Deciphering mechanism underlying neuro-vascular wiring by live-imaging using zebrafish

2014 Fiscal Year Final Research Report

• Project Area: Vasculo-neural wiring and their interdependent crosstalk
• Project/Area Number: 22122003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: MOCHIZUKI Naoki 独立行政法人国立循環器病研究センター, 研究所, 部長 (30311426)
• Co-Investigator(Kenkyū-buntansha): KOICHI Miura 国立循環器病研究センター, 研究所, 研究員 (20360349) ; HIROYUKI Nakajima 国立循環器病研究センター, 研究所, 研究員 (10467657) ; HAJIME Fukui 国立循環器病研究センター, 研究所, 研究員 (80551506) ; HARUKO Takano 国立循環器病研究センター, 研究所, 研究員 (40532891)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: イメージング / 血管 / 神経 / 伴走 / ゼブラフィッシュ

Outline of Final Research Achievements

Physiologocal homeostasis of human bodies is mainly regulated by the neural system and the vascular system delivering endocrine hormones. Both systems are consisted of circuits between central to periphery and vice versa. Therefore, neurons and blood vessels are found to exist side by side in certain anatomical regions.
We tried to search for neuro-vascular wiring system in vivo using zebrafish embryos and identified several regions where blood vessels and neurons exhibit parallel growth during embryogenesis. In addition, we demonstrate a mechanism how artery regulate the parallel growth of motor neurons.

Free Research Field

循環器発生・細胞生物学