1998 Fiscal Year Final Research Report Summary
Evaluation of human diets of two different populations on diseases incidence ; by experimental animal system
Project/Area Number |
09660145
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
食品科学・栄養科学
|
Research Institution | Tokyo University of Agriculture |
Principal Investigator |
KANKE<YUSUKE Tokyo University of Agriculture, Faculty of Applied Biological Science Professor, 応用生物科学部, 教授 (20109565)
|
Co-Investigator(Kenkyū-buntansha) |
AKABANE Masayuki Junior Collage of Tokyo Univ. of Agri., Professor Emeritus, 短期学部・栄養学科, 名誉教授 (50078135)
IWASAKI Masae Tokyo Univ. of Agri., Research Associate Professor, 応用生物科学部, 助手 (70266881)
IWAMA Masahiko Tokyo Univ. of Agri., Assistant Professor, 応用生物科学部, 講師 (10168594)
SEYAMA Yoshiyuki Hoshi College of Pharmacy, Professor, 臨床化学教室, 教授 (90061283)
IITOI Yuji Collage of Tokyo Univ. of Agri., Associate Professor, 短期学部・栄養学科, 助教授 (20078215)
|
Project Period (FY) |
1997 – 1998
|
Keywords | Disease structure / Regional population / Diet evaluation / Animal experiment / Hepatic drug-metabolizing enzymes / Aortic connective tissue / Carbontetrachloride |
Research Abstract |
To clarify the associations between local dietary habits and disease risks, hepatic enzyme system of drug metabolism and aortic connective tissue component levels were investigated in rats fed the complete human diet consumed in the two Japanese prefectures, Akita (A) and Okinawa (O), where the incidence of cancers was quite different : Okinawa had the lowest and Akita the highest age-adjusted mortality rate. Male Wistar rats were divided into three groups of 10 animals each : the first (control, C) group was fed the MF animal diet (Oriental Yeast, Tokyo, Japan), the second (Akita, A) group the freeze-dried powder from Akita's meals, and the third (Okinawa, O) group the mill of Okinawa's meals. After animals were given the corresponding diets for eight weeks, the final body weight of the O diet group was significantly higher than that of the A diet group, presumably because of the difference in food efficiency. However, there were no changes between two groups in the hepatic drug-metabolizing enzyme system (cytochrome P-450 content and activities of sulfotransferase, UDP-glucuronyltransferase, glutathione S-transferase) and aortic connective tissue component levels (collagen, elastin and cholesterol). Moreover, the CClィイD24ィエD2 treatment changed, regardless of human (A and O) diets, the serum and hepatic enzyme levels.
|