2011 Fiscal Year Final Research Report
Regulation of autoimmunity by self-reactive regulatory T cells
Project Area | Immunological Self Recognition and its Disorders |
Project/Area Number |
19059014
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
HORI Shogei 独立行政法人理化学研究所, 免疫恒常性研究ユニット, ユニットリーダー (50392113)
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Project Period (FY) |
2007 – 2011
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Keywords | 自己免疫 / 免疫寛容 / 自己反応性 / T細胞レセプター / 抗原特異性 / 制御性T細胞 / 細胞分化 |
Research Abstract |
Foxp3^+ regulatory T (Treg) cells play a key role in establishing and maintaining natural self-tolerance. We have established a novel method for high-throughput analysis of the T cell receptor (TCR) repertoire using the next generation sequencing technology. By applying this method, we have analyzed the TCR repertoires of Foxp3^+ and Foxp3^- T cells and found that they are largely distinct. While this dissimilarity was established within the thymus, the repertoire of Foxp3^+ T cells was reshaped substantially in the periphery. In addition, we have also found that the normal T cell repertoire harbored a population of Foxp3- helper T cells with previous history of Foxp3 expression and that their TCR repertoire was distinct from Foxp3^+ Treg cells. Our results suggest that TCR specificity plays a central role in the lineage commitment of Treg cells.
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Research Products
(15 results)
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[Journal Article] Induction of colonic regulatory T cells by indigenous Clostridium species2011
Author(s)
Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K.
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Journal Title
Science
Volume: 331
Pages: 337-341
Peer Reviewed
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[Journal Article] Activated regulatory T cells are the major T cell type emigrating from sensitized skin2010
Author(s)
Tomura M, Honda T, Tanizaki H, Otsuka A, Egawa G, Tokura Y, Waldmann H, Hori S, Cyster JG, Watanabe T, Miyachi Y, Kanagawa O, Kabashima K.
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Journal Title
Journal of Clinical Investigation
Volume: 120
Pages: 883-893
Peer Reviewed
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