KAKEN — Research Projects | Researcher Number: 30280770

Search Results: 18 results / Researcher Number: 30280770

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1. Development of novels methods for single cell analysis of antigen specific cells

Research Project

Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Review Section	Medium-sized Section 49:Pathology, infection/immunology, and related fields
Research Institution	Osaka University
Principal Investigator	ウィングジェイムス大阪大学, 感染症総合教育研究拠点, 准教授
Project Period (FY)	2024-06-28 – 2026-03-31Granted
Keywords	Mass Cytometry / B-cells / Single cell analysis
Outline of Research at the Start	We will establish methodology for the multimodal assessment of antigen specific B and T-cell cells by the use of CyTOF and single cell RNA sequencing ...

2. Study on the development and function of regulatory T cells and their application to the treatment of immunological diseases

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Review Section	Medium-sized Section 49:Pathology, infection/immunology, and related fields
Research Institution	Osaka University
Principal Investigator	坂口志文大阪大学, 免疫学フロンティア研究センター, 特任教授(常勤)
Project Period (FY)	2024-04-01 – 2027-03-31Granted
Keywords	制御性T細胞 / 免疫制御 / 自己免疫病 / ゲノム解析 / T細胞分化
Outline of Research at the Start	本研究では、免疫自己寛容、免疫恒常性の確立と維持に不可欠である制御性T細胞（Regulatory T cells、以下Treg）の発生・分化・増殖・機能維持および免疫抑制の分子的基礎を明らかにする。そのため、Treg発生・分化に伴うTreg特異的転写因子の遺伝子発現および機能解析に加えて、単一細胞レ ...

3. 制御性T細胞を用いた移植免疫制御方法の開発

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 55030:Cardiovascular surgery-related
Research Institution	Osaka University
Principal Investigator	宮川繁大阪大学, 大学院医学系研究科, 教授
Project Period (FY)	2022-04-01 – 2025-03-31Granted
Keywords	制御性T細胞 / 心不全 / 心臓移植 / 再生医療 / 移植免疫 / 免疫拒絶反応
Outline of Research at the Start	心臓移植では、術後急性期および慢性期の拒絶反応のコントロールが治療成否の鍵である。免疫抑制剤の進歩により主要組織適合抗原が一致しない移植が可能となっているが、生体内の恒常性維持に必要な免疫反応までも抑制することで発症する副作用が現在の移植医療の最大の課題であり、これを克服し長期にわたる移植臓器の機能 ...
Outline of Annual Research Achievements	治療抵抗性重症心不全に対する最終的な治療選択肢である心臓移植では、術後の拒絶反応の制御が鍵となる。免疫抑制剤の進歩が主要組織適合抗原が一致しない移植を可能とする一方で、その副作用が現在の移植医療の最大の課題である。
Current Status of Research Progress	3: Progress in research has been slightly delayed.

4. Reestablishing immune tolerance and homeostasis in autoimmune and autoinflammatory diseases

Research Project

Research Category	Fund for the Promotion of Joint International Research (International Leading Research )
Review Section	Biological Sciences
Research Institution	Osaka University
Principal Investigator	竹田潔大阪大学, 大学院医学系研究科, 教授
Project Period (FY)	2022-12-20 – 2029-03-31Granted
Keywords	免疫寛容 / 免疫疾患
Outline of Research at the Start	免疫系異常による疾患が近年急速に増加しつつある。これら疾患はQOLを低下させ致死にまで至らす。最近の研究は、これら疾患に関与する種々の免疫細胞亜集団を明らかにしてきている。従って次なる喫緊の課題は、「これら免疫細胞亜集団がどのようにして免疫病態に至るのかのメカニズム研究、その成果に基づき、免疫病態を ...
Outline of Annual Research Achievements	免疫系異常による疾患が近年増加しつつある。自己抗原寛容破綻によって生じる自己免疫疾患、又、腸内細菌、花粉等環境因子に対する過剰免疫反応による炎症性腸炎(IBD)、アレルギー疾患、更に、自然免疫過剰による自己炎症性疾患等である。本研究では、既に、免疫寛容・恒常性維持の基礎研究で国際的に大きな実績のある ...
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

