KAKEN — Research Projects | Researcher Number: 70182194

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1. 哺乳動物の小胞体関連分解における小胞体内イベントの全容解明

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Review Section	Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Research Institution	Kyoto University
Principal Investigator	森和俊京都大学, 高等研究院, 特別教授
Project Period (FY)	2022-04-01 – 2025-03-31Granted
Keywords	小胞体関連分解 / 構造異常の度合い / オルガネラ
Outline of Research at the Start	本研究は小胞体関連分解の分子機構に焦点を当て、小胞体内で連続的に行われるイベントに割り当てられた分子が実際にどのように働いているのかを、構造異常の度合いによって分解経路が変わるという独自の視点下で、ゲノム編集法や生化学的手法により精緻に解析し、シャペロンによる高次構造形成と小胞体関連分解がいかに協調 ...
Outline of Annual Research Achievements	小胞体において構造異常となったタンパク質は細胞質へ逆向き輸送され、ユビキチン・プロテアソーム系により分解されて恒常性が維持される。この小胞体関連分解の哺乳動物における分子機構に関し、申請者は逆遺伝学を初めて導入し、分解基質認識の初期ステップである糖鎖プロセシングに関与する酵素がEDEM2およびEDE ...
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

2. Analysis of sorting zones involved in protein quality control in the endoplasmic reticulum

Planned Research

Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Review Section	Biological Sciences
Research Institution	Kyoto University
Principal Investigator	Mori Kazutoshi 京都大学, 理学研究科, 教授
Project Period (FY)	2017-06-30 – 2022-03-31Completed
Keywords	オルガネラ / オルガネラ・ゾーン / 小胞体 / 輸送 / タンパク質分解 / 小胞体ストレス / 超解像顕微鏡 / ゴルジ体 / 小胞輸送 / 選別 / 応答
Outline of Final Research Achievements	In this study, the following results were obtained for three organelle zones. Sorting zone: we visualized the intracellular transport of the endoplasm ...
Project Area	Toward an integrative understanding of functional zones in organelles

Research Products of this project	Int'l Joint Research (1 results) Journal Article (44 results, of which Int'l Joint Research: 5 results, Peer Reviewed: 42 results, Open Access: 27 results) Presentation (57 results, of which Int'l Joint Research: 8 results, Invited: 14 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results, of which Overseas: 1 results)

3. Toward an integrative understanding of functional zones in organelles

Administrative Group

Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Review Section	Biological Sciences
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Shimizu Shigeomi 東京医科歯科大学, 難治疾患研究所, 教授
Project Period (FY)	2017-06-30 – 2022-03-31Completed
Keywords	オルガネラ / 小胞体 / ゴルジ体 / ミトコンドリア / ゾーン / 細胞生物 / エンドソーム / 超解像顕微鏡
Outline of Final Research Achievements	Each research group demonstrated that more than 30 "organelle zones" exist in organelles in various life phenomena and that they form physiologically ...
Project Area	Toward an integrative understanding of functional zones in organelles

Research Products of this project	Int'l Joint Research (13 results) Journal Article (111 results, of which Int'l Joint Research: 16 results, Peer Reviewed: 93 results, Open Access: 15 results) Presentation (48 results, of which Int'l Joint Research: 44 results, Invited: 26 results) Book (1 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results, of which Overseas: 1 results) Funded Workshop (1 results)

4. Analysis of recognition mechanisms of misfoled proteins accumulated in the endoplasmic reticulum

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Cell biology
Research Institution	Kyoto University
Principal Investigator	Mori Kazutoshi 京都大学, 理学研究科, 教授
Project Period (FY)	2017-04-01 – 2020-03-31Completed
Keywords	構造異常タンパク質 / 認識 / 分解 / 小胞体ストレス応答 / 小胞体関連分解 / 小胞体 / 強制分解 / 認識機構
Outline of Final Research Achievements	Protein must gain correct tertiary and quaternary structure to fulfill its function assigned by the genetic code. Misfolded proteins are harmful to th ...

