1991 Fiscal Year Final Research Report Summary
A new health problem due to trichloroethylene - pneumatosis cystoides intestinalis
| Project/Area Number |
01480198
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Yamanashi Medical College |
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Principal Investigator |
SATO Akio Yamanashi Medical College, Department of Environmental Health, Professor, 医学部, 教授 (40020747)
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| Co-Investigator(Kenkyū-buntansha) |
TASAKA Kachio Yamanashi Medical College, Department of Parasitology and Immunology, Associate, 医学部, 助教授 (40093265)
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| Project Period (FY) |
1989 – 1991
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| Keywords | Trichloroethylene / Pneumatosis cystoides intestinalis / Scleroderma / Methanol / Occupational disease |
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| Research Abstract |
1. A factor-control study was conducted in Niigata Prefecture to survey the relationship between the use of trichloroethylene(TPI)and the occurrence of gastrointestinal, cutaneous and articular manifestations. The particular symptom complex suggesting PCI, which is characterized by abdominal fullness, flatus, abdominal pain, constipation and diarrhea, and foamy, bloody stool appeared more frequently in the exposed females.
As to scleroderma-like symptoms, a symptom complex consisting of skin-sclerosis of extremities, face and trunk, thickening and tightening of the skin of fingers(scierodactily), Raynaud's phenomenon of fingers was observed more frequently in the exposed workers of both sexes. A similar survey was also conducted in Nagano prefecture, where abdominal fullness and abdominal pain were found to be dose-dependently complained of in TRI-exposed workers.
2. Scrutiny of 19 PCI cases thus far collected by us in Nagano Prefecture revealed that 1)three aroups of patients(7 in total)were working in the same factories, 2)most of the PCI patients were workers in small-scale factories having poor working conditions, and 3)PCI patients were often simultaneously exposed to TRI and methanol at high concentrations. The last finding suggests that co-exposure to TRI and methanol may play a role in the development of primary PCI.
3. TRI and methanol were given orally to rats daily for 3 months either singly or in combination. Although abdominal barium enema examination performed twice during the experiment revealed no abnormality, histological examination at autopsy revealed that rats treated with TRI in combination with methanol had submucosal and/or subserosal edemas in the colon. It remains to be studied whether this change, which was completely absent in the control group rats, is etiologically related to the development of PCI.
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[Publications] Owa O,Akamatsu T,Matsuda Y,Matsuo K,Hasebe O,Ushimaru H,Mukawa K,Kamijo T,Fujimori Y,Furuta S,Nasu T,and Sato A.: "A case of pneumatosis cystoides intestinalis associated with trichloroethylene developing typical features during the follow-up of undetermined sigmoid lesions." Digestive Endoscopy. 3(4). 560-564 (1991)
Description
「研究成果報告書概要(和文)」より
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[Publications] Owa O, Akamatsu T, Matsuda Y, Matsuno K, Hasebe O, Ushimaru H, Mukawa K, Kamijo T, Fujimori Y, Furuta S, Nasu T, and Sato A.: "A case of pneumatosis cystoides intestinalis associated with trichloroethylene developing typical features during the follow-up of undetermined sigmoid lesions." Digestive Endoscopy. 3(4). 560-564 (1991)
Description
「研究成果報告書概要(欧文)」より