5. Study of the function and development of regulatory T cells

Research Project

Research Category	Grant-in-Aid for Specially Promoted Research
Review Section	Biological Sciences
Research Institution	Osaka University
Principal Investigator	Shimon Sakaguchi 大阪大学, 免疫学フロンティア研究センター, 特任教授(常勤)
Project Period (FY)	2016-04-26 – 2021-03-31Completed
Keywords	自己免疫寛容 / 制御性T細胞 / 自己免疫疾患 / Foxp3 / エピジェネティクス / 免疫学 / シグナル伝達 / 発現制御 / 発生・分化 / 免疫自己寛容
Outline of Final Research Achievements	This project has attempted to elucidate the molecular basis of immunosuppressive function and development of regulatory T cells (Tregs). In particular ...
Verification Result (Rating)	A
Result (Rating)	A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Research Products of this project	Journal Article (69 results, of which Int'l Joint Research: 22 results, Peer Reviewed: 69 results, Open Access: 68 results) Presentation (46 results, of which Int'l Joint Research: 13 results, Invited: 13 results) Book (5 results) Patent(Industrial Property Rights) (1 results)

6. Transplantation of islets in immune tolerance site under skin induced by bFGF or SEK-1005

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	General surgery
Research Institution	Kyoto University
Principal Investigator	IWATA Hiroo 京都大学, 再生医科学研究所, 教授
Project Period (FY)	2014-04-01 – 2015-03-31Completed
Keywords	ランゲルハンス氏島 / 膵島 / 制御性T細胞 / 糖尿病 / 血糖値 / 移植 / 皮下移植
Outline of Final Research Achievements	We demonstrated that blood glucose levels of diabetic rats were kept stable normal by transplanting islet at subcutaneous sites without immunosuppress ...

Research Products of this project	Presentation (2 results) Patent(Industrial Property Rights) (4 results, of which Overseas: 3 results)

7. Molecular basis and therapeutic target for autoimmune arthritis

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Immunology
Research Institution	Osaka University
Principal Investigator	Sakaguchi Shimon 大阪大学, 免疫学フロンティア研究センター, 教授
Project Period (FY)	2014-04-01 – 2017-03-31Completed
Keywords	SKG / 自己免疫性関節炎 / 関節リウマチ / ZAP-70 / 自己抗原
Outline of Final Research Achievements	In this study, we have developed a new mouse model system with different ZAP-70 functions to understand the development and autoimmune function of T h ...

Research Products of this project	Journal Article (22 results, of which Int'l Joint Research: 2 results, Peer Reviewed: 22 results, Open Access: 21 results, Acknowledgement Compliant: 20 results) Presentation (31 results, of which Invited: 23 results)

8. Mechanisms of regulatory T-cell control of humoral immunity

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Immunology
Research Institution	Osaka University
Principal Investigator	WING James 大阪大学, 免疫学フロンティア研究センター, 特任助教
Project Period (FY)	2013-04-01 – 2015-03-31Completed
Keywords	Regulatory T-cells / T follicular helper / Vaccination / Antibody response / T Follicular helper / Antibody responses / 制御性T細胞 / 免疫制御
Outline of Final Research Achievements	I discovered that Tregs control the formation of Tfh and resulting B-cell germinal center reactions via the suppressive molecule CTLA-4. This is achie ...

Research Products of this project	Journal Article (5 results, of which Peer Reviewed: 5 results, Open Access: 1 results) Presentation (7 results) Book (1 results) Remarks (2 results)

9. 制御性Ｔ細胞による腫瘍内ＣＤ８＋Ｔ細胞の活性抑制に関する研究

Research Project

Research Category	Grant-in-Aid for JSPS Fellows
Research Field	Immunology
Research Institution	Osaka University
Principal Investigator	坂口志文大阪大学, 免疫学フロンティア研究センター, 教授
Project Period (FY)	2012-04-01 – 2015-03-31Completed
Keywords	Regulatory T cell / Cancer / Immunotherapy / CD8 / Exhaustion / Drug / Dysfunction / Protein / T細胞
Outline of Annual Research Achievements	We have demonstrated in the past that “CTLA-4” is a molecule that is critical for Treg function especially in the context of autoimmune disease. In th ...