Research Products of this project	Int'l Joint Research (1 results) Journal Article (11 results, of which Int'l Joint Research: 2 results, Peer Reviewed: 11 results, Open Access: 4 results) Presentation (20 results, of which Int'l Joint Research: 7 results, Invited: 20 results) Remarks (3 results)

5. Elucidation of regulation mechanism of the endoplasmic reticulum membrane-bound transcription factor ATF6 and its role in the evolution of vertebrates

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Cell biology
Research Institution	Kyoto University
Principal Investigator	Mori Kazutoshi 京都大学, 理学(系)研究科(研究院), 教授
Project Period (FY)	2014-04-01 – 2017-03-31Completed
Keywords	タンパク質品質管理 / 小胞体 / 転写因子 / 分子シャペロン / 小胞体関連分解 / ゴルジ体 / エスコート / 進化 / 細部内情報伝達 / 小胞体ストレス / 小胞輸送 / 膜結合性転写因子 / エスコートタンパク質
Outline of Final Research Achievements	The endoplasmic reticulum (ER) membrane-bound transcription factor ATF6 is a protein with a short half-life of 2 h and constitutively subjected to gly ...

Research Products of this project	Journal Article (4 results, of which Peer Reviewed: 4 results, Open Access: 4 results, Acknowledgement Compliant: 4 results) Presentation (8 results, of which Invited: 1 results) Remarks (3 results)

6. Physiological and pathological role of the endoplasmic reticulum stress transducer protein ATF6beta

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Pathological medical chemistry
Research Institution	The University of Tokushima
Principal Investigator	OYADOMARI Seiichi 徳島大学, 先端酵素学研究所(プロテオ), 教授
Project Period (FY)	2013-04-01 – 2017-03-31Completed
Keywords	分子病態学 / 小胞体ストレス / ATF6
Outline of Final Research Achievements	The living organisms have a response against unfolded proteins in the endoplasmic reticulum (ER), the so-called UPR. ATF6 is a main regulator of the U ...

Research Products of this project	Journal Article (13 results, of which Peer Reviewed: 13 results) Presentation (49 results, of which Invited: 1 results) Book (1 results)

7. Analysis of molecular mechanism of sensing endoplasmic reticulum stress and effect of failing in the endoplasmic reticulum stress response

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Cell biology
Research Institution	Kyoto University
Principal Investigator	MORI Kazutoshi Kyoto University
Project Period (FY)	2008 – 2010Completed
Keywords	小胞体 / 分子シャペロン / 転写誘導 / 膜結合性転写因子 / ノックアウトマウス / 選別輸送 / 還元 / 脂肪滴 / アポリポプロテイン / 心不全
Research Abstract	The endoplasmic reticulum (ER) membrane-bound transcription factor ATF6 translocates to the Golgi apparatus upon ER stress to be activated by proteoly ...

Research Products of this project	Journal Article (9 results, of which Peer Reviewed: 9 results) Presentation (4 results) Remarks (2 results)

8. Pathophysiological Role of ER-Ubiquitin/Proteasome System in Cardiovascular Remodeling

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Circulatory organs internal medicine
Research Institution	Osaka University
Principal Investigator	MINAMINO Tetsuo Osaka University
Project Period (FY)	2007 – 2008Completed
Keywords	小胞体ストレス / 心不全 / 心不全指標 / プロテアソーム / 心筋虚血 / 動脈硬化 / CHOP / 冠動脈プラーク破綻
Research Abstract	我が国での心不全患者数は増加しているが、その治療法は確立していない。心不全患者の予後改善・発症予防のためには、1)心筋細胞死の抑制、2)冠動脈プラーク破綻の抑制が有効であると考えられる。本研究では、蛋白の修飾・分解をつかさどる小胞体・ユビキチン/プロテアソーム系の異常が心筋細胞死や冠動脈破綻に深く関 ...

