Integrative omics analysis to explore molecular targets and biomarkers for personalized medicine in cancer

2014 Fiscal Year Final Research Report

• Project Area: Integrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention
• Project/Area Number: 22134002
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: INAZAWA Johji 東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
• Co-Investigator(Kenkyū-buntansha): INOUE Jun 東京医科歯科大学, 難治疾患研究所, 講師 (50568326) ; TANIMOTO Kosuke 東京医科歯科大学, 難治疾患研究所, 助教 (60611613) ; KOZAKI Ken-ichi 岡山大学, 大学院医歯薬学総合研究科, 教授 (50270715)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: がん / ゲノム / エピゲノム / システム生物学 / 分子標的治療 / マイクロRNA

Outline of Final Research Achievements

Integrative omics analysis was performed to explore molecular targets and biomarkers for personalized medicine in cancer. Several experimental models in vitro/ in vivo were established to uncover malignant properties including epithelial-mesenchymal transition (EMT), and invasion and/or metastasis. Bioresource infrastructure was prepared, and human bioresources have been collected and preserved to facilitate multi-omics data analysis in cancer. Consequently, novel and promising targets and biomarkers including tumor suppressor microRNAs were identified, facilitating the understanding of molecular pathogenesis of intractable cancer.

Free Research Field

分子細胞遺伝学