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results)

10. Molecular basis of the function and generation of Foxp3-expressing regulatory T cells

Research Project

Research Category	Grant-in-Aid for Specially Promoted Research
Review Section	Biological Sciences
Research Institution	Osaka University (2011-2012) Kyoto University (2008-2010)
Principal Investigator	SAKAGUCHI Shimon 大阪大学, 免疫学フロンティア研究センター, 教授
Project Period (FY)	2008 – 2012Completed
Keywords	FOXP3 / 制御性T細胞 / 自己免疫病 / Tリンパ球 / CTLA-4 / 免疫制御 / 制御性Ｔ細胞 / エピゲノム / Ｔリンパ球 / Ｔ細胞抗原レセプター / T細胞抗原レセプター
Research Abstract	We have studied the mechanisms of how regulatory T (Treg) cells control immune responses and how their function and lineage stability can be maintaine ...
Verification Result (Rating)	A

Research Products of this project	Journal Article (122 results, of which Peer Reviewed: 68 results) Presentation (105 results, of which Invited: 31 results) Patent(Industrial Property Rights) (4 results, of which Overseas: 1 results)

11. The establishment and clinical application of new immunotherapy for gynecologic cancers by using the activation of self-tolerance

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Obstetrics and gynecology
Research Institution	Kyoto University
Principal Investigator	TAKAKURA Kenji (2007-2008) Kyoto University 藤井信吾 (2006) 京都大学, 医学研究科, 教授
Project Period (FY)	2006 – 2008Completed
Keywords	婦人科腫瘍 / 腫瘍免疫 / PD-1 / 制御性T細胞 / 免疫逃避機構 / BMP / NK細胞 / 免疫回避機構 / 婦人科悪性腫瘍 / PD-L1
Research Abstract	婦人科悪性腫瘍の多くは初期治療反応性は良いが、長期的予後は良くない。このため腫瘍免疫療法等の新しい治療法の開発が必要である。腫瘍は本来不可欠な自己寛容維持機構をうまく利用することで免疫系の攻撃から逃れていると考えられ、本研究で我々は、自己寛容維持のメカニズムを逆に利用して、これを一過性に抑制し、ある ...

Research Products of this project	Journal Article (15 results, of which Peer Reviewed: 8 results) Presentation (15 results)

12. Immune tolerance and regulation towards understanding and cure of autoimmune disease

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Kyoto University
Principal Investigator	SAKAGUCHI Shimon Kyoto University Institute for Frontier Medical Sciences, Professor
Project Period (FY)	2001 – 2006Completed
Keywords	Autoimmune disease / Regulatory T cell / Dendritic cells / Semaphoring / Co-stimulatory molecule / Genetic susceptibilit / Immunological self-tolerance / Foxp3
Research Abstract	The aim of this project is to elucidate the cause and the pathogenetic mechanism of autoimmune disease, and seek for effective ways of its treatment a ...

Research Products of this project	Journal Article (473 results) Book (4 results) Patent(Industrial Property Rights) (5 results) Publications (26 results)

13. Roles of the Autoimmune Regulator (AIRE) Gene in Immune Response

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Endocrinology
Research Institution	Keio University
Principal Investigator	SHIMIZU Nobuyoshi Keio University, School of Medicine, Professor
Project Period (FY)	1999 – 2001Completed
Keywords	APECED / APS-1 / AIRE / Autoimmune disease / Thymus / Antigen presenting cells / CBP / Dendritic cells
Research Abstract	1. AIRE gene expression: We have investigated the expression of the AIRE gene by mRNA in situ hybridization and immunohistochemistry in various human ...

