KAKEN — Research Projects | Researcher Number: 60182929

1. A study on the effects of aromatherapy on menstrual period REM sleep loss

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Lifelong developmental nursing
Research Institution	The University of Shimane
Principal Investigator	Fujita Sayaka 島根県立大学, 看護栄養学部, 教授
Project Period (FY)	2016-04-01 – 2023-03-31Completed
Keywords	月経周期 / 睡眠 / エストラジオール / プロゲステロン / コルチゾール / 芳香療法 / 自律神経機能 / 女性ホルモン / ストレス / ホルモン / 母性・女性看護学
Outline of Final Research Achievements	PMS symptoms include changes in sleep quality.Female hormones fluctuate during the month.The effects of female hormones may affect autonomic nerve fun ...

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results, Open Access: 1 results) Presentation (3 results)

2. A study examining the mechanism underlying the determination of the normal body temperature

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology(including physical medicine and nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE TATSUO 鳥取大学, 医学部, 教授
Project Period (FY)	2015-04-01 – 2018-03-31Completed
Keywords	体温 / 受精卵 / 視床下部 / マウス / 胎生期 / エピジェネティスク / 遺伝子発現 / 次世代シークエンサー / real-time RT-PCR / エポキシゲナーゼ
Outline of Final Research Achievements	We investigated the effect of changes in environmental temperature at the onset of life on the body temperature in mice. As a result, body temperature ...

Research Products of this project	Journal Article (6 results, of which Int'l Joint Research: 5 results, Peer Reviewed: 3 results, Open Access: 4 results) Presentation (9 results, of which Int'l Joint Research: 1 results) Remarks (1 results)

3. Chronic stress and atopic dermatitis:Research on preventive and therapeutic effects of odorant and its mechanism

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE TATSUO 鳥取大学, 医学部, 教授
Project Period (FY)	2012-04-01 – 2015-03-31Completed
Keywords	アトピー性皮膚炎 / 香料 / ストレス / 皮膚バリア / 角質水分量 / ピクリルクロライド
Outline of Final Research Achievements	We investigated whether inhalation of green odor or rose odor cures and/or prevents the atopic dermatitis (AD) induced in mice and human. The green od ...

Research Products of this project	Journal Article (6 results, of which Peer Reviewed: 6 results, Open Access: 1 results) Presentation (6 results) Remarks (1 results)

4. Exercise therapy for hypertension and diabetes mellitus: involvement of cross-adaptation to stress via inhibition of sympathetic nervous system

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Sports science
Research Institution	Tottori University
Principal Investigator	MIYOSHI Michio 鳥取大学, 医学部, 助教
Project Period (FY)	2010 – 2012Completed
Keywords	運動とトレーニング / 慢性運動 / ストレス / 交感神経 / 高血圧 / トレーニング / ノルエピネフリン / SHRラット / 運動療法 / アドレナリン / ノルアドレナリン / 運動 / 糖尿病
Research Abstract	We investigated effects of 4-weeks’ running training on the increases in blood pressure (BP) and catecholamine levels induced by a novel stress (immob ...

Research Products of this project	Journal Article (11 results, of which Peer Reviewed: 11 results) Presentation (10 results) Remarks (3 results)

5. Chronic stress and depressive disorder : Research on preventive effect of odorant and its mechanism

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE Tatsuo 鳥取大学, 医学部, 教授
Project Period (FY)	2009 – 2011Completed
Keywords	ストレス / うつ病 / 前頭前皮質 / 海馬 / 神経新生 / doublecortin / c-fos / Zif268 / 酪酸 / 緑の香り / 強制水泳試験 / 学習性無力試験 / immobility time / failure / ラット / 視床下部 / 下垂体 / 副腎
Research Abstract	We investigated whether inhalation of green odor(a mixture of equal amounts of trans-2-hexenal and cis-3-hexenal) cures and/or prevents the depressive ...

