Mapping device for multimolecular crowding biosystems in cancer microenvironment

2021 Fiscal Year Final Research Report

• Project Area: Chemical Approaches for Miscellaneous / Crowding Live Systems
• Project/Area Number: 17H06354
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Nagoya University
• Principal Investigator: Baba Yoshinobu 名古屋大学, 工学研究科, 教授 (30183916)
• Co-Investigator(Kenkyū-buntansha): 小野島 大介 名古屋大学, 未来社会創造機構, 特任准教授 (40510219)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Keywords: ナノバイオ / 分子夾雑

Outline of Final Research Achievements

In this study, we aimed to create a mapping device for multimolecular crowding biosystems in cancer microenvironment based on development of a nanobiodevice and analysis of intercellular communication in the biosystems. We developed a device which can capture cancer cells at a single-particle level. In addition, using combination of optical measurement and machine learning, classification analysis of single cell was conducted. Moreover, we analyzed multimolecular crowding biosystems in early-stage and advanced cancers from evaluation of exosomes derived from cancer cells.

Free Research Field

分析・応用化学

Academic Significance and Societal Importance of the Research Achievements

本研究により、材料工学・分析化学・腫瘍医学の学際領域の学理に基づいた生体場の化学を取り入れた新しいナノバイオ夾雑環境デバイスが開発され、これを利用した分子夾雑解析の手法が創出されたことに学術的意義を有する。また、今後当該デバイス群を利用した早期及び進行がんの分子夾雑解析を進めることで、健康長寿社会へ貢献できる点において社会的意義があると考えられる。