KAKEN — Research Projects | Researcher Number: 40322218

Search Results: 16 results / Researcher Number: 40322218

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1. 子宮内膜症の病変組織に特徴的なエストロゲン受容体発現を標的とする新規治療薬の開発

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Tottori University
Principal Investigator	伊澤正郎鳥取大学, 医学部, プロジェクト研究員
Project Period (FY)	2022-04-01 – 2025-03-31Granted
Keywords	子宮内膜症病変組織 / エストロゲン応答性遺伝子 / 子宮内膜症 / エストロゲン受容体
Outline of Research at the Start	子宮内膜症は、低エストロゲン状態の誘起を目的とするホルモン製剤治療が第一選択とされるが、治療成績には限界がある。その背景として、申請者らは、子宮内膜症病変組織に特徴的なエピゲノム環境のもとで活性化したアロマターゼ発現を伴う、「局所高濃度エストロゲン環境の影響」を想定した(Izawa M et al. ...
Outline of Annual Research Achievements	子宮内膜症の薬物治療として、低エストロゲン状態の誘起を目的とするホルモン製剤治療が第一選択とされるが、治療成績には限界がある。その背景として、子宮内膜症病変組織に特徴的なエピゲノム環境のもとで活性化したアロマターゼ発現を伴う、「局所高濃度エストロゲン環境の影響」を想定する(Izawa M et al ...
Current Status of Research Progress	4: Progress in research has been delayed.

Research Products of this project	Journal Article (1 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 1 results, Open Access: 1 results) Presentation (1 results, of which Int'l Joint Research: 1 results)

2. 子宮内膜症発生仮説としての「子宮内膜移植説」の解明：腹膜由来分子の役割に注目して

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Tottori University
Principal Investigator	谷口文紀鳥取大学, 医学部, 教授
Project Period (FY)	2021-04-01 – 2024-03-31Granted
Keywords	子宮内膜症 / モデルマウス / 腹膜組織 / 発生機序 / 月経困難症 / 発症機序
Outline of Research at the Start	子宮内膜症の組織は増殖・浸潤することにより周囲臓器と癒着し、痛みや不妊の原因となる。生殖年齢女性の約10%、不妊女性の約50%と罹患率の高い疾患であるにも関わらず、発生原因についてはよく理解されていないのが現状である。「子宮内膜移植説」に基づいて、初期病変の観察目的に開発した発光モデルマウス、ノック ...
Outline of Annual Research Achievements	【目的】子宮内膜症モデルマウスの腹膜組織における遺伝子発現解析により、初期病変の腹膜への接着・浸潤過程に関わる因子を同定し、その役割について検討した。
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

Research Products of this project	Journal Article (3 results) Presentation (4 results)

3. Development of a New Selective Estrogen Receptor Modulator for the Treatment of Endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Tottori University
Principal Investigator	HARADA Tasuku 鳥取大学, 医学部, 教授
Project Period (FY)	2018-04-01 – 2021-03-31Completed
Keywords	子宮内膜症 / Estrogen受容体 / 選択的Estrogen受容体調整薬 / 子宮内膜症間質細胞 / 炎症性サイトカイン / 卵巣チョコレート嚢胞 / エストロゲン受容体調整薬 / SR-16234 / 選択的Estrogen受容体調節薬
Outline of Final Research Achievements	The aim of this study is to develop the novel selective estrogen receptor modulators for endometriosis.Our goal is to develop a novel drugs with a com ...

Research Products of this project	Journal Article (3 results, of which Peer Reviewed: 3 results, Open Access: 3 results)

4. Exploring the target molecules for endometriosis therapy using bioluminescence model mice

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Tottori University
Principal Investigator	TANIGUCHI Fuminori 鳥取大学, 医学部, 准教授
Project Period (FY)	2018-04-01 – 2021-03-31Completed
Keywords	子宮内膜症 / 疾患モデルマウス / 発光マウス / 発行マウス / 動物モデル / 炎症性サイトカイン / 生物発光マウス / 慢性炎症 / 生物発光モデルマウス / 初期病変
Outline of Final Research Achievements	Using a luminescent and endometriosis model mouse with live imaging capability developed based on the endometrial transplantation theory, we analyzed ...