Research Products of this project	Journal Article (15 results, of which Peer Reviewed: 15 results) Presentation (16 results) Remarks (3 results)

6. Investigation on the mechanism underlying antipyretic effect of atrial natriuretic peptide within the brain

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE Tatsuo Tottori University
Project Period (FY)	2007 – 2008Completed
Keywords	心房性利尿ペプチド / 細菌性内毒素 / 発熱 / 脳 / 視床下部 / インターロイキン1 / 心房性ナトリウム利尿ペプチド / LPS / real-time RT-PCR / プロスタグランディン / ANP / 視束前野 / 前部視床下部 / 光顕免疫染色法 / サイトカイン / PGE_2
Research Abstract	本研究では、心房性ナトリウム利尿ペプチド(ANP)が脳内の"どこ"で"どの様"に発熱抑制に働くのかについてin vivoの実験系を用いて詳細に検討した。その結果、視床下部のANPによる発熱抑制と発熱時の視床下部でのANPやC-Type NP (CNP)さらにはインターロイキン1のmRNA発現を見いだ ...

Research Products of this project	Journal Article (5 results, of which Peer Reviewed: 5 results) Presentation (5 results)

7. Angiotensin II inside and outside the brain: investigation on the mechanism of angiotensin II-induced

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General internal medicine (including Psychosomatic medicine)
Research Institution	Tottori University
Principal Investigator	MIYOSHI Michio Tottori University, Faculty of Medicine, Research Associate
Project Period (FY)	2005 – 2006Completed
Keywords	ANG II / LPS / cytokines / microglial cell / NF-κB / AP-1 / NO / morphological change
Research Abstract	We investigated whether proinflammatory transcription factors [nuclear factor-κB (NF-κB) and activator protein-1 (AP-1)] contribute to the angiotensin ...

Research Products of this project	Journal Article (13 results)

8. Investigation on atrial natriuretic peptide as an endogenous antipyretic

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE Tatsuo Tottori University, Faculty of Medicine, Professor
Project Period (FY)	2005 – 2006Completed
Keywords	ANP / LPS / IL-1 / fever / rat / NF-κB / AP-1 / microglial cell
Research Abstract	We investigated whether natriuretic peptide (NP) acts as an endogenous antipyretic inside and/or outside the blood-brain barrier in rats made febrile ...

Research Products of this project	Journal Article (19 results)

9. Taste abnormality induced by stresses and improvement by exercise : Focusing on rare metal ions in plasma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Sports science
Research Institution	Tottori University
Principal Investigator	IMOTO Toshiaki Tottori University, Faculty of Medicine, Associate Prof.
Project Period (FY)	2005 – 2006Completed
Keywords	taste / stress / licking / rat / rare metal ions / two bottle choice method
Research Abstract	Present studies were performed to clarify the effect of various stresses on taste preference and/or sensitivity of rats based on the observation of ta ...

10. Analysis of unknown cryogens existing in the blood of a hypothermic patient

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Shimane University
Principal Investigator	SHIDO Osamu Shimane University Faculty of Medicine, Environmental Physiology, Professor
Project Period (FY)	2004 – 2006Completed
Keywords	hypothermia / cryogen / Protein / thermoregulation
Research Abstract	We further attempted to identify unknown cryogen(s) existing in the blood of a hypothermic patient. The patient's serum was divided into two fractions ...

Research Products of this project	Journal Article (19 results) Book (3 results)

11. Title of project : Mechanisms underlying angiotensin II-stimulated production of proinflammatory cytokines : Are transcription factors involved?

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	National University Corporation Tottori University
Principal Investigator	WATANABE Tatsuo Tottori University, Faculty of Medicine, Professor
Project Period (FY)	2003 – 2004Completed
Keywords	angiotensin II / AT_1 receptor / NF-κB / AP-1 / LPS / IL-1 / rat
Research Abstract	We recently reported an involvement of angiotensin II(ANG II) and ANG type 1(AT1) receptor in the hepatic, splenic and brain expression of IL-1ss indu ...

