2014 Fiscal Year Final Research Report
Neocortical layer structure and function
| Project Area | Neural Diversity and Neocortical Organization |
|---|
| Project/Area Number |
22123008
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Ritsumeikan University (2011-2014)
The University of Tokyo (2010) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
UEMURA Takeshi 信州大学, 医学部, 講師 (00372368)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Tomoyuki 富山大学, 大学院医学薬学研究部, 准教授 (90372367)
|
|---|
| Project Period (FY) |
2010-04-01 – 2015-03-31
|
| Keywords | 神経科学 / 大脳新皮質 / シナプス / 脳神経疾患 / 遺伝子 / 学習 / 知的障害 / 自閉症 |
|---|
| Outline of Final Research Achievements |
We found that IL1-receptor accessory protein-like 1 (IL1RAPL1) responsible for intellectual disability and autism spectrum disorder and IL-1 receptor accessory protein (IL-1RAcP) mediate synapse formation of cortical neurons by interacting with presynaptic protein tyrosine phosphatase (PTP) δ. Correspondingly, spine densities of pyramidal neurons in the neocortex and hippocampus are decreased in IL1RAPL1 knockout mice. Furthermore, IL1RAPL1 knockout mice exhibited impairments of learning abilities in spatial reference and working memory tests and fear conditioning tests. We also showed that medium spiny neurons and dopamine D1 receptor in the striatum are required for the contextual fear conditioning.
|
| Free Research Field |
神経科学
|
