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2016 Fiscal Year Final Research Report

Development and function of thymic microenvironments

Planned Research

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Project AreaAnalysis and synthesis of multi-dimensional immune organ network
Project/Area Number 24111004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokushima

Principal Investigator

TAKAHAMA Yousuke  徳島大学, 先端酵素学研究所, 教授 (20183858)

Project Period (FY) 2012-06-28 – 2017-03-31
Keywords免疫学 / 胸腺 / 胸腺上皮細胞 / ストローマ細胞 / Tリンパ球分化 / レパトア選択
Outline of Final Research Achievements

This study revealed a novel aspect of positive selection, in which T cell antigen-receptor affinity for positively selecting peptides produced by cortical thymic epithelial cells (cTECs) determines the subsequent antigen responsiveness of mature T cells in the periphery. It was also found that cTEC expression of beta5t, which governs positive selection of CD8+ cytotoxic T cells, is directly promoted by transcription factor Foxn1. Moreover, this study identified that postnatal medullary thymic epithelial cells (mTECs), which establish self-tolerance in T cells, are derived from perinatal bipotent progenitors that exhibit cTEC-like gene expression profiles. Essential role of CCL21 expressed by a subpopulation of mTECs in the establishment of central self-tolerance in T cells was also described.

Free Research Field

免疫学

URL: 

Published: 2018-03-22  

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