Research Products of this project	Journal Article (7 results) Publications (3 results)

12. Identification of Novel Human Cryogen and the Mechanism of Hypothermia

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Shimane University, School of Medicine
Principal Investigator	SHIDO Osamu Shimane University, School of Medicine, Environmental Physiology, Professor
Project Period (FY)	2002 – 2003Completed
Keywords	hypothermia / endogenous cryogen / thermogenic threshold / thermoregulation / electrophoresis / mass spectrometr
Research Abstract	We experienced a hypothermic patient, i.e., a young female who suffered from severe hypothermia in a cool environment. Although various medical and ph ...

Research Products of this project	Publications (3 results)

13. Studies on the involvement of intrahypothalamic angiotensin type 2 receptors in the development of fever in rats

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE Tatsuo Tottori University, Faculty of Medicine, Professor
Project Period (FY)	2001 – 2002Completed
Keywords	Angiotensin II / AT2receptor / Fever / Hypothalamus / Immunohistochemistry / LPS / Rat
Research Abstract	We have recently found that angiotensin II (ANG II) type 2 receptors within the hypothalamus (preoptic and anterior hypothalamic region) play an impor ...

Research Products of this project	Publications (6 results)

14. Is angiotensin II involved in dehydration-enhanced fever induced by endotoxin in rats ?

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	MIYOSHI Michio Tottori University, Faculty of Medicine, Assistant
Project Period (FY)	2000 – 2001Completed
Keywords	Angiotensin II / dehydration / angiotensin-converting enzyme inhibitor / Fever / interleukin-1β / interleukin-6 / mRNA / Angiotensin II type 1 receptor antagonist
Research Abstract	It has been reported that a host develops a marked fever under dehydrated conditions compared with normally hydrated conditions. The present study was ...

Research Products of this project	Publications (6 results)

15. Intrahypothalamic secretion of angiotensin II in response to immunological or non-immunological stress in rats : a microdialysis study

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Tottori University
Principal Investigator	WATANABE Tatsuo Tottori University Faculty of Medicine Professor
Project Period (FY)	1999 – 2000Completed
Keywords	Angiotensin II / Microdialysis / Stress / Fever / Hypothalamus
Research Abstract	We previously reported that brain angiotensin II (ANG II) receptors contribute to the fever induced by immunological or non-immunological stress in ra ...

Research Products of this project	Publications (5 results)

16. 母体脳は胎仔脳の発達を制御しているか?

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Embryonic/Neonatal medicine
Research Institution	Yamaguchi University
Principal Investigator	中村彰治山口大学, 医学部, 教授
Project Period (FY)	1998 – 1999Completed
Keywords	母児相関 / 胎盤 / 胎仔 / 胎仔脳 / 視床下部 / 脳の発達 / BDNF / Fos / 発達 / 母体-胎仔相関 / 神経栄養因子
Research Abstract	本研究の目的は、母体脳が胎仔脳の発達・分化に重要な役割をはたしているかどうかを検討することである。そのために,母体脳の視床下部内側部を電気刺激が、胎仔脳での神経栄養因子の発現に影響を与えるかどうかを検討した。まず、この実験を行う前にラット胎仔期での脳由来神経栄養因子(BDNF)の発現の発達についてB ...

Research Products of this project	Publications (11 results)

17. Role of angiotensin II type 2 receptors in the development of stress-induced hyperthermia in mouse : a knockout mouse study

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Yamaguchi University
Principal Investigator	WATANABE Tatsuo Yamaguchi University School of Medicine, Associate Professor
Project Period (FY)	1997 – 1998Completed
Keywords	Angiotensin II / Angiotensin receptors / Stress / Knockout mouse / Fever
Research Abstract	We investigated the effect of angiotensin II type 2 receptor (AT_2)-gene disruption on the hyperthermia induced by immunological [Iinterleukin-1 (IL- ...

