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Search Results: 17 results / Researcher Number: 40322218

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  • 1. モデル動物における新規疼痛評価法の確立による子宮内膜症非ホルモン薬物療法の探索

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Review Section Basic Section 56040:Obstetrics and gynecology-related
    Research Institution Tottori University
    Principal Investigator

    谷口 文紀 鳥取大学, 医学部, 教授

    Project Period (FY) 2025-04-01 – 2028-03-31Adopted
  • 2. 子宮内膜症の病変組織に特徴的なエストロゲン受容体発現を標的とする新規治療薬の開発

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Review Section Basic Section 56040:Obstetrics and gynecology-related
    Research Institution Tottori University
    Principal Investigator

    伊澤 正郎 鳥取大学, 医学部, プロジェクト研究員

    Project Period (FY) 2022-04-01 – 2025-03-31Granted
    Keywords 子宮内膜症病変組織 / エストロゲン応答性遺伝子 / 子宮内膜症 / エストロゲン受容体
    Outline of Research at the Start 子宮内膜症は、低エストロゲン状態の誘起を目的とするホルモン製剤治療が第一選択とされるが、治療成績には限界がある。その背景として、申請者らは、子宮内膜症病変組織に特徴的なエピゲノム環境のもとで活性化したアロマターゼ発現を伴う、「局所高濃度エストロゲン環境の影響」を想定した(Izawa M et al. ...
    Outline of Annual Research Achievements 子宮内膜症の薬物治療として、低エストロゲン状態の誘起を目的とするホルモン製剤治療が第一選択とされるが、治療成績には限界がある。その背景として、子宮内膜症病変組織に特徴的なエピゲノム環境のもとで活性化したアロマターゼ発現を伴う、「局所高濃度エストロゲン環境の影響」を想定する(Izawa M et al ...
    Current Status of Research Progress 4: Progress in research has been delayed.
    Research Products of this project Journal Article (1 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 1 results, Open Access: 1 results)   Presentation (1 results, of which Int'l Joint Research: 1 results)
  • 3. The implantation theory as a hypothesis for the development of endometriosis: focusing on the role of peritoneal-derived molecules.

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Review Section Basic Section 56040:Obstetrics and gynecology-related
    Research Institution Tottori University
    Principal Investigator

    TANIGUCHI Fuminori 鳥取大学, 医学部, 教授

    Project Period (FY) 2021-04-01 – 2024-03-31Completed
    Keywords 子宮内膜症 / 月経困難症 / 不妊 / モデルマウス / 腹膜組織 / 発生機序 / 発症機序
    Outline of Research at the Start 子宮内膜症の組織は増殖・浸潤することにより周囲臓器と癒着し、痛みや不妊の原因となる。生殖年齢女性の約10%、不妊女性の約50%と罹患率の高い疾患であるにも関わらず、発生原因についてはよく理解されていないのが現状である。「子宮内膜移植説」に基づいて、初期病変の観察目的に開発した発光モデルマウス、ノック ...
    Outline of Final Research Achievements We aimed to identify extracellular matrix components that contribute to adhesion to, and invasion of, the peritoneum, proximal to lesions in the early ...
    Research Products of this project Journal Article (8 results, of which Peer Reviewed: 5 results)   Presentation (8 results)
  • 4. Development of a New Selective Estrogen Receptor Modulator for the Treatment of Endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Review Section Basic Section 56040:Obstetrics and gynecology-related
    Research Institution Tottori University
    Principal Investigator

    HARADA Tasuku 鳥取大学, 医学部, 教授

    Project Period (FY) 2018-04-01 – 2021-03-31Completed
    Keywords 子宮内膜症 / Estrogen受容体 / 選択的Estrogen受容体調整薬 / 子宮内膜症間質細胞 / 炎症性サイトカイン / 卵巣チョコレート嚢胞 / エストロゲン受容体調整薬 / SR-16234 / 選択的Estrogen受容体調節薬
    Outline of Final Research Achievements The aim of this study is to develop the novel selective estrogen receptor modulators for endometriosis.Our goal is to develop a novel drugs with a com ...
    Research Products of this project Journal Article (3 results, of which Peer Reviewed: 3 results, Open Access: 3 results)
  • 5. Exploring the target molecules for endometriosis therapy using bioluminescence model mice

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Review Section Basic Section 56040:Obstetrics and gynecology-related
    Research Institution Tottori University
    Principal Investigator