Research Products of this project	Journal Article (8 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 8 results) Presentation (10 results, of which Int'l Joint Research: 3 results)

5. Development of new therapeutic agents for endometriosis: inhibitors of nuclear factor-kappa B pathway

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	HARADA TASUKU 鳥取大学, 医学部, 教授
Project Period (FY)	2015-04-01 – 2018-03-31Completed
Keywords	子宮内膜症 / NF-kB / IAP阻害薬 / NFκB / IAP / 子宮内膜症細胞 / 卵巣チョコレート嚢胞 / TAK1
Outline of Final Research Achievements	Local inflammatory reaction in the peritoneal environment is one of the contributing factors in the pathogenesis of endometriosis. In women with endom ...

Research Products of this project	Journal Article (13 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 12 results, Open Access: 4 results, Acknowledgement Compliant: 4 results) Presentation (9 results, of which Int'l Joint Research: 6 results, Invited: 4 results)

6. Searching for diagnostic molecular markers of endometriosis using genomic DNA methylation modification as an indicator

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	IZAWA MASAO 鳥取大学, 医学部, 特任教授
Project Period (FY)	2015-04-01 – 2018-03-31Completed
Keywords	子宮内膜症 / 疾患特異的DNAメチル化修飾 / メチル化修飾依存性エンハンサー活性 / 疾患特異的遺伝子発現 / 診断分子マーカー / DNAメチル化修飾 / 疾患特異的DNAメチル化 / 活性型エンハンサー / 遺伝子発現制御 / エピゲノム異常 / ゲノムDNAメチル化 / 遺伝子発現 / シスエレメント / エストロゲン / ゲノムワイドメチル化解析 / 特異的DNAメチル化領域
Outline of Final Research Achievements	Our previous studies have suggested a link between genomic DNA methylation modification and gene expression characteristic of endometriosis. The objec ...

Research Products of this project	Journal Article (2 results, of which Peer Reviewed: 2 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (9 results, of which Int'l Joint Research: 7 results)

7. Novel medical therapy targeted NFkB for the infertile patients with endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	Taniguchi Fuminori 鳥取大学, 医学部, 准教授
Project Period (FY)	2014-04-01 – 2017-03-31Completed
Keywords	子宮内膜症 / 炎症 / マウスモデル / モデルマウス
Outline of Final Research Achievements	Local and chronic inflammatory reaction in the peritoneal environment is considered the contributing factors in the pathogenesis of the infertile pati ...

Research Products of this project	Journal Article (8 results, of which Int'l Joint Research: 4 results, Peer Reviewed: 7 results, Acknowledgement Compliant: 8 results, Open Access: 4 results) Presentation (12 results, of which Int'l Joint Research: 4 results)

8. Epigenetic analysis of aromatase gene toward the advanced early diagnostics in endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	IZAWA Masao 鳥取大学, 医学部, 特任教授
Project Period (FY)	2010-04-01 – 2013-03-31Completed
Keywords	子宮内膜症 / エストロゲン産生異常 / アロマターゼ遺伝子 / CpGアイランド / DNAメチル化 / エピゲノム異常 / 早期診断分子マーカー / CpG配列 / アロマターゼ / 網羅的DNAメチル化解析 / 子宮内膜症特異的メチル化CpG / 早期診断分子マーカ / 早期診断法
Research Abstract	A marked up-regulation of aromatase gene leading to a high estrogen environment in endometriotic tissues has been suggested as the aberrant DNA methyl ...

Research Products of this project	Journal Article (12 results, of which Peer Reviewed: 11 results) Presentation (30 results, of which Invited: 3 results) Book (2 results)

9. Inhibition of cell proliferation of human endometriotic cells by parthenolide

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	TANIGUCHI Fuminori 鳥取大学, 医学部附属病院, 講師
Project Period (FY)	2009 – 2011Completed
Keywords	薬用ハーブ / 子宮内膜症 / パルテノライド / エストロゲン
Research Abstract	The aim of this study was to investigate the usefulness of apigenin(flavonoid) and parthenolide(plant feverfew) as a possible therapeutic agent for en ...

