Chromosome Orchestration System

2019 Fiscal Year Final Research Report

• Project Area: Chromosome Orchestration System
• Project/Area Number: 15H05970
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: Shirahige Katsuhiko 東京大学, 定量生命科学研究所, 教授 (90273854)
• Co-Investigator(Kenkyū-buntansha): 伊藤 武彦 東京工業大学, 生命理工学研究科, 教授 (90501106)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: 染色体高次構造 / 染色体機能 / ゲノム情報 / 染色体構築

Outline of Final Research Achievements

In this study, we aimed to understand the mechanism of the harmony of chromosome functions (Chromosome Orchestration System: Chromosome OS) through the reconstruction of three-dimensional structure of chromosomes and the acquisition of four-dimensional information. The knowledge obtained in this area has been integrated into a chromosome OS information platform, compiled into a database, and made available to the public. It is expected to contribute to the further development of life science as a whole, not only in the fields of epigenetics and chromosome biology, but also in the fields of drug discovery, clinical practice, etc. Model chromosomes, which were constructed through biochemical efforts in this field, have also caused a stir in the current genomics-oriented chromosomal field, and have laid the groundwork for biochemical approaches to delving deeper into the conundrum of chromosome structure control.

Free Research Field

ゲノム情報

Academic Significance and Societal Importance of the Research Achievements

本研究課題を通じて構築された染色体OS情報プラットフォームは、今後、染色体動態をゲノム学的視点から理解する基盤情報となるだけでなくエピゲノム、染色体分野をはじめ創薬、再生医療も含めた我が国の生命科学研究全般のさらなる発展に資することが期待できる。また、本分野で生化学的な取り組みにより構築されたモデル染色体も、現在のゲノム学中心の染色体高次構造研究に一石を投じ、染色体3D,4D構造の制御という難問に生化学的に迫ることが可能な基盤を築いた。