2002 Fiscal Year Final Research Report Summary
Analysis of Hswi1 in neuroendocrine tumor
| Project/Area Number |
13670177
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kochi Medical School |
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Principal Investigator |
TAKEUCHI Tamotsu Dept. of Pathology, Kochi Medical School Asist. Prof., 医学部, 助手 (50226990)
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| Project Period (FY) |
2001 – 2002
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| Keywords | hSWI1 / neuroblastoma / T-cadherin |
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| Research Abstract |
In the present study, we cloned and mapped a B120 gene, as a truncated human SWI1 gene, to human chromosome 1p35-36.1 where possible suppressor genes for various neuroendocrine tumors including neuroblastoma have been mapped. Expression of the B120 gene product was immunohistochemically investigated in various neuroendocrine tumors including neuroblastomas. We also examined cell-cell adhesion molecule including T-cadherin as an induced molecule by B120 overexpression in various tumors. We further explored that T-cadherin molecule was down-regulated by epigenetic events in many cancers.
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