性ナトリウム利尿ペプチド / LPS / real-time RT-PCR / プロスタグランディン / ANP / 視束前野 / 前部視床下部 / 光顕免疫染色法 / サイトカイン / PGE_2
Research Abstract	本研究では、心房性ナトリウム利尿ペプチド(ANP)が脳内の"どこ"で"どの様"に発熱抑制に働くのかについてin vivoの実験系を用いて詳細に検討した。その結果、視床下部のANPによる発熱抑制と発熱時の視床下部でのANPやC-Type NP (CNP)さらにはインターロイキン1のmRNA発現を見いだ ...

Research Products of this project	Journal Article (5 results, of which Peer Reviewed: 5 results) Presentation (5 results)

6. Angiotensin II inside and outside the brain: investigation on the mechanism of angiotensin II-induced

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General internal medicine (including Psychosomatic medicine)
Research Institution	Tottori University
Principal Investigator	MIYOSHI Michio Tottori University, Faculty of Medicine, Research Associate
Project Period (FY)	2005 – 2006Completed
Keywords	ANG II / LPS / cytokines / microglial cell / NF-κB / AP-1 / NO / morphological change
Research Abstract	We investigated whether proinflammatory transcription factors [nuclear factor-κB (NF-κB) and activator protein-1 (AP-1)] contribute to the angiotensin ...

Research Products of this project	Journal Article (13 results)

7. Investigation on atrial natriuretic peptide as an endogenous antipyretic

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE Tatsuo Tottori University, Faculty of Medicine, Professor
Project Period (FY)	2005 – 2006Completed
Keywords	ANP / LPS / IL-1 / fever / rat / NF-κB / AP-1 / microglial cell
Research Abstract	We investigated whether natriuretic peptide (NP) acts as an endogenous antipyretic inside and/or outside the blood-brain barrier in rats made febrile ...

Research Products of this project	Journal Article (19 results)

8. Taste abnormality induced by stresses and improvement by exercise : Focusing on rare metal ions in plasma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Sports science
Research Institution	Tottori University
Principal Investigator	IMOTO Toshiaki Tottori University, Faculty of Medicine, Associate Prof.
Project Period (FY)	2005 – 2006Completed
Keywords	taste / stress / licking / rat / rare metal ions / two bottle choice method
Research Abstract	Present studies were performed to clarify the effect of various stresses on taste preference and/or sensitivity of rats based on the observation of ta ...

9. Title of project : Mechanisms underlying angiotensin II-stimulated production of proinflammatory cytokines : Are transcription factors involved?

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	National University Corporation Tottori University
Principal Investigator	WATANABE Tatsuo Tottori University, Faculty of Medicine, Professor
Project Period (FY)	2003 – 2004Completed
Keywords	angiotensin II / AT_1 receptor / NF-κB / AP-1 / LPS / IL-1 / rat
Research Abstract	We recently reported an involvement of angiotensin II(ANG II) and ANG type 1(AT1) receptor in the hepatic, splenic and brain expression of IL-1ss indu ...

Research Products of this project	Journal Article (7 results) Publications (3 results)

10. Studies on the involvement of intrahypothalamic angiotensin type 2 receptors in the development of fever in rats

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE Tatsuo Tottori University, Faculty of Medicine, Professor
Project Period (FY)	2001 – 2002Completed
Keywords	Angiotensin II / AT2receptor / Fever / Hypothalamus / Immunohistochemistry / LPS / Rat
Research Abstract	We have recently found that angiotensin II (ANG II) type 2 receptors within the hypothalamus (preoptic and anterior hypothalamic region) play an impor ...

Research Products of this project	Publications (6 results)

11. Is angiotensin II involved in dehydration-enhanced fever induced by endotoxin in rats ?

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	MIYOSHI Michio Tottori University, Faculty of Medicine, Assistant
Project Period (FY)	2000 – 2001Completed
Keywords	Angiotensin II / dehydration / angiotensin-converting enzyme inhibitor / Fever / interleukin-1β / interleukin-6 / mRNA / Angiotensin II type 1 receptor antagonist
Research Abstract	It has been reported that a host develops a marked fever under dehydrated conditions compared with normally hydrated conditions. The present study was ...

Research Products of this project	Publications (6 results)

12. 天然配糖体ギムネマ酸同族体の糖識別機能に対する抑制作用とその構造・活性相関

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	分析・地球化学
Research Institution	Tottori University (1988) The University of Tokyo (1987)
Principal Investigator	井元敏明 (1988) 鳥取大学, 医学部, 助教授佐藤和郎 (1987) 東京大学, 地震研究所, 講師
Project Period (FY)	1988Completed
Keywords	ギムネマ・シルベスタ / ギムネマ酸 / ブドウ糖輸送 / グルコシルトランスフェラーゼ / 鉱床鉛の同位体比 / 花崗岩 / 変成岩 / ウランートリウム比 / コリア半島 / 安定大陸地殻 / 閉鎖系モデル
Research Abstract	われわれはこれまで、インド産植物ギムネマ・シルベスタの葉から抽出されるトリテルペン配糖体ギムネマ酸が、小腸におけるブドウ糖吸収を抑制したり、抗う蝕効果を示すなど、様々な生理活性を有することを明らかにしてきた。しかしながらこれまでの研究においては、多くの同族体の混合物としてのギムネマ酸が用いられてきた ...

Research Products of this project	Publications (2 results)