Research Products of this project	Journal Article (8 results, of which Peer Reviewed: 8 results) Presentation (4 results) Book (4 results) Patent(Industrial Property Rights) (2 results)

9. Maintenance of the endoplasmic reticulum function by the unfolded protein response (UPR)

Planned Research

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Kyoto University
Principal Investigator	MORI Kazutoshi 京都大学, 大学院・理学研究科, 教授
Project Period (FY)	2007 – 2011Completed
Keywords	小胞体 / 高次構造形成 / 分子シャペロン / タンパク質分解 / 品質管理 / 転写誘導 / 翻訳抑制 / 遺伝子ノックアウト / メダカ / 初期発生 / 脊索 / ニワトリ細胞 / オルガネラ / スプライシング / 翻訳 / 転写 / 脂質 / プロテアソーム / 分解 / フォールディング / 転写透導 / オルガネラ形成 / 生体膜 / リン脂質 / B細胞分化
Research Abstract	We discovered that unfolded proteins accumulate in the endoplasmic reticulum (ER) of the notochord during medaka early embryonic development, that med ...
Project Area	Protein community: organization and maintenance of protein functions

Research Products of this project	Journal Article (29 results, of which Peer Reviewed: 29 results) Presentation (12 results) Remarks (3 results)

10. Integrated promotion of the researches in protein community

Administrative Group

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Nagoya University
Principal Investigator	ENDO Toshiya 名古屋大学, 大学院・理学研究科, 教授
Project Period (FY)	2007 – 2012Completed
Keywords	タンパク質 / 機能発現 / 品質管理 / 分子シャペロン / トランスロケータ / UPR / アミロイド / ERAD
Research Abstract	研究成果取りまとめのための会議を主要メンバーにより,5月4日,5月8日,5月16日,7月12日,8月19日,8月23日,9月11日に行った。海外アドバイザーのUlrich Hartl教授(独マックスプランク研究所)を6月に名古屋に招聘して,本領域のこれまでの研究について評価いただくとともに,今後の研 ...
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.
Project Area	Protein community: organization and maintenance of protein functions

Research Products of this project	Presentation (4 results) Remarks (8 results)

11. Dynamics of the function and regulation of the endoplasmic reticulum

Research Project

Research Category	Grant-in-Aid for Creative Scientific Research
Research Institution	Kyoto University
Principal Investigator	KAZUTOSHI Mori Kyoto University, Graduate School of Science, Professor
Project Period (FY)	2003 – 2007Completed
Keywords	endoplasmic reticulum / transcription factor / Golgi apparatus / proteolysis / knockout mice / embryonic fibroblast / stress sensing / reduction
Research Abstract	In mammals, endoplasmic reticulum (ER) stress is sensed and transduced by three ubiquitously expressed transmembrane proteins in the ER (IRE1, PERK an ...

Research Products of this project	Journal Article (99 results, of which Peer Reviewed: 44 results) Presentation (21 results) Publications (6 results)

12. 小胞体膜結合性転写因子ATF6の細胞内ダイナミックス

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Cell biology
Research Institution	Kyoto University
Principal Investigator	森和俊京大, 生命科学研究科, 助教授
Project Period (FY)	2002 – 2003Completed
Keywords	小胞体 / 膜結合性転写因子 / 分子シャペロン / プロテオリシス / セリンプロテアーゼ / メタロプロテアーゼ / 細胞内輸送 / フォールディング
Research Abstract	ATF6は、小胞体に埋め込まれた形で恒常的に発現している膜結合性転写因子であり、小胞体ストレス下で小胞体内に高次構造の異常なタンパク質が蓄積するとプロテオリシスを受けて活性化される。つまり、切断されて膜から遊離した細胞質側の転写因子ドメインが核へ移行して主として小胞体シャペロンをコードする遺伝子の転 ...

Research Products of this project	Publications (1 results)

13. Analysis of an intracellular signaling from the endoplasmic reticulum to the nucleus

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Kyoto University
Principal Investigator	MORI Kazutoshi Kyoto University, Kyoto University, Graduate School of Science, Professor
Project Period (FY)	2002 – 2006Completed
Keywords	molecular chaperone / endoplasmic reticulum / folding / degradation / transcriptional induction / protease / mRNA splicing / quality control
Research Abstract	The endoplamic reticulum (ER) is the place for folding and quality control of newly synthesized secretory and transmembrane proteins. When unfolded pr ...