    TANIGUCHI Fuminori 鳥取大学, 医学部, 准教授

    Project Period (FY) 2018-04-01 – 2021-03-31Completed
    Keywords 子宮内膜症 / 疾患モデルマウス / 発光マウス / 発行マウス / 動物モデル / 炎症性サイトカイン / 生物発光マウス / 慢性炎症 / 生物発光モデルマウス / 初期病変
    Outline of Final Research Achievements Using a luminescent and endometriosis model mouse with live imaging capability developed based on the endometrial transplantation theory, we analyzed  ...
    Research Products of this project Journal Article (8 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 8 results)   Presentation (10 results, of which Int'l Joint Research: 3 results)
  • 6. Development of new therapeutic agents for endometriosis: inhibitors of nuclear factor-kappa B pathway

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    HARADA TASUKU 鳥取大学, 医学部, 教授

    Project Period (FY) 2015-04-01 – 2018-03-31Completed
    Keywords 子宮内膜症 / NF-kB / IAP阻害薬 / NFκB / IAP / 子宮内膜症細胞 / 卵巣チョコレート嚢胞 / TAK1
    Outline of Final Research Achievements Local inflammatory reaction in the peritoneal environment is one of the contributing factors in the pathogenesis of endometriosis. In women with endom ...
    Research Products of this project Journal Article (13 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 12 results, Open Access: 4 results, Acknowledgement Compliant: 4 results)   Presentation (9 results, of which Int'l Joint Research: 6 results, Invited: 4 results)
  • 7. Searching for diagnostic molecular markers of endometriosis using genomic DNA methylation modification as an indicator

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    IZAWA MASAO 鳥取大学, 医学部, 特任教授

    Project Period (FY) 2015-04-01 – 2018-03-31Completed
    Keywords 子宮内膜症 / 疾患特異的DNAメチル化修飾 / メチル化修飾依存性エンハンサー活性 / 疾患特異的遺伝子発現 / 診断分子マーカー / DNAメチル化修飾 / 疾患特異的DNAメチル化 / 活性型エンハンサー / 遺伝子発現制御 / エピゲノム異常 / ゲノムDNAメチル化 / 遺伝子発現 / シスエレメント / エストロゲン / ゲノムワイドメチル化解析 / 特異的DNAメチル化領域
    Outline of Final Research Achievements Our previous studies have suggested a link between genomic DNA methylation modification and gene expression characteristic of endometriosis. The objec ...
    Research Products of this project Journal Article (2 results, of which Peer Reviewed: 2 results, Open Access: 2 results, Acknowledgement Compliant: 1 results)   Presentation (9 results, of which Int'l Joint Research: 7 results)
  • 8. Novel medical therapy targeted NFkB for the infertile patients with endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    Taniguchi Fuminori 鳥取大学, 医学部, 准教授

    Project Period (FY) 2014-04-01 – 2017-03-31Completed
    Keywords 子宮内膜症 / 炎症 / マウスモデル / モデルマウス
    Outline of Final Research Achievements Local and chronic inflammatory reaction in the peritoneal environment is considered the contributing factors in the pathogenesis of the infertile pati ...
    Research Products of this project Journal Article (8 results, of which Int'l Joint Research: 4 results, Peer Reviewed: 7 results, Acknowledgement Compliant: 8 results, Open Access: 4 results)   Presentation (12 results, of which Int'l Joint Research: 4 results)
  • 9. Epigenetic analysis of aromatase gene toward the advanced early diagnostics in endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    IZAWA Masao 鳥取大学, 医学部, 特任教授

    Project Period (FY) 2010-04-01 – 2013-03-31Completed
    Keywords 子宮内膜症 / エストロゲン産生異常 / アロマターゼ遺伝子 / CpGアイランド / DNAメチル化 / エピゲノム異常 / 早期診断分子マーカー / CpG配列 / アロマターゼ / 網羅的DNAメチル化解析 / 子宮内膜症特異的メチル化CpG / 早期診断分子マーカ / 早期診断法
    Research Abstract A marked up-regulation of aromatase gene leading to a high estrogen environment in endometriotic tissues has been suggested as the aberrant DNA methyl ...
    Research Products of this project Journal Article (12 results, of which Peer Reviewed: 11 results)   Presentation (30 results, of which Invited: 3 results)   Book (2 results)
  • 10. Inhibition of cell proliferation of human endometriotic cells by parthenolide

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    TANIGUCHI Fuminori 鳥取大学, 医学部附属病院, 講師

    Project Period (FY) 2009 – 2011Completed
    Keywords 薬用ハーブ / 子宮内膜症 / パルテノライド / エストロゲン
    Research Abstract The aim of this study was to investigate the usefulness of apigenin(flavonoid) and parthenolide(plant feverfew) as a possible therapeutic agent for en ...
    Research Products of this project Journal Article (16 results, of which Peer Reviewed: 16 results)   Presentation (23 results)
  • 11. The role of apoptosis in growth and survival of endometriotic cells : its implication for treatment of endometrisois

