Assessment of pathopysiologic diagnosis and quantitative evaluation of therapeutic effect in cardiac failure by using myocardial metabolic and receptor imaging.

1998 Fiscal Year Final Research Report Summary

• Project/Area Number: 07407026
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: NISHIMURA Tsunehiko Osaka University Medical School, Professor, 医学部, 教授 (70237733)
• Co-Investigator(Kenkyū-buntansha): OKADA Tomoya Osaka University Medical School, Medical Staff, 医学部・附属病院, 基礎系医員 ; YAMAMOTO Haruko Osaka University Medical School, Medical Staff, 医学部・附属病院, 医員 ; SEIKE Yujiro Osaka University Medical School, Medical Staff, 医学部・附属病院, 医員 ; OKU Naohiko Osaka University Medical School, Medical Staff, 医学部・附属病院, 医員 ; HASHIKAWA Kazuo Osaka University Medical School, Lecturer, 医学部・附属病院, 講師 (70281128)
• Project Period (FY): 1995 – 1998
• Keywords: Metabolism / Receptor / SPECT / PET / Hypertrophic cardiomyopathy / Dilated cardiomyopathy / beta-blocker

Research Abstract

Assessment of pathophysiologic diagnosis and quantitative evaluation of therapeutic effect in cardiac . failure has been investigated by using myocardial metabolic and receptor imaging from 1995 to 1998. The following researches were done from the basic and clinical points.
1. basic research using isolated perfused rat heart and autoradiography
Metabolism of ^<123>I-BMIPP was clarified by isolated perfused rat heart model. Glucose uptake in stunned myocardium was also clarified by ^<31>P-MR spectroscopy and it was confirmed to be caused by the translocation of glucose transporter. Tracer kinetics of ^<99M>Tc-nitroimidazole was also clarified. These tracers were applied to animal models such as DCM hamster (Bio l4_<beta>6) etc. It was conformed that the metabolic and receptor changes were preceded before the flow and functional changes by autoradiography.
2. clinical research using SPECT and PET
^<123>I-BMiPP myocardial SPECT was useful for the assessment of severity of hypertrophic cardiomyopathy (HCMz) and therapeutic effect of Coenzyme Q1O in dilated cardiomyopathy (DCM). ^<123>I-MIBG was useful for the severity and therapeutic effect of BETA-blocker in DCM.Furthermore, ^<18>F-FDG myocardial PET was extremely useful for the pathophysiologic diagnosis of HCM and DCM.These findings should be necessary for the indication of heart transportation.