Research Products of this project	Journal Article (12 results, of which Peer Reviewed: 3 results) Presentation (1 results) Publications (4 results)

14. ウィルス感染と宿主小胞体ストレス応答-ウィルスの増殖と細胞死との分岐点の解析

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section	Biological Sciences
Research Institution	Kyoto University
Principal Investigator	森和俊京都大学, 大学院・生命科学研究科, 助教授
Project Period (FY)	2001Completed
Keywords	ウィルス / ストレス / 小胞体 / 転写誘導 / アポトーシス / ミトコンドリア / マクロファージ / 一酸化窒素
Research Abstract	ウィルスが感染した細胞では小胞体ストレス応答機構を介して、小胞体の恒常性維持(ひいてはウィルスの増殖促進)に働く遺伝子(小胞体に存在する分子シャペロン等)と細胞死を誘起する遺伝子(転写因子CHOP)の両方が活性化されており、生と死を指向するシグナルが小胞体から同時発信していると考えられている。このよ ...

Research Products of this project	Publications (1 results)

15. Life of proteins: maturation, translocation, quality control in the cell

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Tokyo Institute of Technology
Principal Investigator	YOSHIDA Masasuke Tokyo Institute of Technology
Project Period (FY)	2001 – 2007Completed
Keywords	molecular chperone / ER stress / translocation / prion / ERAD / lipoprobin / disulfidebond formation / ATP dependent protease
Research Abstract	2003-2007年度の5年にわたる特定領域研究「蛋白質の一生」の成果取りまとめを以下のように行った。まず、研究成果報告書(250ページ)を作成した。これは、計画班員(12名)と公募班員(115名)の全員が各自の成果を述べて発表論文と海外の国際学会で口頭発表(招待講演、あるいはこれに準じる講演)をリ ...

Research Products of this project	Journal Article (36 results, of which Peer Reviewed: 3 results) Presentation (2 results) Book (3 results) Remarks (1 results) Publications (19 results)

16. Analysis of the UPR, a transcriptional induction process coupled with intracellular signaling from the endoplasmic reticulum to the nucleus

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Cell biology
Research Institution	KYOTO UNIVERSITY
Principal Investigator	MORI Kazutoshi Kyoto University, Graduate School of Biostudies, Associate professor
Project Period (FY)	2000 – 2001Completed
Keywords	endoplasmic reticulum / molecular chaperone / folding enzymes / intracellular signaling / transcriptional induction / transcription factor / proteolysis / nuclear translocation
Research Abstract	By 1999, we showed that the human basic leucine zipper protein ATF6 we isolated as a transcription factor specific to the mammalian UPR is constitutiv ...

Research Products of this project	Publications (12 results)

17. 神経ネットワーク形成における低分子量G蛋白質の役割

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas (A)
Review Section	Biological Sciences
Research Institution	Kyoto University
Principal Investigator	根岸学京都大学, 生命科学研究科, 教授
Project Period (FY)	2000Completed
Keywords	Rho / Rnd / Rac / Cdc42 / NGF / PC12細胞 / 神経突起 / 神経回路
Research Abstract	神経突起の伸長・退縮の調節に、低分子量G蛋白質Rhoファミリーが深く関与しており、細胞骨格の再構築によりRhoは神経突起の退縮を、Rac、Cdc42は突起伸長を引き起こす。我々は、PC12細胞で突起形成能に違いがあるNGFとEGFの細胞内情報伝達の違いを検討した。NGFはPI3K依存的にRac1を活 ...

