1991 Fiscal Year Final Research Report Summary
Comparative Human Ecology of the Resource Exploiting System : The Second Phase of Survey in Bolivia
| Project/Area Number |
01041028
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Field Research |
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| Research Institution | University of Tokyo |
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Principal Investigator |
KASHIWAZAKI Hiroshi Faculty of Medicine, University of Tokyo, 医学部(医), 講師 (60004735)
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| Co-Investigator(Kenkyū-buntansha) |
TAKASAKA Kouichi School of Health Sciences, Kyorin University, 保健学部, 教授 (00146557)
MOJI Kazuhiko Nagasaki University School of Medicine, 医学部, 助教授 (80166321)
ORIAS Rivera ボリビア国家警察病院, 医師
VARGASーPACHE ハ゜チエコ ボリビア高地生物学研究所, 所長
YOSHINAGA Jun Division of Environmental Chemistry, National Institute for Environmental Stuide, 研究員 (70222396)
WATANABE Chiho Tohoku University School of Medicine, 医学部, 助手 (70220902)
SASAKI Akihiko Division of Environmental Physiology and Hygiene, National Institute of Public H, 生理衛生学部・体力生理室, 室長 (70150175)
KOCHI Arata Tuberculosis Unit, World Health Organization, 結核対策課, 課長
TAKEMOTO Tai-ichiro Nagasaki University School of Medicine, 医学部, 教授 (60010005)
ORIAS Jose Hospital Virgen de Copacabana, Policia Nacional de Bolivia
VARGAS Enrique Facultad de Medicina, Instituto Boliviano de Biologia de Altura
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| Project Period (FY) |
1989 – 1991
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| Keywords | Physical Growth at High Altitude / Blood Pressure and Salt Intake / Selenium and GSH-Px / Doubly-Labeled-Water Method / Nutritional Ecology / Cassava and Cyanide / Recognition Threshold for Taste / Aymara and Moseten |
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| Research Abstract |
The major findings from this research project are summarized as follows :
1. In comparison with those of published data for the other Andean rural and urban populations (Aymara, Quechua and Mestizo at high altitudes), our subjects (Aymara children) had smaller chest dimensions (depth and width) than those of Quechua children, suggesting different process of chest growth in Aymara and Quechua populations.
2. Data on food consumption and daily energy expenditure (24-hour heart rate method) in a typical rural Aymara community of the high Andes showed that calcium and vitamin A intakes were far below the Bolivian recommended dietary allowances. Wide variations in both energy intake and expenditure throughout all age groups were observed.
3. Blood pressure in populations at low and high altitudes indicated no significant differences with changes in altitude. In high-altitude subjects, mean amounts of urinary excretion of both sodium (Na) and potassium (K) were more than twice as high as those
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in low-altitude subjects ; the mean daily urinary Na excretion was about 260 mmole/day (15 g of NaCl) at high altitudes. Multiple regression analysis indicated that age, arm circumference, and altitude (or Hb concentration) were the major determinants of blood pressure. The hypoxic environment and high levels of salt and K consumption may have negated altitude's effects on blood pressure.
4. Selenium dependent glutathione peroxidase (GSH-Px) activities (U/ml-blood) were significantly higher in highlanders than in lowlanders. while the difference was reversed if the activities were expressed in U/g-Hb. Even though Hb concentrations were significantly higher in highlanders, the increase in activities of GSH-Px in this population appeared not to be compatible in magnitude with the increase in Hb concentration.
5. Urine samples from 23 high altitude subjects, who were orally administered doubly-labeled water (DLW) with stable isotopes of oxygen-18 and deuterium, were analyzed with ratio mass spectrometer. Energy expenditure estimated by this method showed that their activity levels were higher (1.3-2 times of basal metabolic rate) than would be expected from literature on the Peruvian high Andes, suggesting a need for reconsidering a hypothesis of age-related energy-saving behavior in resource limiting high Andes.
6. Natives to the lowland (mosetenes) appeared to be more sensitive to identify cassava varieties by taste than migrants (Aymara, Quechua and Chipaya). In a community of migrants, a variety of bitter cassava was used and the concentration of cyanide was as high as 100 times the sweet cassava used among the native Mosetenes. Traditional technology to avoid toxic substances from cyanidecontaining cassava, and its health effects on natives and migrants warrant further study. Less
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[Publications] Imai,H.,Kashiwazaki,H.,Suzuki,T.Himeno,S.,Watanabe,C.,Moji,K.,Kim,SW.,Orias,J.,Takemoto,T: "Selenium and glutathione peroxidase activity in blood in an Andean highland population." Journal of Nutritional Science and Vitaminology. (1992)
Description
「研究成果報告書概要(和文)」より
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[Publications] Kashiwazaki,H.,Imai,H.,Orias,J.,Kim,SW.Watanabe,C.,Moji,K.,Takemoto,T.,Takasaka,K.,Suzuki,T.: "Blood Pressure and Salt Intake in High Altitude Bolivian Aymara:In Proceddings of the Seventh International symposium on Salt." Elsevier Science Publishers,Amsterdam., (1992)
Description
「研究成果報告書概要(和文)」より
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[Publications] Kim, Sw., Kashiwazaki, H., Imai, H., Moji, K., Takemoto, T., Orias-Rivera, J.: "Physical Growth of Aymara Children in a Herding Community of the Bolivian Altiplano." Journal of Human Ergology.20. (1991)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Imai, H., Kashiwazaki, H., Suzuki, T., Himeno, S., Watanabe, C., Moji, K., Kim, SW., Orias, J., Takemoto, T.: "Selenium and glutathione peroxidase activity in blood in an Andean highland population." Journal of Nutritional Science and Vitaminology. (1992)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kashiwazaki, H., Imai, H., Orias-Rivera, J., Kim, SW., Watanabe, C., Moji, K., Takemoto, T., Suzuki, T.: Elsevier Science Publishers, Amsterdam. Blood Pressure and Salt Intake in High Altitude Bolivian Aymara. In : Proceeding of 7th International Symposium on Salt., (1992)
Description
「研究成果報告書概要(欧文)」より
