Common priciple underlying memory dynamism based on rodents reconsolidation

2017 Fiscal Year Final Research Report

• Project Area: Principles of memory dynamism elucidated from a diversity of learning systems
• Project/Area Number: 25115002
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: University of Toyama
• Principal Investigator: Inokuchi Kaoru 富山大学, 大学院医学薬学研究部(医学), 教授 (20318827)
• Co-Investigator(Renkei-kenkyūsha): OHKAWA Noriaki 富山大学, 大学院医学薬学研究部(医学), 講師 (80416651) ; SUZUKI Akinobu 富山大学, 大学院医学薬学研究部(医学), 助教 (40424684) ; NOMOTO Masanori 富山大学, 大学院医学薬学研究部(医学), 助教 (20636253)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: 記憶 / 再固定化 / エングラム / 逆行性健忘 / オートファジー / 海馬 / 神経新生 / 長期増強

Outline of Final Research Achievements

Autophagy, a protein degradation system, induces a memory destabilization upon retrieval. Complete retrograde amnesia is accompanied by erasure of memory trace.
Adult neurogenesis plays an important role in the maintenance of hippocampal memory capacity through recovery of saturated neuronal circuits.
Overlapping memory trace is indispensable for linking, but not recall, of individual memories.

Free Research Field

神経科学