2002 Fiscal Year Final Research Report Summary
The diagnostic and pathological significance of soluble CD163 in rheumatoid arthritis
| Project/Area Number |
13670464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | Kagoshima University |
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Principal Investigator |
MATSUYAMA Takami Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (30145479)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Motoyuki Kagoshima University, Faculty of Medicine, Research Associate, 医学部, 助手 (30343362)
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| Project Period (FY) |
2001 – 2002
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| Keywords | soluble CD163 / rheumatoid arthritis / hemoglobin / hepatitis |
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| Research Abstract |
The serum levels of soluble CD163 reflected the activity of rheumatoid arthritis. Additionally, the serum levels of soluble CD163 were elevated in active hepatitis. The shedding of soluble CD163 was inhibited by tissue inhibitor of metalloproteinase 3. This finding suggests that ADAM family proteinase might be involved in the cleavage of membranous CD163.
The complex of haptoglobin and hemoglobin was bound to soluble CD163 as previously reported. Additionally, we found that hemoglobin alone could bind to soluble CD163.
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