Research Products of this project	Publications (5 results)

18. 発熱性サイトカインによるACTH反応及び循環反応への脳内アンギオテンシンIIの関与

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Yamaguchi University
Principal Investigator	渡邊達生山口大学, 医学部, 助教授
Project Period (FY)	1996Completed
Keywords	インターロイキン1 / アンギオテンシンII / アンギオテンシンIIレセプター / プロスタグランディンE / 発熱 / ACTH反応 / 循環反応
Research Abstract	ストレス及び発熱時には、体温、血圧、心拍数の上昇反応が起こる。また同時に血漿ACTH濃度の増大反応が発現する。現在では、これらの反応にインターロイキン1の関与が想定されている。近年私達は、ストレス時の体温上昇反応にアンギオテンシンIIの関与を示唆する結果を得た。そこで今回の研究ではまず、インターロイ ...

Research Products of this project	Publications (3 results)

19. Interleukin-1 production in the brain of febile and stress tolerant rabbits

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Yamaguchi Univ.
Principal Investigator	WATANABE Tatsuo Dept.Physiol., Yamaguchi Univ.Sch.Med., Associate professor
Project Period (FY)	1994 – 1995Completed
Keywords	LPS / Interleukin-1beta / Febrile tolerance / Organum vasculosum laminae terminalis / in situ hybridization / immunohistochemistry
Research Abstract	Interleukin-1beta (IL-1beta) production in the brain was investigated in rabbits made tolerant to lipopolysaccharide (LPS). The LPS-tolerant rabbits w ...

Research Products of this project	Publications (4 results)

20. インターロイキン1によるACTH反応における末梢化学受容器の関与

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Yamaguchi University
Principal Investigator	渡邊達生山口大学, 医学部, 助教授
Project Period (FY)	1993Completed
Keywords	ACTH / インターロイキン1 / プロスタグランディンE / キャプサイシン
Research Abstract	求心性C神経線維のACTH増大反応への関与の有無を調べるために求心性C神経線維を変性させる処置として有名なキャプサイシン脱感作をラットに行ない、インターロイキン1あるいはプロスタグランディンEを全身に投与した。キャプサイシン一回投与後に観察される体温下降はキャプサイシン脱感作により消失するが、この様 ...

Research Products of this project	Publications (1 results)

Project Period (Start Year [FY])

1. A study on the effects of aromatherapy on menstrual period REM sleep loss Research Project

Fujita Sayaka 島根県立大学, 看護栄養学部, 教授

2. A study examining the mechanism underlying the determination of the normal body temperature Research Project

WATANABE TATSUO 鳥取大学, 医学部, 教授

3. Chronic stress and atopic dermatitis:Research on preventive and therapeutic effects of odorant and its mechanism Research Project

WATANABE TATSUO 鳥取大学, 医学部, 教授

4. Exercise therapy for hypertension and diabetes mellitus: involvement of cross-adaptation to stress via inhibition of sympathetic nervous system Research Project

MIYOSHI Michio 鳥取大学, 医学部, 助教

5. Chronic stress and depressive disorder : Research on preventive effect of odorant and its mechanism Research Project

WATANABE Tatsuo 鳥取大学, 医学部, 教授

6. Investigation on the mechanism underlying antipyretic effect of atrial natriuretic peptide within the brain Research Project

WATANABE Tatsuo Tottori University

7. Angiotensin II inside and outside the brain: investigation on the mechanism of angiotensin II-induced Research Project

MIYOSHI Michio Tottori University, Faculty of Medicine, Research Associate

8. Investigation on atrial natriuretic peptide as an endogenous antipyretic Research Project

WATANABE Tatsuo Tottori University, Faculty of Medicine, Professor

9. Taste abnormality induced by stresses and improvement by exercise : Focusing on rare metal ions in plasma Research Project

IMOTO Toshiaki Tottori University, Faculty of Medicine, Associate Prof.

