Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity

2015 Fiscal Year Final Research Report

• Project Area: Coupling of replication, repair and transcription, and their common mechanism of chromatin remodeling
• Project/Area Number: 22131001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Gakushuin University
• Principal Investigator: Hanaoka Fumio 学習院大学, 理学部, 研究員 (50012670)
• Co-Investigator(Kenkyū-buntansha): IKURA Tsuyoshi 京都大学, 放射線生物研究センター, 准教授 (70335686)
• Co-Investigator(Renkei-kenkyūsha): SEKI Masayuki 東北薬科大学, 薬学部, 教授 (70202140) ; URA Kiyoe 千葉大学, 大学院理学研究科, 教授 (80289363) ; YASUI Akira 東北大学, 加齢医学研究所, 教授 (60191110) ; KOHNO Takashi 国立がん研究センター, 研究所, 分野長 (80280783) ; YAMAGATA Yuriko 熊本大学, 生命科学研究部, 教授 (40183678) ; TANAKA Kiyoji 大阪大学, 生命機能研究科, 特任教授 (80144450) ; IDE Hiroshi 広島大学, 理学研究科, 教授 (30223126)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: ゲノム / DNA複製 / DNA修復 / 転写 / ヒストン修飾 / クロマチンリモデリング / 領域運営 / 国際発信

Outline of Final Research Achievements

DNA metabolisms such as replication, repair and transcription all utilize chromatin structure and are functionally coupled with each other. We aimed at promoting the activities of the group research to clarify the common mechanism of chromatin remodeling and to create a new paradigm of these molecular dynamics. We promoted: 1) efficient management of the research group, 2) international visualization of our research, 3) improvement of the research management based on external evaluation, 4) inter-disciplinary and collaborative researches between related research areas and support of meetings, and 5) support for career of young investigators.

Free Research Field

分子生物学