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2002 Fiscal Year Final Research Report Summary

Detection of susceptible genes for Cedar Pollen Allergy using SNPs in HLA region

Research Project

Project/Area Number 13671795
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNara Medical University

Principal Investigator

IDE Takeshi  Nara Medical University, Medicine, Research Associate, 医学部, 助手 (20094550)

Co-Investigator(Kenkyū-buntansha) ISHITANI Akiko  Nara Medical University, Medicine, Research Assistant Professor, 医学部, 講師 (40112544)
Project Period (FY) 2001 – 2002
KeywordsSNPs / HLA / polymorphism / susceptible gene / KIR gene / Japanese cedar pollinosis / allergy
Research Abstract

1. DNA samples from 92 healthy Japanese and 92 Japanese cedar pollinosis patients were studied. The healthy controls used in this study did not have anti-cedar-pollen , anti-Dactylis pollen, anti-Artemisia pollen, nor anti-mite antibody. Cedar-pollinosis patients had only anti-cedar-pollen antibody.
2. In HLA region, 150 SNPs were tested. Twenty-three SNPs of them were not detected polymorphism, and 28 SNPs of them were detected polimorphism less than 10% showing the ethnic difference between Caucasian and Japanese. Another 99 SNPs showed polimorphism more than 10 %.
3. The SNPs datas were analyzed for the association of SNPs and cedar pollinosis. One region with strong association was found, and the chi-square value was 11, P value was 0.001. And Odds ratio was 5.
4. The DNA samples were also studied for the Killer-Immunoglobulin like Receptor (KIR) gene polymophism. In this point, no significant association of KIR gene polymorphism and cedar pollinosis was found.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 石谷昭子他: "Natural killer immunoglobulin-like receptor(KIR)遺伝子の多形解析"DNA多型. 9. 158-160 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Ishitani, et al.: "Definitive high resolution typing of HLA-E allelic polymorphisms : Identifying potential errors in existing allele data"Tissue Antigens. 60. 206-212 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Ishitani, et al.: "Genetics of immune response : identifying immune variation within the MHC and throughout the genome"Immunological Reviews. 190. 69-85 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akiko Ishitani et al.: "Analysis of natural killer immunoglobulin-like reception (KIR) gene polymorphisms"DNA Polymorphism. 9. 158-160 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akiko Ishitani et al.: "Definitive high resolution typing of HLA-E allelic polymorphisms: Identifying potential errors in existing allele data"Tissuere Antigens. 60. 206-212 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akiko Ishitani et al.: "Genetics of immune response: identifying immune variation within the MHC and throughout the genome"Immunological Reviews. 190. 69-85 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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