2012 Fiscal Year Final Research Report
Construction of Densely Packed Hybrid Biointerfase
| Project Area | Molecular Soft-Interface Science |
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| Project/Area Number |
20106011
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Keitaro 東京大学, 総合文化研究科, 准教授 (60392172)
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| Project Period (FY) |
2008 – 2012
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| Keywords | バイオインターフェース |
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| Research Abstract |
In recent years, improvement of culture technique is desired to achieve effective cellular differentiation of not only cell lines but also stem cells. However, cells are subj ected to various stresses when they attach the culture equipment. Accordingly, it is essential to design a new biointerface, which gives minimum or no damage to cells. In this study, we have fbcused on reactive oxygen species (ROS), which is generated by contact with culture substrates. Because excessively generated ROS tends to increase cellular activation, we designed surface coating materials, which scavenge ROS effectively. ROS-induced-differentiation of leukemic cells which contacted with our polymer surface was investigated in this study.
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Research Products
(75 results)
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[Journal Article] Pharmacokinetic Study and In Vivo Cancer Boron Neutron Capture Therapy Based on Core-Polymerized and Boron-Conjugated Micelles2012
Author(s)
Shogo Sumitani, Motoi Oishi, Tatsuya Yaguchi, Hiroki Murotani, Yukichi Horiguchi, Minoru Suzuki, Koji Ono, Hironobu Yanagie, Yukio Nagasaki
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Journal Title
Biomaterials
Volume: Volume 33, Issue 13, May
Pages: 3568-3577
DOI
Peer Reviewed
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[Journal Article] Preparation of Highly Dispersible and Tumor-Accumulative, Iron Oxide Nanoparticles -Multi-point Anchoring of PEG-b-poly(4-vinylbenzylphosphonate) Improves Performance Significantly2011
Author(s)
Kodai Ujiie, Naoki Kanayama, Kei Asai, Mikio Kishimoto, Yusuke Ohara, Yoshimasa Akashi, Keiichi Yamada, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Hideto Yanagihara, Eiji Kita, Masayuki Yamaguchi, Hirofumi Fujii, Yukio Nagasaki
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Journal Title
Colloid and Surface B: Biointreface
Volume: 88
Pages: 771-778
Peer Reviewed
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[Journal Article] Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid2011
Author(s)
Hiroto Hatakeyama, Hidetaka Akita, Erika Itoh, Yasuhiro Hayashi, Motoi Oishi, Yukio Nagasaki, R. Danev, K. Nagayama, N. Kaji, H. Kikuchi, Y. Baba, Harashima H
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Journal Title
Biomaterials
Volume: 32(18)
Pages: 4306-4316
Peer Reviewed
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[Presentation] Self Assembled Polymer Drug2012
Author(s)
Yukio Nagasaki,
Organizer
9th International Symposium on Polymer Therapeutics (ISPT)
Place of Presentation
Centro de Investigacion principe Felipe, Valencia, Spain
Year and Date
2012-05-28
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