Research Products of this project	Journal Article (16 results, of which Peer Reviewed: 16 results) Presentation (23 results)

10. The role of apoptosis in growth and survival of endometriotic cells : its implication for treatment of endometrisois

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	HARADA Tasuku Tottori University
Project Period (FY)	2008 – 2010Completed
Keywords	子宮内膜症 / アポトーシス / survivin / サイトカイン
Research Abstract	Decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis. Endometriotic stromal cells showed re ...

Research Products of this project	Journal Article (18 results, of which Peer Reviewed: 18 results) Presentation (19 results) Remarks (2 results)

11. Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	TERAKAWA Naoki 鳥取大学, 名誉教授
Project Period (FY)	2008 – 2011Completed
Keywords	JEMS / 子宮内膜症 / がん化 / 疫学研究
Research Abstract	This project is the prospective study "Investigation for malignant transformation of endometriosis in Japan". We have analyzed the personal data colle ...

Research Products of this project	Journal Article (32 results, of which Peer Reviewed: 29 results) Presentation (45 results) Remarks (5 results)

12. Exploring the mechanism of cell proliferation and the novel molecular target therapy of endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	TERAKAWA Naoki Tottori University, Professor
Project Period (FY)	2005 – 2007Completed
Keywords	Endometrinsis / TNFα / IL-8 / dienogest / NFkB pathway / ovarian endometrioma / GnRH antagonist / Cetrorelix
Research Abstract	We previous reported that the proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-8 are elevated in the peritoneal f ...

Research Products of this project	Journal Article (33 results, of which Peer Reviewed: 16 results) Presentation (40 results)

13. ヒト卵巣におけるSCF,HGFおよびKGFの発現と細胞間相互作用の解明

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	谷口文紀鳥取大学, 医学部附属病院, 助手
Project Period (FY)	2002 – 2003Completed
Keywords	Ovary / MAPK / Signal transduction / progesterone / StAR / ERK
Research Abstract	ヒト卵巣顆粒膜細胞腫由来のKGN細胞を研究対象とした.KGN細胞におけるHGFとその受容体であるc-met遺伝子の発現をRT-PCRにて検索した.HGFを添加,培養して細胞増殖能をBrdU法で検討した.KGN細胞にゴナドトロピンあるいはHGFを添加し,48時間後の培養上清中のプロゲステロン(P4)濃 ...

Research Products of this project	Publications (5 results)

14. Role of matrix met alloprot einases and cytokines in the development of endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University School of Medicine
Principal Investigator	TERAKAWA Naoki Tottori Univ., Dept.Obst et.Gynecol., Professor
Project Period (FY)	2002 – 2003Completed
Keywords	Endometriosis / Development and progression / Endometriotic stromal cells / Cytokine TNFα / IL-8 / Nuclear fact or-κB / Estrogen / GnRH agonist
Research Abstract	It is believed that the extracellular matrix (ECM) remodeling is relevant to the development and the progression of endometriosis. Tissue remodeling i ...

Research Products of this project	Publications (24 results)

15. Development of anti-cytokine drugs for treatment of endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University School of Medicine
Principal Investigator	HARADA Tasuku Tottori Univ., Dept.Obstet.Gunecol., Assistant Professor
Project Period (FY)	2001 – 2003Completed
Keywords	endometriosis / cytokine / interleukin-8 / tumor necrosis factor alpha / anti-TNF alpha antibody
Research Abstract	Peritoneal fluid (PF) in women with endometriosis contains an increased number of activated macrophages that secrete a variety of cytokines. We have p ...

Research Products of this project	Publications (39 results)

16. 胚着床現象におけるFGF-10の遺伝子発現とその役割

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	谷口文紀鳥取大学, 医学部・附属病院, 助手
Project Period (FY)	2000 – 2001Completed
Keywords	FGF-10 / KGF / 子宮内膜癌 / 子宮内膜細胞 / MAPキナーゼ / FGF / hCG分泌 / トロホブラスト / 子宮内膜間質細胞
Research Abstract	線維芽細胞増殖因子(FGF)は、血管新生、創傷治癒などの領域において多機能な作用を有する生理活性物質である.Keratinocyte growth factor(KGF ; FGF-7)とFGF-10は間質細胞から産生され上皮細胞に作用する細胞増殖因子として注目されている,これまでに,子宮内膜間質細 ...

Research Products of this project	Publications (2 results)