Clarification of bone mineralization process and hard tissue construction

2015 Fiscal Year Final Research Report

• Project Area: Hyper Bio Assembler for 3D Celluler Innovation
• Project/Area Number: 23106010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tohoku University
• Principal Investigator: Suzuki Osamu 東北大学, 歯学研究科(研究院), 教授 (60374948)
• Co-Investigator(Kenkyū-buntansha): ANADA TAKAHISA 東北大学, 大学院歯学研究科, 准教授 (30398466) ; SHIWAKU YUKARI 東北大学, 大学院歯学研究科, 助教 (80736190)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 石灰化 / 骨 / 骨芽細胞 / 細胞システム

Outline of Final Research Achievements

The present study was designed to investigate whether the arrangement of calcium phosphate mineral crystals in the matrix scaffold affects the cellular activity around the crystals, including the differentiation from the precursor cells, in the mineralized tissue formation. It was apparent that the differentiation of mouse bone marrow derived stromal cells is controlled by the chemical environment associated with the crystals, that the differentiation of murine bone marrow derived mesenchymal stem cells is controlled by the crystal phase and the amount of strain of the matrix around the cells, and that the tissue formation, including the formation of the mineralized tissue and the bone-related non-mineralized tissue, is controlled by the dispersion condition of the crystals in the matrix scaffold material. The presence and the characteristics of the mineral crystals could be a factor to control the mineralized tissue formation.

Free Research Field

バイオマテリアル，骨再生