10. Analysis of unknown cryogens existing in the blood of a hypothermic patient Research Project

SHIDO Osamu Shimane University Faculty of Medicine, Environmental Physiology, Professor

11. Title of project : Mechanisms underlying angiotensin II-stimulated production of proinflammatory cytokines : Are transcription factors involved? Research Project

WATANABE Tatsuo Tottori University, Faculty of Medicine, Professor

12. Identification of Novel Human Cryogen and the Mechanism of Hypothermia Research Project

SHIDO Osamu Shimane University, School of Medicine, Environmental Physiology, Professor

13. Studies on the involvement of intrahypothalamic angiotensin type 2 receptors in the development of fever in rats Research Project

WATANABE Tatsuo Tottori University, Faculty of Medicine, Professor

14. Is angiotensin II involved in dehydration-enhanced fever induced by endotoxin in rats ? Research Project

MIYOSHI Michio Tottori University, Faculty of Medicine, Assistant

15. Intrahypothalamic secretion of angiotensin II in response to immunological or non-immunological stress in rats : a microdialysis study Research Project

WATANABE Tatsuo Tottori University Faculty of Medicine Professor

16. 母体脳は胎仔脳の発達を制御しているか? Research Project

中村 彰治 山口大学, 医学部, 教授

17. Role of angiotensin II type 2 receptors in the development of stress-induced hyperthermia in mouse : a knockout mouse study Research Project

WATANABE Tatsuo Yamaguchi University School of Medicine, Associate Professor

18. 発熱性サイトカインによるACTH反応及び循環反応への脳内アンギオテンシンIIの関与 Research Project

渡邊 達生 山口大学, 医学部, 助教授

19. Interleukin-1 production in the brain of febile and stress tolerant rabbits Research Project

WATANABE Tatsuo Dept.Physiol., Yamaguchi Univ.Sch.Med., Associate professor

20. インターロイキン1によるACTH反応における末梢化学受容器の関与 Research Project

渡邊 達生 山口大学, 医学部, 助教授

1. A study on the effects of aromatherapy on menstrual period REM sleep loss

Research Project

2. A study examining the mechanism underlying the determination of the normal body temperature

Research Project

3. Chronic stress and atopic dermatitis:Research on preventive and therapeutic effects of odorant and its mechanism

Research Project

4. Exercise therapy for hypertension and diabetes mellitus: involvement of cross-adaptation to stress via inhibition of sympathetic nervous system

Research Project

5. Chronic stress and depressive disorder : Research on preventive effect of odorant and its mechanism

Research Project

6. Investigation on the mechanism underlying antipyretic effect of atrial natriuretic peptide within the brain

Research Project

7. Angiotensin II inside and outside the brain: investigation on the mechanism of angiotensin II-induced

Research Project

8. Investigation on atrial natriuretic peptide as an endogenous antipyretic

Research Project

9. Taste abnormality induced by stresses and improvement by exercise : Focusing on rare metal ions in plasma

Research Project

10. Analysis of unknown cryogens existing in the blood of a hypothermic patient

Research Project

11. Title of project : Mechanisms underlying angiotensin II-stimulated production of proinflammatory cytokines : Are transcription factors involved?

Research Project

12. Identification of Novel Human Cryogen and the Mechanism of Hypothermia

Research Project

13. Studies on the involvement of intrahypothalamic angiotensin type 2 receptors in the development of fever in rats

Research Project

14. Is angiotensin II involved in dehydration-enhanced fever induced by endotoxin in rats ?

Research Project

15. Intrahypothalamic secretion of angiotensin II in response to immunological or non-immunological stress in rats : a microdialysis study

Research Project

16. 母体脳は胎仔脳の発達を制御しているか?

Research Project

中村彰治山口大学, 医学部, 教授

17. Role of angiotensin II type 2 receptors in the development of stress-induced hyperthermia in mouse : a knockout mouse study

Research Project

18. 発熱性サイトカインによるACTH反応及び循環反応への脳内アンギオテンシンIIの関与

Research Project

渡邊達生山口大学, 医学部, 助教授

19. Interleukin-1 production in the brain of febile and stress tolerant rabbits

Research Project

20. インターロイキン1によるACTH反応における末梢化学受容器の関与

Research Project

渡邊達生山口大学, 医学部, 助教授