2022 Fiscal Year Final Research Report
Synergy pharmaceutical science: understanding and design of compound combination effects by integrating information, material, and life sciences
| Project Area | Synergy pharmaceutical science: understanding and design of compound combination effects by integrating information, material, and life sciences |
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| Project/Area Number |
20H05796
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| Research Category |
Grant-in-Aid for Transformative Research Areas (B)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (IV)
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2020-10-02 – 2023-03-31
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| Keywords | シナジー創薬学 / 化合物相乗効果 / 薬剤シナジー / 生体分子ネットワーク / 生命システム |
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| Outline of Final Research Achievements |
Chemotherapy that utilizes the synergistic effect of a combination of multiple drugs (drug synergy) has been recognized as an effective method for treatment of multifactorial diseases such as cancer and neurodegenerative diseases. In addition to enhancing the therapeutic effect, it has the advantages of reducing the amount of individual drugs and reducing the frequency of serious side effects. In recent years, in the fields of material science and life science, various big data on genes, proteins, drugs and compounds have been generated and accumulated. In this research, we advocate a new academic field called "synergy pharmaceutical science" that systematically studies drug synergies, and aim at understanding of drug synergistic effects and construction of design methods through the collaboration of information science, material science, and life science.
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| Free Research Field |
バイオインフォマティクス
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| Academic Significance and Societal Importance of the Research Achievements |
これまで臨床研究での偶発的発見や限られた薬剤ペアに対する実験的検証に留まっていた薬剤シナジーに対し、本研究では、薬剤全ての組合せをAIで探索することで、これまでのボトルネックであった組合せ爆発の問題の解決に寄与する。薬剤シナジーは多剤併用療法という形で医療に実践されているが、その薬剤選択基準は、医師の経験知に大きく依存しているのが現状であり、疾患の種類や患者の病態に大きく依存する。本研究では、経験知に大きく基づいた従来の多剤併用療法の概念を革新し、科学的根拠に裏付けされた薬剤シナジーによる新しい医療・創薬戦略の確立に貢献する。
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