2021 Fiscal Year Final Research Report

Chemistry for Multimolecular Crowding Biosystems

Administrative Group

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Project Area	Chemical Approaches for Miscellaneous / Crowding Live Systems
Project/Area Number	17H06347
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Allocation Type	Single-year Grants
Review Section	Science and Engineering
Research Institution	Kyoto University
Principal Investigator	Hamachi Itaru 京都大学, 工学研究科, 教授 (90202259)
Co-Investigator(Kenkyū-buntansha)	王子田彰夫九州大学, 薬学研究院, 教授 (10343328) 馬場嘉信名古屋大学, 工学研究科, 教授 (30183916) 杉本直己甲南大学, 先端生命工学研究所, 教授 (60206430)
Project Period (FY)	2017-06-30 – 2022-03-31
Keywords	分子夾雑の生命化学 / 分子夾雑の有機化学 / 分子夾雑の理論・物理化学 / 分子夾雑の分析・応用化学
Outline of Final Research Achievements	In the Grant-in-Aid for Scientific Research on Innovative Area “Chemistry for Multimolecular Crowding Biosystems", which was performed for 5 years from 2017, the administrative group organized the project according to the plan described in the application form. As a comprehensive judgment, we believe that many researches originally planned has made great progress and has been highly admired by researchers in Japan and overseas. In fact, we received high evaluation in the mid-term evaluation of the area in 2019 (Evaluation: A "Progress as expected is recognized in light of the purpose of setting the research area"). Through our activities in the field, we have opened up new research directions on various issues of multimolecular crowding biosystems that have neither been recognized nor explored well to date, at the world top level.
Free Research Field	ケミカルバイオロジー
Academic Significance and Societal Importance of the Research Achievements	細胞を基本単位とする生命システムは、様々な物質（分子）が高濃度雑多に混在する分子夾雑な環境である。これまでそれを無視して、純粋な理想溶液系での生命分子解析や生体機能制御分子の開発が行われてきたため、得られた結果は実際の生命系では適用できないことも多く、大きな壁となってきた。この「分子夾雑」に合成化学、理論・物理化学、分析・応用化学を三つの基軸として取組み、情報科学、工学、薬学、医学など幅広い領域の力を結集して、分野融合的な新学術領域としての“分子夾雑の生命化学”を創成した。今後、分子夾雑環境でこそ機能する新たな分子ツール、解析技術が開拓され、創薬や医療診断を革新すると期待される。