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    HARADA Tasuku Tottori University

    Project Period (FY) 2008 – 2010Completed
    Keywords 子宮内膜症 / アポトーシス / survivin / サイトカイン
    Research Abstract Decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis. Endometriotic stromal cells showed re ...
    Research Products of this project Journal Article (18 results, of which Peer Reviewed: 18 results)   Presentation (19 results)   Remarks (2 results)
  • 12. Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (A)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    TERAKAWA Naoki 鳥取大学, 名誉教授

    Project Period (FY) 2008 – 2011Completed
    Keywords JEMS / 子宮内膜症 / がん化 / 疫学研究
    Research Abstract This project is the prospective study "Investigation for malignant transformation of endometriosis in Japan". We have analyzed the personal data colle ...
    Research Products of this project Journal Article (32 results, of which Peer Reviewed: 29 results)   Presentation (45 results)   Remarks (5 results)
  • 13. Exploring the mechanism of cell proliferation and the novel molecular target therapy of endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    TERAKAWA Naoki Tottori University, Professor

    Project Period (FY) 2005 – 2007Completed
    Keywords Endometrinsis / TNFα / IL-8 / dienogest / NFkB pathway / ovarian endometrioma / GnRH antagonist / Cetrorelix
    Research Abstract We previous reported that the proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-8 are elevated in the peritoneal f ...
    Research Products of this project Journal Article (33 results, of which Peer Reviewed: 16 results)   Presentation (40 results)
  • 14. ヒト卵巣におけるSCF,HGFおよびKGFの発現と細胞間相互作用の解明

    Research Project

    Research Category

    Grant-in-Aid for Young Scientists (B)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    谷口 文紀 鳥取大学, 医学部附属病院, 助手

    Project Period (FY) 2002 – 2003Completed
    Keywords Ovary / MAPK / Signal transduction / progesterone / StAR / ERK
    Research Abstract ヒト卵巣顆粒膜細胞腫由来のKGN細胞を研究対象とした.KGN細胞におけるHGFとその受容体であるc-met遺伝子の発現をRT-PCRにて検索した.HGFを添加,培養して細胞増殖能をBrdU法で検討した.KGN細胞にゴナドトロピンあるいはHGFを添加し,48時間後の培養上清中のプロゲステロン(P4)濃 ...
    Research Products of this project Publications (5 results)
  • 15. Role of matrix met alloprot einases and cytokines in the development of endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University School of Medicine
    Principal Investigator

    TERAKAWA Naoki Tottori Univ., Dept.Obst et.Gynecol., Professor

    Project Period (FY) 2002 – 2003Completed
    Keywords Endometriosis / Development and progression / Endometriotic stromal cells / Cytokine TNFα / IL-8 / Nuclear fact or-κB / Estrogen / GnRH agonist
    Research Abstract It is believed that the extracellular matrix (ECM) remodeling is relevant to the development and the progression of endometriosis. Tissue remodeling i ...
    Research Products of this project Publications (24 results)
  • 16. Development of anti-cytokine drugs for treatment of endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University School of Medicine
    Principal Investigator

    HARADA Tasuku Tottori Univ., Dept.Obstet.Gunecol., Assistant Professor

    Project Period (FY) 2001 – 2003Completed
    Keywords endometriosis / cytokine / interleukin-8 / tumor necrosis factor alpha / anti-TNF alpha antibody
    Research Abstract Peritoneal fluid (PF) in women with endometriosis contains an increased number of activated macrophages that secrete a variety of cytokines. We have p ...
    Research Products of this project Publications (39 results)
  • 17. 胚着床現象におけるFGF-10の遺伝子発現とその役割

    Research Project

    Research Category

    Grant-in-Aid for Encouragement of Young Scientists (A)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    谷口 文紀 鳥取大学, 医学部・附属病院, 助手

    Project Period (FY) 2000 – 2001Completed
    Keywords FGF-10 / KGF / 子宮内膜癌 / 子宮内膜細胞 / MAPキナーゼ / FGF / hCG分泌 / トロホブラスト / 子宮内膜間質細胞
    Research Abstract 線維芽細胞増殖因子(FGF)は、血管新生、創傷治癒などの領域において多機能な作用を有する生理活性物質である.Keratinocyte growth factor(KGF ; FGF-7)とFGF-10は間質細胞から産生され上皮細胞に作用する細胞増殖因子として注目されている,これまでに,子宮内膜間質細 ...
    Research Products of this project Publications (2 results)

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