2016 Fiscal Year Final Research Report
Mathematical modeling and analysis of virus-host interaction
Project Area | Molecular basis of host cell competency in virus infection |
Project/Area Number |
24115008
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | The Graduate University for Advanced Studies |
Principal Investigator |
Sasaki Akira 総合研究大学院大学, 先導科学研究科, 教授 (90211937)
|
Co-Investigator(Kenkyū-buntansha) |
小柳 義夫 京都大学, ウイルス研究所, 教授 (80215417)
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Project Period (FY) |
2012-06-28 – 2017-03-31
|
Keywords | ウイルスと宿主の共進化 / ヒト化マウス / APOBEC / Vif / cell-to-cell感染 / マルチトロピズム / ネットワーク理論 / 時系列解析 |
Outline of Final Research Achievements |
Coevolution of anti-retroviral protein APOBEC3G (A3G) of humans and its inhibitor Vif of HIV-1 is mathematically modeled, and revealed the the conditions with which coevolution ends up with equilibrium or indefinite escalation of their expression levels. Intra-host dynamics of viruses with multiple tropism is also analyzed with the framework of network dynamics, and its R0-centrality analysis revealed the optimum intervention strategy that typically recommends extremely focussed intervention to the most amplifying tissue.
Comparing the time series data of the infection experiments that excluded cell-to-cell infection of HIV-1 and those with both cell-to-cell and cell-free infections, we quantified their relative contributions to the basic reproductive number of viruses. Infection experiments using polymorphic HIV restriction factor A3H reveals the roles of A3H restriction + type and this counteracting Vif type have played in the coevolutionary dynamism between human and HIV-1.
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Free Research Field |
理論ウイルス学
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