Research Products of this project	Publications (23 results)

14. BREAKING IMMUNOLOGICAL TOLERANCE TO TUMOR CELLS AS A NOVEL IMMUNOTHERAPY FOR CANCER

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Experimental pathology
Research Institution	TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY
Principal Investigator	SHIMIZU Jun TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY, DEPARTMENT OF IMMUNOPATHOLOGY, RESEARCH SCIENTIST
Project Period (FY)	1999 – 2000Completed
Keywords	CD25^+ T CELLS / TUMOR IMMUNOLOGY / ANERGY
Research Abstract	We show that removal of a T cell subpopulation can evoke effective tumor immunity in otherwise non-responding animals. Elimination of CD25-expressing ...

Research Products of this project	Publications (31 results)

15. 自己免疫性関節炎を自然発症するマウスモデルの確立とその解析

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Immunology
Research Institution	Tokyo Metropolitan Institute of Gerontology
Principal Investigator	坂口志文財団法人東京都老人総合研究所, 免疫病理部門, 研究室長
Project Period (FY)	1997 – 1998Completed
Keywords	疾患モデル / 慢性関節リウマチ / 自己免疫 / 遺伝子異常 / 関節炎 / 動物モデル / 自己免疫病 / 疾患遺伝子
Research Abstract	我々の維持している正常BALB/cマウスのコロニー中に関節腫張のみられるマウスを発見し、関節炎を自然発症するマウス系統を確立した。現在までに10世代を維持した結果、その遺伝形式は常染色体劣性であり、通常の飼育環境では、その遺伝的浸透率は100%であった。このマウス系統をSPF化したところ、発症頻度が ...

Research Products of this project	Publications (12 results)

16. 発生工学的手法による自己免疫病発症機構の解析

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Experimental pathology
Research Institution	Tokyo Metropolitan Institute of Gerontology
Principal Investigator	坂口志文東京都老人総合研究所, 免疫病理部門, 研究室長
Project Period (FY)	1996 – 1997Completed
Keywords	自己免疫病 / 免疫的自己寛容 / T細胞性制御 / T細胞 / トランスジェニックマウス / 免疫制御
Research Abstract	正常マウス末梢CD4T細胞の約10%を占めるCD25(IL-2α鎖)発現T細胞を除去すると、ヒトの自己免疫病と免疫病理学的に酷似した様々な病変(胃炎、甲状腺炎、副腎炎、糖尿病、卵巣炎等)が高率に発症し、CD25+細胞を一定期間内に補えば病変発症は阻止される。これは、末梢における自己反応性T細胞の活性 ...

Research Products of this project	Publications (13 results)

17. 自己免疫病発症の分子機構:自己反応性T細胞の制御機構について

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Tokyo Metropolitan Institute of Gerontology
Principal Investigator	坂口志文東京都老人総合研究所, 免疫病理部門, 研究室長
Project Period (FY)	1996Completed
Keywords	自己免疫病 / T細胞 / トランスジェニックマウス / 免疫制御
Research Abstract	正常マウス末梢CD4T細胞の約10%を占めるCD25(IL-2 α鎖)発現細胞を除去すると、ヒトの自己免疫病と免疫病理学的に酷似した様々な病変(胃炎、甲状腺炎、副腎炎、糖尿病、卵巣炎等)が高率に発症し、CD25+細胞を一定期間内に補えば病変発症は阻止される。これは、末梢における自己反応性T細胞の活性 ...

Research Products of this project	Publications (6 results)

18. Regulation of Gene Expression

Research Project

Research Category	Grant-in-Aid for international Scientific Research
Research Institution	Chiba University, School of Medicine
Principal Investigator	TANIGUCHI Masaru Chiba University, School of Medicine, Professor
Project Period (FY)	1996Completed
Keywords	T cell / Immunological tolerance / B cell / Transgenics / Polycomb genes / Crystallin gene / Biosensor / Transcriptional factor
Research Abstract	(1) Immunology

Research Products of this project	Publications (9 results)