Reorganization of dynamic network by oscillatory modulation

2019 Fiscal Year Final Research Report

• Project Area: Non-linear Neuro-oscillology: Towards Integrative Understanding of Human Nature
• Project/Area Number: 15H05880
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Ritsumeikan University (2016-2019); Kyoto University (2015)
• Principal Investigator: Mima Tatsuya 立命館大学, 先端総合学術研究科, 教授 (20324618)
• Co-Investigator(Kenkyū-buntansha): 牛場 潤一 慶應義塾大学, 理工学部(矢上), 准教授 (00383985) ; 神作 憲司 獨協医科大学, 医学部, 教授 (60399318) ; Altmann C 京都大学, 学内共同利用施設等, 講師 (20572051)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: オシレーション

Outline of Final Research Achievements

In this study, we proposed a novel hypothesis based on the "network pathology" that the emergence of neuropsychiatric disorders and functional recovery from them involve alterations (reorganization) of dynamic networks based on oscillation. As an experimental intervention research group in this project, we conducted joint research with group A, group C, and other accepted groups to search for new oscillation phenomena in healthy people and patients with neuropsychiatric disorders, and developed biomarkers for movement disorders such as stroke and Parkinson's disease. We have succeeded in developing a human brain plasticity induction method by controlling oscillation and demonstrated the rehabilitation effect in hemiparetic patients with stroke.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

領域内の融合的研究の相乗効果によって、動的ネットワークの再組織化を可能としてネットワーク病態の治療に繋がる新しい発振現象操作の手法を開発した。とくに、A02班と協力してクローズドループの考え方で、歩行リズムとほぼ一致したパターン刺激を出力するシステムを開発したことは、超高齢社会である日本では重要な健康課題を扱った臨床研究として、多くのマスメディアの注目を集めた。さらに多施設で臨床実験と解析を行うとともに、パーキンソン病への臨床応用も進めている。