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1992 Fiscal Year Final Research Report Summary

Antitumor Substances of the Mucilage-secrete Plants in W.U.S.A.

Research Project

Project/Area Number 03042017
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionSetsunan University

Principal Investigator

NAKANISHI Tsutomu  Professor, Faculty of Pharmaceutical Sciences, Setsunan University, 薬学部, 教授 (10028855)

Co-Investigator(Kenkyū-buntansha) MURATA Jin  Lecturer, Faculty of Science, University of Tokyo, 理学部, 講師 (90134452)
YAMAMOTO Hirobumi  Research Associate, Gifu Pharmaceutical University, 助手 (40210554)
TANAKA Toshiyuki  Research Associate, Gifu Pharmaceutical University, 助手 (60137065)
IINUMA Munekazu  Associate Professor, Gifu Pharmaceutical University, 助教授 (70082998)
MIZUNO Mizuo  Professor, Gifu Pharmaceutical University, 教授 (00082967)
FRANK A.LANG  Southern Oregon College, Professor
MURATA Hiroko  Research Associate, Faculty of Pharmaceutical Sciences, Setsunan University, 薬学部, 助手 (20167620)
INADA Akira  Associate Professor, Faculty of Pharmaceutical Sciences, Setsunan University, 薬学部, 助教授 (70095305)
LANG Frank A.  Professor, Department of Botany, Southern Oregon State College
Project Period (FY) 1991 – 1992
KeywordsWestern North American plant / Surface exudate / HIV-1 reverse transcriptase inhibitor / Epstein-Barr virus / Anti tumor-promotor / Cytotoxicity / Anti tumor effect / Anti tumor constituent
Research Abstract

Acetone, ethanol, and/or 70% aqueous ethanol extracts of 3 lichens and 83 species of higher plants (82 Spermatophytes and a Pteridophyte) (containing 46 species of plants with surface exudates), collected from SW Oregon and NW California in Summer of 1991, were tested for their inhibitory effects on HIV-1 reverse transcriptase (RT), their inhibitory effects on the Epstein-Barr virus (EBV) activation, and their cytotoxic activities against cultured P-388 cancer cells, respectively.
Significant inhibitory effects on HIV-1 RT were observed in 46 species and especially, ethanol extracts of polygonum majos, Purshia tridentata, Ceanothus integerrimus, Grindelia nana and other 2 species showed more potent inhibition than 20% at 0.5 mug/ml concentration. Furthermore, beta-sitosterol glucoside (IC_<50>=1.8 mug/ml) isolated from Purshia tridentata, and ursolic and betulinic acids (IC_<50>=1.4 and 0.8 mug/ml,respectively) from Amelanchier alnifolia var. pumila showed potent inhibition on HIV-1 RT.
… More Acetone extracts of 15 species (Eriodictyon californicum and others) and ethanol extracts of 47 species (Sophora leachiana and others) showed significant inhibition on the EBV activation. Furthermore, 3 flavanones [5,7-(OH)_2 flavanone, etc.] isolated from E. californicum and 4 flavonols (ermarin, etc.) from Cordylanthus viscidus gave potent inhibition on the EBV activation.
Cytotoxic activities against P-388 cells were examined in 115 extracts (57 species) which are giving no desirable results at present.
Similarly, acetone, ethanol (or methanol), and/or 70% aqueous ethanol (or methanol) extracts of a lichen and 162 species of higher plants (160 Spermatophytes and 2 Pteridophytes), collected from SE Oregon in Summer of 1992 have been subjected to the before-mentioned three types of the biological tests. Up to date, it has been revealed that 9 extracts from Rosa woodsii, Ribes aureum, and other 3 species showed potent inhibitory activities on HIV-1 RT and 14 extracts from Pentagrama triangularis, Prunus emarginata and other 10 species, potent inhibitory effects on the EBV activation. Less

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Munekazu IINUMA: "Five Noumal Phenolics fron the Underground Parts of Vancouveria hexanda" Heterocycles. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Munekazu IINUMA: "Chemical Constituents in the Genus Achrys" Joumal of Natural Products.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsutomu NAKANISHI: "Antiviral and Antitumour Activities of Some Westem North American Plants with Surface Exudates(1)" Shoyakugaku Zasshi.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsutomu NAKANISHI: "Five Normal Phenolics from the Underground Parts of Vancouveria hexandra" Heterocycles.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Munekazu IINUMA: "Chemical Constituents in the Genus Achrys" Journal of Natural Products.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Munekazu IINUMA: "Antiviral and Antitumour Activities of Some Western North American Plants with Surface Exudates (1)" Shoyakugaku Zasshi.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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