Research Products of this project	Publications (6 results)

18. Development of the Enzyme Immunoassay Systems for the Substances Involved in the Cause of Alzheimer's Disease

Research Project

Research Category	Grant-in-Aid for Developmental Scientific Research
Research Field	Neurology
Research Institution	Gifu Pharmaceutical University
Principal Investigator	HAYASHI Kyozo Gifu Pharmaceutical University Pharmacy Professor
Project Period (FY)	1988 – 1989Completed
Keywords	Alzhermer's disease / cholinergic nerve cells / nerve growth factor (NGF) / superoxide dismutase (SOD) / enzyme immunoassay system (EIA) / antibody / diagnosis / astoglial cells
Research Abstract	Alzheimer's disease is a disease of unknown cause that is characterized by a progressive loss of memory and other cognitive functions, leading to a se ...

Research Products of this project	Publications (46 results)

19. Biochemical Studies on the Molecular Mechanism of Neurotransmission, Centered on Nicotinic Acetylcholine Receptor (nAChR)

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	Neurology
Research Institution	Gifu Pharmaceutical University
Principal Investigator	HAYASHI Kyozo Gifu Pharmaceutical University Pharmacy, Professor
Project Period (FY)	1988 – 1989Completed
Keywords	Nicotinic Acetylcholine Receptor (nAChR) / Glycoprotein / Function / Phosphorylation / Carbohydrate Structure / 43KDa Proteins / Desensitization / Neurotransmission
Research Abstract	Nicotinic acetylcholine receptor (nAChR) is a membrane glycoprotein which functions as transmitter receptor at vertebrate neuromuscular synapses. nACh ...

Research Products of this project	Publications (39 results)

20. Studies on drug delivery and imaging for tumors by use of monoclonal antibodies against membrane enzymes

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	Gifu Pharmaceutical University
Principal Investigator	HIRANO Kazuyuki 岐阜薬科大学, 薬学部, 助教授
Project Period (FY)	1987 – 1988Completed
Keywords	Alkaline phosphatase / testicular tumor / ovarian cancer / imaging
Research Abstract	Contents of alkaline phosphatase isozymes in human normal tissues were determined by use of monoclonal immunocatalytical assays. Normal tissues contai ...

Research Products of this project	Publications (27 results)

Project Period (Start Year [FY])

1. 哺乳動物の小胞体関連分解における小胞体内イベントの全容解明 Research Project

森 和俊 京都大学, 高等研究院, 特別教授

2. Analysis of sorting zones involved in protein quality control in the endoplasmic reticulum Planned Research

Mori Kazutoshi 京都大学, 理学研究科, 教授

3. Toward an integrative understanding of functional zones in organelles Administrative Group

Shimizu Shigeomi 東京医科歯科大学, 難治疾患研究所, 教授

4. Analysis of recognition mechanisms of misfoled proteins accumulated in the endoplasmic reticulum Research Project

Mori Kazutoshi 京都大学, 理学研究科, 教授

5. Elucidation of regulation mechanism of the endoplasmic reticulum membrane-bound transcription factor ATF6 and its role in the evolution of vertebrates Research Project

Mori Kazutoshi 京都大学, 理学(系)研究科(研究院), 教授

6. Physiological and pathological role of the endoplasmic reticulum stress transducer protein ATF6beta Research Project

OYADOMARI Seiichi 徳島大学, 先端酵素学研究所(プロテオ), 教授

7. Analysis of molecular mechanism of sensing endoplasmic reticulum stress and effect of failing in the endoplasmic reticulum stress response Research Project

MORI Kazutoshi Kyoto University

8. Pathophysiological Role of ER-Ubiquitin/Proteasome System in Cardiovascular Remodeling Research Project

MINAMINO Tetsuo Osaka University

9. Maintenance of the endoplasmic reticulum function by the unfolded protein response (UPR) Planned Research

MORI Kazutoshi 京都大学, 大学院・理学研究科, 教授

10. Integrated promotion of the researches in protein community Administrative Group

ENDO Toshiya 名古屋大学, 大学院・理学研究科, 教授

11. Dynamics of the function and regulation of the endoplasmic reticulum Research Project

KAZUTOSHI Mori Kyoto University, Graduate School of Science, Professor

12. 小胞体膜結合性転写因子ATF6の細胞内ダイナミックス Research Project

森 和俊 京大, 生命科学研究科, 助教授

13. Analysis of an intracellular signaling from the endoplasmic reticulum to the nucleus Research Project

MORI Kazutoshi Kyoto University, Kyoto University, Graduate School of Science, Professor

