2022 Fiscal Year Final Research Report

Interplay of developmental clock and extracellular environment in brain formation

Administrative Group

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Project Area	Interplay of developmental clock and extracellular environment in brain formation
Project/Area Number	16H06479
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Allocation Type	Single-year Grants
Review Section	Biological Sciences
Research Institution	Institute of Physical and Chemical Research (2020, 2022) Kyoto University (2016-2019)
Principal Investigator	Kageyama Ryoichiro 国立研究開発法人理化学研究所, 脳神経科学研究センター, センター長 (80224369)
Co-Investigator(Kenkyū-buntansha)	見学美根子京都大学, 高等研究院, 教授 (10303801) 安達泰治京都大学, ウイルス・再生医科学研究所, 教授 (40243323) 永樂元次京都大学, ウイルス・再生医科学研究所, 教授 (40415097) 松田知己大阪大学, 産業科学研究所, 准教授 (50419206) 後藤由季子東京大学, 大学院薬学系研究科(薬学部), 教授 (70252525) 花嶋かりな早稲田大学, 教育・総合科学学術院, 准教授 (80469915) 仲嶋一範慶應義塾大学, 医学部(信濃町), 教授 (90280734)
Project Period (FY)	2016-06-30 – 2021-03-31
Keywords	脳構築 / 発生時計 / 神経幹細胞
Outline of Final Research Achievements	In this research area, researchers interacted with each other by holding an area group meeting and issuing a newsletter every year. As a result, many collaborative researches were carried out between the planning group members and the open recruitment group members. In addition, we supported exchanges of young researchers, collaborative research within the field, dispatch of young researchers to overseas laboratories, and presentations at international conferences. We also held a technical seminar on 3D culture of ES cells and shared this technology within the group. We also promoted the sharing of technologies related to gene expression oscillation imaging technology, optogenetic gene expression control technology, in utero electroporation, FRET probes, and optical manipulation technology. Through these activities, fruitful collaboration between planned research was promoted.
Free Research Field	神経科学
Academic Significance and Societal Importance of the Research Achievements	なぜ発生過程は決まったタイミング・順番で自律的に進むのか、どのような分子機構で発生時間が計られているのか、といった発生学の長年の疑問に対する明確な答えは無かった。本領域では、発生時間に関する解析手法と情報が集積している脳を中心に据え、同様のシステムを共有していると考えられる他の臓器構築過程も含めて、発生時計が場（細胞外環境）と連携して組織構築を制御する基本的な分子機構を明らかにした。