2018 Fiscal Year Final Research Report
Mechanisms underlying Src and Wnt-mediated cell competition and their roles in tumorigenesis
| Project Area | Cell competition: a mechanism for survival of the fittest in the multi-cellular community |
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| Project/Area Number |
26114006
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Gunma University (2017-2018)
Kyushu University (2014-2016) |
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Principal Investigator |
Ishitani Tohru 群馬大学, 生体調節研究所, 教授 (40448428)
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| Co-Investigator(Kenkyū-buntansha) |
岡田 雅人 大阪大学, 微生物病研究所, 教授 (10177058)
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| Research Collaborator |
Shimizu Nobuyuki
Sakuma Megumi
Ishitani Shizuka
Haraoka Yukinari
Akieda Yuki
Ogamino Shohei
Zou Juqi
Furuie Hironobu
Kajiwara Kentaro
Kitano Kisuke
Ookura Hiroya
Kawase Naoyuki
Chen Ping-Kuan
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| Project Period (FY) |
2014-07-10 – 2019-03-31
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| Keywords | Wnt / Src / ゼブラフィッシュ / がん / 初期発生 |
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| Outline of Final Research Achievements |
In this study, we have tried to make clear the mechanisms of Src- and Wnt signaling-driven cell competition and their roles in physiological development and tumor progression. We firstly succeeded to establish the in vivo imaging systems for cell competition processes in zebrafish. Using this, we revealed that Wnt signaling-driven cell competition supports developmental robustness. Wnt signaling-driven cell competition senses and eliminates accidentally generated defective cells during zebrafish embryos, whereas inhibition of the cell competition induces the distortion of embryonic patterning.
On the other hand, we discovered that Src-activated cells are basally extruded from MDCK-I cell sheet, whereas, they are basally extruded from MDCK-II cell sheet. We also made clear part of the mechanisms underlying this difference.
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| Free Research Field |
発生生物学・細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
細胞競合による発がん抑制とその破綻による腫瘍形成のプロセスをゼブラフィッシュをモデルに明らかにした。また、これまで細胞競合の生理機能としてはがん抑制機構が注目されてきたが、生理的な発生過程において、健康な体の構築に寄与することを初めて解明した。この成果は、発生生物学、腫瘍学の理解を大きく進めるだけでなく、将来的には、不良細胞の除去によるがんや疾患の予防法など、新たな医療技術にも繋がるだろう。
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