Research Products

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  • Description: 「研究成果報告書概要(和文)」より
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  • Description: 「研究成果報告書概要(和文)」より
• [Publications] T.Morozumi et al: "Myocardial iodine-123-metaiodobenzylguanidine images and autonomic nerve activity in normal subject" The Journal of Nuclear Medicine. 38. 49-52 (1997)
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• [Publications] Y.Watanabe et al: "Contribution of hypoxia to the development of cardiomyopathy in hamsters" Cardiovascular Research. 35. 217-222 (1997)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] T.Uehara et al: "Myocardial glucose metabolism in patients with hypertrophic cardiomyopathy : Assessment by F-18-FDG PET study" Annals of Nuclear Medicine. 12. 95-103 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] T.Nishimura: "Recent advanced of 123I-BMIPP myocardial SPECT for evaluating ischemic heart disease and cardiomyopathy" Nuklearmedizin. 37. S41-44 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 西村 恒彦: "心筋SPECTの新しい展開" 南江堂, 240 (1994)
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• [Publications] 西村 恒彦: "心臓核医学検査" メディカルビュー社, 180 (1998)
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• [Publications] S.L.Chen et al.: "Myocardial metabolism of ^<123>I-BMIPP in patients with hypertrophic cardiomyopathy : Assessment by radial long-axis SPECT." Nucl Med Commun. 16. 336-343 (1995)
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• [Publications] Y.Yamamichi et al.: "Metabolism of Iodine-123-BMIPP in perfused rat heart." J Nucl Med. 36. 1043-1050 (1995)
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• [Publications] T.Morozumi et al.: "Effect of beta -blockade on regional left entricular function in patients with dilated cardiomyopathy." J Nucl Cardiol. 3. 231-237 (1995)
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• [Publications] T.Shimonagata et al.: "Scintigraphic assessment of silent myocardial ischemia after early infarction using myocardial SPECT imaging with ^<201>Tl and ^<123>I-MIBG." Nucl Med Commun. 16. 893-900 (1995)
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• [Publications] H.Moriwaki et al.: "Functional and anatomic evaluation of carotid atherothrombosis : A combined study of indium-111 platelet scintigraphy and B-Mode ultrasonograph." Arterioscl Thromb Vas. 15. 2234-2240 (1995)
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• [Publications] K.Hashimoto et al.: "Paradoxical uptake of F-18 fluorodeoxyglucose by successfully reperfused myocardium during the sub-acute phase in patients with acute myocardial infarction." Ann Nucl Med. 10. 93-98 (1996)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] K.Fukuchi et al.: "Ischemic and reperfused myocardium detected with technetium-99m-nitroimidazole." J Nucl Med. 37. 761-766 (1996)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] S.Morishita et al.: "Kinetics of radioiodinated species in subcellular fractions from rat hearts following administration of iodine-123-labelled 15-(p=iodophenyl)-3-(R,S)-methylpentadecanoic acid (^<123>I-BMIPP)." Eur J Nucl Med. 23. 383-389 (1996)
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• [Publications] T.Shimonagata et al.: "A case of hypertensive-diabetic cardiomyopathy demonstrating left ventricular wall motion abnormality" Diabetes Care. 19. 887-891 (1996)
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• [Publications] T.Morozumi et al.: "Abnormal iodine-123-MIBG images in healthy volunteers." J Nucl Med. 37. 1686-1688 (1996)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] S.Matsuda et al.: "The effects of proteins on [Ca^<2+>] measurement : Different effects on fluorescent and NMR methods." Cell Calcium. 20. 425-430 (1996)
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• [Publications] S.Fukuoka et al.: "Cerebral hypoperfusion in orthostatic hypotension with globally denrevated myocardium." J Nucl Med. 37. 1824-1826 (1996)
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• [Publications] T.Nishimura et al.: "Prognosis of hypertrophic cardomyoathy : Assessment by ^<123>I-BMIPP myocardial single photon emission comuted tomogrpahy." Ann Nucl Med. 10. 71-78 (1996)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] T.Morozumi et al.: "Myocardial iodine-123-metaiodobenzylguanidine images and autonomic nerve activity on normal subjects." J Nucl Med. 38. 49-52 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] H.Chiba et al.: "Glucose-loading thalium-201 myocardial SPECT." J Nucl Med. 38. 573-577 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] K.Hashimoto et al.: "Enhancement of glucose uptake in stunned myocardium : Role of glucose transporter." Am J Physiol. H1122-H1130 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Y.Kim et al.: "Detection of impaired fatty metabolism in right ventricular hypertrophy : Assessment by I-123 beta-methyl iodophynyl pentadecanoic acid (BMIPP) myocardial single-photon emission computer tomography." Ann Nucl Med. 11. 207-212 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Y.Kim et al.: "Therapeutic effect of co-enzyme Q10 on idiopathic dilated cardiomyopathy : Assessment by iodine-123 labelled 15-(p-iodophenyl)-3 (R,S) -methylpentadecanoic acid myocardial single-photon emission tomorgraphy." Eur J Nucl Med. 24. 629-634 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] K.Fukuchi et al.: "Quantification of systolic count increase in technetium-99m-MBI gated myocardial SPECT." J Nucl Med. 38. 1067-1073 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] E.Tsujimura et al.: "Evaluation of left ventricular ejection fraction from radial long-axis tomography : A new reconstruction algorithm for ECG-gated technetium-99m sestamibi SPECT." Ann Nucl Med. 11. 89-193 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Y.Watanabe et al.: "Contribution of hypoxia to the development of cardiomyopathy in hamsters." Cardiovasc Res. 35. 217-222 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Y.Hirose et al.: "Viable but denervated right ventricular myocardium : A case of eisenmenger reaction." Cardiology. 88. 609-612 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Y.Shimotsu et al.: "Acetazolamide induced myocardial ischemia in patients with severe coronary artery disease." Ann Nucl Med. 12. 21-27 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Y.Shimotsu et al.: "Combined thallium-201 myocardial with techneitum-99m-HMPAO brain SPECT : Myocardial ischemia induced by acetazolamide in severy coronary artery disease." J Nucl Med. 39. 408-410 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Y.Ito et al.: "Comparison of dual-isotope acquisition of ^<201>Tl and ^<99m>Tc-tetrofosmin for the detection of ischemic heart disease and determination of the optimal imaging time of ^<99m>Tc-tetrofosmin." J Med Commun. 19. 119-126 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] T.Uehara et al.: "Myocardial glucose metabolism in patients with hypertrophic cardiomyopathy : Assessment by F-18-FDG PET study." Ann Nucl Med. 12. 95-103 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] K.Imahashi et al.: "Alteration of intracellular Na^+ during ischemia in diabetic rat hearts : The role of reduced activity in Na^+/H^+ exchange against stunning." J Mol Cell Cardiol. 30. 509-517 (1998)
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• [Publications] K.Fukuchi et al.: "Assessment of reperfused myocardium using a new ischaemia-avid imaging agent, technetium-99m HL91 : Comparison with myocardial glucose uptake." Eur J Nucl Med. 25. 361-366 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] T.Shimonagata et al.: "Metabolic changes in hibernating myocardium after percutaneous transluminal coronary angioplasty and the relation between recovery in left ventricular function and free fatty acid metabolism." Am J Cardiol. 82. 559-563 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] T.Nishimura et al.: "Prediction of functional recovery and prognosis in patients with acute myocardial infarction by ^<23>I-BMIPP and ^<201>Tl myocardial single photon emission computed tomography : A multicenter trial." Ann Nucl Med. 12. 237-248 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] H.Kusuoka et al.: "Difference in the mechanisms for compensating ischemic acidosis in diabetic rat hearts." J Mol Cell Cardiol. 30. 1643-1649 (1998)
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• [Publications] H.Nonogi et al.: "Efficacy and limitation of F-18-fluorodeoxyglucose positron emission tomogrphy during fasting to assess myocardial viability in the acute phase of myocardial infarction." Internal Medicine. 37. 653-661 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] K.Sakamoto et al.: "Mechanism of impaired left ventricular wall motion in the diabetic heart withou coronary artery disease." Diabetes Care. 21. 2123-2128 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Y.Shimotsu et al.: "Fluorine-18-fluorodeoxyglucose PET identification of cardiac metastasis arising from uterine cervical carcinoma." J Nucl Med. 39. 2084-2087 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] S.Hasegawa et al.: "Glucose tolerance and myocardial F-18 fluorodeoxyglucose uptake in normal regions in coronary heat disease patients." Ann Nucl Med. 6. 363-368 (1998)
  • Description: 「研究成果報告書概要(欧文)」より