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2000 Fiscal Year Final Research Report Summary

The evaluation of myocardial angiogenesis by contrast echo-cardiogram

Research Project

Project/Area Number 10470169
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOsaka City University

Principal Investigator

YOSHIKAWA Junichi  Department of Internal Medicine and Cardiology, Osaka City University School of Medicine, Professor and Chairman, 医学部, 教授 (60275245)

Co-Investigator(Kenkyū-buntansha) OMURA Takashi  Department of Internal Medicine and Cardiology, Osaka City University, School of Medicine, Assistant Professor, 医学部, 助手 (70295707)
YOSHIYAMA Minoru  Department of Internal Medicine and Cardiology, Osaka City University, School of Medicine, Associate Professor, 医学部, 講師 (30240956)
Project Period (FY) 1998 – 2000
KeywordsMyocardium / Ischemia / Echocardiography / gene expression
Research Abstract

Recently, microbubble can be used as a contrast agent and We try to detect the myocardial perfusion. We also try to make angiogenesis by gene therapy. The purpose of this study is to make angiogenesis by gene therapy and angiogenesis can be evaluated by contrast agent. In the first year, we succeeded to hace myocardila infarcted model in rat and mice. We analyzed signal transduction and mRNA expressions after myocardial infarction and evaluated morphological change and cardiac function by echocardiogram. In the second year, we could get gene transfer method by adeno virus vector and myocardial perfusion could be evaluated by contrast echocardiography. In the last year, we try to transfer gene to the myocardium in vivo model. This protocol is now on going. In clinical, we can detect myocardial perfusion by echo-contrast agent.
In experimental and clinical research, we will detect microcirculation and collateral flow in the myocardium near future.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 大村崇: "Differences in time course of myocardial mRNA expression-"Basic Res Cardiol. 95. 316-23 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大村崇: "Angiotensin blockade inhibits SIF DNA binding activities -"J Mol Cell Cardiol. 32. 23-33 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] 秋岡要: "Prognostic value of Doppler transmittal -"Heart Vessels. 15. 53-60 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 平田久美子: "Reverse redistribition of thallium-201 myocardial -"Jpn Circ J. 64. 345-51 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] 市場直也: "Images in cardiovascular medicine."Circulation. 101. 1754-5 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] 小林芳樹: "Left ventricular electrome chanical mapping -"Circulation. 102. E25-6 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] Akioka K, Takeuchi K, Yanagi S, Hirota K, Sakamoto K, Yoshimura T, Toda I, Yoshikawa J.: "Prognostic value of Doppler transmittal flow patterns and cardiac natriuretic peptides in patients with chronic congestive heart failure admitted for episodes of acute decompensation."Heart Vessels.. 15. 53-60 (2000)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Hirata K, Yamagishi H, Tani T, Sakanoue Y, Akioka K, Takeuchi K, Yoshikawa J, Ochi H.: "Reverse redistribution of thallium-201 myocardial single photon emission tomography and contractile reserve."Jpn Circ J.. 64. 345-51 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichiba N, Shimada K, Hirose M, Kobayashi Y, Hirata K, Sakanoue Y, Toda I, Teragaki M, Akioka K, Takeuchi K, Yoshikawa J.: "Images in cardiovascular medicine. Plaque rupture causing spontaneous coronary artery dissection in a patient with acute myocardial infarction."Circulation.. 101. 1754-5 (2000)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi Y, Shimada K, Yamagishi H, Ehara S, Nakamura Y, Takeuchi K, Yoshikawa J.: "Left ventricular electromechanical mapping in stunned myocardium."Circulation.. 102. E25-6 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Omura T, Yoshiyama M, Takeuchi K, Hanatani A, Kim S, Yoshida K, Izumi Y, Iwao H, Yoshikawa J.: "Differences in time course of myocardial mRNA expression in non-infarcted myocardium after myocardial infarction."Basic Res Cardiol.. 95. 316-23 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Omura T, Yoshiyama M, Takeuchi K, Kim S, Iwao H, Yamagishi H, Toda I, Teragaki M, Akioka K, Yoshikawa J.: "Angiotensin blockade inhibits SIF DNA binding activities via STAT3 after myocardial infarction."J Mol Cell Cardiol.. 32. 23-33 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toda I, Teragaki M, Nishida Y, Kobayashi Y, Shimada K, Yoshiyama M, Akioka K, Takeuchi K, Yoshikawa J.: "[Prediction of restenosis after percutaneous transluminal coronary angioplasty using coronary flow reserve. Kansai Doppler Guide Wire Study Group]."Cardiol.. 35. 165-73 (2000)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Yamagishi H, Akioka K, Hirata K, Sakanoue Y, Toda I, Yoshiyama M, Teragaki M, Takeuchi K, Yoshikawa J, Ochi H.: "A reverse flow-metabolism mismatch pattern : a new marker of viable myocardium with greater contractility during dobutamine stress than myocardium with a flow-metabolism mismatch pattern."Jpn.

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      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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