2001 Fiscal Year Final Research Report Summary
Development of analyzing system for studying human dental pulp repair
| Project/Area Number |
12671856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAGAOKA Shigetaka Kagoshima University, Dental School, Associate Professor, 歯学部, 助教授 (10155913)
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| Co-Investigator(Kenkyū-buntansha) |
MOTOO Kitano Kagoshima University, Dental School, Professor, 歯学部, 教授 (10142118)
TOKUDA Masayuki Kagoshima University, Dental School, Research Associate, 歯学部, 助手 (20253891)
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| Project Period (FY) |
2000 – 2001
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| Keywords | dentin-pulp complex / restorative material / pulp capping agent |
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| Research Abstract |
In this study, we investigated the behavior of thick slices from human teeth drilled immediately after extraction and cultured from 3 days to 1 month. Results show that the damaged pulp beneath the cavity is able to develop, in vitro, some typical aspects correlated to tissue healing, evidenced by cell proliferation, neovascularization, and the presence of functional cuboidal cells close to the injured area. After 30 days of culture, elongated spindle-shaped cells can be seen aligned along the edges of the relevant dentin walls, whereas sound functional odontoblasts are well-preserved beneath healthy areas. Tissue recovery leads us to believe that such a culture model will be a useful system for testing factors regulating pulp repair.
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Research Products
(10 results)
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[Publications] Matsusita,K., Motani,R., Sakuta,T., Yamaguchi,N., Koga,T., Matsuo,S., Nagaoka,S., Abeyama,K., Maruyama,I. & Torii,M.: "The role of vascular endolhelial growth factor in human dental pulp cells: Induction, proliferation, and differentiation and activation of the AP-1-dependent signaling pathway"J. Dent. Res.. 79. 1596-1603 (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Oyama,T., Sakuta,T., Matsushita,K., Maruyama,I., Nagaoka,S., Torii,M.Oyama,T., Sakuta,T., Matsushita,K., Maruyama,I., Nagaoka,S., Torii,M.: "Efforts of Roxithromycin on Tumor necrosis Factor-alpha-nduced Vascular Endothelial Growth Factor Expression in Human Periodontal Ligament Cells in Culture"J. Periodont. 71. 1546-1553 (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Sakuta,T., Matsushita,K., Yamaguchi,N., Oyama,T., Motani,R., Koga,T., Nagaoka.S., Abeyama,K., Maruyama,I., & Torii,M.: "Enhanced production of vascular endothelial growth factor by human monocytic cells stimulated with endotoxin through transcription factor SP-1"J. Med. Microbiol. 50. 233-237
Description
「研究成果報告書概要(欧文)」より
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