1992 Fiscal Year Final Research Report Summary
Studies on New Anti-emetic Principles
| Project/Area Number |
02670965
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meiji College of Pharmacy |
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Principal Investigator |
TAKAHASHI Kunio Meiji coll.Pharm. ,Assoc.Prof. -> 明治薬科大学, 生薬学教室, 助教授 (40102933)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATORI Kaoru (木下 薫) ,Assistant, 生薬学教室, 助手 (40247151)
KOYAMA Kiyotaka ,Lecturer, 生薬学教室, 講師 (20225593)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Anti-emetic / Magnolia obovatl / Forsythia suspensa / Inula britannica / Magnolol / Honokiol / Rutin / Chlorogenic acid |
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| Research Abstract |
A New assay method for the screening of anti-emetic activity using frog, and the usefulness of this method were established. By using this method, the anti-emetic activities of 50 Chinese cude drug extracts were compared with the activities of known drugs, chlorpromazine, metoclopramide and ethyl-p-amino-benzoate. As the results, 18 compounds, [6], [8], [10]-shogaol, [6], [8], [10]-gingerol, magnolol, honokiol, beta-eudesmol, cryptomeridiol, rutin, phillyrin, rengyol, taraxasteryl palmitate, taraxasteryl acetate, IF-3, IF-4 and chlorogenic acid, were isolated as anti-emetic principlesby using modern chromatographical techniques, and the structures were identified by a variety of spectraldata.
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