14. ウィルス感染と宿主小胞体ストレス応答-ウィルスの増殖と細胞死との分岐点の解析 Research Project

森 和俊 京都大学, 大学院・生命科学研究科, 助教授

15. Life of proteins: maturation, translocation, quality control in the cell Research Project

YOSHIDA Masasuke Tokyo Institute of Technology

16. Analysis of the UPR, a transcriptional induction process coupled with intracellular signaling from the endoplasmic reticulum to the nucleus Research Project

MORI Kazutoshi Kyoto University, Graduate School of Biostudies, Associate professor

17. 神経ネットワーク形成における低分子量G蛋白質の役割 Research Project

根岸 学 京都大学, 生命科学研究科, 教授

18. Development of the Enzyme Immunoassay Systems for the Substances Involved in the Cause of Alzheimer's Disease Research Project

HAYASHI Kyozo Gifu Pharmaceutical University Pharmacy Professor

19. Biochemical Studies on the Molecular Mechanism of Neurotransmission, Centered on Nicotinic Acetylcholine Receptor (nAChR) Research Project

HAYASHI Kyozo Gifu Pharmaceutical University Pharmacy, Professor

20. Studies on drug delivery and imaging for tumors by use of monoclonal antibodies against membrane enzymes Research Project

HIRANO Kazuyuki 岐阜薬科大学, 薬学部, 助教授

1. 哺乳動物の小胞体関連分解における小胞体内イベントの全容解明

Research Project

森和俊京都大学, 高等研究院, 特別教授

2. Analysis of sorting zones involved in protein quality control in the endoplasmic reticulum

Planned Research

3. Toward an integrative understanding of functional zones in organelles

Administrative Group

4. Analysis of recognition mechanisms of misfoled proteins accumulated in the endoplasmic reticulum

Research Project

5. Elucidation of regulation mechanism of the endoplasmic reticulum membrane-bound transcription factor ATF6 and its role in the evolution of vertebrates

Research Project

6. Physiological and pathological role of the endoplasmic reticulum stress transducer protein ATF6beta

Research Project

7. Analysis of molecular mechanism of sensing endoplasmic reticulum stress and effect of failing in the endoplasmic reticulum stress response

Research Project

8. Pathophysiological Role of ER-Ubiquitin/Proteasome System in Cardiovascular Remodeling

Research Project

9. Maintenance of the endoplasmic reticulum function by the unfolded protein response (UPR)

Planned Research

10. Integrated promotion of the researches in protein community

Administrative Group

11. Dynamics of the function and regulation of the endoplasmic reticulum

Research Project

12. 小胞体膜結合性転写因子ATF6の細胞内ダイナミックス

Research Project

森和俊京大, 生命科学研究科, 助教授

13. Analysis of an intracellular signaling from the endoplasmic reticulum to the nucleus

Research Project

14. ウィルス感染と宿主小胞体ストレス応答-ウィルスの増殖と細胞死との分岐点の解析

Research Project

森和俊京都大学, 大学院・生命科学研究科, 助教授

15. Life of proteins: maturation, translocation, quality control in the cell

Research Project

16. Analysis of the UPR, a transcriptional induction process coupled with intracellular signaling from the endoplasmic reticulum to the nucleus

Research Project

17. 神経ネットワーク形成における低分子量G蛋白質の役割

Research Project

根岸学京都大学, 生命科学研究科, 教授

18. Development of the Enzyme Immunoassay Systems for the Substances Involved in the Cause of Alzheimer's Disease

Research Project

19. Biochemical Studies on the Molecular Mechanism of Neurotransmission, Centered on Nicotinic Acetylcholine Receptor (nAChR)

Research Project

20. Studies on drug delivery and imaging for tumors by use of monoclonal antibodies against membrane enzymes

Research Project